DGIdb - TNNC1 Gene Record

TNNC1 7134 Druggable Genome

Alternate Names:

7134
TROPONIN C1, SLOW SKELETAL AND CARDIAC TYPE
TNNC1
CMD1Z
CMH13
TN-C
TNC
TNNC
191040
11943
ENSG00000114854
OTTHUMG00000158572
P63316
TROPONIN C
TNNC1_HUMAN
T12966

Gene Info:

Target Class	Miscellaneous
Target Subclass	Enzyme regulator
Target Class	Other
Target Main Class	Other
Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Sorsa et al., 2001, Binding of levosimendan, a calcium sensitizer, to cardiac troponin C., J. Biol. Chem.
Sorsa et al., 2003, Interaction of levosimendan with cardiac troponin C in the presence of cardiac troponin I peptides., J. Mol. Cell. Cardiol.
Levijoki et al., 2000, Further evidence for the cardiac troponin C mediated calcium sensitization by levosimendan: structure-response and binding analysis with analogs of levosimendan., J. Mol. Cell. Cardiol.
Lehmann et al., 2003, [Is levosimendan an inoprotective drug in patients with acute coronary syndrome undergoing surgical revascularization?]., Anasthesiol Intensivmed Notfallmed Schmerzther
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Kleerekoper et al., 1999, Drug binding to cardiac troponin C., J. Biol. Chem.
Wang et al., 2002, Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil., J. Biol. Chem.
MacLachlan et al., 1990, Binding of a calcium sensitizer, bepridil, to cardiac troponin C. A fluorescence stopped-flow kinetic, circular dichroism, and proton nuclear magnetic resonance study., J. Biol. Chem.
Kleerekoper et al., 1998, Identification of binding sites for bepridil and trifluoperazine on cardiac troponin C., J. Biol. Chem.
Abusamhadneh et al., 2001, Interaction of bepridil with the cardiac troponin C/troponin I complex., FEBS Lett.

LEVOSIMENDAN TNNC1

Interaction Score: 55.65

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name Levosimendan

Novel drug target Established target

PMIDs:
11113122 12967628 10731446 12975736 11752352 10446160

Sources:
TdgClinicalTrial TEND TTD
BEPRIDIL TNNC1

Interaction Score: 7.42

Interaction Types & Directionality:

other/unknown

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12060657 2351672 9525919 11591369

Sources:
TdgClinicalTrial TEND
CHEMBL1601846 TNNC1

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PYROGALLOL RED TNNC1

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PURPUROGALLIN TNNC1

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000114854
- Version: 101_38
Alternate Names:

TNNC1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P63316
- Version: January-2014
Alternate Names:

TNNC1 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Enzyme regulator

Target Class Other

Publications:
TEND: P63316
- Version: 01-August-2011
Alternate Names:

TNNC1 Gene Symbol

P63316 Uniprot Accession

TNNC1_HUMAN Uniprot Id

Gene Info:

Target Subclass Enzyme regulator

Target Main Class Other

Publications:
HingoraniCasas: ENSG00000114854
- Version: 31-May-2017
Alternate Names:

ENSG00000114854 Gene Symbol

TNNC1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Troponin C
- Version: 2020.06.01
Alternate Names:

TN-C TTD Gene Abbreviation

T12966 TTD Target ID

Gene Info:

Publications:
DTC: TNNC1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

TNNC1	Gene Symbol
P63316	Uniprot Accession
TNNC1_HUMAN	Uniprot Id

Trial Name	Levosimendan
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

TNNC1 Gene Record

TNNC1 7134 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

LEVOSIMENDAN TNNC1

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name Levosimendan Novel drug target Established target

PMIDs: 11113122 12967628 10731446 12975736 11752352 10446160

Sources: TdgClinicalTrial TEND TTD

BEPRIDIL TNNC1

Interaction Types & Directionality: other/unknown

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 12060657 2351672 9525919 11591369

Sources: TdgClinicalTrial TEND

CHEMBL1601846 TNNC1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

PYROGALLOL RED TNNC1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

PURPUROGALLIN TNNC1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Ensembl: ENSG00000114854

Alternate Names: TNNC1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P63316

Alternate Names: TNNC1 Gene Symbol

Gene Info: Target Class Miscellaneous Target Subclass Enzyme regulator Target Class Other

Publications:

TEND: P63316

Alternate Names: TNNC1 Gene Symbol P63316 Uniprot Accession TNNC1_HUMAN Uniprot Id

Gene Info: Target Subclass Enzyme regulator Target Main Class Other

Publications:

HingoraniCasas: ENSG00000114854

Alternate Names: ENSG00000114854 Gene Symbol TNNC1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TTD: Troponin C

Alternate Names: TN-C TTD Gene Abbreviation T12966 TTD Target ID

Gene Info:

Publications:

DTC: TNNC1

Alternate Names:

Gene Info:

Publications:

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name Levosimendan

Novel drug target Established target

PMIDs:
11113122 12967628 10731446 12975736 11752352 10446160

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

other/unknown

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12060657 2351672 9525919 11591369

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

TNNC1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

TNNC1 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Enzyme regulator

Target Class Other

Alternate Names:

TNNC1 Gene Symbol

P63316 Uniprot Accession

TNNC1_HUMAN Uniprot Id

Gene Info:

Target Subclass Enzyme regulator

Target Main Class Other

Alternate Names:

ENSG00000114854 Gene Symbol

TNNC1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TN-C TTD Gene Abbreviation

T12966 TTD Target ID