7155 |
DNA TOPOISOMERASE II BETA |
TOP2B |
TOPIIB |
top2beta |
126431 |
11990 |
ENSG00000077097 |
OTTHUMG00000155596 |
PA36672 |
DNA topoisomerase II, beta isozyme |
DNA topoisomerase 2-beta |
DNA TOPOISOMERASE II, BETA ISOZYME (EC 5.99.1.3). [SOURCE:UNIPROT/SWISSPROT;ACC:Q02880] |
TOP2B_HUMAN |
Q02880 |
DNA TOPOISOMERASE II |
TOP2 |
T96144 |
T85733 |
BILU |
Human Readable Name | DRUGGABLE GENOME |
Target Class | Enzymes |
Target Subclass | EC:5.99.1.3 |
Interpro Acc | IPR001241 |
Interpro Acc | IPR002205 |
Uniprot Status | Swiss-Prot |
Interpro Short Name | ATPase-like_ATP-bd |
Interpro Short Name | Topo_IIA |
Interpro Type | Family |
Interpro Short Name | Topo_IIA_A/C |
Interpro Type | Domain |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Name | DNA topoisomerase, type IIA, subunit A/C-terminal |
Interpro Name | ATPase-like, ATP-binding domain |
Interpro Acc | IPR003594 |
Interpro Name | DNA topoisomerase, type IIA |
Gene Biotype | PROTEIN_CODING |
DRUGGABLE GENOME |
ENZYME |
inhibitor (inhibitory) |
Trial Name | Voreloxin |
Novel drug target | Established target |
Mechanism of Interaction | DNA topoisomerase II inhibitor |
inhibitor (inhibitory) |
Trial Name | becatecarin, XL 119, rebeccamycin |
Novel drug target | Established target |
Mechanism of Interaction | DNA topoisomerase II inhibitor |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | DNA topoisomerase II inhibitor |
n/a |
Trial Name | amonafide,Quinamed |
Novel drug target | Established target |
inhibitor (inhibitory) |
Mechanism of Interaction | DNA topoisomerase II inhibitor |
Direct Interaction | yes |
n/a |
inhibitor (inhibitory) |
Mechanism of Interaction | DNA topoisomerase II inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Trial Name | CPX-351, cytarabine + daunorubicin |
Novel drug target | Established target |
n/a |
TOP2B | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
TOP2B | Display Id |
ENSG00000077097 | Ensembl Gene Id |
DNA TOPOISOMERASE II, BETA ISOZYME (EC 5.99.1.3). [SOURCE:UNIPROT/SWISSPROT;ACC:Q02880] | Description |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
DNA TOPOISOMERASE 2-BETA | Uniprot Protein Name |
TOP2B | Uniprot Gene Name |
TOP2B_HUMAN | Uniprot Id |
Interpro Acc | IPR001241 |
Interpro Acc | IPR002205 |
Uniprot Status | Swiss-Prot |
DRUGGABLE GENOME |
TOP2B | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:5.99.1.3 |
PA36672 | PharmGKB ID |
TOP2B | TTD Gene Abbreviation |
T85733 | TTD Target ID |
ENSG00000077097 | Gene Symbol |
TOP2B | Ensembl Id |
DRUGGABLE GENOME |
TOP2B | GENE_SYMBOL |
DNA topoisomerase 2-beta | UNIPROT |
DNA topoisomerase II, beta isozyme | UNIPROT |
TOP2 | TTD Gene Abbreviation |
T96144 | TTD Target ID |
DNA topoisomerase 2-beta | Gene Name |
Q02880 | UniProt ID |
ENZYME |