DGIdb - TXN Gene Record

TXN 7295 Druggable Genome

Alternate Names:

7295
THIOREDOXIN
TXN
TRDX
TRX
TRX1
187700
12435
ENSG00000136810
OTTHUMG00000020480
P10599
THIO_HUMAN
THIOREDOXIN (ATL-DERIVED FACTOR) (ADF) (SURFACE ASSOCIATED SULPHYDRYL PROTEIN) (SASP). [SOURCE:UNIPROT/SWISSPROT;ACC:P10599]
T85616
Trx80

Gene Info:

Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR013766
Interpro Short Name	Thioredoxin_domain
Interpro Name	Thioredoxin domain
Human Readable Name	THIOREDOXIN
Uniprot Status	Swiss-Prot
Target Class	Miscellaneous
Target Subclass	Thioredoxin family
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
THIOREDOXIN

Publications:

Yang J et al., 2012, Gambogic acid deactivates cytosolic and mitochondrial thioredoxins by covalent binding to the functional domain., J Nat Prod

PX-12 TXN

Interaction Score: 30.91

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name PX-12

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
BIOTINYLATED GAMBOGIC ACID TXN

Interaction Score: 15.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22663155

Sources:
DTC
GAMBOGENIC ACID TXN

Interaction Score: 15.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22663155

Sources:
DTC
GAMBOGIC ACID TXN

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22663155

Sources:
DTC

Ensembl: ENSG00000136810
- Version: 101_38
Alternate Names:

TXN Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000136810

Version: 26-July-2011

Alternate Names:

TXN Display Id

ENSG00000136810 Ensembl Gene Id

THIOREDOXIN (ATL-DERIVED FACTOR) (ADF) (SURFACE ASSOCIATED SULPHYDRYL PROTEIN) (SASP). [SOURCE:UNIPROT/SWISSPROT;ACC:P10599] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P10599
- Version: January-2014
Alternate Names:

TXN Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Thioredoxin family

Publications:
HopkinsGroom: P10599
- Version: 11-September-2012
Alternate Names:

TXN Uniprot Gene Name

P10599 Uniprot Accession

ENSG00000136810 Ensembl Gene Id

Gene Info:

Interpro Type Domain

Uniprot Evidence 1: Evidence at protein level

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME, THIOREDOXIN

Publications:
DTC: TXN
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Yang J et al., 2012, Gambogic acid deactivates cytosolic and mitochondrial thioredoxins by covalent binding to the functional domain., J Nat Prod
HingoraniCasas: ENSG00000136810
- Version: 31-May-2017
Alternate Names:

ENSG00000136810 Gene Symbol

TXN Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Thioredoxin
- Version: 2020.06.01
Alternate Names:

TXN TTD Gene Abbreviation

T85616 TTD Target ID

Gene Info:

Publications:

TXN	Display Id
ENSG00000136810	Ensembl Gene Id
THIOREDOXIN (ATL-DERIVED FACTOR) (ADF) (SURFACE ASSOCIATED SULPHYDRYL PROTEIN) (SASP). [SOURCE:UNIPROT/SWISSPROT;ACC:P10599]	Description

TXN	Uniprot Gene Name
P10599	Uniprot Accession
ENSG00000136810	Ensembl Gene Id

Trial Name	PX-12
Novel drug target	Novel Target

TXN Gene Record

TXN 7295 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

PX-12 TXN

Interaction Types & Directionality: n/a

Interaction Info: Trial Name PX-12 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial TTD

BIOTINYLATED GAMBOGIC ACID TXN

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22663155

Sources: DTC

GAMBOGENIC ACID TXN

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22663155

Sources: DTC

GAMBOGIC ACID TXN

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22663155

Sources: DTC

Ensembl: ENSG00000136810

Alternate Names: TXN Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000136810

Alternate Names: TXN Display Id ENSG00000136810 Ensembl Gene Id THIOREDOXIN (ATL-DERIVED FACTOR) (ADF) (SURFACE ASSOCIATED SULPHYDRYL PROTEIN) (SASP). [SOURCE:UNIPROT/SWISSPROT;ACC:P10599] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P10599

Alternate Names: TXN Gene Symbol

Gene Info: Target Class Miscellaneous Target Subclass Thioredoxin family

Publications:

HopkinsGroom: P10599

Alternate Names: TXN Uniprot Gene Name P10599 Uniprot Accession ENSG00000136810 Ensembl Gene Id

Gene Info: Interpro Type Domain Uniprot Evidence 1: Evidence at protein level Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME, THIOREDOXIN

Publications:

DTC: TXN

Alternate Names:

Gene Info:

Publications: Yang J et al., 2012, Gambogic acid deactivates cytosolic and mitochondrial thioredoxins by covalent binding to the functional domain., J Nat Prod

HingoraniCasas: ENSG00000136810

Alternate Names: ENSG00000136810 Gene Symbol TXN Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TTD: Thioredoxin

Alternate Names: TXN TTD Gene Abbreviation T85616 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name PX-12

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

PMIDs:
22663155

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22663155

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22663155

Sources:
DTC

Alternate Names:

TXN Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

TXN Display Id

ENSG00000136810 Ensembl Gene Id

THIOREDOXIN (ATL-DERIVED FACTOR) (ADF) (SURFACE ASSOCIATED SULPHYDRYL PROTEIN) (SASP). [SOURCE:UNIPROT/SWISSPROT;ACC:P10599] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TXN Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Thioredoxin family

Alternate Names:

TXN Uniprot Gene Name

P10599 Uniprot Accession

ENSG00000136810 Ensembl Gene Id

Gene Info:

Interpro Type Domain

Uniprot Evidence 1: Evidence at protein level

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME, THIOREDOXIN

Publications:

Yang J et al., 2012, Gambogic acid deactivates cytosolic and mitochondrial thioredoxins by covalent binding to the functional domain., J Nat Prod

Alternate Names:

ENSG00000136810 Gene Symbol

TXN Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TXN TTD Gene Abbreviation

T85616 TTD Target ID