DGIdb - TYR Gene Record

TYR 7299 Druggable Genome

Alternate Names:

7299
TYROSINASE
TYR
ATN
CMM8
OCA1
OCA1A
OCAIA
SHEP3
606933
12442
ENSG00000077498
OTTHUMG00000167294
Tumor rejection antigen AB
SK29-AB
LB24-AB
Monophenol monooxygenase
TYROSINASE PRECURSOR (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) (TUMOR REJECTION ANTIGEN AB) (SK29-AB) (LB24-AB). [SOURCE:UNIPROT/SWISSPROT;ACC:P14679]
P14679
T97035

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Chen et al., 2009, Identification of an Alkylhydroquinone from Rhus succedanea as an Inhibitor of Tyrosinase and Melanogenesis., J. Agric. Food Chem.
Yoshimori A et al., 2014, Structure-activity relationships of the thujaplicins for inhibition of human tyrosinase., Bioorg Med Chem
Patil et al., 2016, Interaction of small molecules with human tyrosinase: A surface plasmon resonance and molecular docking study., Int. J. Biol. Macromol.
Wang HM et al., 2010, (-)-N-Formylanonaine from Michelia alba as a human tyrosinase inhibitor and antioxidant., Bioorg Med Chem
Potter E et al., 2015, Investigation of fatty acid conjugates of 3,5-bisarylmethylene-4-piperidone derivatives as antitumor agents and human topoisomerase-IIα inhibitors., Bioorg Med Chem

PHENYLTHIOUREA TYR

Interaction Score: 15.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20584613

Sources:
DTC
ALPHA-THUJAPLICIN TYR

Interaction Score: 15.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25288494

Sources:
DTC
KOJIC ACID TYR

Interaction Score: 11.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20584613 25577711

Sources:
DTC
MONOBENZONE TYR

Interaction Score: 7.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tyrosinase inhibitor

PMIDs:
19159217

Sources:
ChemblInteractions TTD
MEQUINOL TYR

Interaction Score: 7.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosinase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HYDROQUINONE TYR

Interaction Score: 0.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
27519292

Sources:
TTD
CHRYSIN TYR

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LUTEOLIN TYR

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000077498
- Version: 101_38
Alternate Names:

TYR Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000077498

Version: 26-July-2011

Alternate Names:

TYR Display Id

ENSG00000077498 Ensembl Gene Id

TYROSINASE PRECURSOR (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) (TUMOR REJECTION ANTIGEN AB) (SK29-AB) (LB24-AB). [SOURCE:UNIPROT/SWISSPROT;ACC:P14679] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TTD: Tyrosinase

Version: 2020.06.01

Alternate Names:

TYR TTD Gene Abbreviation

T97035 TTD Target ID

Gene Info:

Publications:

Tarhini AA et al., 2012, Safety and immunogenicity of vaccination with MART-1 (26-35, 27L), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) in adjuvant with PF-3512676 and GM-CSF in metastatic melanoma., J Immunother

DTC: TYR

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Wang HM et al., 2010, (-)-N-Formylanonaine from Michelia alba as a human tyrosinase inhibitor and antioxidant., Bioorg Med Chem

Potter E et al., 2015, Investigation of fatty acid conjugates of 3,5-bisarylmethylene-4-piperidone derivatives as antitumor agents and human topoisomerase-IIα inhibitors., Bioorg Med Chem

Yoshimori A et al., 2014, Structure-activity relationships of the thujaplicins for inhibition of human tyrosinase., Bioorg Med Chem

ChemblInteractions: TYR
- Version: chembl_23
Alternate Names:

TYR GENE_SYMBOL

Tyrosinase UNIPROT

LB24-AB UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000077498
- Version: 31-May-2017
Alternate Names:

ENSG00000077498 Gene Symbol

TYR Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: TYR
- Version: 01-February-2022
Alternate Names:

Tyrosinase Gene Name

P14679 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Direct Interaction	yes
Mechanism of Interaction	Tyrosinase inhibitor

TYR	Display Id
ENSG00000077498	Ensembl Gene Id
TYROSINASE PRECURSOR (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) (TUMOR REJECTION ANTIGEN AB) (SK29-AB) (LB24-AB). [SOURCE:UNIPROT/SWISSPROT;ACC:P14679]	Description

TYR	GENE_SYMBOL
Tyrosinase	UNIPROT
LB24-AB	UNIPROT

TYR Gene Record

TYR 7299 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20584613

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25288494

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20584613 25577711

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Tyrosinase inhibitor

PMIDs: 19159217

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tyrosinase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 27519292

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Ensembl: ENSG00000077498

Alternate Names: TYR Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000077498

Alternate Names: TYR Display Id ENSG00000077498 Ensembl Gene Id TYROSINASE PRECURSOR (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) (TUMOR REJECTION ANTIGEN AB) (SK29-AB) (LB24-AB). [SOURCE:UNIPROT/SWISSPROT;ACC:P14679] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TTD: Tyrosinase

Alternate Names: TYR TTD Gene Abbreviation T97035 TTD Target ID

Gene Info:

Publications: Tarhini AA et al., 2012, Safety and immunogenicity of vaccination with MART-1 (26-35, 27L), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) in adjuvant with PF-3512676 and GM-CSF in metastatic melanoma., J Immunother

DTC: TYR

Alternate Names:

Gene Info:

ChemblInteractions: TYR

Alternate Names: TYR GENE_SYMBOL Tyrosinase UNIPROT LB24-AB UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000077498

Alternate Names: ENSG00000077498 Gene Symbol TYR Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

Pharos: TYR

Alternate Names: Tyrosinase Gene Name P14679 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
20584613

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25288494

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20584613 25577711

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tyrosinase inhibitor

PMIDs:
19159217

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosinase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
27519292

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

TYR Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

TYR Display Id

ENSG00000077498 Ensembl Gene Id

TYROSINASE PRECURSOR (EC 1.14.18.1) (MONOPHENOL MONOOXYGENASE) (TUMOR REJECTION ANTIGEN AB) (SK29-AB) (LB24-AB). [SOURCE:UNIPROT/SWISSPROT;ACC:P14679] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TYR TTD Gene Abbreviation

T97035 TTD Target ID

Publications:

Tarhini AA et al., 2012, Safety and immunogenicity of vaccination with MART-1 (26-35, 27L), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) in adjuvant with PF-3512676 and GM-CSF in metastatic melanoma., J Immunother

Alternate Names:

TYR GENE_SYMBOL

Tyrosinase UNIPROT

LB24-AB UNIPROT

Alternate Names:

ENSG00000077498 Gene Symbol

TYR Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

Tyrosinase Gene Name

P14679 UniProt ID

Gene Categories:

ENZYME