• Full Name: Guide to Pharmacology Genes Version: 4-March-2015

    Genes

    Total: 1969
    In Groups: 1965
    Inter-Gene Interactions: 0

    Drugs

    Total: 0
    In Groups: 0

    Interactions

    Total: 0

    Full Citation

    Pawson, Adam J., et al. "The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands." Nucleic acids research 42.D1 (2014): D1098-D1106. PMID: 24234439

    Trust Information

    Trust Level: Non-curated
    Interaction Precedence: N/A
    Category Precedence: 7th
  • GO

    • Full Name: The Gene Ontology Version: 08-February-2016

    Genes

    Total: 7278
    In Groups: 6440
    Inter-Gene Interactions: 0

    Drugs

    Total: 0
    In Groups: 0

    Interactions

    Total: 0

    Full Citation

    Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Ashburner M, Ball CA, ..., Rubin GM, Sherlock G. Nat Genet. 2000 May;25(1):25-9. PMID: 10802651

    Trust Information

    Trust Level: Non-curated
    Interaction Precedence: N/A
    Category Precedence: 9th
    • Full Name: Memorial Sloan Kettering IMPACT Version: May-2015

    Genes

    Total: 350
    In Groups: 350
    Inter-Gene Interactions: 0

    Drugs

    Total: 0
    In Groups: 0

    Interactions

    Total: 0

    Full Citation

    Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology. Cheng, Donavan T., et al. The Journal of Molecular Diagnostics 17.3 (2015): 251-264. PMID: 25801821

    Trust Information

    Trust Level: Expert curated
    Interaction Precedence: N/A
    Category Precedence: 1st
    • Full Name: Caris Molecular Intelligence Version: 07-October-2015

    Genes

    Total: 66
    In Groups: 57
    Inter-Gene Interactions: 0

    Drugs

    Total: 0
    In Groups: 0

    Interactions

    Total: 0

    Full Citation

    http://www.carismolecularintelligence.com/

    Trust Information

    Trust Level: Expert curated
    Interaction Precedence: N/A
    Category Precedence: 2nd
    • Full Name: Bader Lab Genes Version: February-2014

    Genes

    Total: 300
    In Groups: 297
    Inter-Gene Interactions: 0

    Drugs

    Total: 0
    In Groups: 0

    Interactions

    Total: 0

    Full Citation

    Too many roads not taken: Aled M. Edwards, Ruth Isserlin, Gary D. Bader, Stephen V. Frye, Timothy M. Willson & Frank H. Yu Nature 470, 163–165 (10 February 2011) doi:10.1038/470163a. PMID: 21307913

    Trust Information

    Trust Level: Expert curated
    Interaction Precedence: N/A
    Category Precedence: 8th
    • Full Name: Foundation One Genes Version: 20-September-2013

    Genes

    Total: 243
    In Groups: 243
    Inter-Gene Interactions: 0

    Drugs

    Total: 0
    In Groups: 0

    Interactions

    Total: 0

    Full Citation

    High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing. Wagle N, Berger MF, ..., Meyerson M, Gabriel SB, Garraway LA. Cancer Discov. 2012 Jan;2(1):82-93. PMID: 22585170

    Trust Information

    Trust Level: Expert curated
    Interaction Precedence: N/A
    Category Precedence: 4th
    • Full Name: The druggable genome (Hopkins & Groom, 2002) Version: 11-September-2012

    Genes

    Total: 2676
    In Groups: 2672
    Inter-Gene Interactions: 0

    Drugs

    Total: 0
    In Groups: 0

    Interactions

    Total: 0

    Full Citation

    The druggable genome. Hopkins AL, Groom CR. Nat Rev Drug Discov. 2002 Sep;1(9):727-30. PMID: 12209152

    Trust Information

    Trust Level: Expert curated
    Interaction Precedence: N/A
    Category Precedence: 6th
    • Full Name: The druggable genome: an update (Russ & Lampel, 2005) Version: 26-July-2011

    Genes

    Total: 3361
    In Groups: 3061
    Inter-Gene Interactions: 0

    Drugs

    Total: 0
    In Groups: 0

    Interactions

    Total: 0

    Full Citation

    The druggable genome: an update. Russ AP, Lampel S. Drug Discov Today. 2005 Dec;10(23-24):1607-10. PMID: 16376820

    Trust Information

    Trust Level: Expert curated
    Interaction Precedence: N/A
    Category Precedence: 5th
    • Full Name: dGENE - The Druggable Gene List Version: 27-June-2013

    Genes

    Total: 2257
    In Groups: 2257
    Inter-Gene Interactions: 0

    Drugs

    Total: 0
    In Groups: 0

    Interactions

    Total: 0

    Full Citation

    Prioritizing Potentially Druggable Mutations with dGene: An Annotation Tool for Cancer Genome Sequencing Data. Kumar RD, Chang LW, Ellis MJ, Bose R. PLoS One. 2013 Jun 27;8(6):e67980. PMID: 23826350

    Trust Information

    Trust Level: Expert curated
    Interaction Precedence: N/A
    Category Precedence: 3rd
    • Full Name: My Cancer Genome Version: 13-March-2013

    Genes

    Total: 169
    In Groups: 169
    Inter-Gene Interactions: 0

    Drugs

    Total: 226
    In Groups: 113

    Interactions

    Total: 835

    Full Citation

    DNA-mutation Inventory to Refine and Enhance Cancer Treatment (DIRECT): A catalogue of clinically relevant cancer mutations to enable genome-directed cancer therapy. Yeh P, Chen H, Andrews J, Naser R, Pao W, Horn L. Clin Cancer Res. 2013 Jan 23. [Epub ahead of print]. PMID: 23344264

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    Trust Level: Expert curated
    Interaction Precedence: 3rd
    Category Precedence: N/A
    • Full Name: Clearity Foundation Biomarkers Version: 26-July-2013

    Genes

    Total: 34
    In Groups: 34
    Inter-Gene Interactions: 0

    Drugs

    Total: 64
    In Groups: 37

    Interactions

    Total: 165

    Full Citation

    http://www.clearityfoundation.org/healthcare-pros/drugs-and-biomarkers.aspx

    Trust Information

    Trust Level: Expert curated
    Interaction Precedence: 5th
    Category Precedence: N/A
    • Full Name: DrugBank - Open Data Drug & Drug Target Database Version: 4.3

    Genes

    Total: 2280
    In Groups: 2222
    Inter-Gene Interactions: 0

    Drugs

    Total: 4827
    In Groups: 2867

    Interactions

    Total: 10969

    Full Citation

    DrugBank 4.0: shedding new light on drug metabolism. Law V, Knox C, Djoumbou Y, Jewison T, Guo AC, Liu Y, Maciejewski A, Arndt D, Wilson M, Neveu V, Tang A, Gabriel G, Ly C, Adamjee S, Dame ZT, Han B, Zhou Y, Wishart DS.Nucleic Acids Res. 2014 Jan 1;42(1):D1091-7. PubMed ID: 24203711

    Trust Information

    Trust Level: Non-curated
    Interaction Precedence: 15th
    Category Precedence: N/A
    • Full Name: Cancer Commons Version: 25-July-2013

    Genes

    Total: 48
    In Groups: 48
    Inter-Gene Interactions: 0

    Drugs

    Total: 80
    In Groups: 26

    Interactions

    Total: 109

    Full Citation

    Cancer Commons: Biomedicine in the Internet Age. Shrager J, Tenenbaum JM, and Travers M. Collaborative Computational Technologies for Biomedical Research, (Sean Elkins, Maggie Hupcey, and Antony Williams Eds). Wiley, 2010.

    Trust Information

    Trust Level: Expert curated
    Interaction Precedence: 4th
    Category Precedence: N/A
    • Full Name: Trends in the exploitation of novel drug targets (Rask-Andersen, et al., 2011) Version: 01-August-2011

    Genes

    Total: 437
    In Groups: 435
    Inter-Gene Interactions: 0

    Drugs

    Total: 989
    In Groups: 857

    Interactions

    Total: 2243

    Full Citation

    Trends in the exploitation of novel drug targets. Rask-Andersen M, Almen MS, Schioth HB. Nat Rev Drug Discov. 2011 Aug 1;10(8):579-90. PMID: 21804595

    Trust Information

    Trust Level: Expert curated
    Interaction Precedence: 7th
    Category Precedence: N/A
    • Full Name: Targeted Agents in Lung Cancer (Santa Monica Supplement, 2012) Version: 17-September-2013

    Genes

    Total: 153
    In Groups: 153
    Inter-Gene Interactions: 0

    Drugs

    Total: 285
    In Groups: 116

    Interactions

    Total: 605

    Full Citation

    A tabulated summary of targeted and biologic therapies for non-small-cell lung cancer. Somaiah N, Simon NG, Simon GR. J Thorac Oncol. 2012 Dec;7 (16 Suppl 5):S342-68. PMID: 23160320

    Trust Information

    Trust Level: Expert curated
    Interaction Precedence: 6th
    Category Precedence: N/A
    • Full Name: MyCancerGenome Clinical Trial Version: 30-February-2014

    Genes

    Total: 83
    In Groups: 78
    Inter-Gene Interactions: 0

    Drugs

    Total: 112
    In Groups: 81

    Interactions

    Total: 1913

    Full Citation

    http://www.mycancergenome.org/

    Trust Information

    Trust Level: Expert curated
    Interaction Precedence: 10th
    Category Precedence: N/A
    • Full Name: PharmGKB - The Pharmacogenomics Knowledgebase Version: 12-July-2012

    Genes

    Total: 600
    In Groups: 599
    Inter-Gene Interactions: 0

    Drugs

    Total: 589
    In Groups: 255

    Interactions

    Total: 1952

    Full Citation

    From pharmacogenomic knowledge acquisition to clinical applications: the PharmGKB as a clinical pharmacogenomic biomarker resource. McDonagh EM, Whirl-Carrillo M, Garten Y, Altman RB, Klein TE. Biomark Med. 2011 Dec;5(6):795-806. PMID: 22103613

    Trust Information

    Trust Level: Non-curated
    Interaction Precedence: 13th
    Category Precedence: N/A
    • Full Name: Guide to Pharmacology Interactions Version: 04-March-2015

    Genes

    Total: 1055
    In Groups: 989
    Inter-Gene Interactions: 0

    Drugs

    Total: 5027
    In Groups: 2106

    Interactions

    Total: 10225

    Full Citation

    Pawson, Adam J., et al. "The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands." Nucleic acids research 42.D1 (2014): D1098-D1106. PMID: 24234439

    Trust Information

    Trust Level: Non-curated
    Interaction Precedence: 9th
    Category Precedence: N/A
  • TTD

    • Full Name: Therapeutic Target Database Version: 4.3.02 (25-August-2011)

    Genes

    Total: 691
    In Groups: 502
    Inter-Gene Interactions: 0

    Drugs

    Total: 2720
    In Groups: 1230

    Interactions

    Total: 3049

    Full Citation

    Update of TTD: Therapeutic Target Database. Zhu F, Han BC, ..., Zheng CJ, Chen YZ. Nucleic Acids Res. 38(suppl 1):D787-91, 2010. PMID: 19933260

    Trust Information

    Trust Level: Non-curated
    Interaction Precedence: 14th
    Category Precedence: N/A
    • Full Name: The Druggable Genome: Evaluation of Drug Targets in Clinical Trials Suggests Major Shifts in Molecular Class and Indication (Rask-Andersen, Masuram, Schioth 2014) Version: January-2014

    Genes

    Total: 1016
    In Groups: 988
    Inter-Gene Interactions: 0

    Drugs

    Total: 2419
    In Groups: 1305

    Interactions

    Total: 5998

    Full Citation

    The druggable genome: Evaluation of drug targets in clinical trials suggests major shifts in molecular class and indication. Rask-Andersen M, Masuram S, Schioth HB. Annu Rev Pharmacol Toxicol. 2014;54:9-26. doi: 10.1146/annurev-pharmtox-011613-135943. PMID: 24016212

    Trust Information

    Trust Level: Expert curated
    Interaction Precedence: 12th
    Category Precedence: N/A
    • Full Name: CIViC: Clinical Interpretations of Variants in Cancer Version: 09-February-2016

    Genes

    Total: 99
    In Groups: 99
    Inter-Gene Interactions: 0

    Drugs

    Total: 132
    In Groups: 77

    Interactions

    Total: 252

    Full Citation

    CIViC: Clinical Interpretations of Variants in Cancer

    Trust Information

    Trust Level: Expert curated
    Interaction Precedence: 1st
    Category Precedence: N/A
    • Full Name: Database of Curated Mutations Version: 09-February-2016

    Genes

    Total: 33
    In Groups: 33
    Inter-Gene Interactions: 0

    Drugs

    Total: 36
    In Groups: 30

    Interactions

    Total: 313

    Full Citation

    Manuscript in preparation. Please cite http://docm.genome.wustl.edu/

    Trust Information

    Trust Level: Expert curated
    Interaction Precedence: 2nd
    Category Precedence: N/A
    • Full Name: Clearity Foundation Clinical Trial Version: 15-June-2013

    Genes

    Total: 108
    In Groups: 93
    Inter-Gene Interactions: 0

    Drugs

    Total: 115
    In Groups: 73

    Interactions

    Total: 585

    Full Citation

    https://www.clearityfoundation.org/form/findtrials.aspx

    Trust Information

    Trust Level: Expert curated
    Interaction Precedence: 11th
    Category Precedence: N/A
    • Full Name: The ChEMBL Bioactivity Database Version: chembl_20

    Genes

    Total: 268
    In Groups: 252
    Inter-Gene Interactions: 0

    Drugs

    Total: 906
    In Groups: 680

    Interactions

    Total: 1192

    Full Citation

    The ChEMBL bioactivity database: an update. Bento AP, Gaulton A, Hersey A, Bellis LJ, Chambers J, Davies M, Krüger FA, Light Y, Mak L, McGlinchey S, Nowotka M, Papadatos G, Santos R, Overington JP. Nucleic Acids Res. 42(Database issue):D1083-90. PubMed ID: 24214965

    Trust Information

    Trust Level: Expert curated
    Interaction Precedence: 8th
    Category Precedence: N/A
    • Full Name: NCBI Entrez Gene Version: 08-February-2016

    Genes

    Total: 59905
    In Groups: 59904
    Inter-Gene Interactions: 442274

    Drugs

    Total: 0
    In Groups: 0

    Interactions

    Total: 0

    Full Citation

    Entrez Gene: gene-centered information at NCBI. Maglott D, Ostell J, Pruitt KD, Tatusova T. Nucleic Acids Res. 2011 Jan;39(Database issue)52-7. Epub 2010 Nov 28. PMID: 21115458

    Trust Information

    Trust Level: Expert curated
    Interaction Precedence: N/A
    Category Precedence: N/A
    • Full Name: Ensembl Version: 68_37

    Genes

    Total: 59573
    In Groups: 35604
    Inter-Gene Interactions: 0

    Drugs

    Total: 0
    In Groups: 0

    Interactions

    Total: 0

    Full Citation

    Ensembl 2011. Flicek P, Amode MR, ..., Vogel J, Searle SM. Nucleic Acids Res. 2011 Jan;39(Database issue)800-6. Epub 2010 Nov 2. PMID: 21045057

    Trust Information

    Trust Level: Non-curated
    Interaction Precedence: N/A
    Category Precedence: N/A
    • Full Name: PubChem Version: 09-Feb-2016

    Genes

    Total: 0
    In Groups: 0
    Inter-Gene Interactions: 0

    Drugs

    Total: 14887
    In Groups: 14887

    Interactions

    Total: 0

    Full Citation

    PubChem's BioAssay Database. Wang Y, Xiao J, ..., Gindulyte A, Bryant SH. Nucleic Acids Res. 2012 Jan;40(Database issue):D400-12. Epub 2011 Dec 2. PMID: 22140110

    Trust Information

    Trust Level: Non-curated
    Interaction Precedence: N/A
    Category Precedence: N/A