DGIdb - 6-O-BENZYLGUANINE Drug Record

6-O-BENZYLGUANINE chembl:CHEMBL407874

Alternate Names:

O6-BENZYLGUANINE
NSC-637037
6-O-BENZYLGUANINE

Drug Info:

(0 More Sources)

Publications:

Roy et al., 1995, Human liver oxidative metabolism of O6-benzylguanine., Biochem. Pharmacol.
Pauly GT et al., 2008, Substitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine., J Med Chem
Zhu R et al., 2012, Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase., Bioorg Med Chem Lett

6-O-BENZYLGUANINE MGMT

Interaction Score: 1.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18973327 22932317

Sources:
DTC
6-O-BENZYLGUANINE CYP2B6

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7503788

Sources:
NCI
6-O-BENZYLGUANINE CYP1A2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7503788

Sources:
DTC NCI
6-O-BENZYLGUANINE CYP2C19

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
6-O-BENZYLGUANINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DTC: 6-O-BENZYLGUANINE

Version: 02-September-2020

Alternate Names:

CHEMBL407874 ChEMBL Drug ID

Drug Info:

Publications:

Zhu R et al., 2012, Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase., Bioorg Med Chem Lett

Pauly GT et al., 2008, Substitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine., J Med Chem

NCI: O6-BENZYLGUANINE
- Version: 14-September-2017
Alternate Names:

C1306 NCI drug code

Drug Info:

Publications:

Roy et al., 1995, Human liver oxidative metabolism of O6-benzylguanine., Biochem. Pharmacol.
ChemblDrugs: chembl:CHEMBL407874
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

6-O-BENZYLGUANINE Drug Record

6-O-BENZYLGUANINE chembl:CHEMBL407874

Alternate Names:

Drug Info:

Publications:

6-O-BENZYLGUANINE MGMT

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18973327 22932317

Sources: DTC

6-O-BENZYLGUANINE CYP2B6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7503788

Sources: NCI

6-O-BENZYLGUANINE CYP1A2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7503788

Sources: DTC NCI

6-O-BENZYLGUANINE CYP2C19

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

6-O-BENZYLGUANINE CYP3A4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DTC: 6-O-BENZYLGUANINE

Alternate Names: CHEMBL407874 ChEMBL Drug ID

Drug Info:

NCI: O6-BENZYLGUANINE

Alternate Names: C1306 NCI drug code

Drug Info:

Publications: Roy et al., 1995, Human liver oxidative metabolism of O6-benzylguanine., Biochem. Pharmacol.

ChemblDrugs: chembl:CHEMBL407874

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
18973327 22932317

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
7503788

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7503788

Sources:
DTC NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

CHEMBL407874 ChEMBL Drug ID

Alternate Names:

C1306 NCI drug code

Publications:

Roy et al., 1995, Human liver oxidative metabolism of O6-benzylguanine., Biochem. Pharmacol.