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6-O-BENZYLGUANINE Drug Record

  • Summary
  • Interactions
  • Claims
  • 6-O-BENZYLGUANINE chembl:CHEMBL407874

    Alternate Names:

    O6-BENZYLGUANINE
    NSC-637037
    6-O-BENZYLGUANINE

    Drug Info:

    (0 More Sources)

    Publications:

    Roy et al., 1995, Human liver oxidative metabolism of O6-benzylguanine., Biochem. Pharmacol.
    Pauly GT et al., 2008, Substitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine., J Med Chem
    Zhu R et al., 2012, Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase., Bioorg Med Chem Lett
  • 6-O-BENZYLGUANINE   MGMT

    Interaction Score: 1.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18973327 22932317


    Sources:
    DTC

  • 6-O-BENZYLGUANINE   CYP2B6

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7503788


    Sources:
    NCI

  • 6-O-BENZYLGUANINE   CYP1A2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7503788


    Sources:
    DTC NCI

  • 6-O-BENZYLGUANINE   CYP2C19

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • 6-O-BENZYLGUANINE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DTC: 6-O-BENZYLGUANINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL407874 ChEMBL Drug ID

    Drug Info:

    Publications:
    Zhu R et al., 2012, Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase., Bioorg Med Chem Lett
    Pauly GT et al., 2008, Substitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine., J Med Chem

  • NCI: O6-BENZYLGUANINE

    • Version: 14-September-2017

    Alternate Names:
    C1306 NCI drug code

    Drug Info:

    Publications:
    Roy et al., 1995, Human liver oxidative metabolism of O6-benzylguanine., Biochem. Pharmacol.

  • ChemblDrugs: chembl:CHEMBL407874

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21