DGIdb - 7-ETHYL-10-HYDROXYCAMPTOTHECIN Drug Record

7-ETHYL-10-HYDROXYCAMPTOTHECIN chembl:CHEMBL837 Antineoplastic

Alternate Names:

7-ETHYL-10-HYDROXYCAMPTOTHECIN
NK-012
NK012
IRINOTECAN RELATED COMPOUND B
NK 012
SN 38
SN-38
7-ETHYL-10-HYDROXY-CAMPTOTHECIN
IT-141

Drug Info:

(0 More Sources)

Publications:

Clericuzio M et al., 2006, Cucurbitane triterpenes from the fruiting bodies and cultivated mycelia of Leucopaxillus gentianeus., J Nat Prod
Wang L et al., 2015, Design, synthesis and biological evaluation of novel homocamptothecin analogues as potent antitumor agents., Bioorg Med Chem
Guerrant W et al., 2013, Dual-acting histone deacetylase-topoisomerase I inhibitors., Bioorg Med Chem Lett
Cananzi S et al., 2011, Synthesis and topoisomerase I inhibitory activity of a novel diazaindeno[2,1-b]phenanthrene analogue of Lamellarin D., Bioorg Med Chem
Luo Y et al., 2012, Synthesis and biological evaluation of new homocamptothecin analogs., Eur J Med Chem
Parrino B et al., 2015, Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: in vitro antiproliferative activity and molecular mechanism(s) of action., Eur J Med Chem
Samorì C et al., 2009, Semisynthesis, biological activity, and molecular modeling studies of C-ring-modified camptothecins., J Med Chem
Wang MJ et al., 2014, Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents., J Med Chem
Wang H et al., 2014, Association analysis of UGT1A genotype and haplotype with SN-38 glucuronidation in human livers., Pharmacogenomics
Han JY et al., 2009, Integrated pharmacogenetic prediction of irinotecan pharmacokinetics and toxicity in patients with advanced non-small cell lung cancer., Lung Cancer
Han JY et al., 2006, Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin., J Clin Oncol
Gagné JF et al., 2002, Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38)., Mol Pharmacol
Li M et al., 2018, ABC transporter polymorphisms are associated with irinotecan pharmacokinetics and neutropenia., Pharmacogenomics J
Mbatchi LC et al., 2016, Effect of Single Nucleotide Polymorphisms in the Xenobiotic-sensing Receptors NR1I2 and NR1I3 on the Pharmacokinetics and Toxicity of Irinotecan in Colorectal Cancer Patients., Clin Pharmacokinet
Kim KP et al., 2015, A phase I study of UGT1A1 28/6 genotype-directed dosing of irinotecan (CPT-11) in Korean patients with metastatic colorectal cancer receiving FOLFIRI., Oncology
Jada SR et al., 2007, Role of UGT1A16, UGT1A128 and ABCG2 c.421C>A polymorphisms in irinotecan-induced neutropenia in Asian cancer patients., Cancer Sci
Stewart CF et al., 2007, UGT1A1 promoter genotype correlates with SN-38 pharmacokinetics, but not severe toxicity in patients receiving low-dose irinotecan., J Clin Oncol
de Jong FA et al., 2007, Irinotecan-induced diarrhea: functional significance of the polymorphic ABCC2 transporter protein., Clin Pharmacol Ther
de Jong FA et al., 2006, Prophylaxis of irinotecan-induced diarrhea with neomycin and potential role for UGT1A1*28 genotype screening: a double-blind, randomized, placebo-controlled study., Oncologist
Sai K et al., 2004, UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer., Clin Pharmacol Ther
Innocenti F et al., 2004, Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan., J Clin Oncol
Iyer L et al., 2002, UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity., Pharmacogenomics J
Ciotti M et al., 1999, Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the UGT1 locus., Biochem Biophys Res Commun
Hu ZY et al., 2010, Dose-dependent association between UGT1A1*28 genotype and irinotecan-induced neutropenia: low doses also increase risk., Clin Cancer Res
Ramesh et al., 2010, Irinotecan and its active metabolite, SN-38: review of bioanalytical methods and recent update from clinical pharmacology perspectives., Biomed. Chromatogr.
Onoue M et al., 2009, UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients., Int J Clin Oncol
Cecchin E et al., 2009, Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan., J Clin Oncol
Obradovic M et al., 2008, Cost-effectiveness of UGT1A1 genotyping in second-line, high-dose, once every 3 weeks irinotecan monotherapy treatment of colorectal cancer., Pharmacogenomics
Lankisch TO et al., 2008, Gilbert's Syndrome and irinotecan toxicity: combination with UDP-glucuronosyltransferase 1A7 variants increases risk., Cancer Epidemiol Biomarkers Prev
Hoskins JM et al., 2007, UGT1A1*28 genotype and irinotecan-induced neutropenia: dose matters., J Natl Cancer Inst
Lankisch TO et al., 2006, Gilbert's disease and atazanavir: from phenotype to UDP-glucuronosyltransferase haplotype., Hepatology
Kawato Y et al., 1991, Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11., Cancer Res
Danoff TM et al., 2004, A Gilbert's syndrome UGT1A1 variant confers susceptibility to tranilast-induced hyperbilirubinemia., Pharmacogenomics J
Kishi S et al., 2004, Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia., Blood
Kemp DC et al., 2002, Characterization of raloxifene glucuronidation in vitro: contribution of intestinal metabolism to presystemic clearance., Drug Metab Dispos
Guillemette C et al., 2000, Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene., Pharmacogenetics

7-ETHYL-10-HYDROXYCAMPTOTHECIN UGT1A1

Interaction Score: 1.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27116457 25427841 18221820 17627617 17577039 17185998 16951398 16636344 15179405 15007088 11990381 10381366 20562211 19852077 19390945 19364970 18466101 18349289 17728214 17058217 1651156 14647407 12969965 12181437 12019197 11037804

Sources:
PharmGKB
7-ETHYL-10-HYDROXYCAMPTOTHECIN CES2

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
7-ETHYL-10-HYDROXYCAMPTOTHECIN UGT1A9

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24897286 18221820 16636344 12181437

Sources:
PharmGKB
7-ETHYL-10-HYDROXYCAMPTOTHECIN TOP1

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17190463 25835359 23622981 21783369 22647222 25768699 19530720 25003995

Sources:
DTC PharmGKB TTD
7-ETHYL-10-HYDROXYCAMPTOTHECIN UGT1A10

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
7-ETHYL-10-HYDROXYCAMPTOTHECIN CES1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
7-ETHYL-10-HYDROXYCAMPTOTHECIN UGT1A8

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
7-ETHYL-10-HYDROXYCAMPTOTHECIN UGT1A6

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
7-ETHYL-10-HYDROXYCAMPTOTHECIN UGT1A3

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
7-ETHYL-10-HYDROXYCAMPTOTHECIN UGT1A4

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
7-ETHYL-10-HYDROXYCAMPTOTHECIN HDAC11

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23622981

Sources:
DTC
7-ETHYL-10-HYDROXYCAMPTOTHECIN HDAC9

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23622981

Sources:
DTC
7-ETHYL-10-HYDROXYCAMPTOTHECIN HDAC10

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23622981

Sources:
DTC
7-ETHYL-10-HYDROXYCAMPTOTHECIN HDAC7

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23622981

Sources:
DTC
7-ETHYL-10-HYDROXYCAMPTOTHECIN HDAC5

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23622981

Sources:
DTC
7-ETHYL-10-HYDROXYCAMPTOTHECIN HDAC4

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23622981

Sources:
DTC
7-ETHYL-10-HYDROXYCAMPTOTHECIN HDAC8

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23622981

Sources:
DTC
7-ETHYL-10-HYDROXYCAMPTOTHECIN BCHE

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
7-ETHYL-10-HYDROXYCAMPTOTHECIN HDAC3

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23622981

Sources:
DTC
7-ETHYL-10-HYDROXYCAMPTOTHECIN HDAC6

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23622981

Sources:
DTC
7-ETHYL-10-HYDROXYCAMPTOTHECIN HDAC2

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23622981

Sources:
DTC
7-ETHYL-10-HYDROXYCAMPTOTHECIN ABCC1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27845419

Sources:
PharmGKB
7-ETHYL-10-HYDROXYCAMPTOTHECIN HDAC1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23622981

Sources:
DTC
7-ETHYL-10-HYDROXYCAMPTOTHECIN SLCO1B1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18221820

Sources:
PharmGKB
7-ETHYL-10-HYDROXYCAMPTOTHECIN ABCC2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
7-ETHYL-10-HYDROXYCAMPTOTHECIN ABCG2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
7-ETHYL-10-HYDROXYCAMPTOTHECIN ABCB1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

DTC: 7-ETHYL-10-HYDROXY-CAMPTOTHECIN

Version: 02-September-2020

Alternate Names:

CHEMBL837 ChEMBL Drug ID

Drug Info:

Publications:

Guerrant W et al., 2013, Dual-acting histone deacetylase-topoisomerase I inhibitors., Bioorg Med Chem Lett

Wang MJ et al., 2014, Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents., J Med Chem

Luo Y et al., 2012, Synthesis and biological evaluation of new homocamptothecin analogs., Eur J Med Chem

PharmGKB: SN-38

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Han JY et al., 2009, Integrated pharmacogenetic prediction of irinotecan pharmacokinetics and toxicity in patients with advanced non-small cell lung cancer., Lung Cancer

Kim KP et al., 2015, A phase I study of UGT1A1 28/6 genotype-directed dosing of irinotecan (CPT-11) in Korean patients with metastatic colorectal cancer receiving FOLFIRI., Oncology

Han JY et al., 2006, Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin., J Clin Oncol

TTD: IT-141
- Version: 2020.06.01
Alternate Names:

D0K6QU TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL837
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

7-ETHYL-10-HYDROXYCAMPTOTHECIN Drug Record

7-ETHYL-10-HYDROXYCAMPTOTHECIN chembl:CHEMBL837 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27116457 25427841 18221820 17627617 17577039 17185998 16951398 16636344 15179405 15007088 11990381 10381366 20562211 19852077 19390945 19364970 18466101 18349289 17728214 17058217 1651156 14647407 12969965 12181437 12019197 11037804

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24897286 18221820 16636344 12181437

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17190463 25835359 23622981 21783369 22647222 25768699 19530720 25003995

Sources: DTC PharmGKB TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23622981

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23622981

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23622981

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23622981

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23622981

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23622981

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23622981

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23622981

Interaction Types & Directionality:

n/a

PMIDs:
27116457 25427841 18221820 17627617 17577039 17185998 16951398 16636344 15179405 15007088 11990381 10381366 20562211 19852077 19390945 19364970 18466101 18349289 17728214 17058217 1651156 14647407 12969965 12181437 12019197 11037804

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24897286 18221820 16636344 12181437

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17190463 25835359 23622981 21783369 22647222 25768699 19530720 25003995

Sources:
DTC PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23622981

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23622981

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23622981

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23622981

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23622981

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23622981

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23622981

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23622981

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23622981

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23622981

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
27845419

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23622981

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18221820

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found