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AC-480 Drug Record

  • Summary
  • Interactions
  • Claims
  • AC-480 chembl:CHEMBL1645462 Antineoplastic

    Alternate Names:

    AC480
    AC-480
    BMS-599626
    BMS 599626

    Drug Info:

    FDA Approval not approved
    Drug Class Small molecule
    Drug Indications antineoplastic agent
    Drug Class Kinase Inhibitors
    (4 More Sources)

    Publications:

    Soria et al., 2012, Phase I safety, pharmacokinetic and pharmacodynamic trial of BMS-599626 (AC480), an oral pan-HER receptor tyrosine kinase inhibitor, in patients with advanced solid tumors., Ann. Oncol.
    Gavai et al., 2009, Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases., J. Med. Chem.
  • AC-480   ERBB4

    Interaction Score: 1.87

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name AC480
    Novel drug target Novel Target
    Mechanism of Interaction Receptor protein-tyrosine kinase erbB-4 inhibitor

    PMIDs:
    None found


    Sources:
    TALC MyCancerGenome TdgClinicalTrial ChemblInteractions

  • AC-480   ERBB2

    Interaction Score: 0.95

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name AC480
    Novel drug target Established target
    Mechanism of Interaction Receptor protein-tyrosine kinase erbB-2 inhibitor

    PMIDs:
    21576284 19821562


    Sources:
    TALC DTC MyCancerGenome TdgClinicalTrial JAX-CKB ChemblInteractions TTD

  • AC-480   EGFR

    Interaction Score: 0.83

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name AC480
    Novel drug target Established target
    Mechanism of Interaction Epidermal growth factor receptor erbB1 inhibitor

    PMIDs:
    19821562 21576284


    Sources:
    TALC DTC MyCancerGenome TdgClinicalTrial JAX-CKB ChemblInteractions TTD

  • AC-480   ERBB3

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name AC480
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • MyCancerGenome: BMS-599626

    • Version: 20-Jun-2017

    Alternate Names:
    BMS-599626 Development Name
    AC480 Development Name

    Drug Info:
    Drug Class Kinase Inhibitors

    Publications:

  • TdgClinicalTrial: AC480

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antineoplastic agent
    Drug Class Small molecule
    FDA Approval not approved

    Publications:

  • DTC: AC-480

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1645462 ChEMBL Drug ID

    Drug Info:

    Publications:
    Gavai et al., 2009, Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases., J. Med. Chem.

  • JAX-CKB: AC480

    • Version: 27-September-2017

    Alternate Names:

    Drug Info:

    Publications:
    Soria et al., 2012, Phase I safety, pharmacokinetic and pharmacodynamic trial of BMS-599626 (AC480), an oral pan-HER receptor tyrosine kinase inhibitor, in patients with advanced solid tumors., Ann. Oncol.

  • TALC: BMS-599626

    • Version: 12-May-2016

    Alternate Names:
    BMS-599626 Primary Drug Name
    BMS-599626 Drug Synonym

    Drug Info:

    Publications:

  • TTD: BMS-599626

    • Version: 2020.06.01

    Alternate Names:
    D0U4FF TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1645462

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1645462

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21