• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

ACETAMINOPHEN Drug Record

  • Summary
  • Interactions
  • Claims
  • ACETAMINOPHEN chembl:CHEMBL112 Approved

    Alternate Names:

    CALPOL
    TIXYMOL
    MEDINOL UNDER 6
    CALPOL SIX PLUS FASTMELTS
    MIRADOL
    MEDISED PLAIN
    PANADOL ACTIFAST SOLB
    NSC-109028
    CHILD LEMSIP
    NEOPAP
    PALDESIC
    ABDINE
    RIMADOL
    MEDINOL FOR CHILDREN
    ALVEDON
    INFADROPS
    DISPROL PAED
    PANADOL OA
    CALPOL SIX PLUS
    MEDINOL
    PANADOL ADVAN
    PARAMIN
    PANADOL ACTIFAST
    OFIRMEV
    DISPROL
    NSC-3991
    HEDEX
    PANADOL
    ACEPHEN
    JUNIOR PARAPAED
    TRAMIL 500
    PARAPAED JNR
    PLACIDEX
    MANDANOL
    DISPROL JNR
    PARACETAMOL
    DAFALGAN
    GALPAMOL
    PERFALGAN
    ANGIERS
    PARAPAED SIX PLUS
    PANALEVE 6 PLUS
    APAP
    CUPANOL
    PANADOL JNR
    SALZONE
    DISPROL INFANT
    FENNINGS
    PARAVICT
    PHENAPHEN
    PANALEVE
    DATRIL
    INFANTS' FEVERALL
    ACETAMINOPHEN
    MEDINOL OVER 6
    TYLENOL
    INJECTAPAP
    NORCO
    ACTIMOL CHEWABLE TABLETS
    NAPAP
    GELOCATIL
    EMPRACET
    EXCIPAIN
    RELIV
    SUPOFEN
    ASPIRIN-FREE ANACIN
    PARACETAMOL FECOFAR
    PYROMED
    PARACETAMOLE
    PAEDIALGON
    PARACETAMOL SAAR
    CORICIDIN D
    ACTIMOL JUNIOR STRENGTH CAPLETS
    NEALGYL
    NEODOL
    TYLENOL JUNIOR STRENGTH CHEWABLE TABLETS
    DAROCET
    FEPANIL
    ABENSANIL
    ACTIMOL INFANTS' SUSPENSION
    FEBRANINE
    SINE-OFF SINUS MEDICINE CAPLETS
    ALGOTROPYL
    INFLUBENE N
    DAPA X-S
    BAYER SELECT ALLERGY-SINUS
    P-(ACETYLAMINO)PHENOL
    PASOLIND N
    EU-MED
    TAPAR
    PARACETANOL
    TUSSAPAP
    HOMOOLAN
    TEMPRA CAPLETS
    GERALGINE-P
    PREDIMOL
    ANDOX
    CODRAL PAIN RELIEF
    PYRINAZINE
    CADAFEN
    PASOLIND
    PE-TAM
    PAMOL
    CODALGIN
    N-(4-HYDROXYPHENYL)ACETAMIDE
    FLUPARMOL
    FARMADOL
    PRODOL
    MEXALEN
    PAEDOL
    TOXIMER P
    DURAPAN
    CAUSALON
    CODICET
    4-(ACETYLAMINO)PHENOL
    JANUPAP
    DOLEGRIPPIN
    SUNETHETON
    SETOL
    TOCRIS-1706
    OXYCET
    FENSUM
    PARACETAMOL VON CT
    PARALIEF
    ACETAMOL
    TRALGON
    ALGESIDAL
    TYLENOL CHILDREN'S CHEWABLE TABLETS
    ROUNOX
    PARACÉTAMOL
    PARACETAMOL GENERICON
    TEMPRA DROPS
    QUIET WORLD
    DOLORFUG
    ABENOL
    APACET CAPSULES
    ARFEN
    TABALGIN
    LESTEMP
    HELON N
    SERVIGESIC
    FEVERALL JUNIOR STRENGTH
    AMINOFEN MAX
    VICODIN ES
    GENAPAP EXTRA STRENGTH CAPLETS
    PARASIN
    CLIXODYNE
    RUBIEMOL
    ACETAMINOFÉN
    PARACETAMOL DC
    DIAL-ALPHA-GESIC
    TYLENOL EXTRA STRENGTH CAPLETS
    PARACETAMOL BC
    CODABROL
    BANESIN
    SK-APAP
    DURADYNE DHC
    DOLCOR
    ACTRON
    PERDOLAN MONO
    PANOFEN
    P-HYDROXY-ACETANILID
    TYLENOL ARTHRITIS EXTENDED RELIEF
    DOLOROL FORTE
    ABROL
    ANHIBA
    ILDAMOL
    CURADON
    PARACETAMOL SMITHKLINE BEECHAM
    PARACETAMOL RATIOPHARM
    PACIMOL
    PROMPT
    VIPS
    ASPIRIN-FREE EXCEDRIN CAPLETS
    MIRALGIN
    RUPEMOL
    NALDEGESIC
    ALLAY
    GENAPAP REGULAR STRENGTH TABLETS
    PHENAPHEN CAPLETS
    TEMPANAL
    NOBEDON
    HYDROCET
    MIDOL PM NIGHT TIME FORMULA
    MIDOL REGULAR STRENGTH
    PANASORB
    LIQUAGESIC
    LONARID
    CALMANTICOLD
    ACTIFED PLUS
    APO-ACETAMINOPHEN
    P-HYDROXYPHENOLACETAMIDE
    TYLENOL DROPS
    AFEBRIN
    LONARID MONO
    ANEXSIA 10/660
    PANEX
    LORTAB
    TYL
    PARA-SUPPO
    DOLGESIC
    PARACETAMOL AL
    ST JOSEPH ASPIRIN-FREE
    P-ACETAMINOPHENOL
    PARACOD
    SCENTALGYL
    REDUTEMP
    NAPA
    4'-HYDROXYACETANILIDE
    GENAPAP CHILDREN'S ELIXIR
    PLICET
    PULMOFEN
    ECOSETOL
    CONTRA-SCHMERZ P
    ACENOL
    PAPA-DEINE #4
    VERPOL
    VIVIMED
    PACET
    OLTYL
    FEBRO-GESIC
    ACERTOL
    PHRENILIN
    VICODIN
    DYMADON
    TERMALGIN
    TAVIST ALLERGY/SINUS/HEADACHE
    CHILDREN'S TYLENOL CHEWABLE
    FINIWEH
    PIRAMIN
    ORALGAN
    SPALT N
    SUPPAP-325
    ST JOSEPH ASPIRIN-FREE FOR CHILDREN
    PANADIENE
    LORCET-HD
    TYLOX
    PHENIPIRIN
    REMEDOL
    NAPAFEN
    TRIAPRIN
    CO-GESIC
    TEMPRA D.S
    BUTAPAP
    PEDIAPIRIN
    VALGESIC
    TYLENOL CAPLETS
    TISIODRAZIDA
    MEDOCODENE
    BANCAP
    MINOSET
    ANEXSIA 7.5/650
    TREUPEL MON
    TYLENOL CHILDREN'S SUSPENSION LIQUID
    SEDALITO
    TYLENOL INFANTS DROPS
    CODAPANE
    BENMYO
    CAPTIN
    PARACIN
    SEMOLACIN
    ACETALGIN
    PANADOL JUNIOR STRENGTH CAPLETS
    FEMCET
    FEBRECTOL
    ANACIN-3 EXTRA STRENGTH
    PARACODOL
    ATASOL CAPLETS
    SUPAC
    DEMOGRIPAL
    TRICOTON
    CODISAL
    VERALGINA
    VALORIN EXTRA
    SANICET
    ORAPHEN-PD
    MALIDENS
    PHRENILIN FORTE
    NEO-FEPRAMOL
    LIQUIPRIN INFANTS" DROPS
    APACET REGULAR STRENGTH TABLETS
    DATRIL EXTRA-STRENGTH
    TERMALGINE
    APACET EXTRA STRENGTH TABLETS
    MELABON INFANTIL
    ENELFA
    PAINEX
    PARACETAMOL ANTIPANIN P
    PANADO-CO
    TYCOLET
    THERAFLU
    VERMIDON
    GENEBS REGULAR STRENGTH TABLETS
    CUSTODIAL
    VALORIN
    NILNOCEN
    SINUBID
    TYLENOL ALLERGY SINUS
    PHENAPHEN W/CODEINE
    SCHMERZEX
    NO-FEBRIL
    PARACETAMOL STADA
    STOPAIN
    CORICIDIN
    PREDUALITO
    PANTALGIN
    VIRUFLU
    TACHIPRINA
    SEDAPAP
    PARAPAN
    CLARADOL CODEINE
    GATTAPHEN T
    P-HYDROXYACETANILIDE
    DAYGRIP
    PRESTWICK_13
    SUPPAP-120
    ANEXSIA 5/325
    AFEBRYL
    CALAPOL
    ANAPAP
    PYREGESIC-C
    TREUPEL N
    ATASOL TABLETS
    BICKIE-MOL
    PROVAL #3
    PANADOL EXTRA STRENGTH
    TYLENOL INFANTS" SUSPENSION DROPS
    TRIAD
    ACAMOL
    SYNALGOS-DC-A
    MIDOL MAXIMUM STRENGTH
    TITRALGAN
    PROPACET 100
    EXDOL
    TYLENOL REGULAR STRENGTH TABLETS
    ALPINYL
    ANACIN-3
    LUPOCET
    ROBITUSSIN NIGHT RELIEF
    FEBRIDOL
    CEFALEX
    GENEBS X-TRA
    AMINOFEN
    BAYER SELECT HEADACHE PAIN
    ROXICET 5/500
    TYLENOL REGULAR STRENGTH CAPLETS
    FEBRILIX
    PERCOCET
    CORICIDIN SINUS
    SUPPAP
    TYLENOL®
    PAROMA
    KATAPRIN
    DURACETAMOL
    AFERADOL
    ATASOL DROPS
    LYTECA
    ACTIMOL CHILDREN'S SUSPENSION
    RUBOPHEN
    ASOMAL
    DHC PLUS
    ST. JOSEPH FEVER REDUCER
    PERCOGESIC WITH CODEINE
    BEN-U-RON
    GRIPPOSTAD
    PARANOX
    TRIAMINIC SORE THROAT FORMULA
    PRONTINA
    KORUM
    ENDECON
    ACETAMINOFEN
    PARCETOL
    FIORICET
    PEDIATRIX
    TALACEN
    ASPIRIN FREE ANACIN MAXIMUM STRENGTH CAPLETS
    DYMADON CO
    ANELIX
    PANAMAX
    PARELAN
    TYLEX
    ENERIL
    A-PER
    PARACETAMOL RAFFO
    SIFENOL
    TERMACET
    TYLENOL ELIXIR
    4-ACETAMIDOPHENOL
    INALGEX
    ELIXODYNE
    PARAKE
    PAPA-DEINE #3
    ANTIDOL
    SANICOPYRINE
    PEDRIC
    MAXADOL
    DOLPRONE
    DOLIPRANE
    FEBRINOL
    MEDIGESIC PLUS
    HY-PHEN
    BABIKAN
    DIAL-A-GESIC
    SUPPAP-650
    CODOLIPRANE
    FORTALIDON P
    GELUPRANE
    ANALTER
    TREUPHADOL
    TYLENOL EXTRA STRENGTH ADULT LIQUID PAIN RELIEVER
    PARALINK
    PARACETAMOL DR. SCHMIDGALL
    TISIN
    CUPONOL
    A.F. ANACIN
    TEMPRA
    PARACETAMOL HEUMANN
    PARACETAMOL ROSCH
    PARADOR
    TERMOFREN
    TYLENOL TABLETS
    DEMILETS
    4-HYDROXYACETANILIDE
    PANADO-CO CAPLETS
    CROIX BLANCHE
    LEMSIP
    ST. JOSEPH COLD TABLETS FOR CHILDREN
    PHENDON
    ACÉTAMINOPHÈNE
    PACEMOL
    TENCON
    DHAMOL
    TYLEX CD
    PAROGAL
    MIGRALEVE YELLOW
    VICLOR RICHET
    ASETAM
    NEOTREND
    PANADEINE CO
    MIDOL TEEN FORMULA
    POLMOFEN
    MALGIS
    FEBRECTAL
    VICODIN HP
    PARACETAMOL PB
    DRESAN
    PINEX
    INTENSIN
    PANADOL®
    GENAPAP EXTRA STRENGTH TABLETS
    ABROLET
    STANBACK
    PANACETE
    PROPACET
    NEODOLITO
    PANODIL
    PUERNOL
    PARASEDOL
    DOL-STOP
    PARACETAMOL ITALFARMACO
    CAPITAL WITH CODEINE
    APACET
    EXCEDRIN CAPLETS
    ACTAMIN EXTRA
    PERCOCET-5
    DYMADON FORTE
    PANADOL MAXIMUM STRENGTH CAPLETS
    PARACETAMOL BASICS
    SESKAMOL
    OXYCODONE 5/APAP 500
    TAPANOL EXTRA STRENGTH CAPLETS
    NEW CORTAL FOR CHILDREN
    PARACETAMOL HARKLEY
    TIBINIDE
    GRIPIN BEBE
    PARACETAMOL WINTHROP
    DOLOTEC
    TYLENOL CHILDREN'S ELIXIR
    NORAL
    ROBIGESIC
    ASPAC
    KINDER FINIMAL
    P-ACETYLAMINOPHENOL
    FENDON
    SNAPLETS-FR
    UTRAGIN
    NAPRINOL
    NEOCITRAN
    MULTIN
    PCM PARACETAMOL LICHTENSTEIN
    NODOLEX
    P-ACETAMIDOPHENOL
    EXDOL STRONG
    ACCU-TAP
    APITRELAL
    DIROX
    ACTAMIN
    LYTECA SYRUP
    RIVALGYL
    ANTI-ALGOS
    ACETA TABLETS
    LEMGRIP
    FEBROLIN
    APADON
    DOLEFIN
    PARACETAMOLO
    ROXICET
    DOLOFUGIN
    DOLOREDUCT
    PARACETAMOL HEXAL
    PYRIGESIC
    PARAKAPTON
    PARAMOL
    PARACEMOL
    CONACETOL
    SUPADOL MONO
    FINIMAL
    LIQUIPRIN CHILDREN'S ELIXIR
    TYLOL
    TYLENOL EXTRA STRENGTH TABLETS
    DOLORSTOP
    ATRALIDON
    TEMPRA CHEWABLE TABLETS
    NEURIDON
    LIQUIPRIN
    DESFEBRE
    PACEMO
    TYLENOL EXTRA STRENGTH GELCAPS
    PARACETAMOL HANSELER
    PARAMOLAN
    ANAFLON
    APACET ELIXIR
    KRATOFIN SIMPLEX
    COFAMOL
    N-ACETYL-P-AMINOPHENOL
    ACETAGESIC
    WYGESIC
    TIBIZIDE
    ACETA ELIXIR
    LEKADOL
    ZATINOL
    SETAKOP
    GENEBS EXTRA STRENGTH CAPLETS
    ANEXSIA
    APAMIDE
    VALADOL
    4-HYDROXYANILID KYSELINY OCTOVE
    SINEDOL
    EXCEDRIN
    SINASPRIL
    MEDINOL PAEDIATRIC
    PACECO
    LIQUIGESIC CO
    TEMPRA SYRUP
    PANETS
    PARASPEN
    COSUTONE
    PARADROPS
    FEBRICET
    BAYER SELECT MAXIMUM STRENGTH HEADACHE PAIN RELIEF FORMULA
    ASPLIN
    ANOQUAN
    PARACET
    ULTRACET
    DARVOCET-N 50
    ZOLBEN
    BIOCETAMOL
    PARA-TABS
    ESGIC
    APAMID
    ANADIN DLA DZIECI
    DEMOCYL
    FEBRIN
    PARACETAMOLUM
    TYLENOL JUNIOR STRENGTH CAPLETS
    PHOGOGLANDIN
    DOLENE AP-65
    MAGNIDOL
    ANEXSIA 7.5/325
    PANADEINE
    PANASORBE
    PARACETAMOL NYCOMED
    MALEX N
    ROXILOX
    FEVOR
    SCHERZATABLETTEN REZEPTUR 534
    DOLKO
    OXYCOCET
    DIMINDOL
    ASPIRIN FREE ANACIN MAXIMUM STRENGTH GEL CAPLETS
    ATASOL ORAL SOLUTION
    PARMOL
    NEBS
    JUNIOR DISPROL
    PIRINASOL
    CHILDREN'S ACETAMINOPHEN ELIXIR DROPS
    DARVOCET
    PANADO
    SPALT FUR DIE NACHT
    BAYER SELECT SINUS PAIN RELIEF
    LABAMOL
    TYMOL
    DRISTANCITO
    CODISAL FORTE
    HYCOMINE COMPOUND
    PARALEN
    TEMLO
    BAYER SELECT HEAD COLD
    NINA
    ALPINY
    BUCET
    EXCEDRIN EXTRA STRENGTH CAPLETS
    BACETAMOL
    ACTAMIN SUPER
    ESGIC-PLUS
    PERCOCET-DEMI
    PARACETOL
    ORTENSAN
    BANCAP HC
    PARALYOC
    MONO PRAECIMED
    TIFFY
    GENAPAP CHILDREN'S TABLETS
    PARACENOL
    chembl:CHEMBL112
    drugbank:00316
    chemidplus:103-90-2
    pubchem.compound:1983
    rxcui:161

    Drug Info:

    Year of Approval approved before 1982
    Drug Class antipyretics
    Drug Class analgesics
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications analgesic
    (6 More Sources)

    Publications:

    Sinning C et al., 2008, New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide., J Med Chem
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Hinz et al., 2008, Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man., FASEB J.
    Högestätt et al., 2005, Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system., J. Biol. Chem.
    Lee et al., 2007, Acetaminophen selectively suppresses peripheral prostaglandin E2 release and increases COX-2 gene expression in a clinical model of acute inflammation., Pain
    Weinheimer et al., 2007, Resistance exercise and cyclooxygenase (COX) expression in human skeletal muscle: implications for COX-inhibiting drugs and protein synthesis., Am. J. Physiol. Regul. Integr. Comp. Physiol.
    Pickering G et al., 2020, Paracetamol and Pain Modulation by TRPV1, UGT2B15, SULT1A1 Genotypes: A Randomized Clinical Trial in Healthy Volunteers., Pain Med
    Mallet et al., 2010, TRPV1 in brain is involved in acetaminophen-induced antinociception., PLoS ONE
    Reiter C et al., 1982, Platelet phenol sulfotransferase activity: correlation with sulfate conjugation of acetaminophen., Clin Pharmacol Ther
    Mazaleuskaya LL et al., 2015, PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses., Pharmacogenet Genomics
    McGill MR et al., 2013, Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis., Pharm Res
    Dimova et al., 2005, Acetaminophen decreases intracellular glutathione levels and modulates cytokine production in human alveolar macrophages and type II pneumocytes in vitro., Int. J. Biochem. Cell Biol.
    Prasad et al., 1990, Effects of ethanol and inhibitors on the binding and metabolism of acetaminophen and N-acetyl-p-benzoquinone imine by hepatic microsomes from control and ethanol-treated rats., Biochem. Pharmacol.
    Gadd et al., 2002, Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity., Toxicol. Sci.
    Vevelstad M et al., 2009, O-demethylation of codeine to morphine inhibited by low-dose levomepromazine., Eur J Clin Pharmacol
    Laine JE et al., 2009, Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes., Xenobiotica
    Voronov P et al., 2007, Apnea in a child after oral codeine: a genetic variant - an ultra-rapid metabolizer., Paediatr Anaesth
    Dong H et al., 2000, Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen., Drug Metab Dispos
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Chen W et al., 1998, Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirus-expressed and purified human cytochromes P450 2E1 and 2A6., Chem Res Toxicol
    Ueshima Y et al., 1996, Acetaminophen metabolism in patients with different cytochrome P-4502E1 genotypes., Alcohol Clin Exp Res
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
    Hazai E et al., 2002, Reduction of toxic metabolite formation of acetaminophen., Biochem Biophys Res Commun
    Moffit et al., 2007, Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen., Toxicology
    Sumioka et al., 2004, Potential roles of hepatic heat shock protein 25 and 70i in protection of mice against acetaminophen-induced liver injury., Life Sci.
    Nakagawa T et al., 2012, Acetaminophen administration in a patient with Gilbert's syndrome., Pediatr Int
    Mutlib AE et al., 2006, Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential implications in acetaminophen-induced hepatotoxicity., Chem Res Toxicol
    Court MH et al., 2001, Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms., J Pharmacol Exp Ther
    Raffa et al., 1996, Lack of binding of acetaminophen to 5-HT receptor or uptake sites (or eleven other binding/uptake assays)., Life Sci.
    Chung CW et al., 2012, Fragment-based discovery of bromodomain inhibitors part 1: inhibitor binding modes and implications for lead discovery., J Med Chem
    Liu YC et al., 2012, Human mu-opioid receptor gene A118G polymorphism predicts the efficacy of tramadol/acetaminophen combination tablets (ultracet) in oxaliplatin-induced painful neuropathy., Cancer
    Tankanitlert J et al., 2007, Effects of combined UDP-glucuronosyltransferase (UGT) 1A1*28 and 1A6*2 on paracetamol pharmacokinetics in beta-thalassemia/HbE., Pharmacology
    Krishnaswamy S et al., 2005, UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S)., J Pharmacol Exp Ther
    Cristallo AF et al., 2011, A study of HLA class I and class II 4-digit allele level in Stevens-Johnson syndrome and toxic epidermal necrolysis., Int J Immunogenet
    Neumann et al., Ascorbic acid deficiency and hepatic UDP-glucuronyltransferase., Drug Metab. Dispos.
    Ayuso P et al., 2015, Association study of genetic variants in PLA2G4A, PLCG1, LAT, SYK, and TNFRS11A genes in NSAIDs-induced urticaria and/or angioedema patients., Pharmacogenet Genomics
    Rofe et al., 1998, Paracetamol hepatotoxicity in metallothionein-null mice., Toxicology
    Lee et al., 2006, Ubiquitin-dependent degradation of p53 protein despite phosphorylation at its N terminus by acetaminophen., J. Pharmacol. Exp. Ther.
    Chiu et al., 2003, Role of tumor necrosis factor receptor 1 (p55) in hepatocyte proliferation during acetaminophen-induced toxicity in mice., Toxicol. Appl. Pharmacol.
    Bernand et al., 2000, Multifocal fixed drug eruption to paracetamol, tropisetron and ondansetron induced by interleukin 2., Dermatology (Basel)
    Ganey et al., 2007, Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice., Hepatology
  • ACETAMINOPHEN   SULT1E1

    Interaction Score: 4.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26049587 23462933


    Sources:
    PharmGKB

  • ACETAMINOPHEN   SULT1A1

    Interaction Score: 1.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6957279 30908574 26049587 23462933


    Sources:
    PharmGKB

  • ACETAMINOPHEN   SULT1A4

    Interaction Score: 1.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26049587


    Sources:
    PharmGKB

  • ACETAMINOPHEN   MT2A

    Interaction Score: 1.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9570328


    Sources:
    NCI

  • ACETAMINOPHEN   SULT1A3

    Interaction Score: 1.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26049587 23462933


    Sources:
    PharmGKB

  • ACETAMINOPHEN   UGT2B15

    Interaction Score: 1.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30908574 26049587 16696573


    Sources:
    PharmGKB

  • ACETAMINOPHEN   UGT1A6

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26049587 23462933 23279026 17164591 16696573 15761113 11714888


    Sources:
    PharmGKB

  • ACETAMINOPHEN   NPIPB8

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ACETAMINOPHEN   TNFRSF11A

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26398624


    Sources:
    PharmGKB

  • ACETAMINOPHEN   SULT2A1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26049587


    Sources:
    PharmGKB

  • ACETAMINOPHEN   CYP2E1

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9548799 8659683 26049587 23462933 19219744 18695978 11866476


    Sources:
    PharmGKB

  • ACETAMINOPHEN   PLCG1

    Interaction Score: 0.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26398624


    Sources:
    PharmGKB

  • ACETAMINOPHEN   UGT1A9

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26049587 23279026 16696573 11714888


    Sources:
    PharmGKB

  • ACETAMINOPHEN   BRD2

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22136404


    Sources:
    DTC

  • ACETAMINOPHEN   UGT1A

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ACETAMINOPHEN   PLA2G4A

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26398624


    Sources:
    PharmGKB

  • ACETAMINOPHEN   CYP7B1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2242029


    Sources:
    NCI

  • ACETAMINOPHEN   HLA-DQB1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21545408


    Sources:
    PharmGKB

  • ACETAMINOPHEN   CYP2A6

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9548799 26049587 11866476


    Sources:
    PharmGKB

  • ACETAMINOPHEN   UGT1A4

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2903022


    Sources:
    NCI

  • ACETAMINOPHEN   HSPA8

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15010265


    Sources:
    NCI

  • ACETAMINOPHEN   FAAH

    Interaction Score: 0.23

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Anandamide amidohydrolase inhibitor
    Direct Interaction yes

    PMIDs:
    15987694


    Sources:
    ChemblInteractions NCI

  • ACETAMINOPHEN   TRPV1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Vanilloid receptor opener
    Direct Interaction yes

    PMIDs:
    30908574 20862299 15987694


    Sources:
    ChemblInteractions PharmGKB

  • ACETAMINOPHEN   MARK2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17654741


    Sources:
    NCI

  • ACETAMINOPHEN   PTGS1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cyclooxygenase inhibitor
    Trial Name PTI-701

    PMIDs:
    19053765 11752352 17884974


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND

  • ACETAMINOPHEN   CDKN1A

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16330492


    Sources:
    NCI

  • ACETAMINOPHEN   CCND1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11896290


    Sources:
    NCI

  • ACETAMINOPHEN   NQO1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17188792


    Sources:
    NCI

  • ACETAMINOPHEN   PTGS2

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclooxygenase inhibitor
    Direct Interaction yes
    Trial Name PTI-701

    PMIDs:
    17175104 17884974 17322116 11752352


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • ACETAMINOPHEN   HTR4

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8699917


    Sources:
    NCI

  • ACETAMINOPHEN   IL2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11053919


    Sources:
    NCI

  • ACETAMINOPHEN   CXCL8

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15878691


    Sources:
    NCI

  • ACETAMINOPHEN   CDK2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14644624


    Sources:
    NCI

  • ACETAMINOPHEN   OPRM1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21837673


    Sources:
    PharmGKB

  • ACETAMINOPHEN   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26049587 19308365 19219744 17564651 11095574 22931300


    Sources:
    DTC PharmGKB

  • ACETAMINOPHEN   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26049587 19219744 22931300


    Sources:
    DTC PharmGKB

  • ACETAMINOPHEN   CYP2C9

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • ACETAMINOPHEN   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • ACETAMINOPHEN   CYP3A4

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TEND: ACETAMINOPHEN

    • Version: 01-August-2011

    Alternate Names:
    ACETAMINOPHEN Primary Drug Name

    Drug Info:
    Drug Class analgesics
    Drug Class antipyretics
    Year of Approval approved before 1982

    Publications:

  • TdgClinicalTrial: ACETAMINOPHEN

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications analgesic
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: ACETAMINOPHEN

    • Version: 14-September-2017

    Alternate Names:
    C198 NCI drug code

    Drug Info:

    Publications:
    Högestätt et al., 2005, Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system., J. Biol. Chem.
    Prasad et al., 1990, Effects of ethanol and inhibitors on the binding and metabolism of acetaminophen and N-acetyl-p-benzoquinone imine by hepatic microsomes from control and ethanol-treated rats., Biochem. Pharmacol.
    Gadd et al., 2002, Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity., Toxicol. Sci.

  • NCI: APAP

    • Version: 14-September-2017

    Alternate Names:
    C198 NCI drug code

    Drug Info:

    Publications:
    Moffit et al., 2007, Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen., Toxicology
    Lee et al., 2006, Ubiquitin-dependent degradation of p53 protein despite phosphorylation at its N terminus by acetaminophen., J. Pharmacol. Exp. Ther.
    Ganey et al., 2007, Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice., Hepatology

  • DTC: ACETAMINOPHEN

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL112 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Sinning C et al., 2008, New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide., J Med Chem
    Chung CW et al., 2012, Fragment-based discovery of bromodomain inhibitors part 1: inhibitor binding modes and implications for lead discovery., J Med Chem

  • NCI: PARACETAMOL

    • Version: 14-September-2017

    Alternate Names:
    C198 NCI drug code

    Drug Info:

    Publications:
    Bernand et al., 2000, Multifocal fixed drug eruption to paracetamol, tropisetron and ondansetron induced by interleukin 2., Dermatology (Basel)
    Rofe et al., 1998, Paracetamol hepatotoxicity in metallothionein-null mice., Toxicology

  • PharmGKB: acetaminophen

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Ayuso P et al., 2015, Association study of genetic variants in PLA2G4A, PLCG1, LAT, SYK, and TNFRS11A genes in NSAIDs-induced urticaria and/or angioedema patients., Pharmacogenet Genomics
    Mazaleuskaya LL et al., 2015, PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses., Pharmacogenet Genomics
    Pickering G et al., 2020, Paracetamol and Pain Modulation by TRPV1, UGT2B15, SULT1A1 Genotypes: A Randomized Clinical Trial in Healthy Volunteers., Pain Med

  • TTD: Acetaminophen

    • Version: 2020.06.01

    Alternate Names:
    D0U5QK TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL112

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL112

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21