DGIdb - ACETYLCYSTEINE Drug Record

ACETYLCYSTEINE chembl:CHEMBL600 Approved

Alternate Names:

MUCOSIL-20
ILUBE
SOLMUCOL
N-ACETYL-L-CYSTEINE
CETYLEV
FLUIMUCIL 600
MUCOSIL-10
EN-CYS
ACC-600
FLUIMUCIL LONG
ACETADOTE
ORONAC 600
A-CYS
FLUIMUCIL N
AIRBRON
FLUIMUCIL
FABROL
MUCOSIL
ACETYLCYSTEINE
5052
YOURNAC
NSC-111180
SIRAN
MUCOMYST
PARVOLEX
RESPI-NAC
(R)-2-ACETYLAMINO-3-MERCAPTOPROPANOIC ACID
N-ACETYL-3-MERCAPTOALANINE
(R)-MERCAPTURIC ACID
ACETILCISTEINA
N-ACETYL-L-(+)-CYSTEINE
(2R)-2-ACETYLAMINO-3-SULFANYLPROPANOIC ACID
L-ALPHA-ACETAMIDO-BETA-MERCAPTOPROPIONIC ACID
2-ACETYLAMINO-3-MERCAPTO-PROPIONIC ACID
SODIUM 2-ACETAMIDO-3-MERCAPTOPROPIONATE
FLUIMUCETIN
MERCAPTURIC ACID
2-ACETYLAMINO-3-MERCAPTO-PROPIONATE
N-ACETYLCYSTEINE
L-ACETYLCYSTEINE
FLUMUCETIN
L-Α-ACETAMIDO-Β-MERCAPTOPROPIONIC ACID
NAC
FLUPROWIT
N-ACETY-L-CYSTEINE
(2R)-2-ACETAMIDO-3-SULFANYLPROPANOIC ACID
ACETYLCYSTEINUM
FLUIMICIL INFANTIL
drugbank:06151
chemidplus:616-91-1
pubchem.compound:12035
chembl:CHEMBL600
rxcui:197

Drug Info:

(2 More Sources)

Publications:

Hashimoto et al., 2004, Effects of N-acetyl-L-cysteine on the reduction of brain dopamine transporters in monkey treated with methamphetamine., Ann. N. Y. Acad. Sci.
Saccani et al., 2000, Redox regulation of chemokine receptor expression., Proc. Natl. Acad. Sci. U.S.A.
Kelly et al., 2002, Type I insulin-like growth factor receptor expression on colorectal adenocarcinoma cell lines is decreased in response to the chemopreventive agent N-acetyl-l-cysteine., Ann. N. Y. Acad. Sci.
Ren et al., 1995, Mechanism of metallothionein gene regulation by heme-hemopexin. Roles of protein kinase C, reactive oxygen species, and cis-acting elements., J. Biol. Chem.
Rieber et al., 2003, N-Acetylcysteine enhances UV-mediated caspase-3 activation, fragmentation of E2F-4, and apoptosis in human C8161 melanoma: inhibition by ectopic Bcl-2 expression., Biochem. Pharmacol.
Knudsen et al., 2005, Effect of intravenous N-acetylcysteine infusion on haemostatic parameters in healthy subjects., Gut
Shimoyama et al., 2006, Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation., Metab. Clin. Exp.
Kamata et al., 2005, Redox regulation of nerve growth factor-induced neuronal differentiation of PC12 cells through modulation of the nerve growth factor receptor, TrkA., Arch. Biochem. Biophys.
McLaughlin et al., 1996, The role of oxygen in thymocyte apoptosis., Eur. J. Immunol.
Zheng et al., 2002, The effects of chylomicron remnants enriched in n-3 or n-6 polyunsaturated fatty acids on the transcription of genes regulating their uptake and metabolism by the liver: influence of cellular oxidative state., Free Radic. Biol. Med.
Khalak et al., 1999, Antagonistic effects of pyrrolidine dithiocarbamate and N-acetyl-L-cysteine on surfactant protein A and B mRNAs., Exp. Lung Res.
Kurz et al., 2004, Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species., J. Biol. Chem.
Gehring et al., 1999, Inactivation of both RNA binding and aconitase activities of iron regulatory protein-1 by quinone-induced oxidative stress., J. Biol. Chem.

ACETYLCYSTEINE ACO1

Interaction Score: 8.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10037708

Sources:
NCI
ACETYLCYSTEINE MT1E

Interaction Score: 8.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7592595

Sources:
NCI
ACETYLCYSTEINE TOLLIP

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ACETYLCYSTEINE H2AX

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15489221

Sources:
NCI
ACETYLCYSTEINE SFTPA1

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10533675

Sources:
NCI
ACETYLCYSTEINE NR4A1

Interaction Score: 0.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8647183

Sources:
NCI
ACETYLCYSTEINE CXCR2

Interaction Score: 0.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10716998

Sources:
NCI
ACETYLCYSTEINE VWF

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15753537

Sources:
NCI
ACETYLCYSTEINE E2F1

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12754095

Sources:
NCI
ACETYLCYSTEINE LDLR

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12031897

Sources:
NCI
ACETYLCYSTEINE IGF1R

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12485928

Sources:
NCI
ACETYLCYSTEINE SLC2A4

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16713429

Sources:
NCI
ACETYLCYSTEINE NTRK1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15629104

Sources:
NCI
ACETYLCYSTEINE SLC6A3

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15542721

Sources:
NCI
ACETYLCYSTEINE KDM4E

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

NCI: N-ACETYL-L-CYSTEINE

Version: 14-September-2017

Alternate Names:

C200 NCI drug code

Drug Info:

Publications:

Hashimoto et al., 2004, Effects of N-acetyl-L-cysteine on the reduction of brain dopamine transporters in monkey treated with methamphetamine., Ann. N. Y. Acad. Sci.

Saccani et al., 2000, Redox regulation of chemokine receptor expression., Proc. Natl. Acad. Sci. U.S.A.

NCI: NAC

Version: 14-September-2017

Alternate Names:

C200 NCI drug code

Drug Info:

Publications:

Khalak et al., 1999, Antagonistic effects of pyrrolidine dithiocarbamate and N-acetyl-L-cysteine on surfactant protein A and B mRNAs., Exp. Lung Res.

Zheng et al., 2002, The effects of chylomicron remnants enriched in n-3 or n-6 polyunsaturated fatty acids on the transcription of genes regulating their uptake and metabolism by the liver: influence of cellular oxidative state., Free Radic. Biol. Med.

Ren et al., 1995, Mechanism of metallothionein gene regulation by heme-hemopexin. Roles of protein kinase C, reactive oxygen species, and cis-acting elements., J. Biol. Chem.

NCI: N-ACETYLCYSTEINE

Version: 14-September-2017

Alternate Names:

C200 NCI drug code

Drug Info:

Publications:

Kurz et al., 2004, Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species., J. Biol. Chem.

Knudsen et al., 2005, Effect of intravenous N-acetylcysteine infusion on haemostatic parameters in healthy subjects., Gut

Gehring et al., 1999, Inactivation of both RNA binding and aconitase activities of iron regulatory protein-1 by quinone-induced oxidative stress., J. Biol. Chem.

DTC: ACETYLCYSTEINE
- Version: 02-September-2020
Alternate Names:

CHEMBL600 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL600
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: acetylcysteine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

ACETYLCYSTEINE Drug Record

ACETYLCYSTEINE chembl:CHEMBL600 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10037708

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7592595

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15489221

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10533675

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8647183

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10716998

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15753537

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12754095

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12031897

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12485928

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16713429

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15629104

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15542721

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

NCI: N-ACETYL-L-CYSTEINE

Alternate Names: C200 NCI drug code

Drug Info:

Publications: Hashimoto et al., 2004, Effects of N-acetyl-L-cysteine on the reduction of brain dopamine transporters in monkey treated with methamphetamine., Ann. N. Y. Acad. Sci. Saccani et al., 2000, Redox regulation of chemokine receptor expression., Proc. Natl. Acad. Sci. U.S.A.

NCI: NAC

Alternate Names: C200 NCI drug code

Drug Info:

NCI: N-ACETYLCYSTEINE

Alternate Names: C200 NCI drug code

Drug Info:

DTC: ACETYLCYSTEINE

Alternate Names: CHEMBL600 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL600

Interaction Types & Directionality:

n/a

PMIDs:
10037708

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7592595

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15489221

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10533675

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8647183

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10716998

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15753537

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12754095

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12031897

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12485928

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16713429

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15629104

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15542721

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

C200 NCI drug code

Publications:

Hashimoto et al., 2004, Effects of N-acetyl-L-cysteine on the reduction of brain dopamine transporters in monkey treated with methamphetamine., Ann. N. Y. Acad. Sci.

Saccani et al., 2000, Redox regulation of chemokine receptor expression., Proc. Natl. Acad. Sci. U.S.A.

Alternate Names:

C200 NCI drug code

Alternate Names:

C200 NCI drug code

Alternate Names:

CHEMBL600 ChEMBL Drug ID