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ADINAZOLAM Drug Record

  • Summary
  • Interactions
  • Claims
  • ADINAZOLAM chembl:CHEMBL328250

    Alternate Names:

    U-41123
    ADINAZOLAM
    ADINAZOLAMUM
    8-CHLORO-1-((DIMETHYLAMINO)METHYL)-6-PHENYL-4H-S-TRIAZOLO(4,3-A)(1,4)BENZODIAZEPINE
    chemidplus:37115-32-5
    drugbank:00546
    pubchem.compound:37632
    chembl:CHEMBL328250

    Drug Info:

    Drug Class anticonvulsant
    Year of Approval not approved by the fda
    Drug Class anti-anxiety agents
    FDA Approval not approved by the FDA
    Drug Class small molecule
    Drug Indications anticonvulsant
    Drug Indications Anti-anxiety Agents
    Drug Categories nervous system
    Drug Groups experimental
    Drug Categories benzodiazepines and benzodiazepine derivatives
    Drug Categories central nervous system depressants
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 substrates
    Drug Categories heterocyclic compounds, fused-ring
    Drug Categories triazolobenzodiazepines
    (1 More Sources)

    Publications:

    Sethy et al., 1984, Determination of biological activity of adinazolam and its metabolites., J. Pharm. Pharmacol.
    Lahti et al., 1983, Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine., Neuropharmacology
    Zhu S et al., 2018, Structure of a human synaptic GABA<sub>A</sub> receptor., Nature
    Sigel E et al., 2012, Structure, function, and modulation of GABA(A) receptors., J Biol Chem
  • ADINAZOLAM   GABRR3

    Interaction Score: 0.46

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    6148400 6320036


    Sources:
    TEND TdgClinicalTrial

  • ADINAZOLAM   GABRR2

    Interaction Score: 0.46

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    6148400 6320036


    Sources:
    TEND TdgClinicalTrial

  • ADINAZOLAM   GABRR1

    Interaction Score: 0.43

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    6148400 6320036


    Sources:
    TEND TdgClinicalTrial

  • ADINAZOLAM   GABRE

    Interaction Score: 0.22

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    6148400 6320036


    Sources:
    TEND TdgClinicalTrial

  • ADINAZOLAM   GABRP

    Interaction Score: 0.22

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    6148400 6320036


    Sources:
    TEND TdgClinicalTrial

  • ADINAZOLAM   GABRD

    Interaction Score: 0.21

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    6148400 6320036


    Sources:
    TEND TdgClinicalTrial

  • ADINAZOLAM   GABRG1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    6148400 6320036


    Sources:
    TEND TdgClinicalTrial

  • ADINAZOLAM   GABRB1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    6148400 6320036


    Sources:
    TEND TdgClinicalTrial

  • ADINAZOLAM   GABRB3

    Interaction Score: 0.2

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    6148400 6320036


    Sources:
    TEND TdgClinicalTrial

  • ADINAZOLAM   GABRB2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    6148400 6320036


    Sources:
    TEND TdgClinicalTrial

  • ADINAZOLAM   GABRA1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    6148400 6320036 29950725 23038269


    Sources:
    TEND TdgClinicalTrial DrugBank

  • ADINAZOLAM   GABRG3

    Interaction Score: 0.18

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    6148400 6320036


    Sources:
    TEND TdgClinicalTrial

  • ADINAZOLAM   GABRA5

    Interaction Score: 0.16

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    6148400 6320036


    Sources:
    TEND TdgClinicalTrial

  • ADINAZOLAM   GABRA2

    Interaction Score: 0.15

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    6148400 6320036


    Sources:
    TEND TdgClinicalTrial

  • ADINAZOLAM   GABRA3

    Interaction Score: 0.15

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    6148400 6320036


    Sources:
    TEND TdgClinicalTrial

  • ADINAZOLAM   GABRG2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    potentiator

    Interaction Info:

    PMIDs:
    6148400 6320036


    Sources:
    TEND

  • ADINAZOLAM   TSPO

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • DrugBank: DB00546

    • Version: 5.1.7

    Alternate Names:
    ADINAZOLAM DrugBank Drug Name
    37115-32-5 CAS Number
    Deracyn Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups experimental
    Drug Categories anti-anxiety agents

    Publications:
    Zhu S et al., 2018, Structure of a human synaptic GABA<sub>A</sub> receptor., Nature
    Sigel E et al., 2012, Structure, function, and modulation of GABA(A) receptors., J Biol Chem

  • TEND: ADINAZOLAM

    • Version: 01-August-2011

    Alternate Names:
    ADINAZOLAM Primary Drug Name

    Drug Info:
    Drug Class anti-anxiety agents
    Year of Approval not approved by the fda
    Drug Class anticonvulsant

    Publications:

  • TdgClinicalTrial: ADINAZOLAM

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Anti-anxiety Agents
    Drug Indications anticonvulsant
    Drug Class small molecule

    Publications:

  • TTD: Adinazolam

    • Version: 2020.06.01

    Alternate Names:
    D0E7FS TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL328250

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2021-04-13