DGIdb - ALBUTEROL Drug Record

ALBUTEROL chembl:CHEMBL714 Approved

Alternate Names:

SALAMOL E-BREATHE
SALAPIN
COMBIVENT
AEROLIN 400
MAXIVENT
ASMAVENT
KENTAMOL
VENTOLIN
VENTOLIN HFA
COMBIVENT UDVS
SALBUTAMOL
VENTMAX SR
PROVENTIL HFA
RIMASAL
LIBETIST
VENTOLIN E-BREATHE
PROVENTIL-HFA
PROAIR HFA
VENTOLIN CR
AEROLIN AUTO
ASMASAL CLICKHALER
PROVENTIL
SALBUVENT
AEROLIN
VENTODISKS
SALIPRANEB
ALBUTEROL
AIRSALB
ASMASAL SPACEHALER
COBUTOLIN
ASMAVEN
STERI-NEB SALAMOL
SCH 13949W
ACCUNEB
VOLMAX
AIROMIR
SCH-13949W
IPRAMOL STERI-NEB
SALBULIN NOVOLIZER
DUONEB
BTA204
(±)-SALBUTAMOL
chembl:CHEMBL714
rxcui:435
drugbank:01001
chemidplus:18559-94-9

Drug Info:

Year of Approval	1968
Drug Class	bronchodilator agents
Drug Indications	for treatment of symptomatic exophthalmos associated with thyroid-related eye disease
Drug Indications	for treatment of chronic obstructive pulmonary disorder (COPD)
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	bronchodilator

(4 More Sources)

Publications:

MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol
el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
Bandaru S et al., 2017, Molecular dynamic simulations reveal suboptimal binding of salbutamol in T164I variant of β2 adrenergic receptor., PLoS One
Zuurhout MJ et al., 2013, Arg16 ADRB2 genotype increases the risk of asthma exacerbation in children with a reported use of long-acting β2-agonists: results of the PACMAN cohort., Pharmacogenomics
Lipworth BJ et al., 2013, Tailored second-line therapy in asthmatic children with the Arg(16) genotype., Clin Sci (Lond)
Basu K et al., 2009, Adrenergic beta(2)-receptor genotype predisposes to exacerbations in steroid-treated asthmatic patients taking frequent albuterol or salmeterol., J Allergy Clin Immunol
Bleecker ER et al., 2007, Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies., Lancet
Israel E et al., 2004, Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial., Lancet
Brichetto et al., 2003, Beclomethasone rapidly ablates allergen-induced beta 2-adrenoceptor pathway dysfunction in human isolated bronchi., Am. J. Physiol. Lung Cell Mol. Physiol.
Brouri et al., 2004, Blockade of beta 1- and desensitization of beta 2-adrenoceptors reduce isoprenaline-induced cardiac fibrosis., Eur. J. Pharmacol.
Chong et al., 2003, Desensitization of beta2-adrenoceptor-mediated responses by short-acting beta2-adrenoceptor agonists in human lung mast cells., Br. J. Pharmacol.
Yamanishi et al., 2003, Role of beta-adrenoceptor subtypes in mediating relaxation of the pig bladder trigonal muscle in vitro., Neurourol. Urodyn.
Choudhry et al., 2005, Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma., Am. J. Respir. Crit. Care Med.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Duan QL et al., 2014, A genome-wide association study of bronchodilator response in asthmatics., Pharmacogenomics J
Jin Y et al., 2010, Dual-specificity phosphatase 1 as a pharmacogenetic modifier of inhaled steroid response among asthmatic patients., J Allergy Clin Immunol

ALBUTEROL CLOCK

Interaction Score: 10.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23508266

Sources:
PharmGKB
ALBUTEROL COL22A1

Interaction Score: 10.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ALBUTEROL DUSP1

Interaction Score: 7.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20673984

Sources:
PharmGKB
ALBUTEROL CRHR2

Interaction Score: 2.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ALBUTEROL ADRB2

Interaction Score: 1.62

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor agonist

Direct Interaction yes

Trial Name albuterol,Ventolin

PMIDs:
16680159 2903243 29053759 24279851 23126384 19800676 18156033 15500895 12388338 14757145 12569076 12808710 15557128 11752352

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology PharmGKB TTD
ALBUTEROL GLP1R

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: SALBUTAMOL
- Version: 01-August-2011
Alternate Names:

SALBUTAMOL Primary Drug Name

Drug Info:

Drug Class bronchodilator agents

Year of Approval 1968

Publications:
TdgClinicalTrial: SALBUTAMOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications bronchodilator

Drug Class Small Molecule

FDA Approval approved

Publications:

DTC: ALBUTEROL

Version: 02-September-2020

Alternate Names:

CHEMBL714 ChEMBL Drug ID

Drug Info:

Publications:

el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem

MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol

PharmGKB: salbutamol

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Duan QL et al., 2014, A genome-wide association study of bronchodilator response in asthmatics., Pharmacogenomics J

Lipworth BJ et al., 2013, Tailored second-line therapy in asthmatic children with the Arg(16) genotype., Clin Sci (Lond)

Bandaru S et al., 2017, Molecular dynamic simulations reveal suboptimal binding of salbutamol in T164I variant of β2 adrenergic receptor., PLoS One

TTD: Salbutamol
- Version: 2020.06.01
Alternate Names:

D0K5CB TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135650977
- Version: 29-September-2020
Alternate Names:

SALBUTAMOL GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL714
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL714
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Beta-2 adrenergic receptor agonist
Direct Interaction	yes
Trial Name	albuterol,Ventolin

ALBUTEROL Drug Record

ALBUTEROL chembl:CHEMBL714 Approved

Alternate Names:

Drug Info:

Publications:

ALBUTEROL CLOCK

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23508266

Sources: PharmGKB

ALBUTEROL COL22A1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

ALBUTEROL DUSP1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20673984

Sources: PharmGKB

ALBUTEROL CRHR2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

ALBUTEROL ADRB2

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Beta-2 adrenergic receptor agonist Direct Interaction yes Trial Name albuterol,Ventolin

PMIDs: 16680159 2903243 29053759 24279851 23126384 19800676 18156033 15500895 12388338 14757145 12569076 12808710 15557128 11752352

Sources: DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology PharmGKB TTD

ALBUTEROL GLP1R

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: SALBUTAMOL

Alternate Names: SALBUTAMOL Primary Drug Name

Drug Info: Drug Class bronchodilator agents Year of Approval 1968

Publications:

TdgClinicalTrial: SALBUTAMOL

Alternate Names:

Drug Info: Drug Indications bronchodilator Drug Class Small Molecule FDA Approval approved

Publications:

DTC: ALBUTEROL

Alternate Names: CHEMBL714 ChEMBL Drug ID

Drug Info:

Publications: el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol

PharmGKB: salbutamol

Alternate Names:

Drug Info:

TTD: Salbutamol

Alternate Names: D0K5CB TTD Drug ID

Drug Info:

Publications:

GuideToPharmacology: 135650977

Alternate Names: SALBUTAMOL GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL714

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL714

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
23508266

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20673984

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Beta-2 adrenergic receptor agonist

Direct Interaction yes

Trial Name albuterol,Ventolin

PMIDs:
16680159 2903243 29053759 24279851 23126384 19800676 18156033 15500895 12388338 14757145 12569076 12808710 15557128 11752352

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

SALBUTAMOL Primary Drug Name

Drug Info:

Drug Class bronchodilator agents

Year of Approval 1968

Drug Info:

Drug Indications bronchodilator

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

CHEMBL714 ChEMBL Drug ID

Publications:

el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem

MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol

Alternate Names:

D0K5CB TTD Drug ID

Alternate Names:

SALBUTAMOL GuideToPharmacology Ligand Name