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ALBUTEROL Drug Record

  • Summary
  • Interactions
  • Claims
  • ALBUTEROL chembl:CHEMBL714 Approved

    Alternate Names:

    SALAMOL E-BREATHE
    SALAPIN
    COMBIVENT
    AEROLIN 400
    MAXIVENT
    ASMAVENT
    KENTAMOL
    VENTOLIN
    VENTOLIN HFA
    COMBIVENT UDVS
    SALBUTAMOL
    VENTMAX SR
    PROVENTIL HFA
    RIMASAL
    LIBETIST
    VENTOLIN E-BREATHE
    PROVENTIL-HFA
    PROAIR HFA
    VENTOLIN CR
    AEROLIN AUTO
    ASMASAL CLICKHALER
    PROVENTIL
    SALBUVENT
    AEROLIN
    VENTODISKS
    SALIPRANEB
    ALBUTEROL
    AIRSALB
    ASMASAL SPACEHALER
    COBUTOLIN
    ASMAVEN
    STERI-NEB SALAMOL
    SCH 13949W
    ACCUNEB
    VOLMAX
    AIROMIR
    SCH-13949W
    IPRAMOL STERI-NEB
    SALBULIN NOVOLIZER
    DUONEB
    BTA204
    (±)-SALBUTAMOL
    chembl:CHEMBL714
    rxcui:435
    drugbank:01001
    chemidplus:18559-94-9

    Drug Info:

    Year of Approval 1968
    Drug Class bronchodilator agents
    Drug Indications for treatment of symptomatic exophthalmos associated with thyroid-related eye disease
    Drug Indications for treatment of chronic obstructive pulmonary disorder (COPD)
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications bronchodilator
    (3 More Sources)

    Publications:

    MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol
    el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
    Bandaru S et al., 2017, Molecular dynamic simulations reveal suboptimal binding of salbutamol in T164I variant of β2 adrenergic receptor., PLoS One
    Zuurhout MJ et al., 2013, Arg16 ADRB2 genotype increases the risk of asthma exacerbation in children with a reported use of long-acting β2-agonists: results of the PACMAN cohort., Pharmacogenomics
    Lipworth BJ et al., 2013, Tailored second-line therapy in asthmatic children with the Arg(16) genotype., Clin Sci (Lond)
    Basu K et al., 2009, Adrenergic beta(2)-receptor genotype predisposes to exacerbations in steroid-treated asthmatic patients taking frequent albuterol or salmeterol., J Allergy Clin Immunol
    Bleecker ER et al., 2007, Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetic analysis of two randomised studies., Lancet
    Israel E et al., 2004, Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial., Lancet
    Brichetto et al., 2003, Beclomethasone rapidly ablates allergen-induced beta 2-adrenoceptor pathway dysfunction in human isolated bronchi., Am. J. Physiol. Lung Cell Mol. Physiol.
    Brouri et al., 2004, Blockade of beta 1- and desensitization of beta 2-adrenoceptors reduce isoprenaline-induced cardiac fibrosis., Eur. J. Pharmacol.
    Chong et al., 2003, Desensitization of beta2-adrenoceptor-mediated responses by short-acting beta2-adrenoceptor agonists in human lung mast cells., Br. J. Pharmacol.
    Yamanishi et al., 2003, Role of beta-adrenoceptor subtypes in mediating relaxation of the pig bladder trigonal muscle in vitro., Neurourol. Urodyn.
    Choudhry et al., 2005, Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma., Am. J. Respir. Crit. Care Med.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Duan QL et al., 2014, A genome-wide association study of bronchodilator response in asthmatics., Pharmacogenomics J
    Jin Y et al., 2010, Dual-specificity phosphatase 1 as a pharmacogenetic modifier of inhaled steroid response among asthmatic patients., J Allergy Clin Immunol
  • ALBUTEROL   CLOCK

    Interaction Score: 10.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23508266


    Sources:
    PharmGKB

  • ALBUTEROL   COL22A1

    Interaction Score: 10.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ALBUTEROL   DUSP1

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20673984


    Sources:
    PharmGKB

  • ALBUTEROL   CRHR2

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ALBUTEROL   ADRB2

    Interaction Score: 1.61

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Beta-2 adrenergic receptor agonist
    Direct Interaction yes
    Trial Name albuterol,Ventolin

    PMIDs:
    16680159 2903243 29053759 24279851 23126384 19800676 18156033 15500895 12388338 14757145 12569076 12808710 15557128 11752352


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

  • ALBUTEROL   GLP1R

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: SALBUTAMOL

    • Version: 01-August-2011

    Alternate Names:
    SALBUTAMOL Primary Drug Name

    Drug Info:
    Drug Class bronchodilator agents
    Year of Approval 1968

    Publications:

  • TdgClinicalTrial: SALBUTAMOL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications bronchodilator
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • DTC: ALBUTEROL

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL714 ChEMBL Drug ID

    Drug Info:

    Publications:
    el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
    MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol

  • PharmGKB: salbutamol

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Duan QL et al., 2014, A genome-wide association study of bronchodilator response in asthmatics., Pharmacogenomics J
    Lipworth BJ et al., 2013, Tailored second-line therapy in asthmatic children with the Arg(16) genotype., Clin Sci (Lond)
    Bandaru S et al., 2017, Molecular dynamic simulations reveal suboptimal binding of salbutamol in T164I variant of β2 adrenergic receptor., PLoS One

  • TTD: Salbutamol

    • Version: 2020.06.01

    Alternate Names:
    D0K5CB TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL714

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL714

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21