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ALCOHOL Drug Record

  • Summary
  • Interactions
  • Claims
  • ALCOHOL chembl:CHEMBL545 Approved

    Alternate Names:

    SPIRIGEL
    E1510
    ETHYL ALCOHOL
    METHYLATED MINERAL
    ALCOHOL
    ALCOHOL, DILUTED
    B3324
    ALCOHOL DETERMINATION--ALCOHOL
    ETHANOL
    ANHYDROUS ETHANOL
    VODKA
    ABLYSINOL
    SURG
    ALCOHOL, RUBBING
    FEMA NO. 2419
    NCI-C03134
    PM-6193-200
    NSC-85228
    ABSOLUTE ALCOHOL
    DESINFEKTOL EL
    1-HYDROXYETHANE
    ABSOLUTE ETHANOL
    ALCOOL ÉTHYLIQUE
    ETHYL ALCOHOL USP
    SYNASOL
    ALKOHOL
    UNDENATURED ETHANOL
    PYRO
    ALCARE HAND DEGERMER
    ANHYDROL
    ÉTHANOL
    ETHYL ALCOHOL ANHYDROUS
    MOLASSES ALCOHOL
    SPIRT
    HINETOLESS
    ÄTHYLALKOHOL
    LUX
    TECSOL C
    INFINITY PURE
    TECSOL
    ALCOHOL DENATURED
    ANHYDROUS ALCOHOL
    ETHYL HYDROXIDE
    ALCOHOL, DENATURED
    DENATURED ETHANOL
    ALCOHOL (ETHYL)
    COLOGNE SPIRITS
    SPIRITS OF WINE
    ETHANOL 200 PROOF
    ALGRAIN
    THANOL
    ÄTHANOL
    ETHANOL SOLUTION
    DEHYDRATED ALCOHOL
    ALCOHOL ETÍLICO
    HYDROXYETHANE
    JAYSOL S
    DILUTED ALCOHOL
    DRINKING ALCOHOL
    ETOH
    FERMENTATION ALCOHOL
    JAYSOL
    PUNCTILIOUS ETHYL ALCOHOL
    GRAIN ALCOHOL
    DISTILLED SPIRITS
    POTATO ALCOHOL
    ETANOL
    ALCOHOLS
    C2H5OH
    ETHYL ALC
    ETHYL HYDRATE
    ABSOLUTE ETHYL ALCOHOL
    SPIRITUS VINI
    ALCOHOL ANHYDROUS
    SPIRIT
    DENATURED ALCOHOL
    DEHYDRATED ETHANOL
    METHYLCARBINOL
    COLOGNE SPIRIT
    ETHICAP
    chembl:CHEMBL545
    drugbank:00898
    rxcui:448
    pubchem.compound:702
    chemidplus:64-17-5

    Drug Info:

    (0 More Sources)

    Publications:

    Mordasini et al., 1982, [Alcohol and plasma lipoproteins in acute and long-term studies]., Schweiz Med Wochenschr
    Pronko et al., 2002, Acinar distribution of rat liver arylamine N-acetyltransferase: effect of chronic ethanol and endotoxin exposure., Pharmacol. Toxicol.
    Miller RT et al., 2014, Ethanol self-administration and nicotine treatment increase brain levels of CYP2D in African green monkeys., Br J Pharmacol
    Le Marchand et al., 2005, The MTHFR C677T polymorphism and colorectal cancer: the multiethnic cohort study., Cancer Epidemiol. Biomarkers Prev.
    Lau et al., 1995, Ethanol modulates apolipoprotein B mRNA editing in the rat., J. Lipid Res.
    Leisewitz et al., 2003, Ethanol specifically decreases peroxisome proliferator activated receptor beta in B12 oligodendrocyte-like cells., J. Neurochem.
    Hendricson et al., 2003, Suppression of L-type voltage-gated calcium channel-dependent synaptic plasticity by ethanol: analysis of miniature synaptic currents and dendritic calcium transients., J. Pharmacol. Exp. Ther.
    Mosheva M et al., 2020, Association between CANCA1C gene rs1034936 polymorphism and alcohol dependence in bipolar disorder., J Affect Disord
    Calabrò M et al., 2020, Psychiatric disorders and SLC6A4 gene variants: possible effects on alcohol dependence and alzheimer's disease., Mol Biol Rep
    Dopico et al., 2009, Acute alcohol action and desensitization of ligand-gated ion channels., Pharmacol. Rev.
    Hendrickson et al., 2013, Neuronal nicotinic acetylcholine receptors: common molecular substrates of nicotine and alcohol dependence., Front Psychiatry
    Santos-Perez et al., 1996, T-cell activation, expression of adhesion molecules and response to ethanol in alcoholic cirrhosis., Immunol. Lett.
    Hallikainen et al., 2003, Ethanol consumption and DRD2 gene TaqI a polymorphism among socially drinking males., Am. J. Med. Genet. A
    Comings DE et al., 1994, The dopamine D2 receptor gene: a genetic risk factor in substance abuse., Drug Alcohol Depend
    Balldin J et al., 2018, TAQ1A1 Allele of the DRD2 Gene Region Contribute to Shorter Survival Time in Alcohol Dependent Individuals When Controlling for the Influence of Age and Gender. A Follow-up Study of 18 Years., Alcohol Alcohol
    Ragia G et al., 2016, Association study of DRD2 A2/A1, DRD3 Ser9Gly, DβH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A polymorphisms with alcohol dependence., Drug Metab Pers Ther
    Pieters S et al., 2012, The moderating effect of alcohol-specific parental rule-setting on the relation between the dopamine D2 receptor gene (DRD2), the μ-opioid receptor gene (OPRM1) and alcohol use in young adolescents., Alcohol Alcohol
    Bolos AM et al., 1990, Population and pedigree studies reveal a lack of association between the dopamine D2 receptor gene and alcoholism., JAMA
    Blum K et al., 1990, Allelic association of human dopamine D2 receptor gene in alcoholism., JAMA
    Blum K et al., 1991, Association of the A1 allele of the D2 dopamine receptor gene with severe alcoholism., Alcohol
    Smith L et al., 2008, Meta-analysis of the association of the Taq1A polymorphism with the risk of alcohol dependency: a HuGE gene-disease association review., Am J Epidemiol
    Blomqvist O et al., 2000, Family-based study of DRD2 alleles in alcohol and drug dependence., Am J Med Genet
    Town T et al., 1999, Association of a functional mu-opioid receptor allele (+118A) with alcohol dependency., Am J Med Genet
    Huang CY et al., 2018, No association of CYP2E1 genetic polymorphisms with alcohol dependence in Han Taiwanese population., J Formos Med Assoc
    Mazaleuskaya LL et al., 2015, PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses., Pharmacogenet Genomics
    Plemenitas A et al., 2015, Genetic variability in CYP2E1 and catalase gene among currently and formerly alcohol-dependent male subjects., Alcohol Alcohol
    Kim SA et al., 2004, Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients., Alcohol
    Messing et al., 1991, Chronic ethanol exposure increases levels of protein kinase C delta and epsilon and protein kinase C-mediated phosphorylation in cultured neural cells., J. Biol. Chem.
    Holmes et al., 1987, Baboon alcohol dehydrogenase isozymes: phenotypic changes in liver following chronic consumption of alcohol., Isozymes Curr. Top. Biol. Med. Res.
    Kasuda et al., 2006, Inhibition of PAR4 signaling mediates ethanol-induced attenuation of platelet function in vitro., Alcohol. Clin. Exp. Res.
    Ferrer et al., 2007, Regulation of brain anandamide by acute administration of ethanol., Biochem. J.
    Zhou H et al., 2020, Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits., Nat Neurosci
    Zhang et al., 1999, Chronic ethanol consumption disrupts complexation between EGF receptor and phospholipase C-gamma1: relevance to impaired hepatocyte proliferation., Biochem. Biophys. Res. Commun.
    Farinati et al., 1989, Effects of chronic ethanol consumption on carcinogen activating and detoxifying systems in rat upper alimentary tract tissue., Alcohol. Clin. Exp. Res.
    Choi et al., 2004, The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference., Nat. Neurosci.
    Allen-Gipson et al., 2009, Ethanol blocks adenosine uptake via inhibiting the nucleoside transport system in bronchial epithelial cells., Alcohol. Clin. Exp. Res.
    Schroeder et al., 2005, The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats., Psychopharmacology (Berl.)
    Röjdmark et al., 2001, Alcohol ingestion decreases both diurnal and nocturnal secretion of leptin in healthy individuals., Clin. Endocrinol. (Oxf)
    Aschner et al., 1997, Induction of metallothionein-I (MT-I) mRNA in primary astrocyte cultures is mediated by hypotonicity and not ethanol (EtOH) per se., Brain Res.
    Lu et al., 1999, Effect of ethanol and high-fat feeding on hepatic gamma-glutamylcysteine synthetase subunit expression in the rat., Hepatology
    Pritchard et al., 2007, Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice., Gastroenterology
    Zhu et al., 2008, The ethanol response gene Cab45 can modulate the impairment elicited by ethanol and ultraviolet in PC12 cells., J Genet Genomics
    Tang et al., 2006, Ethanol inhibits L1 cell adhesion molecule activation of mitogen-activated protein kinases., J. Neurochem.
    Seng KY et al., 2013, Population pharmacokinetics and pharmacogenetics of alcohol in Chinese and Indians in Singapore., J Clin Pharm Ther
    Edenberg HJ et al., 2006, Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis., Hum Mol Genet
    Blanco et al., 2005, Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes., J. Immunol.
    Fries et al., 1999, Experimental colitis increases small intestine permeability in the rat., Lab. Invest.
    Pyroh et al., [Metabolism of C2-C6-substrates under mixotrophic growth of Acinetobacter sp. B-7005 and B-7005 (1HG) strains]., Ukr Biokhim Zh (1999)
    Samokhvalov et al., 2004, Inhibition of Krebs cycle and activation of glyoxylate cycle in the course of chronological aging of Saccharomyces cerevisiae. Compensatory role of succinate oxidation., Biochimie
    Isaev et al., [Administration of the omega-3 polyunsaturated fatty acid drug eiferol decreases alcohol motivation in albino rats by elevating the level of antibodies to alcohol dehydrogenase]., Patol Fiziol Eksp Ter
    Wang et al., 2005, Effect of chronic ethanol administration on hepatic eNOS activity and its association with caveolin-1 and calmodulin in female rats., Am. J. Physiol. Gastrointest. Liver Physiol.
    Laso et al., 2000, Alcoholic liver cirrhosis is associated with a decreased expression of the CD28 costimulatory molecule, a lower ability of T cells to bind exogenous IL-2, and increased soluble CD8 levels., Cytometry
    Resnicoff et al., 1994, Ethanol inhibits insulin-like growth factor-1-mediated signalling and proliferation of C6 rat glioblastoma cells., Lab. Invest.
    Kondili et al., 2005, The hepatoprotective effect of hepatic stimulator substance (HSS) against liver regeneration arrest induced by acute ethanol intoxication., Dig. Dis. Sci.
    Liatsos et al., 2003, Effect of acute ethanol exposure on hepatic stimulator substance (HSS) levels during liver regeneration: protective function of HSS., Dig. Dis. Sci.
    Sun Y et al., 2019, Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence., Mol Psychiatry
    Lopes et al., Effects of trehalose and ethanol on yeast cytosolic pyrophosphatase., Z. Naturforsch., C, J. Biosci.
    Kim et al., 2003, Effects of ethanol on the rat glutamate excitatory amino acid transporter type 3 expressed in Xenopus oocytes: role of protein kinase C and phosphatidylinositol 3-kinase., Alcohol. Clin. Exp. Res.
    Lee YJ et al., 2019, The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea., Alcohol
    Ribeiro AF et al., 2017, Possible involvement of ACSS2 gene in alcoholism., J Neural Transm (Vienna)
    Landgren S et al., 2008, Association of pro-ghrelin and GHS-R1A gene polymorphisms and haplotypes with heavy alcohol use and body mass., Alcohol Clin Exp Res
    Pandey et al., 2001, Effects of chronic ethanol intake and its withdrawal on the expression and phosphorylation of the creb gene transcription factor in rat cortex., J. Pharmacol. Exp. Ther.
    Earl et al., 2011, Inhibition of recombinant L-type voltage-gated calcium channels by positive allosteric modulators of GABAA receptors., J. Pharmacol. Exp. Ther.
    Davies, 2003, The role of GABAA receptors in mediating the effects of alcohol in the central nervous system., J Psychiatry Neurosci
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Santhakumar et al., 2007, Ethanol acts directly on extrasynaptic subtypes of GABAA receptors to increase tonic inhibition., Alcohol
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Zhang Y et al., 2018, Single-nucleotide rs738409 polymorphisms in the PNPLA3 gene are strongly associated with alcoholic liver disease in Han Chinese males., Hepatol Int
    Tabakoff et al., 2003, Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors., J. Neurosci.
    Uesugi et al., 2001, Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice., Hepatology
    Casamenti et al., 1993, Long-term ethanol consumption by rats: effect on acetylcholine release in vivo, choline acetyltransferase activity, and behavior., Neuroscience
    Soliman et al., 1985, Brain cholinergic involvement in the rapid development of tolerance to the hypothermic action of ethanol., Gen. Pharmacol.
    Murphy et al., 2006, Lack of evidence of a role for the neurosteroid allopregnanolone in ethanol-induced reward and c-fos expression in DBA/2 mice., Brain Res.
    Valenzuela et al., 1998, Acute effects of ethanol on recombinant kainate receptors: lack of role of protein phosphorylation., Alcohol. Clin. Exp. Res.
    Markoulaki et al., 2004, Fertilization stimulates long-lasting oscillations of CaMKII activity in mouse eggs., Dev. Biol.
    Ray LA, 2011, Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes., Alcohol Clin Exp Res
    Wu et al., 2000, Roles of tissue transglutaminase in ethanol-induced inhibition of hepatocyte proliferation and alpha 1-adrenergic signal transduction., J. Biol. Chem.
    McAlhany et al., 1999, Ethanol decreases Glial-Derived Neurotrophic Factor (GDNF) protein release but not mRNA expression and increases GDNF-stimulated Shc phosphorylation in the developing cerebellum., Alcohol. Clin. Exp. Res.
    Matsumoto et al., 1996, Mitochondrial ALDH polymorphism affects ethanol-derived acetate disposition in Wistar rats., Alcohol. Clin. Exp. Res.
    Nishizawa D et al., 2006, Association of mu-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population., Neuropsychobiology
    Adler et al., 2006, The effects of solvents on embryonic stem cell differentiation., Toxicol In Vitro
    Joshi et al., 2005, Chronic ethanol ingestion in rats decreases granulocyte-macrophage colony-stimulating factor receptor expression and downstream signaling in the alveolar macrophage., J. Immunol.
    Erwin et al., 1997, Common quantitative trait loci for alcohol-related behaviors and central nervous system neurotensin measures: hypnotic and hypothermic effects., J. Pharmacol. Exp. Ther.
    Duncan et al., Neurotensin modulates K(+)-stimulated dopamine release from the caudate-putamen but not the nucleus accumbens of mice with differential sensitivity to ethanol., Alcohol
    Campbell et al., 1991, Regional characterization of brain neurotensin receptor subtypes in LS and SS mice., Alcohol. Clin. Exp. Res.
    de Waziers et al., 1992, Effects of ethanol, dexamethasone and RU 486 on expression of cytochromes P450 2B, 2E, 3A and glutathione transferase pi in a rat hepatoma cell line (Fao)., Pharmacogenetics
    Kershaw et al., 1992, Degradation and metal composition of hepatic isometallothioneins in rats., Toxicol. Appl. Pharmacol.
    Lupoli et al., 1993, [Treatment of hot thyroid nodule with percutaneous ethanol injection. Our experience]., Minerva Endocrinol.
    Dong et al., 2008, Nrf2-mediated transcriptional induction of antioxidant response in mouse embryos exposed to ethanol in vivo: implications for the prevention of fetal alcohol spectrum disorders., Antioxid. Redox Signal.
    Brennan P et al., 2004, Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review., Am J Epidemiol
    Prakash et al., 2002, Ethanol decreases the efficiency of phosphorylation of thymidine kinase in a human T-lymphocytic cell line., Alcohol. Clin. Exp. Res.
    Avdulov et al., 2000, Cholesterol efflux to high-density lipoproteins and apolipoprotein A-I phosphatidylcholine complexes is inhibited by ethanol: role of apolipoprotein structure and cooperative interaction of phosphatidylcholine and cholesterol., Biochemistry
  • ALCOHOL   THSD7B

    Interaction Score: 1.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32451486


    Sources:
    PharmGKB

  • ALCOHOL   SLC4A8

    Interaction Score: 1.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32451486


    Sources:
    PharmGKB

  • ALCOHOL   FUT2

    Interaction Score: 1.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32451486


    Sources:
    PharmGKB

  • ALCOHOL   GCKR

    Interaction Score: 1.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32451486


    Sources:
    PharmGKB

  • ALCOHOL   MED19

    Interaction Score: 1.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32451486


    Sources:
    PharmGKB

  • ALCOHOL   CRHBP

    Interaction Score: 1.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21039637


    Sources:
    PharmGKB

  • ALCOHOL   RNF112

    Interaction Score: 1.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12805289


    Sources:
    NCI

  • ALCOHOL   CADM2

    Interaction Score: 1.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32451486


    Sources:
    PharmGKB

  • ALCOHOL   SRPRB

    Interaction Score: 1.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31002879


    Sources:
    PharmGKB

  • ALCOHOL   PPA1

    Interaction Score: 1.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10349738


    Sources:
    NCI

  • ALCOHOL   TNRC6A

    Interaction Score: 1.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32451486


    Sources:
    PharmGKB

  • ALCOHOL   SDF4

    Interaction Score: 1.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18355758


    Sources:
    NCI

  • ALCOHOL   MT1JP

    Interaction Score: 1.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9372231


    Sources:
    NCI

  • ALCOHOL   SLC39A8

    Interaction Score: 1.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32451486


    Sources:
    PharmGKB

  • ALCOHOL   TMX2

    Interaction Score: 1.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32451486


    Sources:
    PharmGKB

  • ALCOHOL   CAT

    Interaction Score: 1.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25514903


    Sources:
    PharmGKB

  • ALCOHOL   NAPEPLD

    Interaction Score: 1.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17302558


    Sources:
    NCI

  • ALCOHOL   ADH4

    Interaction Score: 1.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3610585


    Sources:
    NCI

  • ALCOHOL   ALDH2

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8986223 31002879 16679777 15902904


    Sources:
    NCI PharmGKB

  • ALCOHOL   ADH1B

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32451486 23240771 16571603 15902904


    Sources:
    PharmGKB

  • ALCOHOL   MT2A

    Interaction Score: 0.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1733046


    Sources:
    NCI

  • ALCOHOL   CAV1

    Interaction Score: 0.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15845868


    Sources:
    NCI

  • ALCOHOL   KLB

    Interaction Score: 0.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ALCOHOL   CD55

    Interaction Score: 0.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17383432


    Sources:
    NCI

  • ALCOHOL   TAS2R16

    Interaction Score: 0.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ALCOHOL   DPP6

    Interaction Score: 0.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32451486


    Sources:
    PharmGKB

  • ALCOHOL   RABGAP1L

    Interaction Score: 0.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ALCOHOL   PIP5K1C

    Interaction Score: 0.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ALCOHOL   ANKK1

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8033754 27447243 1979357 1969501 1839129 17989061 11054774 10490697


    Sources:
    PharmGKB

  • ALCOHOL   CHRNA5

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19270242 23641218


    Sources:
    PharmGKB

  • ALCOHOL   ALDH3A1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15909415 14987799 12652939


    Sources:
    NCI

  • ALCOHOL   ADH1C

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32451486 14693654


    Sources:
    PharmGKB

  • ALCOHOL   DTYMK

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11923581


    Sources:
    NCI

  • ALCOHOL   NTS

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9023306 1733422 1686369


    Sources:
    NCI

  • ALCOHOL   POU5F1

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16112835


    Sources:
    NCI

  • ALCOHOL   CREB1

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11181917


    Sources:
    NCI

  • ALCOHOL   ANKS1B

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31462767


    Sources:
    PharmGKB

  • ALCOHOL   TJP1

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9952110


    Sources:
    NCI

  • ALCOHOL   GCLC

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10385658


    Sources:
    NCI

  • ALCOHOL   FTO

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32451486


    Sources:
    PharmGKB

  • ALCOHOL   GDNF

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10550003


    Sources:
    NCI

  • ALCOHOL   PNPLA3

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30132178


    Sources:
    PharmGKB

  • ALCOHOL   ACSS2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28550509


    Sources:
    PharmGKB

  • ALCOHOL   SLC1A1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14574224


    Sources:
    NCI

  • ALCOHOL   IL1R1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16272348


    Sources:
    NCI

  • ALCOHOL   CHAT

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8247273 3996882


    Sources:
    NCI

  • ALCOHOL   IRS1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7526037


    Sources:
    NCI

  • ALCOHOL   LIPC

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7163806


    Sources:
    NCI

  • ALCOHOL   SLC29A1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15258586 19298329


    Sources:
    NCI

  • ALCOHOL   APOA1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10956052


    Sources:
    NCI

  • ALCOHOL   ADH1A

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ALCOHOL   IGFBP1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11894976


    Sources:
    NCI

  • ALCOHOL   CYP2E1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29588096 26049587 25514903 15902904


    Sources:
    PharmGKB

  • ALCOHOL   FOS

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16750178


    Sources:
    NCI

  • ALCOHOL   GHSR

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18828808


    Sources:
    PharmGKB

  • ALCOHOL   CHRNA3

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19270242 23641218


    Sources:
    PharmGKB

  • ALCOHOL   TLR4

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11431739


    Sources:
    NCI

  • ALCOHOL   MAP2K4

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ALCOHOL   CAMK2B

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9756045 15242787


    Sources:
    NCI

  • ALCOHOL   GRM5

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15717208


    Sources:
    NCI

  • ALCOHOL   UGT1A4

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2502039


    Sources:
    NCI

  • ALCOHOL   F2R

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16930224


    Sources:
    NCI

  • ALCOHOL   TG

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8289752


    Sources:
    NCI

  • ALCOHOL   CTLA4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11025487


    Sources:
    NCI

  • ALCOHOL   APOB

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8576634


    Sources:
    NCI

  • ALCOHOL   NAT2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12071337


    Sources:
    NCI

  • ALCOHOL   CHRNA4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15902904 19270242 23641218


    Sources:
    PharmGKB

  • ALCOHOL   ITGB2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8803617


    Sources:
    NCI

  • ALCOHOL   CACNA1C

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12970385 31634677


    Sources:
    PharmGKB

  • ALCOHOL   TGM2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10801782


    Sources:
    NCI

  • ALCOHOL   MTHFR

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15894672


    Sources:
    NCI

  • ALCOHOL   DRD2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12749054 8033754 29236941 27447243 22798433 1979357 1969501 1839129 17989061 11054774 10490697


    Sources:
    NCI PharmGKB

  • ALCOHOL   GABRA1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    21262851 12921221 11752352 17591544 17016423 17139284


    Sources:
    TTD

  • ALCOHOL   GFER

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15745088 14627336


    Sources:
    NCI

  • ALCOHOL   PRKCD

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1744136


    Sources:
    NCI

  • ALCOHOL   PDE4B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32451486


    Sources:
    PharmGKB

  • ALCOHOL   CSF2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16272341


    Sources:
    NCI

  • ALCOHOL   GSTP1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1302037


    Sources:
    NCI

  • ALCOHOL   SLC6A4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31595439


    Sources:
    PharmGKB

  • ALCOHOL   FGFR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16478533


    Sources:
    NCI

  • ALCOHOL   PPARD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12641735


    Sources:
    NCI

  • ALCOHOL   OPRK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ALCOHOL   EGFR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10092515


    Sources:
    NCI

  • ALCOHOL   CYP2D6

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24611668


    Sources:
    PharmGKB

  • ALCOHOL   ALDH1A1

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ALCOHOL   NFE2L2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18759561


    Sources:
    NCI

  • NCI: ETHANOL

    • Version: 14-September-2017

    Alternate Names:
    C216 NCI drug code

    Drug Info:

    Publications:
    Mordasini et al., 1982, [Alcohol and plasma lipoproteins in acute and long-term studies]., Schweiz Med Wochenschr
    Pronko et al., 2002, Acinar distribution of rat liver arylamine N-acetyltransferase: effect of chronic ethanol and endotoxin exposure., Pharmacol. Toxicol.
    Le Marchand et al., 2005, The MTHFR C677T polymorphism and colorectal cancer: the multiethnic cohort study., Cancer Epidemiol. Biomarkers Prev.

  • PharmGKB: ethanol

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Miller RT et al., 2014, Ethanol self-administration and nicotine treatment increase brain levels of CYP2D in African green monkeys., Br J Pharmacol
    Zhou H et al., 2020, Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits., Nat Neurosci
    Sun Y et al., 2019, Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence., Mol Psychiatry

  • TTD: Ethanol

    • Version: 2020.06.01

    Alternate Names:
    D00AMQ TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL545

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21