DGIdb - ALITRETINOIN Drug Record

ALITRETINOIN chembl:CHEMBL705 ApprovedAntineoplastic

Alternate Names:

LG100057
LG-100057
TOCTINO
PANRETIN
RETINOIC ACID 9-CIS-FORM
NSC-659772
AGN-192013
LGD1057
ALITRETINOIN
ALRT-1057
LGD-1057
BAL-4079
ALRT1057
ALITRETINOIN [USAN]
(2E,4E,6Z,8E)-3,7-DIMETHYL-9-(2,6,6-TRIMETHYLCYCLOHEX-1-EN-1-YL)NONA-2,4,6,8-TETRAENOIC ACID
TRETINOIN/ALL-TRANS RETINOATE
A-ACIDO (ARGENTINA)
PANRETIN (TN)
ALPHA-VITAMINSYRE [DENMARK]
ALL-TRANS-BETA-RETINOIC ACID
RETINOVA
PANREXIN
TRANS-RETINOATE
TRETINOINO [INN-SPANISH]
TRETINOINUM [INN-LATIN]
TRANS-VITAMIN A ACID
EFFEDERM [FRANCE]
EPI-ABEREL
PANRETIN GEL
ATRAGEN
TRETINOINE [INN-FRENCH]
9-CIS-RETINOIC ACID
ALL-TRANS-BETA-RETINOATE
VESANOID
RETACNYL
PANRETYN
ALL-TRANS-B-RETINOIC ACID
TOCTINO®
ABEREL
BETA-RETINOATE
(2E,4E,6Z,8E)-3,7-DIMETHYL-9-(2,6,6-TRIMETHYL-1-CYCLOHEXEN-1-YL)-2,4,6,8-NONATETRAENOIC ACID
EUDYNA
TRANS-RETINOIC ACID
B-RETINOIC ACID
9-CIS-RETINOATE
PANRETIN®
TRETINOIN/ALL-TRANS RETINOIC ACID
15-APO-BETA-CAROTEN-15-OATE
(7E,9Z,11E,13E)-RETINOIC ACID
BETA-RETINOIC ACID
15-APO-BETA-CAROTEN-15-OIC ACID
TRETINOINA [INN-SPANISH]
AKNOTEN
ISOTRETINOIN RETINOIC ACID
ABERELA [NORWAY]
VESNAROID
RETIN A (TN)
ACIDE RETINOIQUE (FRENCH) (DSL)
RETIN A
RENOVA
ALITRETINOINUM
ALPHA-ACIDO (ARGENTINA)
9-RETINOATE
RETINOIC ACID
TRETINON
9-CIS-TRETINOIN
RETINOATE
TRETINOIN (JAN/USP)
ALITRETINOÍNA
EFFEDERM
TRETINOIN
RETIN-A MICRO
9-RETINOIC ACID
TRETINOIN (TN)
B-RETINOATE
ALITRÉTINOÏNE
ALITRETINOIN (USAN)
ISOTRETINOIN RETINOATE
ALL-TRANS-B-RETINOATE
ALL-TRANS-VITAMIN A ACID
TRETINOINE (FRENCH) (EINECS)
AVITOIN [NORWAY]
AVITA
RETIN-A
TRETINOIN [USAN:BAN:INN]
AIROL
ALL-TRANS- VITAMIN A1 ACID
9(Z)-RETINOIC ACID
DERMAIROL
rxcui:81864
chemidplus:5300-03-8
pubchem.compound:449171
drugbank:00523
chembl:CHEMBL705

Drug Info:

Year of Approval	1999
Drug Class	antineoplastic agents

(2 More Sources)

Publications:

Brtko, 2007, Role of retinoids and their cognate nuclear receptors in breast cancer chemoprevention., Cent. Eur. J. Public Health
Adamczewski et al., [Application of 13-cis-retinoic acid in patients with 131I scintigraphically-negative metastases of differentiated thyroid carcinoma]., Endokrynol Pol
Day et al., 2006, Retinoic acid inhibits airway smooth muscle cell migration., Am. J. Respir. Cell Mol. Biol.
Garnock-Jones et al., 2009, Alitretinoin: in severe chronic hand eczema., Drugs
Germain et al., 2006, International Union of Pharmacology. LXIII. Retinoid X receptors., Pharmacol. Rev.
He et al., 2007, Retinoic acid inhibits HIV-1-induced podocyte proliferation through the cAMP pathway., J. Am. Soc. Nephrol.
Okitsu T et al., 2011, Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity., Bioorg Med Chem
Chen F et al., 2014, Identification of a New RXRα Antagonist Targeting the Coregulator-Binding Site., ACS Med Chem Lett
Pathirana C et al., 1994, Identification of an activator of the retinoid X receptor., J Nat Prod
Cheng et al., 2008, Alitretinoin: a comprehensive review., Expert Opin Investig Drugs
Zhelyaznik et al., 2006, Regulation of retinoic acid receptors alpha, beta and retinoid X receptor alpha after sciatic nerve injury., Neuroscience
Bartholin et al., 2006, TGIF inhibits retinoid signaling., Mol. Cell. Biol.
Calléja et al., 2006, Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes., Genes Dev.
Fukasawa et al., 2006, [Retinoid therapy for autoimmune diseases]., Nihon Rinsho Meneki Gakkai Kaishi
Mizuguchi et al., 2006, Antitumoral activity of 13-demethyl or 13-substituted analogues of all-trans retinoic acid and 9-cis retinoic acid in the human myeloid leukemia cell line HL-60., Biol. Pharm. Bull.
Ritter et al., 2006, Inhibition of retinoic acid receptor signaling by Ski in acute myeloid leukemia., Leukemia
Schrage et al., 2006, Macrophages and neurons are targets of retinoic acid signaling after spinal cord contusion injury., Eur. J. Neurosci.
Baumann et al., 2005, Open-label pilot study of alitretinoin gel 0.1% in the treatment of photoaging., Cutis
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Milliano et al., 2005, Rat hepatic stellate cells become retinoid unresponsive during activation., Hepatol. Res.
Rasooly et al., 2005, Retinoid x receptor agonists increase bcl2a1 expression and decrease apoptosis of naive T lymphocytes., J. Immunol.
Mizuiri et al., 2005, DNA methylation of genes linked to retinoid signaling in squamous cell carcinoma of the esophagus: DNA methylation of CRBP1 and TIG1 is associated with tumor stage., Cancer Sci.
Nalbandian et al., 2005, A novel function of differentiation revealed by cDNA microarray profiling of p75NTR-regulated gene expression., Differentiation
Husson et al., 2006, Retinoic acid normalizes nuclear receptor mediated hypo-expression of proteins involved in beta-amyloid deposits in the cerebral cortex of vitamin A deprived rats., Neurobiol. Dis.
Liu et al., 2005, 5-Aza-2'-deoxycytidine induces retinoic acid receptor-beta(2) demethylation and growth inhibition in esophageal squamous carcinoma cells., Cancer Lett.
Bergheim et al., 2005, Role of retinoic acid receptors in squamous-cell carcinoma in human esophagus., J Carcinog
Hoegberg et al., 2005, Retinoid status and responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking retinoid binding protein or retinoid receptor forms., Chem. Biol. Interact.
Li et al., 2006, Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis., Proc. Natl. Acad. Sci. U.S.A.
Parrella et al., 2006, Antitumor activity of the retinoid-related molecules (E)-3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid (ST1926) and 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) in F9 teratocarcinoma: Role of retinoic acid receptor gamma and retinoid-independent pathways., Mol. Pharmacol.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Dzhagalov et al., 2007, Regulation of CD8+ T lymphocyte effector function and macrophage inflammatory cytokine production by retinoic acid receptor gamma., J. Immunol.

ALITRETINOIN RXRG

Interaction Score: 8.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

Specific Action of the Ligand Agonist

PMIDs:
17491551 17006844 16456186 19678713 17132853 17182884

Sources:
ChemblInteractions TEND GuideToPharmacology TTD
ALITRETINOIN RXRB

Interaction Score: 7.88

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
18321241 17491551 16420438 19678713 17132853 16277658 16109390

Sources:
ChemblInteractions TEND TTD
ALITRETINOIN RARB

Interaction Score: 4.73

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

Specific Action of the Ligand Agonist

PMIDs:
16128742 16316409 19678713 16253547 16531051 16297713

Sources:
ChemblInteractions TEND GuideToPharmacology TTD
ALITRETINOIN RARG

Interaction Score: 3.75

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
16880407 19678713 16788091 10592235 17277115

Sources:
ChemblInteractions TEND GuideToPharmacology TTD
ALITRETINOIN RARA

Interaction Score: 2.74

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
7807131 18321241 16424870 16420438 16144296 11752352 16253547 16339527

Sources:
DTC ChemblInteractions TEND GuideToPharmacology
ALITRETINOIN RXRA

Interaction Score: 1.46

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? True

Specific Action of the Ligand Agonist

Mechanism of Interaction Retinoid receptor agonist

PMIDs:
21489804 25057340 7807131 18321241 16782282 16428452 16751185 19678713 16819260 16946489

Sources:
DTC ChemblInteractions TEND GuideToPharmacology TTD
ALITRETINOIN VKORC1

Interaction Score: 0.64

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
ALITRETINOIN VDR

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALITRETINOIN EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: ALITRETINOIN
- Version: 01-August-2011
Alternate Names:

ALITRETINOIN Primary Drug Name

Drug Info:

Drug Class antineoplastic agents

Year of Approval 1999

Publications:

DTC: ALITRETINOIN

Version: 02-September-2020

Alternate Names:

CHEMBL705 ChEMBL Drug ID

Drug Info:

Publications:

Pathirana C et al., 1994, Identification of an activator of the retinoid X receptor., J Nat Prod

Okitsu T et al., 2011, Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity., Bioorg Med Chem

Chen F et al., 2014, Identification of a New RXRα Antagonist Targeting the Coregulator-Binding Site., ACS Med Chem Lett

TTD: Alitretinoin
- Version: 2020.06.01
Alternate Names:

D0G3PI TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135651418
- Version: 29-September-2020
Alternate Names:

ALITRETINOIN GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL705
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL705
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Retinoid receptor agonist
Direct Interaction	yes
Specific Action of the Ligand	Agonist

Specific Action of the Ligand	Agonist
Endogenous Drug?	False
Direct Interaction?	True

ALITRETINOIN Drug Record

ALITRETINOIN chembl:CHEMBL705 ApprovedAntineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoid receptor agonist Direct Interaction yes Specific Action of the Ligand Agonist

PMIDs: 17491551 17006844 16456186 19678713 17132853 17182884

Sources: ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoid receptor agonist Direct Interaction yes

PMIDs: 18321241 17491551 16420438 19678713 17132853 16277658 16109390

Sources: ChemblInteractions TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoid receptor agonist Direct Interaction yes Specific Action of the Ligand Agonist

PMIDs: 16128742 16316409 19678713 16253547 16531051 16297713

Sources: ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction? True

PMIDs: 16880407 19678713 16788091 10592235 17277115

Sources: ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction? True

PMIDs: 7807131 18321241 16424870 16420438 16144296 11752352 16253547 16339527

Sources: DTC ChemblInteractions TEND GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Endogenous Drug? True Specific Action of the Ligand Agonist Mechanism of Interaction Retinoid receptor agonist

PMIDs: 21489804 25057340 7807131 18321241 16782282 16428452 16751185 19678713 16819260 16946489

Sources: DTC ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: ALITRETINOIN

Alternate Names: ALITRETINOIN Primary Drug Name

Drug Info: Drug Class antineoplastic agents Year of Approval 1999

Publications:

DTC: ALITRETINOIN

Alternate Names: CHEMBL705 ChEMBL Drug ID

Drug Info:

TTD: Alitretinoin

Alternate Names: D0G3PI TTD Drug ID

Drug Info:

Publications:

GuideToPharmacology: 135651418

Alternate Names: ALITRETINOIN GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL705

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL705

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

Specific Action of the Ligand Agonist

PMIDs:
17491551 17006844 16456186 19678713 17132853 17182884

Sources:
ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
18321241 17491551 16420438 19678713 17132853 16277658 16109390

Sources:
ChemblInteractions TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

Specific Action of the Ligand Agonist

PMIDs:
16128742 16316409 19678713 16253547 16531051 16297713

Sources:
ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
16880407 19678713 16788091 10592235 17277115

Sources:
ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
7807131 18321241 16424870 16420438 16144296 11752352 16253547 16339527

Sources:
DTC ChemblInteractions TEND GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? True

Specific Action of the Ligand Agonist

Mechanism of Interaction Retinoid receptor agonist

PMIDs:
21489804 25057340 7807131 18321241 16782282 16428452 16751185 19678713 16819260 16946489

Sources:
DTC ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

ALITRETINOIN Primary Drug Name

Drug Info:

Drug Class antineoplastic agents

Year of Approval 1999

Alternate Names:

CHEMBL705 ChEMBL Drug ID

Alternate Names:

D0G3PI TTD Drug ID

Alternate Names:

ALITRETINOIN GuideToPharmacology Ligand Name