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ALITRETINOIN Drug Record

  • Summary
  • Interactions
  • Claims
  • ALITRETINOIN chembl:CHEMBL705 ApprovedAntineoplastic

    Alternate Names:

    LG100057
    LG-100057
    TOCTINO
    PANRETIN
    RETINOIC ACID 9-CIS-FORM
    NSC-659772
    AGN-192013
    LGD1057
    ALITRETINOIN
    ALRT-1057
    LGD-1057
    BAL-4079
    ALRT1057
    ALITRETINOIN [USAN]
    (2E,4E,6Z,8E)-3,7-DIMETHYL-9-(2,6,6-TRIMETHYLCYCLOHEX-1-EN-1-YL)NONA-2,4,6,8-TETRAENOIC ACID
    TRETINOIN/ALL-TRANS RETINOATE
    A-ACIDO (ARGENTINA)
    PANRETIN (TN)
    ALPHA-VITAMINSYRE [DENMARK]
    ALL-TRANS-BETA-RETINOIC ACID
    RETINOVA
    PANREXIN
    TRANS-RETINOATE
    TRETINOINO [INN-SPANISH]
    TRETINOINUM [INN-LATIN]
    TRANS-VITAMIN A ACID
    EFFEDERM [FRANCE]
    EPI-ABEREL
    PANRETIN GEL
    ATRAGEN
    TRETINOINE [INN-FRENCH]
    9-CIS-RETINOIC ACID
    ALL-TRANS-BETA-RETINOATE
    VESANOID
    RETACNYL
    PANRETYN
    ALL-TRANS-B-RETINOIC ACID
    TOCTINO®
    ABEREL
    BETA-RETINOATE
    (2E,4E,6Z,8E)-3,7-DIMETHYL-9-(2,6,6-TRIMETHYL-1-CYCLOHEXEN-1-YL)-2,4,6,8-NONATETRAENOIC ACID
    EUDYNA
    TRANS-RETINOIC ACID
    B-RETINOIC ACID
    9-CIS-RETINOATE
    PANRETIN®
    TRETINOIN/ALL-TRANS RETINOIC ACID
    15-APO-BETA-CAROTEN-15-OATE
    (7E,9Z,11E,13E)-RETINOIC ACID
    BETA-RETINOIC ACID
    15-APO-BETA-CAROTEN-15-OIC ACID
    TRETINOINA [INN-SPANISH]
    AKNOTEN
    ISOTRETINOIN RETINOIC ACID
    ABERELA [NORWAY]
    VESNAROID
    RETIN A (TN)
    ACIDE RETINOIQUE (FRENCH) (DSL)
    RETIN A
    RENOVA
    ALITRETINOINUM
    ALPHA-ACIDO (ARGENTINA)
    9-RETINOATE
    RETINOIC ACID
    TRETINON
    9-CIS-TRETINOIN
    RETINOATE
    TRETINOIN (JAN/USP)
    ALITRETINOÍNA
    EFFEDERM
    TRETINOIN
    RETIN-A MICRO
    9-RETINOIC ACID
    TRETINOIN (TN)
    B-RETINOATE
    ALITRÉTINOÏNE
    ALITRETINOIN (USAN)
    ISOTRETINOIN RETINOATE
    ALL-TRANS-B-RETINOATE
    ALL-TRANS-VITAMIN A ACID
    TRETINOINE (FRENCH) (EINECS)
    AVITOIN [NORWAY]
    AVITA
    RETIN-A
    TRETINOIN [USAN:BAN:INN]
    AIROL
    ALL-TRANS- VITAMIN A1 ACID
    9(Z)-RETINOIC ACID
    DERMAIROL
    rxcui:81864
    chemidplus:5300-03-8
    pubchem.compound:449171
    drugbank:00523
    chembl:CHEMBL705

    Drug Info:

    Year of Approval 1999
    Drug Class antineoplastic agents
    (1 More Sources)

    Publications:

    Brtko, 2007, Role of retinoids and their cognate nuclear receptors in breast cancer chemoprevention., Cent. Eur. J. Public Health
    Adamczewski et al., [Application of 13-cis-retinoic acid in patients with 131I scintigraphically-negative metastases of differentiated thyroid carcinoma]., Endokrynol Pol
    Day et al., 2006, Retinoic acid inhibits airway smooth muscle cell migration., Am. J. Respir. Cell Mol. Biol.
    Garnock-Jones et al., 2009, Alitretinoin: in severe chronic hand eczema., Drugs
    Germain et al., 2006, International Union of Pharmacology. LXIII. Retinoid X receptors., Pharmacol. Rev.
    He et al., 2007, Retinoic acid inhibits HIV-1-induced podocyte proliferation through the cAMP pathway., J. Am. Soc. Nephrol.
    Okitsu T et al., 2011, Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity., Bioorg Med Chem
    Chen F et al., 2014, Identification of a New RXRα Antagonist Targeting the Coregulator-Binding Site., ACS Med Chem Lett
    Pathirana C et al., 1994, Identification of an activator of the retinoid X receptor., J Nat Prod
    Cheng et al., 2008, Alitretinoin: a comprehensive review., Expert Opin Investig Drugs
    Zhelyaznik et al., 2006, Regulation of retinoic acid receptors alpha, beta and retinoid X receptor alpha after sciatic nerve injury., Neuroscience
    Bartholin et al., 2006, TGIF inhibits retinoid signaling., Mol. Cell. Biol.
    Calléja et al., 2006, Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes., Genes Dev.
    Fukasawa et al., 2006, [Retinoid therapy for autoimmune diseases]., Nihon Rinsho Meneki Gakkai Kaishi
    Mizuguchi et al., 2006, Antitumoral activity of 13-demethyl or 13-substituted analogues of all-trans retinoic acid and 9-cis retinoic acid in the human myeloid leukemia cell line HL-60., Biol. Pharm. Bull.
    Ritter et al., 2006, Inhibition of retinoic acid receptor signaling by Ski in acute myeloid leukemia., Leukemia
    Schrage et al., 2006, Macrophages and neurons are targets of retinoic acid signaling after spinal cord contusion injury., Eur. J. Neurosci.
    Baumann et al., 2005, Open-label pilot study of alitretinoin gel 0.1% in the treatment of photoaging., Cutis
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Milliano et al., 2005, Rat hepatic stellate cells become retinoid unresponsive during activation., Hepatol. Res.
    Rasooly et al., 2005, Retinoid x receptor agonists increase bcl2a1 expression and decrease apoptosis of naive T lymphocytes., J. Immunol.
    Mizuiri et al., 2005, DNA methylation of genes linked to retinoid signaling in squamous cell carcinoma of the esophagus: DNA methylation of CRBP1 and TIG1 is associated with tumor stage., Cancer Sci.
    Nalbandian et al., 2005, A novel function of differentiation revealed by cDNA microarray profiling of p75NTR-regulated gene expression., Differentiation
    Husson et al., 2006, Retinoic acid normalizes nuclear receptor mediated hypo-expression of proteins involved in beta-amyloid deposits in the cerebral cortex of vitamin A deprived rats., Neurobiol. Dis.
    Liu et al., 2005, 5-Aza-2'-deoxycytidine induces retinoic acid receptor-beta(2) demethylation and growth inhibition in esophageal squamous carcinoma cells., Cancer Lett.
    Bergheim et al., 2005, Role of retinoic acid receptors in squamous-cell carcinoma in human esophagus., J Carcinog
    Hoegberg et al., 2005, Retinoid status and responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking retinoid binding protein or retinoid receptor forms., Chem. Biol. Interact.
    Li et al., 2006, Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis., Proc. Natl. Acad. Sci. U.S.A.
    Parrella et al., 2006, Antitumor activity of the retinoid-related molecules (E)-3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid (ST1926) and 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) in F9 teratocarcinoma: Role of retinoic acid receptor gamma and retinoid-independent pathways., Mol. Pharmacol.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Dzhagalov et al., 2007, Regulation of CD8+ T lymphocyte effector function and macrophage inflammatory cytokine production by retinoic acid receptor gamma., J. Immunol.
  • ALITRETINOIN   RXRG

    Interaction Score: 8.69

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoid receptor agonist
    Direct Interaction yes

    PMIDs:
    17491551 17006844 16456186 19678713 17132853 17182884


    Sources:
    ChemblInteractions TEND TTD

  • ALITRETINOIN   RXRB

    Interaction Score: 8.59

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoid receptor agonist
    Direct Interaction yes

    PMIDs:
    18321241 17491551 16420438 19678713 17132853 16277658 16109390


    Sources:
    ChemblInteractions TEND TTD

  • ALITRETINOIN   RARB

    Interaction Score: 4.97

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoid receptor agonist
    Direct Interaction yes

    PMIDs:
    16128742 16316409 19678713 16253547 16531051 16297713


    Sources:
    ChemblInteractions TEND TTD

  • ALITRETINOIN   RARG

    Interaction Score: 3.86

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoid receptor agonist
    Direct Interaction yes

    PMIDs:
    16880407 19678713 16788091 10592235 17277115


    Sources:
    ChemblInteractions TEND TTD

  • ALITRETINOIN   RARA

    Interaction Score: 2.83

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoid receptor agonist
    Direct Interaction yes

    PMIDs:
    7807131 18321241 16424870 16420438 16144296 11752352 16253547 16339527


    Sources:
    DTC ChemblInteractions TEND

  • ALITRETINOIN   RXRA

    Interaction Score: 1.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoid receptor agonist
    Direct Interaction yes

    PMIDs:
    21489804 25057340 7807131 18321241 16782282 16428452 16751185 19678713 16819260 16946489


    Sources:
    DTC ChemblInteractions TEND TTD

  • ALITRETINOIN   VDR

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ALITRETINOIN   EHMT2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: ALITRETINOIN

    • Version: 01-August-2011

    Alternate Names:
    ALITRETINOIN Primary Drug Name

    Drug Info:
    Drug Class antineoplastic agents
    Year of Approval 1999

    Publications:

  • DTC: ALITRETINOIN

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL705 ChEMBL Drug ID

    Drug Info:

    Publications:
    Pathirana C et al., 1994, Identification of an activator of the retinoid X receptor., J Nat Prod
    Okitsu T et al., 2011, Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity., Bioorg Med Chem
    Chen F et al., 2014, Identification of a New RXRα Antagonist Targeting the Coregulator-Binding Site., ACS Med Chem Lett

  • TTD: Alitretinoin

    • Version: 2020.06.01

    Alternate Names:
    D0G3PI TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL705

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL705

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21