DGIdb - ALLOPURINOL Drug Record

ALLOPURINOL chembl:CHEMBL1467 Approved

Alternate Names:

HAMARIN 100
ALORAL
ZYLOPRIM
COSURIC
BW-56158
ALLOPURINOL
XANTHOMAX-100
LOPURIN
URICTO
ZYLORIC-300
LEDOPUR
NSC-101655
CAPLENAL
NSC-1390
XANTHOMAX-300
HAMARIN 300
ALULINE 100
BW-56-158
ALULINE 300
ZYLORIC
4-HYDROXYPYRAZOLOPYRIMIDINE
ALLOPURINOLUM
1H-PYRAZOLO(3,4-D)PYRIMIDIN-4-OL
1,5-DIHYDRO-4H-PYRAZOLO(3,4-D)PYRIMIDIN-4-ONE
1H,2H,4H-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONE
4'-HYDROXYPYRAZOLOL(3,4-D)PYRIMIDINE
ZYLOPRIM®
4-HYDROXYPYRAZOLYL(3,4-D)PYRIMIDINE
4-HPP
ALLOPURINOLUM [INN-LATIN]
ALOPURINOL
4-HYDROXYPYRAZOLO(3,4-D)PYRIMIDINE
4-HYDROXY-1H-PYRAZOLO(3,4-D)PYRIMIDINE
4-HYDROXY-3,4-PYRAZOLOPYRIMIDINE
ALOPURINOL [INN-SPANISH]
4H-PYRAZOLO(3,4-D)PYRIMIDIN-4-ONE
1,5-DIHYDRO-4H-PYRAZOLO(3,4-D)PYRIMIDINE-4-ONE
ALOPRIM®
AL-100
drugbank:00437
rxcui:519
chemidplus:315-30-0
chembl:CHEMBL1467
pubchem.compound:2094

Drug Info:

Year of Approval	1980
Drug Class	gout suppressants
Drug Categories	preparations inhibiting uric acid production
Drug Categories	free radical scavengers
Drug Indications	antiuricemic agent
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	for treatment of gout
Drug Categories	bcrp/abcg2 substrates
Drug Categories	drugs that are mainly renally excreted
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	oat3/slc22a8 substrates
Drug Categories	uricosuric agents
Drug Categories	xanthine oxidase inhibitors

(5 More Sources)

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Génin E et al., 2011, Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe., Orphanet J Rare Dis
Cheng L et al., 2018, The minor alleles HCP5 rs3099844 A and PSORS1C1 rs3131003 G are associated with allopurinol-induced severe cutaneous adverse reactions in Han Chinese: a multicentre retrospective case-control clinical study., Br J Dermatol
Pacher et al., 2006, Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol., Pharmacol. Rev.
Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int
Okamoto, 2008, [Inhibitors of xanthine oxidoreductase]., Nippon Rinsho
Carro et al., 2010, Effects of allopurinol on uric acid concentrations, xanthine oxidoreductase activity and oxidative stress in broiler chickens., Comp. Biochem. Physiol. C Toxicol. Pharmacol.
Suzuki et al., 2009, Allopurinol, an inhibitor of uric acid synthesis--can it be used for the treatment of metabolic syndrome and related disorders?, Drugs Today
Taha et al., 2009, Effects of allopurinol on ischemia and reperfusion in rabbit livers., Transplant. Proc.
Kelley et al., 1970, Effects of allopurinol and oxipurinol on purine synthesis in cultured human cells., J. Clin. Invest.
George et al., 2009, Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress., Vasc Health Risk Manag
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
McDonagh EM et al., 2014, PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics., Pharmacogenet Genomics
Higgins et al., 2009, The potential for xanthine oxidase inhibition in the prevention and treatment of cardiovascular and cerebrovascular disease., Cardiovasc Psychiatry Neurol
Terkeltaub, 2010, Update on gout: new therapeutic strategies and options., Nat Rev Rheumatol
Dincer et al., 2002, Asymptomatic hyperuricemia: to treat or not to treat., Cleve Clin J Med
Brackman DJ et al., 2019, Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol., Clin Pharmacol Ther
Wright DFB et al., 2018, The impact of diuretic use and ABCG2 genotype on the predictive performance of a published allopurinol dosing tool., Br J Clin Pharmacol
Roberts RL et al., 2017, ABCG2 loss-of-function polymorphism predicts poor response to allopurinol in patients with gout., Pharmacogenomics J

ALLOPURINOL TSHZ2

Interaction Score: 3.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29193002

Sources:
PharmGKB
ALLOPURINOL NTNG1

Interaction Score: 3.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30924126

Sources:
PharmGKB
ALLOPURINOL GREM2

Interaction Score: 3.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30924126

Sources:
PharmGKB
ALLOPURINOL TRIB2

Interaction Score: 3.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30924126

Sources:
PharmGKB
ALLOPURINOL TBL1XR1

Interaction Score: 3.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30924126

Sources:
PharmGKB
ALLOPURINOL PSORS1C3

Interaction Score: 3.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21801394

Sources:
PharmGKB
ALLOPURINOL MYT1L

Interaction Score: 3.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30924126

Sources:
PharmGKB
ALLOPURINOL PKD2

Interaction Score: 3.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30924126

Sources:
PharmGKB
ALLOPURINOL CYCSP5

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21801394 29193002

Sources:
PharmGKB
ALLOPURINOL XDH

Interaction Score: 1.57

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Xanthine dehydrogenase inhibitor

Trial Name NU1618, tranilast + allopurinol

PMIDs:
16507884 27798726 18409526 19654053 19584965 19376361 5415686 19436671 11752352 24915143 20029618 20046204 12184468

Sources:
TEND PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions
ALLOPURINOL PSORS1C1

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21801394 29193002

Sources:
PharmGKB
ALLOPURINOL POU5F1

Interaction Score: 0.98

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21801394

Sources:
PharmGKB
ALLOPURINOL NOTCH4

Interaction Score: 0.98

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29193002

Sources:
PharmGKB
ALLOPURINOL AOX1

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27798726

Sources:
PharmGKB
ALLOPURINOL UGT1A5

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27798726

Sources:
PharmGKB
ALLOPURINOL UGT1A7

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27798726

Sources:
PharmGKB
ALLOPURINOL UGT1A10

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27798726

Sources:
PharmGKB
ALLOPURINOL UGT1A8

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27798726

Sources:
PharmGKB
ALLOPURINOL UGT1A6

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27798726

Sources:
PharmGKB
ALLOPURINOL UGT1A4

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27798726

Sources:
PharmGKB
ALLOPURINOL UGT1A3

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27798726

Sources:
PharmGKB
ALLOPURINOL UGT1A9

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27798726

Sources:
PharmGKB
ALLOPURINOL ABCG2

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29341237 26810134 30924126

Sources:
PharmGKB
ALLOPURINOL UGT1A1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27798726

Sources:
PharmGKB
ALLOPURINOL CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
ALLOPURINOL CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
ALLOPURINOL CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
ALLOPURINOL CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
ALLOPURINOL CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

DrugBank: DB00437

Version: 5.1.7

Alternate Names:

ALLOPURINOL DrugBank Drug Name

315-30-0 CAS Number

Adenock Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories antigout preparations

Publications:

Pacher et al., 2006, Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol., Pharmacol. Rev.

Okamoto, 2008, [Inhibitors of xanthine oxidoreductase]., Nippon Rinsho

Carro et al., 2010, Effects of allopurinol on uric acid concentrations, xanthine oxidoreductase activity and oxidative stress in broiler chickens., Comp. Biochem. Physiol. C Toxicol. Pharmacol.

TEND: ALLOPURINOL
- Version: 01-August-2011
Alternate Names:

ALLOPURINOL Primary Drug Name

Drug Info:

Drug Class gout suppressants

Year of Approval 1980

Publications:
TdgClinicalTrial: ALLOPURINOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of gout

Drug Class Small Molecule

FDA Approval approved

Publications:
DTC: ALLOPURINOL
- Version: 02-September-2020
Alternate Names:

CHEMBL1467 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

PharmGKB: allopurinol

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Génin E et al., 2011, Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe., Orphanet J Rare Dis

Cheng L et al., 2018, The minor alleles HCP5 rs3099844 A and PSORS1C1 rs3131003 G are associated with allopurinol-induced severe cutaneous adverse reactions in Han Chinese: a multicentre retrospective case-control clinical study., Br J Dermatol

Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int

TTD: Allopurinol
- Version: 2020.06.01
Alternate Names:

D04KYY TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 178103401
- Version: 29-September-2020
Alternate Names:

ALLOPURINOL GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1467
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1467
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Xanthine dehydrogenase inhibitor
Trial Name	NU1618, tranilast + allopurinol

ALLOPURINOL	DrugBank Drug Name
315-30-0	CAS Number
Adenock	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	antigout preparations

ALLOPURINOL Drug Record

ALLOPURINOL chembl:CHEMBL1467 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29193002

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30924126

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30924126

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30924126

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30924126

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21801394

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30924126

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30924126

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21801394 29193002

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Xanthine dehydrogenase inhibitor Trial Name NU1618, tranilast + allopurinol

PMIDs: 16507884 27798726 18409526 19654053 19584965 19376361 5415686 19436671 11752352 24915143 20029618 20046204 12184468

Sources: TEND PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21801394 29193002

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21801394

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29193002

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27798726

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27798726

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27798726

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27798726

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27798726

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27798726

Interaction Types & Directionality:

n/a

PMIDs:
29193002

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
30924126

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
30924126

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
30924126

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
30924126

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21801394

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
30924126

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
30924126

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21801394 29193002

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Xanthine dehydrogenase inhibitor

Trial Name NU1618, tranilast + allopurinol

PMIDs:
16507884 27798726 18409526 19654053 19584965 19376361 5415686 19436671 11752352 24915143 20029618 20046204 12184468

Sources:
TEND PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
21801394 29193002

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21801394

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29193002

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27798726

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27798726

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27798726

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27798726

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27798726

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27798726

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27798726

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27798726

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27798726

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29341237 26810134 30924126

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27798726

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a