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ALPRENOLOL Drug Record

  • Summary
  • Interactions
  • Claims
  • ALPRENOLOL chembl:CHEMBL266195

    Alternate Names:

    ALPRENOLOL
    ALFEPROL
    1-(O-ALLYLPHENOXY)-3-(ISOPROPYLAMINO)-2-PROPANOL
    1-(2-ALLYLPHENOXY)-3-ISOPROPYLAMINO-2-PROPANOL
    ATENENOL®
    pubchem.compound:2119
    chemidplus:13655-52-2
    chembl:CHEMBL266195
    rxcui:597
    drugbank:00866

    Drug Info:

    FDA Approval not approved by the FDA
    Drug Class small molecule
    Drug Indications Antihypertensive Agents
    Drug Indications Anti-Arrhythmia Agents
    Year of Approval not approved by the fda
    Drug Class anti-arrhythmia agents
    Drug Class antihypertensive agents
    (0 More Sources)

    Publications:

    Abrahamsson, 1986, The beta 1- and beta 2-adrenoceptor stimulatory effects of alprenolol, oxprenolol and pindolol: a study in the isolated right atrium and uterus of the rat., Br. J. Pharmacol.
    Brodde et al., 1986, Effect of propranolol, alprenolol, pindolol, and bopindolol on beta 2-adrenoceptor density in human lymphocytes., J. Cardiovasc. Pharmacol.
    Brodde et al., 1985, Effects of beta-adrenoceptor antagonist administration on beta 2-adrenoceptor density in human lymphocytes. The role of the "intrinsic sympathomimetic activity"., Naunyn Schmiedebergs Arch. Pharmacol.
    el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
    De Ponti et al., 1995, Inhibitory effects of SR 58611A on canine colonic motility: evidence for a role of beta 3-adrenoceptors., Br. J. Pharmacol.
    Surman et al., 1993, Alprenolol and bromoacetylalprenololmenthane are competitive slowly reversible antagonists at the beta 1-adrenoceptors of rat left atria., J. Cardiovasc. Pharmacol.
    Im et al., 1988, Interactions of pure beta gamma-subunits of G-proteins with purified beta 1-adrenoceptor., FEBS Lett.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Brahmadevara et al., 2003, Evidence against beta 3-adrenoceptors or low affinity state of beta 1-adrenoceptors mediating relaxation in rat isolated aorta., Br. J. Pharmacol.
    Varma et al., 1999, Inverse agonist activities of beta-adrenoceptor antagonists in rat myocardium., Br. J. Pharmacol.
  • ALPRENOLOL   ADRB1

    Interaction Score: 3.72

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    7606348 7678677 2828119 11752352 12522078 10433496 2903243


    Sources:
    DTC TdgClinicalTrial TEND

  • ALPRENOLOL   ADRB2

    Interaction Score: 1.69

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    2871880 2439825 2859531 2903243


    Sources:
    DTC TdgClinicalTrial TEND

  • TEND: ALPRENOLOL

    • Version: 01-August-2011

    Alternate Names:
    ALPRENOLOL Primary Drug Name

    Drug Info:
    Drug Class antihypertensive agents
    Drug Class anti-arrhythmia agents
    Year of Approval not approved by the fda

    Publications:

  • TdgClinicalTrial: ALPRENOLOL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Anti-Arrhythmia Agents
    Drug Indications Antihypertensive Agents
    Drug Class small molecule

    Publications:

  • DTC: ALPRENOLOL

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL266195 ChEMBL Drug ID

    Drug Info:

    Publications:
    el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem

  • ChemblDrugs: chembl:CHEMBL266195

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21