DGIdb - ALPRENOLOL Drug Record

ALPRENOLOL chembl:CHEMBL266195

Alternate Names:

ALPRENOLOL
ALFEPROL
1-(O-ALLYLPHENOXY)-3-(ISOPROPYLAMINO)-2-PROPANOL
1-(2-ALLYLPHENOXY)-3-ISOPROPYLAMINO-2-PROPANOL
ATENENOL®
pubchem.compound:2119
chemidplus:13655-52-2
chembl:CHEMBL266195
rxcui:597
drugbank:00866

Drug Info:

FDA Approval	not approved by the FDA
Drug Class	small molecule
Drug Indications	Antihypertensive Agents
Drug Indications	Anti-Arrhythmia Agents
Year of Approval	not approved by the fda
Drug Class	anti-arrhythmia agents
Drug Class	antihypertensive agents

(1 More Sources)

Publications:

Abrahamsson, 1986, The beta 1- and beta 2-adrenoceptor stimulatory effects of alprenolol, oxprenolol and pindolol: a study in the isolated right atrium and uterus of the rat., Br. J. Pharmacol.
Brodde et al., 1986, Effect of propranolol, alprenolol, pindolol, and bopindolol on beta 2-adrenoceptor density in human lymphocytes., J. Cardiovasc. Pharmacol.
Brodde et al., 1985, Effects of beta-adrenoceptor antagonist administration on beta 2-adrenoceptor density in human lymphocytes. The role of the "intrinsic sympathomimetic activity"., Naunyn Schmiedebergs Arch. Pharmacol.
el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
De Ponti et al., 1995, Inhibitory effects of SR 58611A on canine colonic motility: evidence for a role of beta 3-adrenoceptors., Br. J. Pharmacol.
Surman et al., 1993, Alprenolol and bromoacetylalprenololmenthane are competitive slowly reversible antagonists at the beta 1-adrenoceptors of rat left atria., J. Cardiovasc. Pharmacol.
Im et al., 1988, Interactions of pure beta gamma-subunits of G-proteins with purified beta 1-adrenoceptor., FEBS Lett.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Brahmadevara et al., 2003, Evidence against beta 3-adrenoceptors or low affinity state of beta 1-adrenoceptors mediating relaxation in rat isolated aorta., Br. J. Pharmacol.
Varma et al., 1999, Inverse agonist activities of beta-adrenoceptor antagonists in rat myocardium., Br. J. Pharmacol.

ALPRENOLOL ADRB1

Interaction Score: 3.47

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
7606348 7678677 2828119 11752352 12522078 10433496 2903243

Sources:
DTC TdgClinicalTrial TEND
ALPRENOLOL ADRB2

Interaction Score: 1.85

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
2871880 2439825 2859531 2903243

Sources:
DTC TdgClinicalTrial TEND GuideToPharmacology

TEND: ALPRENOLOL
- Version: 01-August-2011
Alternate Names:

ALPRENOLOL Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Drug Class anti-arrhythmia agents

Year of Approval not approved by the fda

Publications:
TdgClinicalTrial: ALPRENOLOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anti-Arrhythmia Agents

Drug Indications Antihypertensive Agents

Drug Class small molecule

Publications:
DTC: ALPRENOLOL
- Version: 02-September-2020
Alternate Names:

CHEMBL266195 ChEMBL Drug ID

Drug Info:

Publications:

el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
GuideToPharmacology: 135649926
- Version: 29-September-2020
Alternate Names:

ALPRENOLOL GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL266195
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target
Specific Action of the Ligand	Antagonist

ALPRENOLOL Drug Record

ALPRENOLOL chembl:CHEMBL266195

Alternate Names:

Drug Info:

Publications:

ALPRENOLOL ADRB1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 7606348 7678677 2828119 11752352 12522078 10433496 2903243

Sources: DTC TdgClinicalTrial TEND

ALPRENOLOL ADRB2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Specific Action of the Ligand Antagonist

PMIDs: 2871880 2439825 2859531 2903243

Sources: DTC TdgClinicalTrial TEND GuideToPharmacology

TEND: ALPRENOLOL

Alternate Names: ALPRENOLOL Primary Drug Name

Drug Info: Drug Class antihypertensive agents Drug Class anti-arrhythmia agents Year of Approval not approved by the fda

Publications:

TdgClinicalTrial: ALPRENOLOL

Alternate Names:

Drug Info: Drug Indications Anti-Arrhythmia Agents Drug Indications Antihypertensive Agents Drug Class small molecule

Publications:

DTC: ALPRENOLOL

Alternate Names: CHEMBL266195 ChEMBL Drug ID

Drug Info:

Publications: el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem

GuideToPharmacology: 135649926

Alternate Names: ALPRENOLOL GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL266195

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
7606348 7678677 2828119 11752352 12522078 10433496 2903243

Sources:
DTC TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
2871880 2439825 2859531 2903243

Sources:
DTC TdgClinicalTrial TEND GuideToPharmacology

Alternate Names:

ALPRENOLOL Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Drug Class anti-arrhythmia agents

Year of Approval not approved by the fda

Drug Info:

Drug Indications Anti-Arrhythmia Agents

Drug Indications Antihypertensive Agents

Drug Class small molecule

Alternate Names:

CHEMBL266195 ChEMBL Drug ID

Publications:

el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem

Alternate Names:

ALPRENOLOL GuideToPharmacology Ligand Name