DGIdb - ALPROSTADIL Drug Record

ALPROSTADIL chembl:CHEMBL495 Approved

Alternate Names:

PGE1
CAVERJECT
EDEX
PROSTIN
VITAROS
VIRIDAL 20
VIRIDAL DUO
NSC-165559
U-10136
PROSTAGLANDIN E1
PROSTIN VR PEDIATRIC
CAVERJECT IMPULSE
VIRIDAL 5
ONO-1608
ALPROSTADIL
PROSTIN VR
VIRIDAL 10
(+)-3-HYDROXY-2-(3-HYDROXY-1-OCTENYL)-5-OXO-CYCLOPENTANEHEPTANOATE
MUSE
(13E)-(15S)-11-ALPHA,15-DIHYDROXY-9-OXOPROST-13-ENOATE
(+)-3-HYDROXY-2-(3-HYDROXY-1-OCTENYL)-5-OXO-CYCLOPENTANEHEPTANOIC ACID
(13E)-(15S)-11,15-DIHYDROXY-9-OXOPROST-13-ENOATE
7-[(1R,2R,3R)-3-HYDROXY-2-[(1E,3S)-3-HYDROXYOCT-1-EN-1-YL]-5-OXOCYCLOPENTYL]HEPTANOIC ACID
11,15-DIHYDROXY-9-OXOPROST-13-EN-1-OIC ACID (ACD/NAME 4.0)
(13E)-(15S)-11,15-DIHYDROXY-9-OXOPROST-13-ENOIC ACID
(-)-3-HYDROXY-2-(3-HYDROXY-1-OCTENYL)-5-OXO-CYCLOPENTANEHEPTANOATE
11ALPHA,15ALPHA-DIHYDROXY-9-OXO-13-TRANS-PROSTENOIC ACID
PRINK (TN)
(-)-PROSTAGLANDIN E1
(13E)-(15S)-11-ALPHA,15-DIHYDROXY-9-OXOPROST-13-ENOIC ACID
PGE-1
11,15-DIHYDROXY-9-OXOPROST-13-EN-1-OATE
(11ALPHA,13E,15S)-11,15-DIHYDROXY-9-OXOPROST-13-EN-1-OIC ACID
3-HYDROXY-2-(3-HYDROXY-1-OCTENYL)-5-OXO-CYCLOPENTANEHEPTANOIC ACID
MR-256
11,15-DIHYDROXY-9-OXOPROST-13-EN-1-OIC ACID
(13E)-(15S)-11ALPHA,15-DIHYDROXY-9-OXOPROST-13-ENOIC ACID
ALPROSTADIL(USAN)
PGE1 Α-CD
(13E)-(15S)-11ALPHA,15-DIHYDROXY-9-OXOPROST-13-ENOATE
L-PROSTAGLANDIN E1
ALPROSTADIL ALFADEX
(-)-3-HYDROXY-2-(3-HYDROXY-1-OCTENYL)-5-OXO-CYCLOPENTANEHEPTANOIC ACID
ALPROSTADIL®
3-HYDROXY-2-(3-HYDROXY-1-OCTENYL)-5-OXO-CYCLOPENTANEHEPTANOATE
ALPROSTADILUM
BEFAR
PGE₁
ALPROSTADIL PROSTOGLANDIN E1
PRINK
chembl:CHEMBL495
pubchem.compound:5280723
rxcui:598
chemidplus:745-65-3
drugbank:00770

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	for treatment of erectile dysfunction,for treatment of sexual dysfunction in women
Year of Approval	1995
Drug Class	anti-impotence agents

(2 More Sources)

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Matlhagela et al., 2006, Involvement of EP1 and EP2 receptors in the regulation of the Na,K-ATPase by prostaglandins in MDCK cells., Prostaglandins Other Lipid Mediat.
Norel et al., 2004, Vasoconstriction induced by activation of EP1 and EP3 receptors in human lung: effects of ONO-AE-248, ONO-DI-004, ONO-8711 or ONO-8713., Prostaglandins Other Lipid Mediat.
Ito et al., 2000, The prostaglandin E series modulates high-voltage-activated calcium channels probably through the EP3 receptor in rat paratracheal ganglia., Neuropharmacology
Takahashi et al., 2003, Unique regulation profile of prostaglandin e1 on adhesion molecule expression and cytokine production in human peripheral blood mononuclear cells., J. Pharmacol. Exp. Ther.
Tokuda et al., 2001, p38 mitogen-activated protein (MAP) kinase but not p44/p42 MAP kinase is involved in prostaglandin E1-induced vascular endothelial growth factor synthesis in osteoblasts., J. Endocrinol.
Dijkstra et al., 1999, Flow after prostaglandin E1 is mediated by receptor-coupled adenylyl cyclase in human anterior segments., Invest. Ophthalmol. Vis. Sci.
Takahashi et al., 2005, Differential effect of prostaglandins E1 and E2 on lipopolysaccharide-induced adhesion molecule expression on human monocytes., Eur. J. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

ALPROSTADIL PTGER1

Interaction Score: 6.87

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Prostanoid EP1 receptor agonist

Direct Interaction yes

Trial Name topical alprostadil cream,Alprox-TD, Befar, Vitaros

PMIDs:
16516814 15560119 10670413 14561849 11524243

Sources:
TdgClinicalTrial ChemblInteractions TEND
ALPROSTADIL PTGER2

Interaction Score: 5.41

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name alprostadil,Alista

Novel drug target Established target

Trial Name alprostadil,Femprox

PMIDs:
10509658 15840408 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
ALPROSTADIL TBXA2R

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ALPROSTADIL CYP2C9

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
ALPROSTADIL CYP2C19

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
ALPROSTADIL CYP1A2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
ALPROSTADIL CYP2D6

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
ALPROSTADIL CYP3A4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

TEND: ALPROSTADIL
- Version: 01-August-2011
Alternate Names:

ALPROSTADIL Primary Drug Name

Drug Info:

Drug Class anti-impotence agents

Year of Approval 1995

Publications:
TdgClinicalTrial: ALPROSTADIL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of erectile dysfunction,for treatment of sexual dysfunction in women

Drug Class Small Molecule

FDA Approval approved

Publications:
DTC: ALPROSTADIL
- Version: 02-September-2020
Alternate Names:

CHEMBL495 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
TTD: Alprostadil
- Version: 2020.06.01
Alternate Names:

D0I4DQ TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL495
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL495
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Prostanoid EP1 receptor agonist
Direct Interaction	yes
Trial Name	topical alprostadil cream,Alprox-TD, Befar, Vitaros

Trial Name	alprostadil,Alista
Novel drug target	Established target
Trial Name	alprostadil,Femprox

ALPROSTADIL Drug Record

ALPROSTADIL chembl:CHEMBL495 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Prostanoid EP1 receptor agonist Direct Interaction yes Trial Name topical alprostadil cream,Alprox-TD, Befar, Vitaros

PMIDs: 16516814 15560119 10670413 14561849 11524243

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name alprostadil,Alista Novel drug target Established target Trial Name alprostadil,Femprox

PMIDs: 10509658 15840408 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

TEND: ALPROSTADIL

Alternate Names: ALPROSTADIL Primary Drug Name

Drug Info: Drug Class anti-impotence agents Year of Approval 1995

Publications:

TdgClinicalTrial: ALPROSTADIL

Alternate Names:

Drug Info: Drug Indications for treatment of erectile dysfunction,for treatment of sexual dysfunction in women Drug Class Small Molecule FDA Approval approved

Publications:

DTC: ALPROSTADIL

Alternate Names: CHEMBL495 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

TTD: Alprostadil

Alternate Names: D0I4DQ TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL495

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL495

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Prostanoid EP1 receptor agonist

Direct Interaction yes

Trial Name topical alprostadil cream,Alprox-TD, Befar, Vitaros

PMIDs:
16516814 15560119 10670413 14561849 11524243

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name alprostadil,Alista

Novel drug target Established target

Trial Name alprostadil,Femprox

PMIDs:
10509658 15840408 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

ALPROSTADIL Primary Drug Name

Drug Info:

Drug Class anti-impotence agents

Year of Approval 1995

Drug Info:

Drug Indications for treatment of erectile dysfunction,for treatment of sexual dysfunction in women

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

CHEMBL495 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

D0I4DQ TTD Drug ID