• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

ALTEPLASE Drug Record

  • Summary
  • Interactions
  • Claims
  • ALTEPLASE chembl:CHEMBL1201593 Approved

    Alternate Names:

    ACTILYSE
    TISSUE PLASMINOGEN ACTIVATOR ALTEPLASE
    RETAVASE
    TNKASE
    ACTIVASE
    CATHFLO ACTIVASE
    ALTEPLASE (GENETICAL RECOMBINATION)
    RT-PA
    ACTILYSE CATHFLO
    ALTEPLASE
    TISSUE-TYPE PLASMINOGEN ACTIVATOR PRECURSOR
    T-PLASMINOGEN ACTIVATOR
    T-PA
    TPA
    rxcui:8410
    drugbank:00009
    chembl:CHEMBL1201593
    chemidplus:105857-23-6

    Drug Info:

    Drug Class thrombolytic agents
    Year of Approval 1996
    FDA Approval approved
    Drug Class recombinant protein
    Drug Indications Thrombolytic agent
    (2 More Sources)

    Publications:

    Melandri et al., 2009, Review of tenecteplase (TNKase) in the treatment of acute myocardial infarction., Vasc Health Risk Manag
    Longstaff et al., 2008, Fibrin binding and the regulation of plasminogen activators during thrombolytic therapy., Cardiovasc Hematol Agents Med Chem
    Hilleman et al., 2007, Fibrinolytic agents for the management of ST-segment elevation myocardial infarction., Pharmacotherapy
    Thompson et al., 1980, Failure of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate to enhance sister chromatid exchange, mitotic segregation, or expression of mutations in Chinese hamster cells., Cancer Res.
    Muros et al., 1994, Modulation of contractile proteins in embryonic and fetal chick cardiac cells by phorbol ester, gamma-interferon, 5-azacytidine and diacylglycerols., Life Sci.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Ellis et al., 2002, Plasminogen activation is stimulated by prion protein and regulated in a copper-dependent manner., Biochemistry
    Delgado et al., 1992, Differential expression of ras protooncogenes during in vitro differentiation of human erythroleukemia cells., Cancer Res.
    Chang et al., 2002, Novel protein kinase C isoforms and mitogen-activated kinase kinase mediate phorbol ester-induced osteopontin expression., Int. J. Biochem. Cell Biol.
    Bozdagi et al., 2008, The neurotrophin-inducible gene Vgf regulates hippocampal function and behavior through a brain-derived neurotrophic factor-dependent mechanism., J. Neurosci.
    Lochner et al., 2008, Efficient copackaging and cotransport yields postsynaptic colocalization of neuromodulators associated with synaptic plasticity., Dev Neurobiol
    Gogusev et al., Regulation of TNF-alpha and IL-1 gene expression during TPA-induced differentiation of "Malignant histiocytosis" DEL cell line t(5;6) (q35:p21)., Anticancer Res.
    Yoshioka et al., 1995, Antitumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression., Proc. Natl. Acad. Sci. U.S.A.
    Laverrière et al., 1989, Thyroliberin and dihydropyridines modulate prolactin gene expression through interacting pathways in GH3 cells., Neuroendocrinology
    Nolin et al., 2008, tPA-mediated generation of plasmin is catalyzed by the proteoglycan NG2., Glia
    Tsunobuchi et al., 2004, Expressions of inhibitory Smads, Smad6 and Smad7, are differentially regulated by TPA in human lung fibroblast cells., Biochem. Biophys. Res. Commun.
    Klobusická et al., 1992, Cytochemical study of activated peritoneal macrophages in normal and tumor-bearing rats., Neoplasma
    Iwata et al., 1996, Neurotrophin-3 increases the DNA-binding activities of several transcription factors in a mouse osteoblastic cell line., Biochim. Biophys. Acta
    Nakayama et al., 2000, Transcriptional control of adrenomedullin induction by phorbol ester in human monocytic leukemia cells., Eur. J. Biochem.
    Ni et al., 2001, gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase., Science
    Scortegagna et al., 2008, HIF-1alpha regulates epithelial inflammation by cell autonomous NFkappaB activation and paracrine stromal remodeling., Blood
    Afaq et al., 2004, Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion markers in CD-1 mouse skin by oleandrin., Toxicol. Appl. Pharmacol.
  • ALTEPLASE   CSPG4

    Interaction Score: 6.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18000864


    Sources:
    NCI

  • ALTEPLASE   FOSL1

    Interaction Score: 6.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7761434


    Sources:
    NCI

  • ALTEPLASE   APRT

    Interaction Score: 6.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6933001


    Sources:
    NCI

  • ALTEPLASE   SMAD7

    Interaction Score: 3.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15033458


    Sources:
    NCI

  • ALTEPLASE   DES

    Interaction Score: 3.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7507197


    Sources:
    NCI

  • ALTEPLASE   ACP5

    Interaction Score: 1.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1436243


    Sources:
    NCI

  • ALTEPLASE   FGA

    Interaction Score: 1.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name alteplase,Activase, Actilyse
    Novel drug target Established target

    PMIDs:
    19436656 18673235 17963464


    Sources:
    TdgClinicalTrial

  • ALTEPLASE   CXCL2

    Interaction Score: 1.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18199827


    Sources:
    NCI

  • ALTEPLASE   PLG

    Interaction Score: 1.12

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name alteplase,Activase, Actilyse
    Mechanism of Interaction Plasminogen activator

    PMIDs:
    19436656 18673235 11752352 17963464 12033920


    Sources:
    TdgClinicalTrial ChemblInteractions NCI TEND TTD

  • ALTEPLASE   SPP1

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12009309


    Sources:
    NCI

  • ALTEPLASE   ADM

    Interaction Score: 0.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10848972


    Sources:
    NCI

  • ALTEPLASE   NTF3

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8630334


    Sources:
    NCI

  • ALTEPLASE   NRG1

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11679632


    Sources:
    NCI

  • ALTEPLASE   PRL

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2482456


    Sources:
    NCI

  • ALTEPLASE   IL1B

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8615653


    Sources:
    NCI

  • ALTEPLASE   BDNF

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18815270 18563704


    Sources:
    NCI

  • ALTEPLASE   NRAS

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1394224


    Sources:
    NCI

  • ALTEPLASE   TNF

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8615653


    Sources:
    NCI

  • ALTEPLASE   PIK3CG

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15020199


    Sources:
    NCI

  • TEND: ALTEPLASE

    • Version: 01-August-2011

    Alternate Names:
    ALTEPLASE Primary Drug Name

    Drug Info:
    Year of Approval 1996
    Drug Class thrombolytic agents

    Publications:

  • TdgClinicalTrial: ALTEPLASE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Thrombolytic agent
    Drug Class recombinant protein
    FDA Approval approved

    Publications:

  • NCI: TPA

    • Version: 14-September-2017

    Alternate Names:
    C866 NCI drug code
    C39607 NCI drug code

    Drug Info:

    Publications:
    Thompson et al., 1980, Failure of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate to enhance sister chromatid exchange, mitotic segregation, or expression of mutations in Chinese hamster cells., Cancer Res.
    Gogusev et al., Regulation of TNF-alpha and IL-1 gene expression during TPA-induced differentiation of "Malignant histiocytosis" DEL cell line t(5;6) (q35:p21)., Anticancer Res.
    Nakayama et al., 2000, Transcriptional control of adrenomedullin induction by phorbol ester in human monocytic leukemia cells., Eur. J. Biochem.

  • TTD: Alteplase

    • Version: 2020.06.01

    Alternate Names:
    D07BQE TTD Drug ID

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1201593

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1201593

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21