DGIdb - ALTEPLASE Drug Record

ALTEPLASE chembl:CHEMBL1201593 Approved

Alternate Names:

ACTILYSE
TISSUE PLASMINOGEN ACTIVATOR ALTEPLASE
RETAVASE
TNKASE
ACTIVASE
CATHFLO ACTIVASE
ALTEPLASE (GENETICAL RECOMBINATION)
RT-PA
ACTILYSE CATHFLO
ALTEPLASE
TISSUE-TYPE PLASMINOGEN ACTIVATOR PRECURSOR
T-PLASMINOGEN ACTIVATOR
T-PA
TPA
rxcui:8410
drugbank:00009
chembl:CHEMBL1201593
chemidplus:105857-23-6

Drug Info:

Drug Class	thrombolytic agents
Year of Approval	1996
FDA Approval	approved
Drug Class	recombinant protein
Drug Indications	Thrombolytic agent

(2 More Sources)

Publications:

Melandri et al., 2009, Review of tenecteplase (TNKase) in the treatment of acute myocardial infarction., Vasc Health Risk Manag
Longstaff et al., 2008, Fibrin binding and the regulation of plasminogen activators during thrombolytic therapy., Cardiovasc Hematol Agents Med Chem
Hilleman et al., 2007, Fibrinolytic agents for the management of ST-segment elevation myocardial infarction., Pharmacotherapy
Thompson et al., 1980, Failure of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate to enhance sister chromatid exchange, mitotic segregation, or expression of mutations in Chinese hamster cells., Cancer Res.
Muros et al., 1994, Modulation of contractile proteins in embryonic and fetal chick cardiac cells by phorbol ester, gamma-interferon, 5-azacytidine and diacylglycerols., Life Sci.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Ellis et al., 2002, Plasminogen activation is stimulated by prion protein and regulated in a copper-dependent manner., Biochemistry
Delgado et al., 1992, Differential expression of ras protooncogenes during in vitro differentiation of human erythroleukemia cells., Cancer Res.
Chang et al., 2002, Novel protein kinase C isoforms and mitogen-activated kinase kinase mediate phorbol ester-induced osteopontin expression., Int. J. Biochem. Cell Biol.
Bozdagi et al., 2008, The neurotrophin-inducible gene Vgf regulates hippocampal function and behavior through a brain-derived neurotrophic factor-dependent mechanism., J. Neurosci.
Lochner et al., 2008, Efficient copackaging and cotransport yields postsynaptic colocalization of neuromodulators associated with synaptic plasticity., Dev Neurobiol
Gogusev et al., Regulation of TNF-alpha and IL-1 gene expression during TPA-induced differentiation of "Malignant histiocytosis" DEL cell line t(5;6) (q35:p21)., Anticancer Res.
Yoshioka et al., 1995, Antitumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression., Proc. Natl. Acad. Sci. U.S.A.
Laverrière et al., 1989, Thyroliberin and dihydropyridines modulate prolactin gene expression through interacting pathways in GH3 cells., Neuroendocrinology
Nolin et al., 2008, tPA-mediated generation of plasmin is catalyzed by the proteoglycan NG2., Glia
Tsunobuchi et al., 2004, Expressions of inhibitory Smads, Smad6 and Smad7, are differentially regulated by TPA in human lung fibroblast cells., Biochem. Biophys. Res. Commun.
Klobusická et al., 1992, Cytochemical study of activated peritoneal macrophages in normal and tumor-bearing rats., Neoplasma
Iwata et al., 1996, Neurotrophin-3 increases the DNA-binding activities of several transcription factors in a mouse osteoblastic cell line., Biochim. Biophys. Acta
Nakayama et al., 2000, Transcriptional control of adrenomedullin induction by phorbol ester in human monocytic leukemia cells., Eur. J. Biochem.
Ni et al., 2001, gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase., Science
Scortegagna et al., 2008, HIF-1alpha regulates epithelial inflammation by cell autonomous NFkappaB activation and paracrine stromal remodeling., Blood
Afaq et al., 2004, Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion markers in CD-1 mouse skin by oleandrin., Toxicol. Appl. Pharmacol.

ALTEPLASE CSPG4

Interaction Score: 6.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18000864

Sources:
NCI
ALTEPLASE FOSL1

Interaction Score: 6.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7761434

Sources:
NCI
ALTEPLASE APRT

Interaction Score: 6.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6933001

Sources:
NCI
ALTEPLASE SMAD7

Interaction Score: 3.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15033458

Sources:
NCI
ALTEPLASE DES

Interaction Score: 3.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7507197

Sources:
NCI
ALTEPLASE ACP5

Interaction Score: 1.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1436243

Sources:
NCI
ALTEPLASE FGA

Interaction Score: 1.63

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name alteplase,Activase, Actilyse

Novel drug target Established target

PMIDs:
19436656 18673235 17963464

Sources:
TdgClinicalTrial
ALTEPLASE CXCL2

Interaction Score: 1.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18199827

Sources:
NCI
ALTEPLASE PLG

Interaction Score: 1.12

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Novel drug target Established target

Trial Name alteplase,Activase, Actilyse

Mechanism of Interaction Plasminogen activator

PMIDs:
19436656 18673235 11752352 17963464 12033920

Sources:
TdgClinicalTrial ChemblInteractions NCI TEND TTD
ALTEPLASE SPP1

Interaction Score: 1.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12009309

Sources:
NCI
ALTEPLASE ADM

Interaction Score: 0.93

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10848972

Sources:
NCI
ALTEPLASE NTF3

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8630334

Sources:
NCI
ALTEPLASE NRG1

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11679632

Sources:
NCI
ALTEPLASE PRL

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2482456

Sources:
NCI
ALTEPLASE IL1B

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8615653

Sources:
NCI
ALTEPLASE BDNF

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18815270 18563704

Sources:
NCI
ALTEPLASE NRAS

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1394224

Sources:
NCI
ALTEPLASE TNF

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8615653

Sources:
NCI
ALTEPLASE PIK3CG

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15020199

Sources:
NCI

TEND: ALTEPLASE
- Version: 01-August-2011
Alternate Names:

ALTEPLASE Primary Drug Name

Drug Info:

Year of Approval 1996

Drug Class thrombolytic agents

Publications:
TdgClinicalTrial: ALTEPLASE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Thrombolytic agent

Drug Class recombinant protein

FDA Approval approved

Publications:

NCI: TPA

Version: 14-September-2017

Alternate Names:

C866 NCI drug code

C39607 NCI drug code

Drug Info:

Publications:

Thompson et al., 1980, Failure of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate to enhance sister chromatid exchange, mitotic segregation, or expression of mutations in Chinese hamster cells., Cancer Res.

Gogusev et al., Regulation of TNF-alpha and IL-1 gene expression during TPA-induced differentiation of "Malignant histiocytosis" DEL cell line t(5;6) (q35:p21)., Anticancer Res.

Nakayama et al., 2000, Transcriptional control of adrenomedullin induction by phorbol ester in human monocytic leukemia cells., Eur. J. Biochem.

TTD: Alteplase
- Version: 2020.06.01
Alternate Names:

D07BQE TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL1201593
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1201593
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	alteplase,Activase, Actilyse
Novel drug target	Established target

ALTEPLASE Drug Record

ALTEPLASE chembl:CHEMBL1201593 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18000864

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7761434

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6933001

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15033458

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7507197

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1436243

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: Trial Name alteplase,Activase, Actilyse Novel drug target Established target

PMIDs: 19436656 18673235 17963464

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18199827

Sources: NCI

Interaction Types & Directionality: activator (activating)

Interaction Info: Novel drug target Established target Trial Name alteplase,Activase, Actilyse Mechanism of Interaction Plasminogen activator

PMIDs: 19436656 18673235 11752352 17963464 12033920

Sources: TdgClinicalTrial ChemblInteractions NCI TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12009309

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10848972

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8630334

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11679632

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2482456

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8615653

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18815270 18563704

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1394224

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8615653

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15020199

Interaction Types & Directionality:

n/a

PMIDs:
18000864

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7761434

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6933001

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15033458

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7507197

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1436243

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name alteplase,Activase, Actilyse

Novel drug target Established target

PMIDs:
19436656 18673235 17963464

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
18199827

Sources:
NCI

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Novel drug target Established target

Trial Name alteplase,Activase, Actilyse

Mechanism of Interaction Plasminogen activator

PMIDs:
19436656 18673235 11752352 17963464 12033920

Sources:
TdgClinicalTrial ChemblInteractions NCI TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
12009309

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10848972

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8630334

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11679632

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2482456

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8615653

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18815270 18563704

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1394224

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8615653

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15020199

Sources:
NCI

Alternate Names:

ALTEPLASE Primary Drug Name

Drug Info:

Year of Approval 1996

Drug Class thrombolytic agents

Drug Info:

Drug Indications Thrombolytic agent

Drug Class recombinant protein

FDA Approval approved

Alternate Names:

C866 NCI drug code

C39607 NCI drug code

Alternate Names:

D07BQE TTD Drug ID