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AMITRIPTYLINE Drug Record

  • Summary
  • Interactions
  • Claims
  • AMITRIPTYLINE chembl:CHEMBL629 Approved

    Alternate Names:

    AMITRIL
    ELAVIL
    AMITRIPTYLINE
    ENDEP
    AMITID
    ETRAFON-FORTE
    LIMBITROL
    ETRAFON-A
    10,11-DIHYDRO-N,N-DIMETHYL-5H-DIBENZO(A,D)HEPTALENE-DELTA(5),GAMMA-PROPYLAMINE
    AMITRYPTILINE
    5-(3-DIMETHYLAMINOPROPYLIDENE)-10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTATRIENE
    ELAVIL®
    10,11-DIHYDRO-5-(GAMMA-DIMETHYLAMINOPROPYLIDENE)-5H-DIBENZO(A,D)CYCLOHEPTENE
    5-(3-DIMETHYLAMINOPROPYLIDENE)-10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTENE
    5-(GAMMA-DIMETHYLAMINOPROPYLIDENE)-5H-DIBENZO[A,D][1,4]CYCLOHEPTADIENE
    AMITRIPTILINA
    3-(10,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5-YLIDENE)-N,N-DIMETHYLPROPAN-1-AMINE
    AMITRIPTYLINUM
    AMITRIPTYLIN
    ENDEP®
    3-(10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDENE)-N,N-DIMETHYL-1-PROPANAMINE
    pubchem.compound:2160
    chembl:CHEMBL629
    chemidplus:50-48-6
    drugbank:00321
    rxcui:704

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications analgesic
    Year of Approval 1961
    Drug Class antidepressive agents, tricyclic
    (4 More Sources)

    Publications:

    Ushijima et al., 2005, Chronopharmacological study of antidepressants in forced swimming test of mice., J. Pharmacol. Exp. Ther.
    Werling et al., 2007, A comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: treatment of involuntary emotional expression disorder., Exp. Neurol.
    Vaishnavi et al., 2004, Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity., Biol. Psychiatry
    Kalia, 2005, Neurobiological basis of depression: an update., Metab. Clin. Exp.
    Tatsumi et al., 1997, Pharmacological profile of antidepressants and related compounds at human monoamine transporters., Eur. J. Pharmacol.
    Troelsen et al., 2005, Chronic treatment with duloxetine is necessary for an anxiolytic-like response in the mouse zero maze: the role of the serotonin transporter., Psychopharmacology (Berl.)
    Gould et al., 2006, A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters., Biol. Psychiatry
    Bryson HM et al., 1996, Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states., Drugs Aging
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Breitenstein B et al., 2016, Association of ABCB1 gene variants, plasma antidepressant concentration, and treatment response: Results from a randomized clinical study., J Psychiatr Res
    Huang X et al., 2013, ABCB6, ABCB1 and ABCG1 genetic polymorphisms and antidepressant response of SSRIs in Chinese depressive patients., Pharmacogenomics
    de Klerk OL et al., 2013, ABCB1 gene variants influence tolerance to selective serotonin reuptake inhibitors in a large sample of Dutch cases with major depressive disorder., Pharmacogenomics J
    Uhr M et al., 2008, Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression., Neuron
    Kucia et al., Effect of antidepressants on the phospholipase A2 activity in plasma membranes of the rat brain cortex., Pol J Pharmacol
    Kubera et al., 2000, The effect of repeated amitriptyline and desipramine administration on cytokine release in C57BL/6 mice., Psychoneuroendocrinology
    Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
    Pandey DK et al., 2010, A novel 5-HT(2A) receptor antagonist exhibits antidepressant-like effects in a battery of rodent behavioural assays: approaching early-onset antidepressants., Pharmacol Biochem Behav
    Schlienger et al., [Different effects of tricyclic (clomipramine and amitriptyline) and tetracyclic (maprotiline) antidepressors on the release of thyroid stimulating hormone, prolactin and growth hormone to thyrostimulating releasing hormone in patients with psychoaffective disorders (author's transl)]., Acta Psychiatr Belg
    Linkowski et al., 1983, Prolactin and growth hormone response to levodopa in affective illness., Neuropsychobiology
    Ozgocmen et al., 2006, Antioxidant status, lipid peroxidation and nitric oxide in fibromyalgia: etiologic and therapeutic concerns., Rheumatol. Int.
  • AMITRIPTYLINE   SLC6A4

    Interaction Score: 0.91

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name amitriptyline + ketamine,Epicept NP-1
    Novel drug target Established target
    Trial Name OMS-103HP

    PMIDs:
    16079297 17689532 14744476 15877309 9537821 16032412 16140280 8736630


    Sources:
    TdgClinicalTrial TEND

  • AMITRIPTYLINE   ADA

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16283318


    Sources:
    NCI

  • AMITRIPTYLINE   SLC6A2

    Interaction Score: 0.61

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name OMS-103HP
    Novel drug target Established target
    Trial Name amitriptyline + ketamine,Epicept NP-1

    PMIDs:
    14744476 9537821 8736630


    Sources:
    TdgClinicalTrial TEND

  • AMITRIPTYLINE   IFNG

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10996474


    Sources:
    NCI

  • AMITRIPTYLINE   PRL

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6786002 6621850


    Sources:
    NCI

  • AMITRIPTYLINE   PLA2G1B

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12856820


    Sources:
    NCI

  • AMITRIPTYLINE   HTR2A

    Interaction Score: 0.14

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name OMS-103HP
    Novel drug target Established target

    PMIDs:
    7855217 19800913


    Sources:
    TdgClinicalTrial

  • AMITRIPTYLINE   ABCB1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26704739 24192121 22641028 18215618


    Sources:
    PharmGKB

  • AMITRIPTYLINE   DRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AMITRIPTYLINE   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC FDA

  • AMITRIPTYLINE   CYP2C9

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • AMITRIPTYLINE   CYP3A4

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300 9187528


    Sources:
    DTC PharmGKB

  • AMITRIPTYLINE   CYP1A2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TEND: AMITRIPTYLINE

    • Version: 01-August-2011

    Alternate Names:
    AMITRIPTYLINE Primary Drug Name

    Drug Info:
    Drug Class antidepressive agents, tricyclic
    Year of Approval 1961

    Publications:

  • TdgClinicalTrial: AMITRIPTYLINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications analgesic
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: AMITRIPTYLINE

    • Version: 14-September-2017

    Alternate Names:
    C28819 NCI drug code

    Drug Info:

    Publications:
    Rajtar et al., 2007, Amitriptyline affects histamine-N-methyltransferase and diamine oxidase activity in rats and guinea pigs., Eur. J. Pharmacol.
    Ozgocmen et al., 2006, Antioxidant status, lipid peroxidation and nitric oxide in fibromyalgia: etiologic and therapeutic concerns., Rheumatol. Int.
    Kubera et al., 2000, The effect of repeated amitriptyline and desipramine administration on cytokine release in C57BL/6 mice., Psychoneuroendocrinology

  • DTC: AMITRIPTYLINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL629 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • PharmGKB: amitriptyline

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Huang X et al., 2013, ABCB6, ABCB1 and ABCG1 genetic polymorphisms and antidepressant response of SSRIs in Chinese depressive patients., Pharmacogenomics
    Uhr M et al., 2008, Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression., Neuron
    Breitenstein B et al., 2016, Association of ABCB1 gene variants, plasma antidepressant concentration, and treatment response: Results from a randomized clinical study., J Psychiatr Res

  • TTD: Amitriptyline

    • Version: 2020.06.01

    Alternate Names:
    D0Y5UG TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL629

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Amitriptyline

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21