DGIdb - AMLODIPINE Drug Record

AMLODIPINE chembl:CHEMBL1491 Approved

Alternate Names:

AMLODIPINE
NORVASC
CKD-330 COMPONENT AMLODIPINE
NORVAS
HGP0904
ISTIN
ASTUDAL 5
HGP-0904

Drug Info:

Year of Approval	1992
Drug Class	antihypertensive agents
Drug Class	Small molecule
Drug Indications	antihypertensive agent, cardiovascular agent
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antihypertensive agent

(1 More Sources)

Publications:

Irvin MR et al., 2010, Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study., J Hypertens
Peterson et al., 2006, Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore., Mol. Pharmacol.
Kim KA et al., 2006, Effect of CYP3A5*3 genotype on the pharmacokinetics and pharmacodynamics of amlodipine in healthy Korean subjects., Clin Pharmacol Ther
Sinnegger-Brauns et al., 2009, Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms., Mol. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Tang L et al., 2016, Structural basis for inhibition of a voltage-gated Ca<sup>2+</sup> channel by Ca<sup>2+</sup> antagonist drugs., Nature
Bodi I et al., 2005, The L-type calcium channel in the heart: the beat goes on., J Clin Invest
Furukawa et al., 1997, Voltage and pH dependent block of cloned N-type Ca2+ channels by amlodipine., Br. J. Pharmacol.
Qu et al., 1998, Comparison of binding affinities of omega-conotoxin and amlodipine to N-type Ca2+ channels in rat brain., Zhongguo Yao Li Xue Bao
Furukawa et al., 1999, Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes., J. Pharmacol. Exp. Ther.
Miyashita et al., 2010, A region of N-type Ca(2+) channel critical for blockade by the dihydropyridine amlodipine., Eur. J. Pharmacol.
Ogihara et al., 2009, Evaluation of the inhibitory effect of dihydropyridines on N-type calcium channel by virtual three-dimensional pharmacophore modeling., Arzneimittelforschung
Murakami et al., 2001, Antinociceptive action of amlodipine blocking N-type Ca2+ channels at the primary afferent neurons in mice., Eur. J. Pharmacol.
Godfraind T, 2017, Discovery and Development of Calcium Channel Blockers., Front Pharmacol
Lynch AI et al., 2008, Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension., JAMA

AMLODIPINE NPPA

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18212314

Sources:
PharmGKB
AMLODIPINE CACNA1B

Interaction Score: 1.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
9249249 10374627 10525060 20097194 19634509 11426839 28611661

Sources:
TEND
AMLODIPINE CACNB2

Interaction Score: 1.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Tribenzor

Novel drug target Established target

Trial Name aliskiren + amlodipine,Tekamlo

PMIDs:
11752352

Sources:
TdgClinicalTrial
AMLODIPINE CACNA2D1

Interaction Score: 0.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name aliskiren + amlodipine,Tekamlo

Novel drug target Established target

Trial Name amlodipine besylate,Norvasc

PMIDs:
11752352

Sources:
TdgClinicalTrial TTD
AMLODIPINE CACNA1C

Interaction Score: 0.66

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name aliskiren + amlodipine,Tekamlo

Novel drug target Established target

Trial Name amlodipine besylate,Norvasc

PMIDs:
11752352 27556947 16322774

Sources:
TdgClinicalTrial
AMLODIPINE CACNA1D

Interaction Score: 0.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name aliskiren + amlodipine,Tekamlo

Novel drug target Established target

Trial Name amlodipine besylate,Norvasc

PMIDs:
19029287

Sources:
TdgClinicalTrial
AMLODIPINE CACNG1

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
AMLODIPINE AGT

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
AMLODIPINE CACNA1S

Interaction Score: 0.33

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name amlodipine besylate,Norvasc

Novel drug target Established target

Trial Name Amturnide

PMIDs:
16675661

Sources:
TdgClinicalTrial
AMLODIPINE ACE

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20577119

Sources:
PharmGKB
AMLODIPINE CYP3A5

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17178265

Sources:
PharmGKB
AMLODIPINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

TdgClinicalTrial: AMLODIPINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Publications:
TEND: AMLODIPINE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1992

Publications:

PharmGKB: amlodipine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Irvin MR et al., 2010, Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study., J Hypertens

Kim KA et al., 2006, Effect of CYP3A5*3 genotype on the pharmacokinetics and pharmacodynamics of amlodipine in healthy Korean subjects., Clin Pharmacol Ther

Lynch AI et al., 2008, Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension., JAMA

TTD: Amlodipine
- Version: 2020.06.01
Alternate Names:

D08JIV TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1491
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	Tribenzor
Novel drug target	Established target
Trial Name	aliskiren + amlodipine,Tekamlo

Trial Name	amlodipine besylate,Norvasc
Novel drug target	Established target
Trial Name	Amturnide

AMLODIPINE Drug Record

AMLODIPINE chembl:CHEMBL1491 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18212314

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 9249249 10374627 10525060 20097194 19634509 11426839 28611661

Sources: TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Tribenzor Novel drug target Established target Trial Name aliskiren + amlodipine,Tekamlo

PMIDs: 11752352

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name aliskiren + amlodipine,Tekamlo Novel drug target Established target Trial Name amlodipine besylate,Norvasc

PMIDs: 11752352

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name aliskiren + amlodipine,Tekamlo Novel drug target Established target Trial Name amlodipine besylate,Norvasc

PMIDs: 11752352 27556947 16322774

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name aliskiren + amlodipine,Tekamlo Novel drug target Established target Trial Name amlodipine besylate,Norvasc

PMIDs: 19029287

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name amlodipine besylate,Norvasc Novel drug target Established target Trial Name Amturnide

PMIDs: 16675661

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20577119

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17178265

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

TdgClinicalTrial: AMLODIPINE

Alternate Names:

Drug Info: Drug Indications antihypertensive agent Drug Class Small Molecule FDA Approval approved

Publications:

TEND: AMLODIPINE

Alternate Names:

Drug Info: Drug Class antihypertensive agents Year of Approval 1992

Publications:

PharmGKB: amlodipine

Alternate Names:

Drug Info:

TTD: Amlodipine

Alternate Names: D08JIV TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1491

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
18212314

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
9249249 10374627 10525060 20097194 19634509 11426839 28611661

Sources:
TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Tribenzor

Novel drug target Established target

Trial Name aliskiren + amlodipine,Tekamlo

PMIDs:
11752352

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name aliskiren + amlodipine,Tekamlo

Novel drug target Established target

Trial Name amlodipine besylate,Norvasc

PMIDs:
11752352

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name aliskiren + amlodipine,Tekamlo

Novel drug target Established target

Trial Name amlodipine besylate,Norvasc

PMIDs:
11752352 27556947 16322774

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name aliskiren + amlodipine,Tekamlo

Novel drug target Established target

Trial Name amlodipine besylate,Norvasc

PMIDs:
19029287

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name amlodipine besylate,Norvasc

Novel drug target Established target

Trial Name Amturnide

PMIDs:
16675661

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
20577119

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17178265

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1992

Alternate Names:

D08JIV TTD Drug ID