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AMOBARBITAL Drug Record

  • Summary
  • Interactions
  • Claims
  • AMOBARBITAL chembl:CHEMBL267894

    Alternate Names:

    AMOBARBITAL
    AMYTAL
    PENTYMAL
    AMYLOBARBITONE
    5-ETHYL-5-(3-METHYLBUTYL)-2,4,6(1H,3H,5H)-PYRIMIDINETRIONE
    5-ETHYL-5-ISOPENTYLBARBITURIC ACID
    5-ETHYL-5-ISOAMYLBARBITURIC ACID
    BARBAMIL
    5-ETHYL-5-(3-METHYLBUTYL)BARBITURIC ACID
    BARBAMYL
    rxcui:719
    chembl:CHEMBL267894
    pubchem.compound:2164
    chemidplus:57-43-2
    drugbank:01351

    Drug Info:

    Drug Categories anticholinergic agents
    Drug Categories anticonvulsants
    Drug Categories cytochrome p-450 cyp3a inducers
    Drug Categories cytochrome p-450 cyp3a4 inducers
    Drug Categories cytochrome p-450 cyp3a4 inducers (strength unknown)
    Drug Categories cytochrome p-450 enzyme inducers
    Drug Categories nicotinic antagonists
    (0 More Sources)

    Publications:

    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.
    Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.
    Whiting, 2003, The GABAA receptor gene family: new opportunities for drug development., Curr Opin Drug Discov Devel
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
  • AMOBARBITAL   GRIK2

    Interaction Score: 0.77

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 10487207


    Sources:
    DrugBank

  • AMOBARBITAL   CHRNA4

    Interaction Score: 0.4

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 16248797 10487207


    Sources:
    DrugBank

  • AMOBARBITAL   CHRNA7

    Interaction Score: 0.35

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 16248797 10487207


    Sources:
    DrugBank

  • AMOBARBITAL   GRIA2

    Interaction Score: 0.35

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 10487207


    Sources:
    DrugBank

  • AMOBARBITAL   GABRA1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    potentiator

    Interaction Info:

    PMIDs:
    14579514 11264449 11752352 10209232 10487207


    Sources:
    TTD DrugBank

  • AMOBARBITAL   GABRA6

    Interaction Score: 0.22

    Interaction Types & Directionality:
    potentiator

    Interaction Info:

    PMIDs:
    11264449 10209232


    Sources:
    DrugBank

  • AMOBARBITAL   GABRA5

    Interaction Score: 0.2

    Interaction Types & Directionality:
    potentiator

    Interaction Info:

    PMIDs:
    11264449 10209232


    Sources:
    DrugBank

  • AMOBARBITAL   GABRA2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    potentiator

    Interaction Info:

    PMIDs:
    11264449 10209232


    Sources:
    DrugBank

  • AMOBARBITAL   GABRA3

    Interaction Score: 0.19

    Interaction Types & Directionality:
    potentiator

    Interaction Info:

    PMIDs:
    11264449 10209232


    Sources:
    DrugBank

  • AMOBARBITAL   GABRA4

    Interaction Score: 0.15

    Interaction Types & Directionality:
    potentiator

    Interaction Info:

    PMIDs:
    10209232


    Sources:
    DrugBank

  • DrugBank: DB01351

    • Version: 5.1.7

    Alternate Names:
    AMOBARBITAL DrugBank Drug Name
    57-43-2 CAS Number
    Amytal Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups illicit

    Publications:
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.
    Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.

  • TTD: Amobarbital

    • Version: 2020.06.01

    Alternate Names:
    D0R6BR TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL267894

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21