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AMODIAQUINE Drug Record

  • Summary
  • Interactions
  • Claims
  • AMODIAQUINE chembl:CHEMBL682 Approved

    Alternate Names:

    GNF-PF-5648
    NSC-13453
    AMODIAQUINE
    SJ000110703
    AMODIAQUIN
    AMODIAQUINUM
    CAMOQUIN
    FLAVOQUINE
    AMODIAQUINA
    rxcui:720
    drugbank:00613
    pubchem.compound:2165
    chembl:CHEMBL682
    chemidplus:86-42-0

    Drug Info:

    (0 More Sources)

    Publications:

    Gil JP, 2008, Amodiaquine pharmacogenetics., Pharmacogenomics
    Parikh S et al., 2007, Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa., Clin Pharmacol Ther
    Cavaco I et al., 2013, CYP2C8 status of patients with malaria influences selection of Plasmodium falciparum pfmdr1 alleles after amodiaquine-artesunate treatment., J Infect Dis
    Paganotti GM et al., 2011, Human genetic variation is associated with Plasmodium falciparum drug resistance., J Infect Dis
    Yokoyama et al., 2007, Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice., Eur. J. Pharmacol.
    Barth et al., 1975, Effect of amodiaquine on gastric histamine methyltransferase and on histamine-stimulated gastric secretion., Br. J. Pharmacol.
    Nowak et al., 1980, Effect of amodiaquine on histamine level and histamine-methyltransferase activity in the rat brain., Arch. Immunol. Ther. Exp. (Warsz.)
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
  • AMODIAQUINE   HNMT

    Interaction Score: 12.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    17222819 1203620 6789797 11752352


    Sources:
    TTD

  • AMODIAQUINE   CYP2C8

    Interaction Score: 2.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18855526 17361129 23204183 21998472


    Sources:
    PharmGKB

  • AMODIAQUINE   CYP1A1

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • AMODIAQUINE   CYP1B1

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • AMODIAQUINE   G6PD

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PharmGKB: amodiaquine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Parikh S et al., 2007, Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa., Clin Pharmacol Ther
    Paganotti GM et al., 2011, Human genetic variation is associated with Plasmodium falciparum drug resistance., J Infect Dis
    Cavaco I et al., 2013, CYP2C8 status of patients with malaria influences selection of Plasmodium falciparum pfmdr1 alleles after amodiaquine-artesunate treatment., J Infect Dis

  • TTD: Amodiaquine

    • Version: 2020.06.01

    Alternate Names:
    D04NQI TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL682

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21