DGIdb - AMUVATINIB Drug Record

AMUVATINIB chembl:CHEMBL2103851 Antineoplastic

Alternate Names:

HPK 56
HPK-56
MP 470
AMUVATINIB
HPK56
MP-470

Drug Info:

Drug Class	Kinase Inhibitors
FDA Approval	not approved
Drug Class	Small molecule
Drug Indications	antineoplastic agent

(2 More Sources)

Publications:

Phillip et al., 2013, Targeting MET kinase with the small-molecule inhibitor amuvatinib induces cytotoxicity in primary myeloma cells and cell lines., J Hematol Oncol
Mahadevan et al., 2007, A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors., Oncogene

AMUVATINIB RAD51

Interaction Score: 8.83

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name MP-470

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
AMUVATINIB KIT

Interaction Score: 0.72

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MP-470

Novel drug target Established target

Mechanism of Interaction Stem cell growth factor receptor inhibitor

PMIDs:
17325667

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions
AMUVATINIB MET

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Hepatocyte growth factor receptor inhibitor

Direct Interaction yes

Trial Name MP-470

PMIDs:
24326130

Sources:
TALC MyCancerGenome TdgClinicalTrial JAX-CKB ChemblInteractions
AMUVATINIB RET

Interaction Score: 0.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name MP-470

Novel drug target Established target

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial
AMUVATINIB FLT3

Interaction Score: 0.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tyrosine-protein kinase receptor FLT3 inhibitor

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions
AMUVATINIB PDGFRA

Interaction Score: 0.41

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name MP-470

Mechanism of Interaction Platelet-derived growth factor receptor alpha inhibitor

PMIDs:
None found

Sources:
MyCancerGenome TdgClinicalTrial ChemblInteractions
AMUVATINIB PDGFRB

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name MP-470

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

MyCancerGenome: AMUVATINIB
- Version: 20-Jun-2017
Alternate Names:

MP-470 Development Name

AMUVATINIB Generic Name

Drug Info:

Drug Class Kinase Inhibitors

Publications:
TdgClinicalTrial: AMUVATINIB
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antineoplastic agent

Drug Class Small molecule

FDA Approval not approved

Publications:
JAX-CKB: Amuvatinib
- Version: 27-September-2017
Alternate Names:

Drug Info:

Publications:

Phillip et al., 2013, Targeting MET kinase with the small-molecule inhibitor amuvatinib induces cytotoxicity in primary myeloma cells and cell lines., J Hematol Oncol
TALC: AMUVATINIB
- Version: 12-May-2016
Alternate Names:

AMUVATINIB Primary Drug Name

AMUVATINIB Drug Generic Name

MP-470 Drug Synonym

Drug Info:

Publications:
ChemblInteractions: CHEMBL2103851
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL2103851
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	MP-470
Novel drug target	Established target
Mechanism of Interaction	Stem cell growth factor receptor inhibitor

Mechanism of Interaction	Hepatocyte growth factor receptor inhibitor
Direct Interaction	yes
Trial Name	MP-470

Direct Interaction	yes
Mechanism of Interaction	Tyrosine-protein kinase receptor FLT3 inhibitor
Notes

AMUVATINIB	Primary Drug Name
AMUVATINIB	Drug Generic Name
MP-470	Drug Synonym

AMUVATINIB Drug Record

AMUVATINIB chembl:CHEMBL2103851 Antineoplastic

Alternate Names:

Drug Info:

Publications:

AMUVATINIB RAD51

Interaction Types & Directionality: n/a

Interaction Info: Trial Name MP-470 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

AMUVATINIB KIT

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name MP-470 Novel drug target Established target Mechanism of Interaction Stem cell growth factor receptor inhibitor

PMIDs: 17325667

Sources: TALC MyCancerGenome TdgClinicalTrial ChemblInteractions

AMUVATINIB MET

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Hepatocyte growth factor receptor inhibitor Direct Interaction yes Trial Name MP-470

PMIDs: 24326130

Sources: TALC MyCancerGenome TdgClinicalTrial JAX-CKB ChemblInteractions

AMUVATINIB RET

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Trial Name MP-470 Novel drug target Established target

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial

AMUVATINIB FLT3

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Tyrosine-protein kinase receptor FLT3 inhibitor Notes

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial ChemblInteractions

AMUVATINIB PDGFRA

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name MP-470 Mechanism of Interaction Platelet-derived growth factor receptor alpha inhibitor

PMIDs: None found

Sources: MyCancerGenome TdgClinicalTrial ChemblInteractions

AMUVATINIB PDGFRB

Interaction Types & Directionality: n/a

Interaction Info: Trial Name MP-470 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

MyCancerGenome: AMUVATINIB

Alternate Names: MP-470 Development Name AMUVATINIB Generic Name

Drug Info: Drug Class Kinase Inhibitors

Publications:

TdgClinicalTrial: AMUVATINIB

Alternate Names:

Drug Info: Drug Indications antineoplastic agent Drug Class Small molecule FDA Approval not approved

Publications:

JAX-CKB: Amuvatinib

Alternate Names:

Drug Info:

Publications: Phillip et al., 2013, Targeting MET kinase with the small-molecule inhibitor amuvatinib induces cytotoxicity in primary myeloma cells and cell lines., J Hematol Oncol

TALC: AMUVATINIB

Alternate Names: AMUVATINIB Primary Drug Name AMUVATINIB Drug Generic Name MP-470 Drug Synonym

Drug Info:

Publications:

ChemblInteractions: CHEMBL2103851

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL2103851

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name MP-470

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MP-470

Novel drug target Established target

Mechanism of Interaction Stem cell growth factor receptor inhibitor

PMIDs:
17325667

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Hepatocyte growth factor receptor inhibitor

Direct Interaction yes

Trial Name MP-470

PMIDs:
24326130

Sources:
TALC MyCancerGenome TdgClinicalTrial JAX-CKB ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name MP-470

Novel drug target Established target

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tyrosine-protein kinase receptor FLT3 inhibitor

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name MP-470

Mechanism of Interaction Platelet-derived growth factor receptor alpha inhibitor

PMIDs:
None found

Sources:
MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name MP-470

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Alternate Names:

MP-470 Development Name

AMUVATINIB Generic Name

Drug Info:

Drug Class Kinase Inhibitors

Drug Info:

Drug Indications antineoplastic agent

Drug Class Small molecule

FDA Approval not approved

Publications:

Phillip et al., 2013, Targeting MET kinase with the small-molecule inhibitor amuvatinib induces cytotoxicity in primary myeloma cells and cell lines., J Hematol Oncol

Alternate Names:

AMUVATINIB Primary Drug Name

AMUVATINIB Drug Generic Name

MP-470 Drug Synonym