DGIdb - ANAKINRA Drug Record

ANAKINRA chembl:CHEMBL1201570 ApprovedAntineoplasticImmunotherapy

Alternate Names:

KINERET
ANTRIL
ANAKINRA
INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN PRECURSOR
IL1 INHIBITOR
ICIL-1RA
IL-1RN
IRAP
IL-1RA
drugbank:00026
chemidplus:143090-92-0
rxcui:72435
chembl:CHEMBL1201570

Drug Info:

FDA Approval	approved
Drug Class	recombinant protein
Drug Indications	antiinflammatory agent,DMARD
Drug Class	antirheumatic agents
Year of Approval	2003

(4 More Sources)

Publications:

Vannier et al., 1999, Elevated circulating levels of soluble interleukin-1 receptor type II during interleukin-2 immunotherapy., Eur. Cytokine Netw.
So et al., 2007, A pilot study of IL-1 inhibition by anakinra in acute gout., Arthritis Res. Ther.
Do et al., 2006, Exhaustive genotyping of the interleukin-1 family genes and associations with AIDS progression in a French cohort., J. Infect. Dis.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Tang et al., 2007, [Effects of Panax notoginseng saponins on mRNA expressions of interleukin-1 beta, its correlative factors and cysteinyl-aspartate specific protease after cerebral ischemia-reperfusion in rats]., Zhong Xi Yi Jie He Xue Bao
Vamvakopoulos et al., 2002, Genetic control of IL-1beta bioactivity through differential regulation of the IL-1 receptor antagonist., Eur. J. Immunol.
Dayer, 2003, The pivotal role of interleukin-1 in the clinical manifestations of rheumatoid arthritis., Rheumatology (Oxford)
Haq et al., 1998, Role of IL-1 in renal ischemic reperfusion injury., J. Am. Soc. Nephrol.
Dhar et al., 1997, Interleukin-1 alpha upregulates the expression of surfactant protein-A in rabbit lung explants., Biol. Neonate
Sun et al., 1996, Protective effect of interleukin-1 receptor antagonist on oleic acid-induced lung injury., Chin. Med. J.
Hawkins et al., 2004, Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra., Arthritis Rheum.
Bevan et al., 1991, IL-1 receptor antagonist regulation of acute phase protein synthesis in human hepatoma cells., J. Immunol.
Damtew et al., 1993, IL-1 receptor antagonist affects the plasma protein response of Hep 3B cells to conditioned medium from lipopolysaccharide-stimulated monocytes., J. Immunol.
Wang et al., 2006, LPS inhibits fasted plasma ghrelin levels in rats: role of IL-1 and PGs and functional implications., Am. J. Physiol. Gastrointest. Liver Physiol.

ANAKINRA IL1R1

Interaction Score: 16.75

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-1 receptor antagonist

Direct Interaction yes

Trial Name anakinra,Kineret

PMIDs:
10210771 17352828 17083033 11752352 17498496 12355453 12817089 9555664

Sources:
TdgClinicalTrial ChemblInteractions NCI TEND TTD
ANAKINRA SAA1

Interaction Score: 7.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1717568

Sources:
NCI
ANAKINRA IL1R2

Interaction Score: 7.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
ANAKINRA SFTPA1

Interaction Score: 1.93

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8996657

Sources:
NCI
ANAKINRA NLRP3

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14872505

Sources:
NCI
ANAKINRA GHRL

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16959954

Sources:
NCI
ANAKINRA CP

Interaction Score: 1.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7682588

Sources:
NCI
ANAKINRA NOS1

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9206098

Sources:
NCI

TEND: ANAKINRA
- Version: 01-August-2011
Alternate Names:

ANAKINRA Primary Drug Name

Drug Info:

Year of Approval 2003

Drug Class antirheumatic agents

Publications:
TdgClinicalTrial: ANAKINRA
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiinflammatory agent,DMARD

Drug Class recombinant protein

FDA Approval approved

Publications:

NCI: IL-1RA

Version: 14-September-2017

Alternate Names:

C2486 NCI drug code

Drug Info:

Publications:

Haq et al., 1998, Role of IL-1 in renal ischemic reperfusion injury., J. Am. Soc. Nephrol.

Wang et al., 2006, LPS inhibits fasted plasma ghrelin levels in rats: role of IL-1 and PGs and functional implications., Am. J. Physiol. Gastrointest. Liver Physiol.

Sun et al., 1996, Protective effect of interleukin-1 receptor antagonist on oleic acid-induced lung injury., Chin. Med. J.

NCI: ANAKINRA
- Version: 14-September-2017
Alternate Names:

C38717 NCI drug code

Drug Info:

Publications:

Hawkins et al., 2004, Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra., Arthritis Rheum.
TTD: Anakinra
- Version: 2020.06.01
Alternate Names:

D02DES TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1201570
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1201570
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ClearityFoundationClinicalTrial: ANAKINRA
- Version: 15-June-2013
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Interleukin-1 receptor antagonist
Direct Interaction	yes
Trial Name	anakinra,Kineret

antagonist (inhibitory)
inhibitor (inhibitory)

ANAKINRA Drug Record

ANAKINRA chembl:CHEMBL1201570 ApprovedAntineoplasticImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Interleukin-1 receptor antagonist Direct Interaction yes Trial Name anakinra,Kineret

PMIDs: 10210771 17352828 17083033 11752352 17498496 12355453 12817089 9555664

Sources: TdgClinicalTrial ChemblInteractions NCI TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1717568

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8996657

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14872505

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16959954

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7682588

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9206098

Sources: NCI

TEND: ANAKINRA

Alternate Names: ANAKINRA Primary Drug Name

Drug Info: Year of Approval 2003 Drug Class antirheumatic agents

Publications:

TdgClinicalTrial: ANAKINRA

Alternate Names:

Drug Info: Drug Indications antiinflammatory agent,DMARD Drug Class recombinant protein FDA Approval approved

Publications:

NCI: IL-1RA

Alternate Names: C2486 NCI drug code

Drug Info:

NCI: ANAKINRA

Alternate Names: C38717 NCI drug code

Drug Info:

Publications: Hawkins et al., 2004, Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra., Arthritis Rheum.

TTD: Anakinra

Alternate Names: D02DES TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1201570

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1201570

Alternate Names:

Drug Info:

Publications:

ClearityFoundationClinicalTrial: ANAKINRA

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-1 receptor antagonist

Direct Interaction yes

Trial Name anakinra,Kineret

PMIDs:
10210771 17352828 17083033 11752352 17498496 12355453 12817089 9555664

Sources:
TdgClinicalTrial ChemblInteractions NCI TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
1717568

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
8996657

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14872505

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16959954

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7682588

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9206098

Sources:
NCI

Alternate Names:

ANAKINRA Primary Drug Name

Drug Info:

Year of Approval 2003

Drug Class antirheumatic agents

Drug Info:

Drug Indications antiinflammatory agent,DMARD

Drug Class recombinant protein

FDA Approval approved

Alternate Names:

C2486 NCI drug code

Alternate Names:

C38717 NCI drug code

Publications:

Hawkins et al., 2004, Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra., Arthritis Rheum.

Alternate Names:

D02DES TTD Drug ID