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ANDROSTANOLONE Drug Record

  • Summary
  • Interactions
  • Claims
  • ANDROSTANOLONE wikidata:Q31686490

    Alternate Names:

    DHT
    ANDRACTIM
    STANOLONE
    DIHYDROTESTOSTERONE

    Drug Info:

    (0 More Sources)

    Publications:

    Gupta et al., 1991, Androgen-estrogen synergy in the regulation of energy metabolism in epididymis and vas deferens of rhesus monkey., Endocr. Res.
    Singh et al., 2000, Castration increases and androgens decrease nitric oxide synthase activity in the brain: physiologic implications., Proc. Natl. Acad. Sci. U.S.A.
    Kwack et al., 2008, Dihydrotestosterone-inducible dickkopf 1 from balding dermal papilla cells causes apoptosis in follicular keratinocytes., J. Invest. Dermatol.
    Angelucci et al., Apoptosis-related gene expression affected by a GnRH analogue without induction of programmed cell death in LNCaP cells., Anticancer Res.
    Wilson, 2003, A double life: academic physician and androgen physiologist., Annu. Rev. Physiol.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Askew et al., 2007, Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone., J. Biol. Chem.
    Rogers et al., 2007, Effect of sex hormones on renal estrogen and angiotensin type 1 receptors in female and male rats., Am. J. Physiol. Regul. Integr. Comp. Physiol.
    Uemura et al., 2006, Renin-angiotensin system is an important factor in hormone refractory prostate cancer., Prostate
    Shen et al., 2000, Effects of androgen and ageing on gene expression of vasoactive intestinal polypeptide in rat corpus cavernosum., BJU Int.
    Singh et al., 2003, Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway., Endocrinology
    Sheflin et al., 2001, Androgen regulates the level and subcellular distribution of the AU-rich ribonucleic acid-binding protein HuR both in vitro and in vivo., Endocrinology
    Iacopino et al., 2006, Leuprorelin acetate affects ERK1/2 activity in prostate cancer cells., Int. J. Oncol.
    Puliyanda et al., 2003, Calpain-mediated AQP2 proteolysis in inner medullary collecting duct., Biochem. Biophys. Res. Commun.
    Lustig et al., 1994, An in vitro model for the effects of androgen on neurons employing androgen receptor-transfected PC12 cells., Mol. Cell. Neurosci.
    Ormandy et al., 1992, Androgen regulation of prolactin-receptor gene expression in MCF-7 and MDA-MB-453 human breast cancer cells., Int. J. Cancer
    Slee et al., 2001, Differentiation-dependent expression of connective tissue growth factor and lysyl oxidase messenger ribonucleic acids in rat granulosa cells., Endocrinology
    Leman et al., 2003, Effects of 1,25-dihydroxyvitamin D3 on the distribution of androgen and vitamin D receptors in human prostate neonatal epithelial cells., J. Cell. Biochem.
    Tsihlias et al., 2000, Involvement of p27Kip1 in G1 arrest by high dose 5 alpha-dihydrotestosterone in LNCaP human prostate cancer cells., Oncogene
    Mason et al., 1997, Effects of dihydrotestosterone on bone biochemical markers in sham and oophorectomized rats., J. Bone Miner. Res.
    Vandenput et al., 2002, Evidence from the aged orchidectomized male rat model that 17beta-estradiol is a more effective bone-sparing and anabolic agent than 5alpha-dihydrotestosterone., J. Bone Miner. Res.
    Gruber et al., BMP-6-induced osteogenic differentiation of mesenchymal cell lines is not modulated by sex steroids and resveratrol., Cytokine
    Le et al., 2006, DHT and testosterone, but not DHEA or E2, differentially modulate IGF-I, IGFBP-2, and IGFBP-3 in human prostatic stromal cells., Am. J. Physiol. Endocrinol. Metab.
    Owasoyo, 1983, Effects of orchidectomy and dihydrotestosterone on the choline acetyltransferase activity of specific rat brain areas., Gen. Pharmacol.
    Drici et al., 1996, Sex hormones prolong the QT interval and downregulate potassium channel expression in the rabbit heart., Circulation
    Pelletier, 2002, Effects of estradiol on prostate epithelial cells in the castrated rat., J. Histochem. Cytochem.
    Oliveira et al., 2005, Aquaporin-1 and -9 are differentially regulated by oestrogen in the efferent ductule epithelium and initial segment of the epididymis., Biol. Cell
    Wright et al., 1996, Upregulation of prostate-specific membrane antigen after androgen-deprivation therapy., Urology
  • ANDROSTANOLONE   IGFBP5

    Interaction Score: 5.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16368782


    Sources:
    NCI

  • ANDROSTANOLONE   PEBP1

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12417618


    Sources:
    NCI

  • ANDROSTANOLONE   ELAVL1

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11356683


    Sources:
    NCI

  • ANDROSTANOLONE   PRLR

    Interaction Score: 1.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1544711


    Sources:
    NCI

  • ANDROSTANOLONE   CAST

    Interaction Score: 1.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12646165


    Sources:
    NCI

  • ANDROSTANOLONE   AQP9

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15850448


    Sources:
    NCI

  • ANDROSTANOLONE   ME3

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1811987


    Sources:
    NCI

  • ANDROSTANOLONE   DKK1

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17657240


    Sources:
    NCI

  • ANDROSTANOLONE   VIP

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10886097


    Sources:
    NCI

  • ANDROSTANOLONE   MYOD1

    Interaction Score: 0.6

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12960001


    Sources:
    NCI

  • ANDROSTANOLONE   CHAT

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6873629


    Sources:
    NCI

  • ANDROSTANOLONE   FOLH1

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8753752


    Sources:
    NCI

  • ANDROSTANOLONE   KCNA5

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8823008


    Sources:
    NCI

  • ANDROSTANOLONE   BGLAP

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9286759 12412816 12967649


    Sources:
    NCI

  • ANDROSTANOLONE   CCN2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11181522


    Sources:
    NCI

  • ANDROSTANOLONE   AGTR1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16990489 16482568


    Sources:
    NCI

  • ANDROSTANOLONE   NOS1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10725371


    Sources:
    NCI

  • ANDROSTANOLONE   MAPK3

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16773205


    Sources:
    NCI

  • ANDROSTANOLONE   BAX

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15517879


    Sources:
    NCI

  • ANDROSTANOLONE   NTRK1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7704433


    Sources:
    NCI

  • ANDROSTANOLONE   CDK2

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10698512


    Sources:
    NCI

  • ANDROSTANOLONE   AR

    Interaction Score: 0.02

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    12500968 10592235 17591767


    Sources:
    NCI TTD

  • ANDROSTANOLONE   VDR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12532336


    Sources:
    NCI

  • NCI: DIHYDROTESTOSTERONE

    • Version: 14-September-2017

    Alternate Names:
    C29619 NCI drug code
    C29618 NCI drug code

    Drug Info:

    Publications:
    Owasoyo, 1983, Effects of orchidectomy and dihydrotestosterone on the choline acetyltransferase activity of specific rat brain areas., Gen. Pharmacol.
    Drici et al., 1996, Sex hormones prolong the QT interval and downregulate potassium channel expression in the rabbit heart., Circulation
    Wright et al., 1996, Upregulation of prostate-specific membrane antigen after androgen-deprivation therapy., Urology

  • NCI: DHT

    • Version: 14-September-2017

    Alternate Names:
    C29618 NCI drug code
    C29619 NCI drug code

    Drug Info:

    Publications:
    Gupta et al., 1991, Androgen-estrogen synergy in the regulation of energy metabolism in epididymis and vas deferens of rhesus monkey., Endocr. Res.
    Lustig et al., 1994, An in vitro model for the effects of androgen on neurons employing androgen receptor-transfected PC12 cells., Mol. Cell. Neurosci.
    Slee et al., 2001, Differentiation-dependent expression of connective tissue growth factor and lysyl oxidase messenger ribonucleic acids in rat granulosa cells., Endocrinology

  • TTD: Dihydrotestosterone

    • Version: 2020.06.01

    Alternate Names:
    D04DJN TTD Drug ID

    Drug Info:

    Publications:

  • Wikidata: wikidata:Q31686490

    • Version: 12-August-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21