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ARTESUNATE Drug Record

  • Summary
  • Interactions
  • Claims
  • ARTESUNATE chembl:CHEMBL361497 Approved

    Alternate Names:

    ARTESUNATE
    ARSUMAX
    NSC-712571
    (3R,5AS,6R,8AS,9R,10S,12R,12AR)-DECAHYDRO-3,6,9-TRIMETHYL-3,12-EPOXY-12H-PYRANO(4,3-J)-1,2-BENZODIOXEPIN-10-OL HYDROGEN SUCCINATE
    ARTESUNATUM
    ARTESUNIC ACID
    ARTESUNATO
    BUTANEDIOIC ACID, 1-[(3R,5AS,6R,8AS,9R,10S,12R,12AR)-DECAHYDRO-3,6,9-TRIMETHYL-3,12-EPOXY-12H-PYRANO[4,3-J]-1,2-BENZODIOXEPIN-10-YL] ESTER
    DIHYDROQINGHASU HEMSUCCINATE
    AS
    rxcui:18346
    chembl:CHEMBL361497
    pubchem.compound:6917864
    drugbank:09274
    chemidplus:88495-63-0

    Drug Info:

    (0 More Sources)

    Publications:

    Simonsson US et al., 2003, Artemisinin autoinduction is caused by involvement of cytochrome P450 2B6 but not 2C9., Clin Pharmacol Ther
    Kerb R et al., 2009, Pharmacogenetics of antimalarial drugs: effect on metabolism and transport., Lancet Infect Dis
    Medhi B et al., 2009, Pharmacokinetic and toxicological profile of artemisinin compounds: an update., Pharmacology
    Veiga MI et al., 2009, Pharmacogenomics of CYP2A6, CYP2B6, CYP2C19, CYP2D6, CYP3A4, CYP3A5 and MDR1 in Vietnam., Eur J Clin Pharmacol
    Elsherbiny DA et al., 2008, A model based assessment of the CYP2B6 and CYP2C19 inductive properties by artemisinin antimalarials: implications for combination regimens., J Pharmacokinet Pharmacodyn
    Asimus S et al., 2008, Artemisinin and CYP2A6 activity in healthy subjects., Eur J Clin Pharmacol
    Li XQ et al., 2003, Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data., Eur J Clin Pharmacol
    Okorji UP et al., 2014, A semi-synthetic derivative of artemisinin, artesunate inhibits prostaglandin E2 production in LPS/IFNγ-activated BV2 microglia., Bioorg Med Chem
  • ARTESUNATE   CYP2A6

    Interaction Score: 2.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12844133 19926036 19851082 18979093 18350255 18064444 12920490


    Sources:
    PharmGKB

  • ARTESUNATE   IKBKG

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ARTESUNATE   ATP2A1

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ARTESUNATE   NFKB2

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25074847


    Sources:
    DTC

  • ARTESUNATE   RELA

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25074847


    Sources:
    DTC

  • ARTESUNATE   NFKB1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25074847


    Sources:
    DTC

  • ARTESUNATE   G6PD

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DTC: ARTESUNATE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL361497 ChEMBL Drug ID

    Drug Info:

    Publications:
    Okorji UP et al., 2014, A semi-synthetic derivative of artemisinin, artesunate inhibits prostaglandin E2 production in LPS/IFNγ-activated BV2 microglia., Bioorg Med Chem

  • PharmGKB: artesunate

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Asimus S et al., 2008, Artemisinin and CYP2A6 activity in healthy subjects., Eur J Clin Pharmacol
    Veiga MI et al., 2009, Pharmacogenomics of CYP2A6, CYP2B6, CYP2C19, CYP2D6, CYP3A4, CYP3A5 and MDR1 in Vietnam., Eur J Clin Pharmacol
    Kerb R et al., 2009, Pharmacogenetics of antimalarial drugs: effect on metabolism and transport., Lancet Infect Dis

  • TTD: Artesunate

    • Version: 2020.06.01

    Alternate Names:
    D0D4JO TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL361497

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21