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ASPIRIN Drug Record

  • Summary
  • Interactions
  • Claims
  • ASPIRIN chembl:CHEMBL25 Approved

    Alternate Names:

    NU-SEALS 75
    ACETYLSALIC ACID
    ECOTRIN
    EQUI-PRIN
    PAYNOCIL
    SALICYLIC ACID ACETATE
    DISPRIN DIRECT
    NU-SEALS CARDIO 75
    8-HOUR BAYER
    MICROPIRIN EC
    BAYER EXTRA STRENGTH
    ANADIN ALL NIGHT
    BAY1019036
    DANAMEP
    ENPRIN
    VAZALORE
    ALKA RAPID
    ACETYLSALICYLIC ACID
    NU-SEALS 600
    PLATET
    ANGETTES 75
    NSC-406186
    LEVIUS
    POSTMI 300
    ASPRO CLR
    GENCARDIA
    ACETOSALIC ACID
    MAX STRGH ASPRO CLR
    POSTMI 75
    MEASURIN
    PLATET 300
    NU-SEALS 300
    ASPIRIN
    DURLAZA
    NSC-27223
    DISPRIN CV
    ACENTERINE
    ASPERGUM
    AZETYLSALIZYLSÄURE
    BENASPIR
    O-(ACETYLOXY)BENZOIC ACID
    O-ACETOXYBENZOIC ACID
    CAPRIN
    PHARMACIN
    2-ACETOXYBENZENECARBOXYLIC ACID
    ACYLPYRIN
    ACETYLSALICYLATE
    BUFFERIN
    O-ACETYLSALICYLIC ACID
    SALCETOGEN
    ACETYONYL
    TRIAMINICIN
    ACETOPHEN®
    ACIDE ACÉTYLSALICYLIQUE
    SALETIN
    ACETICYL
    SOLPYRON
    ASPIRDROPS
    ACETOPHEN
    EASPRIN
    ÁCIDO ACETILSALICÍLICO
    ACETONYL
    ACETOSAL
    ACETYSALICYLIC ACID
    ASATARD
    SOLPRIN
    PERSISTIN
    O-CARBOXYPHENYL ACETATE
    2-ACETOXYBENZOATE
    ENDOSPRIN
    ECOLEN
    ACETYSAL
    2-CARBOXYPHENYL ACETATE
    ACIDUM ACETYLSALICYLICUM
    ACETOL
    SOLPRIN ACID
    TEMPERAL
    TOLDEX
    ASPIRIN®
    ASA
    TASPRIN
    ENDYDOL
    2-(ACETYLOXY)BENZOATE
    ACETYLIN
    BIALPIRINIA
    ACARD
    POLOPIRYNA
    2-ACETOXYBENZOIC ACID
    PREMASPIN
    RHODINE
    ACIDE 2-(ACÉTYLOXY)BENZOÏQUE
    O-(ACETYLOXY)BENZOATE
    EMPIRIN
    SALOSPIR
    ACETOSALIN
    CARDIOASPIRINA
    O-ACETOXYBENZOATE
    RHEUMINTABLETTEN
    ACETYLSALICYLSÄURE
    ACETARD
    pubchem.compound:2244
    chemidplus:50-78-2
    chembl:CHEMBL25
    drugbank:00945
    rxcui:1191

    Drug Info:

    Drug Class anti-inflammatory agents, non-steroidal
    Drug Class anticoagulants
    Year of Approval not approved by the fda
    (5 More Sources)

    Publications:

    Lee HY et al., 2009, The HLA allele marker for differentiating ASA hypersensitivity phenotypes., Allergy
    Kim SH et al., 2005, The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria., Clin Exp Allergy
    Verschuren JJ et al., 2013, Value of platelet pharmacogenetics in common clinical practice of patients with ST-segment elevation myocardial infarction., Int J Cardiol
    Li Q et al., 2007, Frequency of genetic polymorphisms of COX1, GPIIIa and P2Y1 in a Chinese population and association with attenuated response to aspirin., Pharmacogenomics
    Jefferson BK et al., 2005, Aspirin resistance and a single gene., Am J Cardiol
    Vitale P et al., 2013, Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors., J Med Chem
    Sangkuhl K et al., 2011, Platelet aggregation pathway., Pharmacogenet Genomics
    Lepäntalo A et al., 2006, Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients., Thromb Haemost
    Abiru et al., 2002, Aspirin and NS-398 inhibit hepatocyte growth factor-induced invasiveness of human hepatoma cells., Hepatology
    Kim BS et al., 2010, Effect of single nucleotide polymorphisms within the interleukin-4 promoter on aspirin intolerance in asthmatics and interleukin-4 promoter activity., Pharmacogenet Genomics
    Whitehead et al., 2007, Effects of triflusal and aspirin in a rat model of cerebral ischemia., Stroke
    Jayaraj et al., 2000, Duodenal ulcer prevalence: experimental evidence for the possible role of dietary lipids., J. Gastroenterol. Hepatol.
    Kim SH et al., 2007, Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma., Pharmacogenet Genomics
    Shiotani A et al., 2009, The preventive factors for aspirin-induced peptic ulcer: aspirin ulcer and corpus atrophy., J Gastroenterol
    Domhan et al., 2004, Role of apoptosis and CD95-receptor/ligand system in aspirin- and Helicobacter pylori-induced cell death., Eur. J. Clin. Invest.
    Oh SH et al., 2011, Association analysis of thromboxane A synthase 1 gene polymorphisms with aspirin intolerance in asthmatic patients., Pharmacogenomics
    Dror et al., 1994, Aplasia cutis congenita, elevated alpha-fetoprotein, and a distinct amniotic fluid acetylcholinesterase electrophoretic band., Am J Perinatol
    Kim SH et al., 2009, Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma., Respir Med
    Ma et al., 2001, Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release., Proc. Natl. Acad. Sci. U.S.A.
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Liao X et al., 2012, Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival., N Engl J Med
    Hedberg ML et al., 2019, Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for <i>PIK3CA</i>-altered head and neck cancer., J Exp Med
    Xiang Q et al., 2017, Genetic Variants of PEAR1 are Associated with Platelet Function and Antiplatelet Drug Efficacy: A Systematic Review and Meta-Analysis., Curr Pharm Des
    Xiang Q et al., 2013, Identification of PEAR1 SNPs and their influences on the variation in prasugrel pharmacodynamics., Pharmacogenomics
    Lewis JP et al., 2013, Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes., Circ Cardiovasc Genet
    Jalil NJ et al., 2015, The Implication of the Polymorphisms of COX-1, UGT1A6, and CYP2C9 among Cardiovascular Disease (CVD) Patients Treated with Aspirin., J Pharm Pharm Sci
    Harmsze AM et al., 2010, CYP2C19*2 and CYP2C9*3 alleles are associated with stent thrombosis: a case-control study., Eur Heart J
    Floyd CN et al., 2014, The PlA1/A2 polymorphism of glycoprotein IIIa in relation to efficacy of antiplatelet drugs: a systematic review and meta-analysis., Br J Clin Pharmacol
    Cayla G et al., 2011, Clinical, angiographic, and genetic factors associated with early coronary stent thrombosis., JAMA
    Abderrazek F et al., 2010, The GPIIIa PlA polymorphism and the platelet hyperactivity in Tunisian patients with stable coronary artery disease treated with aspirin., Thromb Res
    Lim E et al., 2007, Dose-related efficacy of aspirin after coronary surgery in patients With Pl(A2) polymorphism (NCT00262275)., Ann Thorac Surg
    Dropinski J et al., 2007, Antithrombotic effects of aspirin based on PLA1/A2 glycoprotein IIIa polymorphism in patients with coronary artery disease., Thromb Res
    Lev EI et al., 2007, Genetic polymorphisms of the platelet receptors P2Y(12), P2Y(1) and GP IIIa and response to aspirin and clopidogrel., Thromb Res
    Cooke GE et al., 2006, Effect of platelet antigen polymorphism on platelet inhibition by aspirin, clopidogrel, or their combination., J Am Coll Cardiol
    Morawski W et al., 2005, Prediction of the excessive perioperative bleeding in patients undergoing coronary artery bypass grafting: role of aspirin and platelet glycoprotein IIIa polymorphism., J Thorac Cardiovasc Surg
    Papp E et al., 2005, Glycoprotein IIIA gene (PlA) polymorphism and aspirin resistance: is there any correlation?, Ann Pharmacother
    Undas A et al., 2001, Pl(A2) polymorphism of beta(3) integrins is associated with enhanced thrombin generation and impaired antithrombotic action of aspirin at the site of microvascular injury., Circulation
    Szczeklik A et al., 2000, Relationship between bleeding time, aspirin and the PlA1/A2 polymorphism of platelet glycoprotein IIIa., Br J Haematol
    Michelson AD et al., 2000, Platelet GP IIIa Pl(A) polymorphisms display different sensitivities to agonists., Circulation
    Undas A et al., 1999, Platelet glycoprotein IIIa polymorphism, aspirin, and thrombin generation., Lancet
    Chung et al., 1998, Effects of aspirin on arylamine N-acetyltransferase activity in Klebsiella pneumoniae., Drug Chem Toxicol
    Kim JM et al., 2010, Association analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmatics., Pharmacogenomics
    Slattery et al., 2008, Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions., Int. J. Cancer
    Iglesias-Serret et al., 2003, Transcriptional and translational control of Mcl-1 during apoptosis., Arch. Biochem. Biophys.
    Giusti B et al., 2008, Role of glycoprotein Ia gene polymorphisms in determining platelet function in myocardial infarction patients undergoing percutaneous coronary intervention on dual antiplatelet treatment., Atherosclerosis
    Angiolillo DJ et al., 2005, Variability in platelet aggregation following sustained aspirin and clopidogrel treatment in patients with coronary heart disease and influence of the 807 C/T polymorphism of the glycoprotein Ia gene., Am J Cardiol
    Angiolillo DJ et al., 2004, 807 C/T Polymorphism of the glycoprotein Ia gene and pharmacogenetic modulation of platelet response to dual antiplatelet treatment., Blood Coagul Fibrinolysis
    Pasaje CF et al., 2011, A possible association of EMID2 polymorphisms with aspirin hypersensitivity in asthma., Immunogenetics
    Chan et al., 2007, Aspirin and the risk of colorectal cancer in relation to the expression of COX-2., N. Engl. J. Med.
    Heath et al., 1996, Glycation-induced inactivation of malate dehydrogenase protection by aspirin and a lens molecular chaperone, alpha-crystallin., Biochim. Biophys. Acta
    Yeh et al., Effects of aspirin on arylamine N -acetyltransferase activity and DNA adducts in human bladder tumour cells., J Appl Toxicol
    Chen et al., 2003, Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer., Clin. Cancer Res.
    Park HJ et al., 2008, Association between a TGFbeta1 promoter polymorphism and the phenotype of aspirin-intolerant chronic urticaria in a Korean population., J Clin Pharm Ther
    Shuvalova YA et al., 2012, Association between polymorphisms of eNOS and GPx-1 genes, activity of free-radical processes and in-stent restenosis., Mol Cell Biochem
    Kim SH et al., 2009, Histamine N-methyltransferase 939A>G polymorphism affects mRNA stability in patients with acetylsalicylic acid-intolerant chronic urticaria., Allergy
    Kim TH et al., 2008, Association of angiotensin I-converting enzyme gene polymorphisms with aspirin intolerance in asthmatics., Clin Exp Allergy
    Towndrow et al., 2000, Stress- and growth-related gene expression are independent of chemical-induced prostaglandin E(2) synthesis in renal epithelial cells., Chem. Res. Toxicol.
    López-Farré et al., 2007, Relationship between vitamin D binding protein and aspirin resistance in coronary ischemic patients: a proteomic study., J. Proteome Res.
    Mousa et al., 2001, Comparison of the effect of different platelet GPIIb/IIa antagonists on the dynamics of platelet/fibrin-mediated clot strength induced using thromboelastography., Thromb. Res.
    Weksler, 2000, Antiplatelet agents in stroke prevention. combination therapy: present and future., Cerebrovasc. Dis.
    Cho SH et al., 2013, Association analysis of tapasin polymorphisms with aspirin-exacerbated respiratory disease in asthmatics., Pharmacogenet Genomics
    Kawashima et al., 1985, Aspirin inhibition of 1 alpha-hydroxyvitamin D3 or parathyroid hormone induced hypercalcemia in vivo in rats. A mechanism independent of prostaglandin biosynthesis inhibition., Biochem. Pharmacol.
    Hull et al., 1997, Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration., Gut
    Pasaje CF et al., 2010, Association of SLC6A12 variants with aspirin-intolerant asthma in a Korean population., Ann Hum Genet
    Serebruany et al., 2004, Magnitude and time course of platelet inhibition with Aggrenox and Aspirin in patients after ischemic stroke: the AGgrenox versus Aspirin Therapy Evaluation (AGATE) trial., Eur. J. Pharmacol.
    Shiotani A et al., 2011, Renin-angiotensin system associated with risk of upper GI mucosal injury induced by low dose aspirin: renin angiotensin system genes' polymorphism., Dig Dis Sci
    Palikhe NS et al., 2008, Association of three sets of high-affinity IgE receptor (FcepsilonR1) polymorphisms with aspirin-intolerant asthma., Respir Med
    Palikhe N et al., 2008, Analysis of high-affinity IgE receptor (FcepsilonR1) polymorphisms in patients with aspirin-intolerant chronic urticaria., Allergy Asthma Proc
    Wang Z et al., 2013, Polymorphisms and high on-aspirin platelet reactivity after off-pump coronary artery bypass grafting., Scand Cardiovasc J
    Fujiwara T et al., 2007, Exploratory aspirin resistance trial in healthy Japanese volunteers (J-ART) using platelet aggregation as a measure of thrombogenicity., Pharmacogenomics J
    Kim SH et al., 2005, Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma., Clin Exp Allergy
    Ayuso P et al., 2015, Association study of genetic variants in PLA2G4A, PLCG1, LAT, SYK, and TNFRS11A genes in NSAIDs-induced urticaria and/or angioedema patients., Pharmacogenet Genomics
    Esmaeilzadeh H et al., 2015, Pharmacogenetic tests to predict the efficacy of aspirin desensitization in patients with aspirin-exacerbated respiratory diseases; HLA-DQB302., Expert Rev Respir Med
    Kupstyte N et al., 2015, Effect of clinical factors and gene polymorphism of CYP2C19*2, *17 and CYP4F2*3 on early stent thrombosis., Pharmacogenomics
    Tatarunas V et al., 2014, The role of clinical parameters and of CYP2C19 G681 and CYP4F2 G1347A polymorphisms on platelet reactivity during dual antiplatelet therapy., Blood Coagul Fibrinolysis
    Sánchez-Borges M et al., 2009, The A-444C polymorphism in the leukotriene C4 synthase gene is associated with aspirin-induced urticaria., J Investig Allergol Clin Immunol
    Mastalerz L et al., 2006, Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant., Br J Dermatol
    Mastalerz L et al., 2004, Hypersensitivity to aspirin: common eicosanoid alterations in urticaria and asthma., J Allergy Clin Immunol
    Grosser et al., 2003, Heme oxygenase-1 induction may explain the antioxidant profile of aspirin., Biochem. Biophys. Res. Commun.
    Matsubara Y et al., 2008, Enhancing effect of the (145)Met-allele of GPIb alpha on platelet sensitivity to aspirin under high-shear conditions., Thromb Res
    Undas A et al., 2003, Aspirin alters the cardioprotective effects of the factor XIII Val34Leu polymorphism., Circulation
    Choi JH et al., 2004, HLA association in aspirin-intolerant asthma: DPB1*0301 as a strong marker in a Korean population., J Allergy Clin Immunol
    Dekker JW et al., 1997, Aspirin-induced asthma and HLA-DRB1 and HLA-DPB1 genotypes., Clin Exp Allergy
  • ASPIRIN   GP1BA

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18417193 17245331


    Sources:
    PharmGKB

  • ASPIRIN   FCER1G

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18595682 18534082


    Sources:
    PharmGKB

  • ASPIRIN   HLA-DPB1

    Interaction Score: 2.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15007363 15784113 19392989 9179433


    Sources:
    PharmGKB

  • ASPIRIN   F13A1

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12515735


    Sources:
    PharmGKB

  • ASPIRIN   LTC4S

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19862937 16433794 15100686


    Sources:
    PharmGKB

  • ASPIRIN   SLC6A12

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20597903


    Sources:
    PharmGKB

  • ASPIRIN   TAPBP

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23736108


    Sources:
    PharmGKB

  • ASPIRIN   GP6

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16493486


    Sources:
    PharmGKB

  • ASPIRIN   P2RY1

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22940005 17559347 15757620


    Sources:
    PharmGKB

  • ASPIRIN   ITGA2

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22940005 17157856 16493486 16214444 15205592


    Sources:
    PharmGKB

  • ASPIRIN   ITGB3

    Interaction Score: 0.92

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23834376 22028352 20138334 17184645 16675000 16581111 16493486 16458133 16153930 15840736 11723016 11054089 10704169 10459913


    Sources:
    PharmGKB

  • ASPIRIN   ZBTB22

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ASPIRIN   HLA-DPB2

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ASPIRIN   SLC30A9

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ASPIRIN   CHIA

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ASPIRIN   FSIP1

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ASPIRIN   COL26A1

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21086123


    Sources:
    PharmGKB

  • ASPIRIN   CEP68

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ASPIRIN   PEAR1

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28820077 23859572 23392654


    Sources:
    PharmGKB

  • ASPIRIN   TBXAS1

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21449675


    Sources:
    PharmGKB

  • ASPIRIN   IRS2

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18059035


    Sources:
    NCI

  • ASPIRIN   TNFRSF11A

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26398624


    Sources:
    PharmGKB

  • ASPIRIN   HMOX1

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12927812


    Sources:
    NCI

  • ASPIRIN   B4GALT2

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ASPIRIN   IL4

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20921925


    Sources:
    PharmGKB

  • ASPIRIN   TBXA2R

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23688183 17245331 15898979


    Sources:
    PharmGKB

  • ASPIRIN   HNMT

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19178400


    Sources:
    PharmGKB

  • ASPIRIN   ME3

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8611656


    Sources:
    NCI

  • ASPIRIN   CYP4F2

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25712182 24418943


    Sources:
    PharmGKB

  • ASPIRIN   ITGA2B

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11583738 11096182


    Sources:
    NCI

  • ASPIRIN   PLCG1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26398624


    Sources:
    PharmGKB

  • ASPIRIN   PTGER3

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17496729


    Sources:
    PharmGKB

  • ASPIRIN   HLA-DQB1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26366802 19392989 15784113


    Sources:
    PharmGKB

  • ASPIRIN   TSC1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ASPIRIN   GC

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17555340


    Sources:
    NCI

  • ASPIRIN   TLR3

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ASPIRIN   COL18A1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11353854


    Sources:
    NCI

  • ASPIRIN   PLA2G4A

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26398624


    Sources:
    PharmGKB

  • ASPIRIN   NAT2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9839158 20602614


    Sources:
    NCI PharmGKB

  • ASPIRIN   PTGER2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17496729


    Sources:
    PharmGKB

  • ASPIRIN   AFP

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7515237


    Sources:
    NCI

  • ASPIRIN   PTGIR

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17496729


    Sources:
    PharmGKB

  • ASPIRIN   HGF

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11981761


    Sources:
    NCI

  • ASPIRIN   AGT

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20824505


    Sources:
    PharmGKB

  • ASPIRIN   PTGS1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclooxygenase inhibitor
    Direct Interaction yes

    PMIDs:
    23651359 22940005 20938371 16493486


    Sources:
    DTC ChemblInteractions TEND PharmGKB

  • ASPIRIN   F2R

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15381054


    Sources:
    NCI

  • ASPIRIN   PTH

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    4004906


    Sources:
    NCI

  • ASPIRIN   THRA

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ASPIRIN   FAS

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15200494


    Sources:
    NCI

  • ASPIRIN   HLA-DRB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19392989 15784113


    Sources:
    PharmGKB

  • ASPIRIN   FGF2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9071932


    Sources:
    NCI

  • ASPIRIN   NOS3

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22890915


    Sources:
    PharmGKB

  • ASPIRIN   NRG1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10921413


    Sources:
    NCI

  • ASPIRIN   GFAP

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17194886


    Sources:
    NCI

  • ASPIRIN   DDIT3

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10688535


    Sources:
    NCI

  • ASPIRIN   UGT1A6

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ASPIRIN   ADORA1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19019667


    Sources:
    PharmGKB

  • ASPIRIN   PTGS2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclooxygenase inhibitor
    Direct Interaction yes

    PMIDs:
    17522398


    Sources:
    ChemblInteractions TEND CIViC PharmGKB

  • ASPIRIN   NTRK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28820077 23859572


    Sources:
    PharmGKB

  • ASPIRIN   TGFB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19138248


    Sources:
    PharmGKB

  • ASPIRIN   IL1B

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19448967


    Sources:
    PharmGKB

  • ASPIRIN   HMGCR

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ASPIRIN   MCL1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12941295


    Sources:
    NCI

  • ASPIRIN   ACE

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18727619


    Sources:
    PharmGKB

  • ASPIRIN   CXCL8

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12576442


    Sources:
    NCI

  • ASPIRIN   NAT1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10547619


    Sources:
    NCI

  • ASPIRIN   PIK3CA

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23094721 30683736


    Sources:
    CIViC

  • ASPIRIN   CYP2C9

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26517138 20833683 22931300


    Sources:
    DTC PharmGKB

  • ASPIRIN   PPARG

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ASPIRIN   CYP2D6

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC PharmGKB

  • ASPIRIN   CYP1A2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • ASPIRIN   CYP3A4

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TEND: ASPIRIN

    • Version: 01-August-2011

    Alternate Names:
    ASPIRIN Primary Drug Name

    Drug Info:
    Year of Approval not approved by the fda
    Drug Class anticoagulants
    Drug Class anti-inflammatory agents, non-steroidal

    Publications:

  • NCI: ASPIRIN

    • Version: 14-September-2017

    Alternate Names:
    C287 NCI drug code

    Drug Info:

    Publications:
    Whitehead et al., 2007, Effects of triflusal and aspirin in a rat model of cerebral ischemia., Stroke
    Ma et al., 2001, Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release., Proc. Natl. Acad. Sci. U.S.A.
    Kawashima et al., 1985, Aspirin inhibition of 1 alpha-hydroxyvitamin D3 or parathyroid hormone induced hypercalcemia in vivo in rats. A mechanism independent of prostaglandin biosynthesis inhibition., Biochem. Pharmacol.

  • NCI: ASA

    • Version: 14-September-2017

    Alternate Names:
    C287 NCI drug code

    Drug Info:

    Publications:
    López-Farré et al., 2007, Relationship between vitamin D binding protein and aspirin resistance in coronary ischemic patients: a proteomic study., J. Proteome Res.

  • DTC: ASPIRIN

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL25 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Vitale P et al., 2013, Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors., J Med Chem

  • PharmGKB: aspirin

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Kim BS et al., 2010, Effect of single nucleotide polymorphisms within the interleukin-4 promoter on aspirin intolerance in asthmatics and interleukin-4 promoter activity., Pharmacogenet Genomics
    Kim SH et al., 2009, Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma., Respir Med
    Kim SH et al., 2007, Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma., Pharmacogenet Genomics

  • CIViC: ASPIRIN

    • Version: 14-September-2020

    Alternate Names:

    Drug Info:

    Publications:
    Hedberg ML et al., 2019, Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for <i>PIK3CA</i>-altered head and neck cancer., J Exp Med
    Liao X et al., 2012, Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival., N Engl J Med
    Chan et al., 2007, Aspirin and the risk of colorectal cancer in relation to the expression of COX-2., N. Engl. J. Med.

  • TTD: Aspirin

    • Version: 2020.06.01

    Alternate Names:
    D0GY5Z TTD Drug ID

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL25

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL25

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21