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AXITINIB Drug Record

  • Summary
  • Interactions
  • Claims
  • AXITINIB chembl:CHEMBL1289926 ApprovedAntineoplastic

    Alternate Names:

    AG-13736
    INLYTA
    AXITINIB
    AG-013736
    AXITINIBUM
    AG 013736
    N-METHYL-2-({3-[(E)-2-(PYRIDIN-2-YL)VINYL]-1H-INDAZOL-6-YL}SULFANYL)BENZAMIDE
    INLYTA®
    AG013736
    drugbank:06626
    chemidplus:319460-85-0
    chembl:CHEMBL1289926
    rxcui:1242999
    pubchem.compound:6450551

    Drug Info:

    FDA Approval Renal cell carcinoma
    Drug Class Kinase Inhibitors
    FDA Approval approved
    Drug Class Small molecule
    Drug Indications antineoplastic agent
    Pharmaceutical Developer Pfizer
    Pharmaceutical Developer Novartis
    Source Reported Drug Name(s) Axitinib/AG013736/Inlyta
    Drug Class Kinase Inhibitor
    (7 More Sources)

    Publications:

    Cohen et al., 2008, Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: results from a phase II study., J. Clin. Oncol.
    Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
    Pemovska T et al., 2015, Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation., Nature
    Zientek MA et al., 2016, In Vitro Kinetic Characterization of Axitinib Metabolism., Drug Metab Dispos
    Ehmann F et al., 2014, European Medicines Agency initiatives and perspectives on pharmacogenomics., Br J Clin Pharmacol
    Escudier B et al., 2015, Genotype Correlations With Blood Pressure and Efficacy From a Randomized Phase III Trial of Second-Line Axitinib Versus Sorafenib in Metastatic Renal Cell Carcinoma., Clin Genitourin Cancer
  • AXITINIB   PDGFB

    Interaction Score: 1.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Reported Cancer Type Prostate

    PMIDs:
    None found


    Sources:
    CancerCommons

  • AXITINIB   FLT1

    Interaction Score: 0.58

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Reported Cancer Type Prostate
    Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor
    Direct Interaction yes

    PMIDs:
    18541897 20124951


    Sources:
    TALC MyCancerGenome TdgClinicalTrial ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial PharmGKB

  • AXITINIB   FLT4

    Interaction Score: 0.43

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Reported Cancer Type Prostate
    Direct Interaction yes
    Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

    PMIDs:
    18541897


    Sources:
    TALC MyCancerGenome TdgClinicalTrial ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial

  • AXITINIB   KDR

    Interaction Score: 0.41

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor
    Reported Cancer Type Prostate

    PMIDs:
    20124951 18541897


    Sources:
    TALC MyCancerGenome TdgClinicalTrial ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial PharmGKB TTD

  • AXITINIB   KIT

    Interaction Score: 0.34

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name axitinib, AG-013736
    Novel drug target Established target
    Reported Cancer Type Prostate

    PMIDs:
    None found


    Sources:
    TALC MyCancerGenome TdgClinicalTrial CancerCommons

  • AXITINIB   UGT1A1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26512042


    Sources:
    PharmGKB

  • AXITINIB   ABL1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25686603


    Sources:
    CIViC PharmGKB

  • AXITINIB   PDGFRB

    Interaction Score: 0.22

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Trial Name axitinib, AG-013736
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TALC MyCancerGenome TdgClinicalTrial

  • AXITINIB   CYP3A5

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24433361


    Sources:
    PharmGKB

  • AXITINIB   PDGFRA

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name axitinib, AG-013736
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • AXITINIB   HIF1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25816720


    Sources:
    PharmGKB

  • AXITINIB   YES1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CancerCommons: AXITINIB

    • Version: 25-July-2013

    Alternate Names:
    Axitinib PubChem Drug Name
    6450551 PubChem Drug ID
    Inlyta Drug Trade Name

    Drug Info:
    Drug Class Kinase Inhibitor
    Source Reported Drug Name(s) Axitinib/AG013736/Inlyta
    Pharmaceutical Developer Novartis

    Publications:

  • MyCancerGenome: AXITINIB

    • Version: 20-Jun-2017

    Alternate Names:
    AG-013736 Development Name
    AXITINIB Generic Name
    INLYTA Trade Name

    Drug Info:
    Drug Class Kinase Inhibitors
    FDA Approval Renal cell carcinoma

    Publications:

  • TdgClinicalTrial: AXITINIB

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antineoplastic agent
    Drug Class Small molecule
    FDA Approval approved

    Publications:

  • PharmGKB: axitinib

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
    Zientek MA et al., 2016, In Vitro Kinetic Characterization of Axitinib Metabolism., Drug Metab Dispos
    Ehmann F et al., 2014, European Medicines Agency initiatives and perspectives on pharmacogenomics., Br J Clin Pharmacol

  • CIViC: AXITINIB

    • Version: 14-September-2020

    Alternate Names:

    Drug Info:

    Publications:
    Pemovska T et al., 2015, Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation., Nature

  • TALC: AXITINIB

    • Version: 12-May-2016

    Alternate Names:
    AXITINIB Primary Drug Name
    AXITINIB Drug Generic Name
    INLYTA Drug Trade Name

    Drug Info:

    Publications:

  • DTC: AXITINIB

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1289926 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Axitinib

    • Version: 2020.06.01

    Alternate Names:
    D01ZRI TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1289926

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • MyCancerGenomeClinicalTrial: AXITINIB

    • Version: 30-February-2014

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1289926

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21