DGIdb - AXITINIB Drug Record

AXITINIB chembl:CHEMBL1289926 ApprovedAntineoplastic

Alternate Names:

AG-13736
INLYTA
AXITINIB
AG-013736
AXITINIBUM
AG 013736
N-METHYL-2-({3-[(E)-2-(PYRIDIN-2-YL)VINYL]-1H-INDAZOL-6-YL}SULFANYL)BENZAMIDE
INLYTA®
AG013736
drugbank:06626
chemidplus:319460-85-0
chembl:CHEMBL1289926
rxcui:1242999
pubchem.compound:6450551

Drug Info:

FDA Approval	Renal cell carcinoma
Drug Class	Kinase Inhibitors
FDA Approval	approved
Drug Class	Small molecule
Drug Indications	antineoplastic agent
Pharmaceutical Developer	Pfizer
Pharmaceutical Developer	Novartis
Source Reported Drug Name(s)	Axitinib/AG013736/Inlyta
Drug Class	Kinase Inhibitor

(7 More Sources)

Publications:

Cohen et al., 2008, Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: results from a phase II study., J. Clin. Oncol.
Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
Pemovska T et al., 2015, Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation., Nature
Zientek MA et al., 2016, In Vitro Kinetic Characterization of Axitinib Metabolism., Drug Metab Dispos
Ehmann F et al., 2014, European Medicines Agency initiatives and perspectives on pharmacogenomics., Br J Clin Pharmacol
Escudier B et al., 2015, Genotype Correlations With Blood Pressure and Efficacy From a Randomized Phase III Trial of Second-Line Axitinib Versus Sorafenib in Metastatic Renal Cell Carcinoma., Clin Genitourin Cancer

AXITINIB PDGFB

Interaction Score: 1.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Prostate

PMIDs:
None found

Sources:
CancerCommons
AXITINIB FLT1

Interaction Score: 0.58

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Prostate

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
18541897 20124951

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial PharmGKB
AXITINIB FLT4

Interaction Score: 0.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Prostate

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
18541897

Sources:
CancerCommons MyCancerGenomeClinicalTrial ChemblInteractions TALC MyCancerGenome TdgClinicalTrial
AXITINIB KDR

Interaction Score: 0.41

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Reported Cancer Type Prostate

PMIDs:
20124951 18541897

Sources:
TTD MyCancerGenomeClinicalTrial MyCancerGenome ChemblInteractions CancerCommons TdgClinicalTrial PharmGKB TALC
AXITINIB KIT

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name axitinib, AG-013736

Novel drug target Established target

Reported Cancer Type Prostate

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial CancerCommons
AXITINIB UGT1A1

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26512042

Sources:
PharmGKB
AXITINIB ABL1

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25686603

Sources:
CIViC PharmGKB
AXITINIB PDGFRB

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name axitinib, AG-013736

Novel drug target Established target

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial
AXITINIB CYP3A5

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24433361

Sources:
PharmGKB
AXITINIB PDGFRA

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name axitinib, AG-013736

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
AXITINIB HIF1A

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25816720

Sources:
PharmGKB
AXITINIB YES1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

CancerCommons: AXITINIB
- Version: 25-July-2013
Alternate Names:

Axitinib PubChem Drug Name

6450551 PubChem Drug ID

Inlyta Drug Trade Name

Drug Info:

Drug Class Kinase Inhibitor

Source Reported Drug Name(s) Axitinib/AG013736/Inlyta

Pharmaceutical Developer Novartis

Publications:
MyCancerGenome: AXITINIB
- Version: 20-Jun-2017
Alternate Names:

AG-013736 Development Name

AXITINIB Generic Name

INLYTA Trade Name

Drug Info:

Drug Class Kinase Inhibitors

FDA Approval Renal cell carcinoma

Publications:
TdgClinicalTrial: AXITINIB
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antineoplastic agent

Drug Class Small molecule

FDA Approval approved

Publications:

PharmGKB: axitinib

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

Zientek MA et al., 2016, In Vitro Kinetic Characterization of Axitinib Metabolism., Drug Metab Dispos

Ehmann F et al., 2014, European Medicines Agency initiatives and perspectives on pharmacogenomics., Br J Clin Pharmacol

CIViC: AXITINIB
- Version: 14-September-2020
Alternate Names:

Drug Info:

Publications:

Pemovska T et al., 2015, Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation., Nature
TALC: AXITINIB
- Version: 12-May-2016
Alternate Names:

AXITINIB Primary Drug Name

AXITINIB Drug Generic Name

INLYTA Drug Trade Name

Drug Info:

Publications:
DTC: AXITINIB
- Version: 02-September-2020
Alternate Names:

CHEMBL1289926 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Axitinib
- Version: 2020.06.01
Alternate Names:

D01ZRI TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1289926
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
MyCancerGenomeClinicalTrial: AXITINIB
- Version: 30-February-2014
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1289926
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Reported Cancer Type	Prostate
Mechanism of Interaction	Vascular endothelial growth factor receptor inhibitor
Direct Interaction	yes

Trial Name	axitinib, AG-013736
Novel drug target	Established target
Reported Cancer Type	Prostate

Notes
Trial Name	axitinib, AG-013736
Novel drug target	Established target

Axitinib	PubChem Drug Name
6450551	PubChem Drug ID
Inlyta	Drug Trade Name

AG-013736	Development Name
AXITINIB	Generic Name
INLYTA	Trade Name

AXITINIB	Primary Drug Name
AXITINIB	Drug Generic Name
INLYTA	Drug Trade Name

AXITINIB Drug Record

AXITINIB chembl:CHEMBL1289926 ApprovedAntineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Reported Cancer Type Prostate

PMIDs: None found

Sources: CancerCommons

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Reported Cancer Type Prostate Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Direct Interaction yes

PMIDs: 18541897 20124951

Sources: TALC MyCancerGenome TdgClinicalTrial ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Reported Cancer Type Prostate Direct Interaction yes Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs: 18541897

Sources: CancerCommons MyCancerGenomeClinicalTrial ChemblInteractions TALC MyCancerGenome TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Reported Cancer Type Prostate

PMIDs: 20124951 18541897

Sources: TTD MyCancerGenomeClinicalTrial MyCancerGenome ChemblInteractions CancerCommons TdgClinicalTrial PharmGKB TALC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name axitinib, AG-013736 Novel drug target Established target Reported Cancer Type Prostate

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial CancerCommons

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26512042

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25686603

Sources: CIViC PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Trial Name axitinib, AG-013736 Novel drug target Established target

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24433361

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info: Trial Name axitinib, AG-013736 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25816720

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

CancerCommons: AXITINIB

Alternate Names: Axitinib PubChem Drug Name 6450551 PubChem Drug ID Inlyta Drug Trade Name

Drug Info: Drug Class Kinase Inhibitor Source Reported Drug Name(s) Axitinib/AG013736/Inlyta Pharmaceutical Developer Novartis

Publications:

MyCancerGenome: AXITINIB

Alternate Names: AG-013736 Development Name AXITINIB Generic Name INLYTA Trade Name

Drug Info: Drug Class Kinase Inhibitors FDA Approval Renal cell carcinoma

Publications:

TdgClinicalTrial: AXITINIB

Alternate Names:

Drug Info: Drug Indications antineoplastic agent Drug Class Small molecule FDA Approval approved

Publications:

PharmGKB: axitinib

Alternate Names:

Drug Info:

CIViC: AXITINIB

Alternate Names:

Drug Info:

Publications: Pemovska T et al., 2015, Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation., Nature

TALC: AXITINIB

Alternate Names: AXITINIB Primary Drug Name AXITINIB Drug Generic Name INLYTA Drug Trade Name

Drug Info:

Publications:

DTC: AXITINIB

Alternate Names: CHEMBL1289926 ChEMBL Drug ID

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Prostate

PMIDs:
None found

Sources:
CancerCommons

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Prostate

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
18541897 20124951

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Prostate

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
18541897

Sources:
CancerCommons MyCancerGenomeClinicalTrial ChemblInteractions TALC MyCancerGenome TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Reported Cancer Type Prostate

PMIDs:
20124951 18541897

Sources:
TTD MyCancerGenomeClinicalTrial MyCancerGenome ChemblInteractions CancerCommons TdgClinicalTrial PharmGKB TALC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name axitinib, AG-013736

Novel drug target Established target

Reported Cancer Type Prostate

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial CancerCommons

Interaction Types & Directionality:

n/a

PMIDs:
26512042

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25686603

Sources:
CIViC PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name axitinib, AG-013736

Novel drug target Established target

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
24433361

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name axitinib, AG-013736

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
25816720

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

Axitinib PubChem Drug Name

6450551 PubChem Drug ID

Inlyta Drug Trade Name

Drug Info:

Drug Class Kinase Inhibitor

Source Reported Drug Name(s) Axitinib/AG013736/Inlyta

Pharmaceutical Developer Novartis

Alternate Names:

AG-013736 Development Name

AXITINIB Generic Name

INLYTA Trade Name

Drug Info:

Drug Class Kinase Inhibitors

FDA Approval Renal cell carcinoma

Drug Info:

Drug Indications antineoplastic agent

Drug Class Small molecule

FDA Approval approved

Publications:

Pemovska T et al., 2015, Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation., Nature

Alternate Names:

AXITINIB Primary Drug Name

AXITINIB Drug Generic Name

INLYTA Drug Trade Name

Alternate Names:

CHEMBL1289926 ChEMBL Drug ID

Alternate Names:

D01ZRI TTD Drug ID