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BARBITAL Drug Record

  • Summary
  • Interactions
  • Claims
  • BARBITAL chembl:CHEMBL444 Approved

    Alternate Names:

    BARBITAL
    DIETHYLBARBITURIC ACID
    DIEMAL
    BARBITONE

    Drug Info:

    Drug Categories hypnotics and sedatives
    Drug Categories anticholinergic agents
    Drug Categories anticonvulsants
    Drug Categories cytochrome p-450 cyp2c19 inducers
    Drug Categories cytochrome p-450 cyp2c19 inducers (strength unknown)
    Drug Categories cytochrome p-450 cyp2c19 substrates
    Drug Categories cytochrome p-450 cyp3a inducers
    Drug Categories cytochrome p-450 cyp3a4 inducers
    Drug Categories cytochrome p-450 cyp3a4 inducers (strength unknown)
    Drug Categories cytochrome p-450 enzyme inducers
    Drug Categories cytochrome p-450 substrates
    Drug Categories nicotinic antagonists
    (0 More Sources)

    Publications:

    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.
    Whiting, 2003, The GABAA receptor gene family: new opportunities for drug development., Curr Opin Drug Discov Devel
    Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.
    Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.
  • BARBITAL   GRIK2

    Interaction Score: 0.77

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 10487207


    Sources:
    DrugBank

  • BARBITAL   CHRNA4

    Interaction Score: 0.4

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 16248797 10487207


    Sources:
    DrugBank

  • BARBITAL   CHRNA7

    Interaction Score: 0.35

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 16248797 10487207


    Sources:
    DrugBank

  • BARBITAL   GRIA2

    Interaction Score: 0.35

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 10487207


    Sources:
    DrugBank

  • BARBITAL   GABRA1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    potentiator

    Interaction Info:

    PMIDs:
    14579514 11264449 10209232 10487207


    Sources:
    TTD DrugBank

  • BARBITAL   GABRA6

    Interaction Score: 0.22

    Interaction Types & Directionality:
    potentiator

    Interaction Info:

    PMIDs:
    11264449 10209232


    Sources:
    DrugBank

  • BARBITAL   GABRA5

    Interaction Score: 0.2

    Interaction Types & Directionality:
    potentiator

    Interaction Info:

    PMIDs:
    11264449 10209232


    Sources:
    DrugBank

  • BARBITAL   GABRA2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    potentiator

    Interaction Info:

    PMIDs:
    11264449 10209232


    Sources:
    DrugBank

  • BARBITAL   GABRA3

    Interaction Score: 0.19

    Interaction Types & Directionality:
    potentiator

    Interaction Info:

    PMIDs:
    11264449 10209232


    Sources:
    DrugBank

  • BARBITAL   GABRA4

    Interaction Score: 0.15

    Interaction Types & Directionality:
    potentiator

    Interaction Info:

    PMIDs:
    10209232


    Sources:
    DrugBank

  • DrugBank: DB01483

    • Version: 5.1.7

    Alternate Names:
    BARBITAL DrugBank Drug Name
    57-44-3 CAS Number
    CHEMBL444 ChEMBL ID

    Drug Info:
    Drug Type small molecule
    Drug Groups illicit
    Drug Categories anticholinergic agents

    Publications:
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.
    Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.

  • TTD: Barbital

    • Version: 2020.06.01

    Alternate Names:
    D0E0WQ TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL444

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2021-04-13