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BELINOSTAT Drug Record

  • Summary
  • Interactions
  • Claims
  • BELINOSTAT chembl:CHEMBL408513 ApprovedAntineoplasticImmunotherapy

    Alternate Names:

    PXD-101
    PX-105684
    NSC726630
    BELINOSTAT
    BELEODAQ
    rxcui:1543543
    chembl:CHEMBL408513
    pubchem.compound:6918638
    chemidplus:866323-14-0
    drugbank:05015

    Drug Info:

    FDA Approval Peripheral T-cell lymphoma
    Drug Class Small molecule inhibitor
    FDA Approval not approved
    Drug Class Small molecule
    Drug Indications antineoplastic agent
    (5 More Sources)

    Publications:

    Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett
    Hood K et al., 2016, Belinostat for Relapsed or Refractory Peripheral T-Cell Lymphoma., J Adv Pract Oncol
    Goey et al., 2016, Effects of UGT1A1 genotype on the pharmacokinetics, pharmacodynamics, and toxicities of belinostat administered by 48-hour continuous infusion in patients with cancer., J Clin Pharmacol
    He et al., 2013, Mcl-1 and FBW7 control a dominant survival pathway underlying HDAC and Bcl-2 inhibitor synergy in squamous cell carcinoma., Cancer Discov
  • BELINOSTAT   FBXW7

    Interaction Score: 1.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type hematologic cancer
    Response Type sensitive
    Approval Status Preclinical

    PMIDs:
    23274910


    Sources:
    JAX-CKB

  • BELINOSTAT   HDAC7

    Interaction Score: 0.82

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Mechanism of Interaction Histone deacetylase inhibitor
    Direct Interaction yes

    PMIDs:
    25937017


    Sources:
    TALC DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

  • BELINOSTAT   HDAC9

    Interaction Score: 0.74

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Trial Name PXD101
    Novel drug target Established target

    PMIDs:
    25937017


    Sources:
    TALC DTC MyCancerGenome TdgClinicalTrial

  • BELINOSTAT   HDAC4

    Interaction Score: 0.73

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name PXD101
    Notes

    PMIDs:
    25937017


    Sources:
    TALC DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

  • BELINOSTAT   HDAC10

    Interaction Score: 0.72

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name PXD101
    Novel drug target Established target
    Direct Interaction yes

    PMIDs:
    25937017


    Sources:
    TALC DTC TdgClinicalTrial ChemblInteractions

  • BELINOSTAT   HDAC1

    Interaction Score: 0.71

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name PXD101
    Novel drug target Established target
    Notes

    PMIDs:
    25937017 28090369


    Sources:
    TALC DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

  • BELINOSTAT   HDAC5

    Interaction Score: 0.68

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name PXD101
    Novel drug target Established target
    Mechanism of Interaction Histone deacetylase inhibitor

    PMIDs:
    25937017


    Sources:
    TALC DTC TdgClinicalTrial ChemblInteractions

  • BELINOSTAT   HDAC8

    Interaction Score: 0.64

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Trial Name PXD101
    Novel drug target Established target

    PMIDs:
    25937017


    Sources:
    TALC DTC TdgClinicalTrial ChemblInteractions

  • BELINOSTAT   HDAC11

    Interaction Score: 0.63

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Histone deacetylase inhibitor
    Trial Name PXD101

    PMIDs:
    25937017


    Sources:
    DTC TdgClinicalTrial ChemblInteractions

  • BELINOSTAT   HDAC3

    Interaction Score: 0.63

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Histone deacetylase inhibitor
    Direct Interaction yes
    Trial Name PXD101

    PMIDs:
    25937017


    Sources:
    TALC DTC TdgClinicalTrial ChemblInteractions

  • BELINOSTAT   HDAC6

    Interaction Score: 0.61

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Mechanism of Interaction Histone deacetylase inhibitor
    Direct Interaction yes

    PMIDs:
    25937017


    Sources:
    TALC DTC TdgClinicalTrial ChemblInteractions

  • BELINOSTAT   HDAC2

    Interaction Score: 0.61

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Direct Interaction yes
    Mechanism of Interaction Histone deacetylase inhibitor

    PMIDs:
    25937017


    Sources:
    TALC DTC TdgClinicalTrial ChemblInteractions

  • BELINOSTAT   UGT1A1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26313268


    Sources:
    CIViC FDA

  • MyCancerGenome: BELINOSTAT

    • Version: 20-Jun-2017

    Alternate Names:
    BELEODAQ Trade Name

    Drug Info:
    Drug Class Small molecule inhibitor
    FDA Approval Peripheral T-cell lymphoma

    Publications:

  • TdgClinicalTrial: BELINOSTAT

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antineoplastic agent
    Drug Class Small molecule
    FDA Approval not approved

    Publications:

  • DTC: BELINOSTAT

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL408513 ChEMBL Drug ID

    Drug Info:

    Publications:
    Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett

  • JAX-CKB: Belinostat

    • Version: 27-September-2017

    Alternate Names:

    Drug Info:

    Publications:
    He et al., 2013, Mcl-1 and FBW7 control a dominant survival pathway underlying HDAC and Bcl-2 inhibitor synergy in squamous cell carcinoma., Cancer Discov

  • CIViC: BELINOSTAT

    • Version: 14-September-2020

    Alternate Names:

    Drug Info:

    Publications:
    Goey et al., 2016, Effects of UGT1A1 genotype on the pharmacokinetics, pharmacodynamics, and toxicities of belinostat administered by 48-hour continuous infusion in patients with cancer., J Clin Pharmacol

  • TALC: BELINOSTAT

    • Version: 12-May-2016

    Alternate Names:
    BELINOSTAT Primary Drug Name
    BELINOSTAT Drug Generic Name
    PXD 101 Drug Synonym

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL408513

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL408513

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Belinostat

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21