DGIdb - BENAZEPRIL Drug Record

BENAZEPRIL chembl:CHEMBL838 Approved

Alternate Names:

C09AA07
BENAZEPRIL
LOTENSIN
CGS-14824A
LOTREL
BENAZEPRILUM
LOTENSIN®
1H-1-BENZAZEPINE-1-ACETIC ACID, 3-((1-(ETHOXYCARBONYL)-3-PHENYLPROPYL)AMINO)-2,3,4,5-TETRAHYDRO-2-OXO-, (S-(R,R))-
CIB824
chembl:CHEMBL838
drugbank:00542
chemidplus:86541-75-5
rxcui:18867
pubchem.compound:5362124

Drug Info:

Drug Class	antihypertensive agents
Year of Approval	1991
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antihypertensive agent

(2 More Sources)

Publications:

Zhang Y et al., 2009, E112D polymorphism in the prolylcarboxypeptidase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients., Chin Med J (Engl)
Song et al., 2002, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update., Clin Pharmacokinet
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
He H et al., 2005, A study of the relationships between angiotensin- converting enzyme gene, chymase gene polymorphisms, pharmacological treatment with ACE inhibitor and regression of left ventricular hypertrophy in essential hypertension patients treated with benazepril., Ann Hum Biol
Kohno M et al., 1999, Association between angiotensin-converting enzyme gene polymorphisms and regression of left ventricular hypertrophy in patients treated with angiotensin-converting enzyme inhibitors., Am J Med
Penno G et al., 1998, Effect of angiotensin-converting enzyme (ACE) gene polymorphism on progression of renal disease and the influence of ACE inhibition in IDDM patients: findings from the EUCLID Randomized Controlled Trial. EURODIAB Controlled Trial of Lisinopril in IDDM., Diabetes
Zee RY et al., 1998, Three candidate genes and angiotensin-converting enzyme inhibitor-related cough: a pharmacogenetic analysis., Hypertension
Ohmichi N et al., 1997, Relationship between the response to the angiotensin converting enzyme inhibitor imidapril and the angiotensin converting enzyme genotype., Am J Hypertens
Sasaki M et al., 1996, Relationship between the angiotensin converting enzyme gene polymorphism and the effects of enalapril on left ventricular hypertrophy and impaired diastolic filling in essential hypertension: M-mode and pulsed Doppler echocardiographic studies., J Hypertens
Rudnicki M et al., 2009, Significance of genetic polymorphisms of the renin-angiotensin-aldosterone system in cardiovascular and renal disease., Pharmacogenomics
Arnett DK et al., 2005, Pharmacogenetic association of the angiotensin-converting enzyme insertion/deletion polymorphism on blood pressure and cardiovascular risk in relation to antihypertensive treatment: the Genetics of Hypertension-Associated Treatment (GenHAT) study., Circulation
Yu Y et al., 2005, Associations of baseline blood pressure levels and efficacy of Benazepril treatment with interaction of alpha-adducin and ACE gene polymorphisms in hypertensives., Clin Exp Hypertens
Takahashi T et al., 2001, The ACE gene polymorphism and cough threshold for capsaicin after cilazapril usage., Respir Med
Ha SK et al., 2000, ACE DD genotype is more susceptible than ACE II and ID genotypes to the antiproteinuric effect of ACE inhibitors in patients with proteinuric non-insulin-dependent diabetes mellitus., Nephrol Dial Transplant
Stavroulakis GA et al., 2000, Predicting response to chronic antihypertensive treatment with fosinopril: the role of angiotensin-converting enzyme gene polymorphism., Cardiovasc Drugs Ther
Yu HM et al., 2006, Associations between CYP11B2 gene polymorphisms and the response to angiotensin-converting enzyme inhibitors., Clin Pharmacol Ther
Jiang S et al., 2005, A common haplotype on methylenetetrahydrofolate reductase gene modifies the effect of angiotensin-converting enzyme inhibitor on blood pressure in essential hypertension patients--a family-based association study., Clin Exp Hypertens
Jiang S et al., 2004, The C677T polymorphism of the methylenetetrahydrofolate reductase gene is associated with the level of decrease on diastolic blood pressure in essential hypertension patients treated by angiotensin-converting enzyme inhibitor., Thromb Res
Huang G et al., 2004, Beta2 adrenergic receptor gene Arg16Gly polymorphism is associated with therapeutic efficacy of benazepril on essential hypertension in Chinese., Clin Exp Hypertens
Yu H et al., 2014, A core promoter variant of angiotensinogen gene and interindividual variation in response to angiotensin-converting enzyme inhibitors., J Renin Angiotensin Aldosterone Syst
Su X et al., 2007, Association between angiotensinogen, angiotensin II receptor genes, and blood pressure response to an angiotensin-converting enzyme inhibitor., Circulation
Zhang et al., 2004, D919G polymorphism of methionine synthase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients., J. Hum. Genet.

BENAZEPRIL PRCP

Interaction Score: 18.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20079160

Sources:
PharmGKB
BENAZEPRIL MTR

Interaction Score: 6.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15148588

Sources:
PharmGKB
BENAZEPRIL CYP11B2

Interaction Score: 3.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16765146

Sources:
PharmGKB
BENAZEPRIL ACE

Interaction Score: 2.62

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
11929321 11752352 15788353 10335726 9726242 9535416 9270093 8986921 19290794 15967849 15773232 11217909 11007831 10999650

Sources:
TdgClinicalTrial TEND GuideToPharmacology PharmGKB TTD
BENAZEPRIL AGT

Interaction Score: 1.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25143324 17261659

Sources:
PharmGKB
BENAZEPRIL MTHFR

Interaction Score: 1.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16081343 15226090

Sources:
PharmGKB
BENAZEPRIL ADRB2

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15554460

Sources:
PharmGKB

TEND: BENAZEPRIL
- Version: 01-August-2011
Alternate Names:

BENAZEPRIL Primary Drug Name

Drug Info:

Year of Approval 1991

Drug Class antihypertensive agents

Publications:
TdgClinicalTrial: BENAZEPRIL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Publications:

PharmGKB: benazepril

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Yu HM et al., 2006, Associations between CYP11B2 gene polymorphisms and the response to angiotensin-converting enzyme inhibitors., Clin Pharmacol Ther

Zhang Y et al., 2009, E112D polymorphism in the prolylcarboxypeptidase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients., Chin Med J (Engl)

Su X et al., 2007, Association between angiotensinogen, angiotensin II receptor genes, and blood pressure response to an angiotensin-converting enzyme inhibitor., Circulation

GuideToPharmacology: 178102992
- Version: 29-September-2020
Alternate Names:

BENAZEPRIL GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Benazepril
- Version: 2020.06.01
Alternate Names:

D0U3EC TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL838
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

BENAZEPRIL Drug Record

BENAZEPRIL chembl:CHEMBL838 Approved

Alternate Names:

Drug Info:

Publications:

BENAZEPRIL PRCP

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20079160

Sources: PharmGKB

BENAZEPRIL MTR

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15148588

Sources: PharmGKB

BENAZEPRIL CYP11B2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16765146

Sources: PharmGKB

BENAZEPRIL ACE

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: 11929321 11752352 15788353 10335726 9726242 9535416 9270093 8986921 19290794 15967849 15773232 11217909 11007831 10999650

Sources: TdgClinicalTrial TEND GuideToPharmacology PharmGKB TTD

BENAZEPRIL AGT

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25143324 17261659

Sources: PharmGKB

BENAZEPRIL MTHFR

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16081343 15226090

Sources: PharmGKB

BENAZEPRIL ADRB2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15554460

Sources: PharmGKB

TEND: BENAZEPRIL

Alternate Names: BENAZEPRIL Primary Drug Name

Drug Info: Year of Approval 1991 Drug Class antihypertensive agents

Publications:

TdgClinicalTrial: BENAZEPRIL

Alternate Names:

Drug Info: Drug Indications antihypertensive agent Drug Class Small Molecule FDA Approval approved

Publications:

PharmGKB: benazepril

Alternate Names:

Drug Info:

GuideToPharmacology: 178102992

Alternate Names: BENAZEPRIL GuideToPharmacology Ligand Name

Drug Info:

Publications:

TTD: Benazepril

Alternate Names: D0U3EC TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL838

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
20079160

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15148588

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16765146

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
11929321 11752352 15788353 10335726 9726242 9535416 9270093 8986921 19290794 15967849 15773232 11217909 11007831 10999650

Sources:
TdgClinicalTrial TEND GuideToPharmacology PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
25143324 17261659

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16081343 15226090

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15554460

Sources:
PharmGKB

Alternate Names:

BENAZEPRIL Primary Drug Name

Drug Info:

Year of Approval 1991

Drug Class antihypertensive agents

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

BENAZEPRIL GuideToPharmacology Ligand Name

Alternate Names:

D0U3EC TTD Drug ID