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BREXPIPRAZOLE Drug Record

  • Summary
  • Interactions
  • Claims
  • BREXPIPRAZOLE chembl:CHEMBL2105760 Approved

    Alternate Names:

    REXULTI
    BREXPIPRAZOLE
    OPC-34712
    OPC 34712
    chembl:CHEMBL2105760
    pubchem.compound:11978813
    drugbank:09128
    chemidplus:913611-97-9
    rxcui:1658314

    Drug Info:

    FDA Approval not approved
    Drug Class small molecule
    Drug Indications antidepressant
    (2 More Sources)

    Publications:

    Maeda et al., 2014, Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator., J. Pharmacol. Exp. Ther.
  • BREXPIPRAZOLE   HTR1A

    Interaction Score: 0.88

    Interaction Types & Directionality:
    partial agonist (activating)
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name OPC-34712
    Direct Interaction yes

    PMIDs:
    24947465


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • BREXPIPRAZOLE   HTR7

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name OPC-34712
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • BREXPIPRAZOLE   HTR2A

    Interaction Score: 0.37

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes
    Trial Name OPC-34712

    PMIDs:
    24947465


    Sources:
    TdgClinicalTrial ChemblInteractions

  • BREXPIPRAZOLE   DRD2

    Interaction Score: 0.3

    Interaction Types & Directionality:
    partial agonist (activating)
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Dopamine D2 receptor partial agonist
    Direct Interaction yes
    Novel drug target Established target

    PMIDs:
    24947465


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • BREXPIPRAZOLE   CYP2D6

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • TdgClinicalTrial: OPC-34712

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antidepressant
    Drug Class small molecule
    FDA Approval not approved

    Publications:

  • TTD: OPC-34712

    • Version: 2020.06.01

    Alternate Names:
    D0P0OU TTD Drug ID

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL2105760

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL2105760

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Brexpiprazole

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

  • PharmGKB: brexpiprazole

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21