DGIdb - BRIMONIDINE Drug Record

BRIMONIDINE chembl:CHEMBL844 Approved

Alternate Names:

UK-1430418 FREE BASE
AGN-190342 FREE BASE
BRIMONIDINE
UK-14304
5-BROMO-6-(2-IMIDAZOLIN-2-YLAMINO)QUINOXALINE
UK14,304
UK14304
BRIMONIDINUM
ALPHAGAN®
BROMOXIDINE
BRIMONIDINA
MIRVASO®
pubchem.compound:2435
chemidplus:59803-98-4
drugbank:00484
rxcui:134615
chembl:CHEMBL844

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	for treatment of glaucoma
Year of Approval	1996
Drug Class	antiglaucomic agents

(2 More Sources)

Publications:

Bohmann et al., 1993, Methoxamine inhibits noradrenaline release through activation of alpha 1- and alpha 2-adrenoceptors in rat isolated kidney: involvement of purines and prostaglandins., Naunyn Schmiedebergs Arch. Pharmacol.
Trendelenburg et al., 2003, All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons., Naunyn Schmiedebergs Arch. Pharmacol.
Prinster et al., 2006, Alpha2C-adrenergic receptors exhibit enhanced surface expression and signaling upon association with beta2-adrenergic receptors., J. Pharmacol. Exp. Ther.
Zhang et al., 2003, The alpha2C-adrenoceptor modulates GABA release in mouse striatum., Brain Res. Mol. Brain Res.
Orito et al., 2001, alpha(2)-adrenoceptor antagonist properties of OPC-28326, a novel selective peripheral vasodilator., Br. J. Pharmacol.
Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol
Rauly et al., 2000, alpha(2A)-adrenoceptor: G(alphai1) protein-mediated pertussis toxin-resistant attenuation of G(s) coupling to the cyclic AMP pathway., Biochem. Pharmacol.
Meana et al., 1992, Decreased density of presynaptic alpha 2-adrenoceptors in postmortem brains of patients with Alzheimer's disease., J. Neurochem.
Wikberg-Matsson et al., 2001, Potent alpha(2A)-adrenoceptor-mediated vasoconstriction by brimonidine in porcine ciliary arteries., Invest. Ophthalmol. Vis. Sci.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

BRIMONIDINE ADRA2A

Interaction Score: 0.97

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name brimonidine tartrate,Alphagan

Novel drug target Established target

Trial Name brimonidine tartrate/timolol maleate,Combigan

PMIDs:
16407989 10799649 1373179 11481271 11752352

Sources:
DTC TdgClinicalTrial TEND PharmGKB TTD
BRIMONIDINE ADRA2C

Interaction Score: 0.78

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
16757535 12670699 11606316 14610637

Sources:
TEND PharmGKB TTD
BRIMONIDINE ADRA2B

Interaction Score: 0.56

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
8097565 14610637

Sources:
TEND PharmGKB
BRIMONIDINE RGS4

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BRIMONIDINE HPGD

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BRIMONIDINE KDM4E

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BRIMONIDINE ALDH1A1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BRIMONIDINE VDR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BRIMONIDINE EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: BRIMONIDINE
- Version: 01-August-2011
Alternate Names:

BRIMONIDINE Primary Drug Name

Drug Info:

Drug Class antiglaucomic agents

Year of Approval 1996

Publications:
TdgClinicalTrial: BRIMONIDINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of glaucoma

Drug Class Small Molecule

FDA Approval approved

Publications:
DTC: BRIMONIDINE
- Version: 02-September-2020
Alternate Names:

CHEMBL844 ChEMBL Drug ID

Drug Info:

Publications:

Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol
TTD: Brimonidine
- Version: 2020.06.01
Alternate Names:

D0AE3X TTD Drug ID

Drug Info:

Publications:
PharmGKB: brimonidine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL844
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	brimonidine tartrate,Alphagan
Novel drug target	Established target
Trial Name	brimonidine tartrate/timolol maleate,Combigan

BRIMONIDINE Drug Record

BRIMONIDINE chembl:CHEMBL844 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name brimonidine tartrate,Alphagan Novel drug target Established target Trial Name brimonidine tartrate/timolol maleate,Combigan

PMIDs: 16407989 10799649 1373179 11481271 11752352

Sources: DTC TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 16757535 12670699 11606316 14610637

Sources: TEND PharmGKB TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 8097565 14610637

Sources: TEND PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: BRIMONIDINE

Alternate Names: BRIMONIDINE Primary Drug Name

Drug Info: Drug Class antiglaucomic agents Year of Approval 1996

Publications:

TdgClinicalTrial: BRIMONIDINE

Alternate Names:

Drug Info: Drug Indications for treatment of glaucoma Drug Class Small Molecule FDA Approval approved

Publications:

DTC: BRIMONIDINE

Alternate Names: CHEMBL844 ChEMBL Drug ID

Drug Info:

Publications: Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol

TTD: Brimonidine

Alternate Names: D0AE3X TTD Drug ID

Drug Info:

Publications:

PharmGKB: brimonidine

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL844

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name brimonidine tartrate,Alphagan

Novel drug target Established target

Trial Name brimonidine tartrate/timolol maleate,Combigan

PMIDs:
16407989 10799649 1373179 11481271 11752352

Sources:
DTC TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

agonist (activating)

PMIDs:
16757535 12670699 11606316 14610637

Sources:
TEND PharmGKB TTD

Interaction Types & Directionality:

agonist (activating)

PMIDs:
8097565 14610637

Sources:
TEND PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

BRIMONIDINE Primary Drug Name

Drug Info:

Drug Class antiglaucomic agents

Year of Approval 1996

Drug Info:

Drug Indications for treatment of glaucoma

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

CHEMBL844 ChEMBL Drug ID

Publications:

Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol

Alternate Names:

D0AE3X TTD Drug ID