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BRIMONIDINE Drug Record

  • Summary
  • Interactions
  • Claims
  • BRIMONIDINE chembl:CHEMBL844 Approved

    Alternate Names:

    UK-1430418 FREE BASE
    AGN-190342 FREE BASE
    BRIMONIDINE
    UK-14304
    5-BROMO-6-(2-IMIDAZOLIN-2-YLAMINO)QUINOXALINE
    UK14,304
    UK14304
    BRIMONIDINUM
    ALPHAGAN®
    BROMOXIDINE
    BRIMONIDINA
    MIRVASO®
    pubchem.compound:2435
    chemidplus:59803-98-4
    drugbank:00484
    rxcui:134615
    chembl:CHEMBL844

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications for treatment of glaucoma
    Year of Approval 1996
    Drug Class antiglaucomic agents
    (2 More Sources)

    Publications:

    Bohmann et al., 1993, Methoxamine inhibits noradrenaline release through activation of alpha 1- and alpha 2-adrenoceptors in rat isolated kidney: involvement of purines and prostaglandins., Naunyn Schmiedebergs Arch. Pharmacol.
    Trendelenburg et al., 2003, All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons., Naunyn Schmiedebergs Arch. Pharmacol.
    Prinster et al., 2006, Alpha2C-adrenergic receptors exhibit enhanced surface expression and signaling upon association with beta2-adrenergic receptors., J. Pharmacol. Exp. Ther.
    Zhang et al., 2003, The alpha2C-adrenoceptor modulates GABA release in mouse striatum., Brain Res. Mol. Brain Res.
    Orito et al., 2001, alpha(2)-adrenoceptor antagonist properties of OPC-28326, a novel selective peripheral vasodilator., Br. J. Pharmacol.
    Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol
    Rauly et al., 2000, alpha(2A)-adrenoceptor: G(alphai1) protein-mediated pertussis toxin-resistant attenuation of G(s) coupling to the cyclic AMP pathway., Biochem. Pharmacol.
    Meana et al., 1992, Decreased density of presynaptic alpha 2-adrenoceptors in postmortem brains of patients with Alzheimer's disease., J. Neurochem.
    Wikberg-Matsson et al., 2001, Potent alpha(2A)-adrenoceptor-mediated vasoconstriction by brimonidine in porcine ciliary arteries., Invest. Ophthalmol. Vis. Sci.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
  • BRIMONIDINE   ADRA2A

    Interaction Score: 0.97

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name brimonidine tartrate,Alphagan
    Novel drug target Established target
    Trial Name brimonidine tartrate/timolol maleate,Combigan

    PMIDs:
    16407989 10799649 1373179 11481271 11752352


    Sources:
    DTC TdgClinicalTrial TEND PharmGKB TTD

  • BRIMONIDINE   ADRA2C

    Interaction Score: 0.78

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    16757535 12670699 11606316 14610637


    Sources:
    TEND PharmGKB TTD

  • BRIMONIDINE   ADRA2B

    Interaction Score: 0.56

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    8097565 14610637


    Sources:
    TEND PharmGKB

  • BRIMONIDINE   RGS4

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BRIMONIDINE   HPGD

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BRIMONIDINE   KDM4E

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BRIMONIDINE   ALDH1A1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BRIMONIDINE   VDR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BRIMONIDINE   EHMT2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: BRIMONIDINE

    • Version: 01-August-2011

    Alternate Names:
    BRIMONIDINE Primary Drug Name

    Drug Info:
    Drug Class antiglaucomic agents
    Year of Approval 1996

    Publications:

  • TdgClinicalTrial: BRIMONIDINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications for treatment of glaucoma
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • DTC: BRIMONIDINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL844 ChEMBL Drug ID

    Drug Info:

    Publications:
    Vilardaga JP et al., 2005, Molecular basis of inverse agonism in a G protein-coupled receptor., Nat Chem Biol

  • TTD: Brimonidine

    • Version: 2020.06.01

    Alternate Names:
    D0AE3X TTD Drug ID

    Drug Info:

    Publications:

  • PharmGKB: brimonidine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL844

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21