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BRIVANIB Drug Record

  • Summary
  • Interactions
  • Claims
  • BRIVANIB chembl:CHEMBL377300 Antineoplastic

    Alternate Names:

    BRIVANIB
    BMS-540215

    Drug Info:

    Drug Class Kinase Inhibitors
    (3 More Sources)

    Publications:

    Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
    Gozgit et al., 2012, Ponatinib (AP24534), a multitargeted pan-FGFR inhibitor with activity in multiple FGFR-amplified or mutated cancer models., Mol. Cancer Ther.
  • BRIVANIB   FGFR3P1

    Interaction Score: 11.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20124951


    Sources:
    PharmGKB

  • BRIVANIB   FGFRL1

    Interaction Score: 11.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20124951


    Sources:
    PharmGKB

  • BRIVANIB   CEP43

    Interaction Score: 11.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20124951


    Sources:
    PharmGKB

  • BRIVANIB   FGFR1OP2

    Interaction Score: 11.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20124951


    Sources:
    PharmGKB

  • BRIVANIB   FGFR4

    Interaction Score: 0.65

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Fibroblast growth factor receptor inhibitor

    PMIDs:
    20124951


    Sources:
    ChemblInteractions PharmGKB

  • BRIVANIB   FGFR2

    Interaction Score: 0.55

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Response Type decreased response
    Indication/Tumor Type Advanced Solid Tumor
    Response Type sensitive

    PMIDs:
    22238366 20124951


    Sources:
    JAX-CKB ChemblInteractions PharmGKB

  • BRIVANIB   FGFR3

    Interaction Score: 0.45

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Fibroblast growth factor receptor inhibitor
    Direct Interaction yes
    Indication/Tumor Type Advanced Solid Tumor

    PMIDs:
    22238366 20124951


    Sources:
    JAX-CKB ChemblInteractions PharmGKB

  • BRIVANIB   FGFR1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Indication/Tumor Type Advanced Solid Tumor
    Response Type no benefit
    Approval Status Preclinical

    PMIDs:
    22238366 20124951


    Sources:
    JAX-CKB ChemblInteractions PharmGKB

  • BRIVANIB   KDR

    Interaction Score: 0.27

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor
    Direct Interaction yes

    PMIDs:
    20124951


    Sources:
    TALC MyCancerGenome ChemblInteractions PharmGKB TTD

  • BRIVANIB   FLT1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BRIVANIB   FLT4

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MyCancerGenome: BRIVANIB

    • Version: 20-Jun-2017

    Alternate Names:
    BRIVANIB Generic Name

    Drug Info:
    Drug Class Kinase Inhibitors

    Publications:

  • JAX-CKB: Brivanib

    • Version: 27-September-2017

    Alternate Names:

    Drug Info:

    Publications:
    Gozgit et al., 2012, Ponatinib (AP24534), a multitargeted pan-FGFR inhibitor with activity in multiple FGFR-amplified or mutated cancer models., Mol. Cancer Ther.

  • PharmGKB: brivanib

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

  • TALC: BRIVANIB

    • Version: 12-May-2016

    Alternate Names:
    BRIVANIB Primary Drug Name
    BRIVANIB Drug Generic Name

    Drug Info:

    Publications:

  • TTD: Brivanib

    • Version: 2020.06.01

    Alternate Names:
    D0HS5V TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL377300

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL377300

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21