DGIdb - BROMOCRIPTINE Drug Record

BROMOCRIPTINE chembl:CHEMBL493 Approved

Alternate Names:

BROMOCRIPTINE
SANDOZ 15-754
PARLODEL
CB-154
2-BROMOERGOCRYPTINE
PLO154
2-BROMO-Α-ERGOKRYPTINE
2-BROMO-ALPHA-ERGOKRYPTIN
BROMOCRYPTINE
2-BROMO-Α-ERGOCRYPTINE
BROMOCRIPTINA
2-BROMO-ALPHA-ERGOKRYPTINE
PARLODEL®
(5'ALPHA)-2-BROMO-12'-HYDROXY-2'-(1-METHYLETHYL)-5'-(2-METHYLPROPYL)-3',6',18-TRIOXOERGOTAMAN
2-BROMO-Α-ERGOKRYPTIN
BROMOERGOCRYPTINE
BROMOERGOCRIPTINE
(5'ALPHA)-2-BROMO-12'-HYDROXY-5'-ISOBUTYL-2'-ISOPROPYL-3',6',18-TRIOXOERGOTAMAN
2-BROMO-ALPHA-ERGOCRYPTINE
BROMOCRIPTINUM
(5'ALPHA)-2-BROMO-12'-HYDROXY-2'-(1-METHYLETHYL)-5'-(2-METHYLPROPYL)ERGOTAMAN-3',6',18-TRIONE
drugbank:01200
chemidplus:25614-03-3
pubchem.compound:31101
rxcui:1760
chembl:CHEMBL493

Drug Info:

Drug Class	antiparkinson agents
Year of Approval	1978
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antidiabetic

(3 More Sources)

Publications:

Doknic et al., 2002, Dopaminergic tone and obesity: an insight from prolactinomas treated with bromocriptine., Eur. J. Endocrinol.
Figueroa et al., 1993, [Pharmacological modification of prolactinemia. Effects on cellular immune function in normal subjects]., Rev Med Chil
Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
Lam, 2000, Clinical pharmacology of dopamine agonists., Pharmacotherapy
Palestine et al., 1987, Bromocriptine and low dose cyclosporine in the treatment of experimental autoimmune uveitis in the rat., J. Clin. Invest.
de Leeuw van Weenen et al., 2010, The dopamine receptor D2 agonist bromocriptine inhibits glucose-stimulated insulin secretion by direct activation of the alpha2-adrenergic receptors in beta cells., Biochem. Pharmacol.
Cussac et al., 2008, Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells., Eur. J. Pharmacol.
Burdman et al., 2001, Bromocriptine and the expression of c-myc and c-fos in human prolactinomas., Neurol. Res.
Pelletier et al., 1991, Dopaminergic regulation of pre-proNPY mRNA levels in the rat arcuate nucleus., Neurosci. Lett.
Orlowski et al., 1998, Bromocriptine modulates P-glycoprotein function., Biochem. Biophys. Res. Commun.
Shiraki et al., 2002, Bromocriptine reverses P-glycoprotein-mediated multidrug resistance in tumor cells., Jpn. J. Cancer Res.
Lim et al., 2008, Bromocriptine activates NQO1 via Nrf2-PI3K/Akt signaling: novel cytoprotective mechanism against oxidative damage., Pharmacol. Res.
Cavallotti et al., Age-related changes in dopamine D2 receptors in rat heart and coronary vessels., Clin. Exp. Pharmacol. Physiol.
Lahlou, 1999, Cardiovascular responses to intrathecal dopamine receptor agonists in conscious DOCA-salt hypertensive rats., Fundam Clin Pharmacol
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Lahlou et al., 2003, Blunted central bromocriptine-induced tachycardia in conscious, malnourished rats., Pharmacol. Toxicol.
Stefaneanu et al., 2001, Dopamine D2 receptor gene expression in human adenohypophysial adenomas., Endocrine
Lahlou et al., 2000, Effects of long-term pretreatment with isoproterenol on bromocriptine-induced tachycardia in conscious rats., Can. J. Physiol. Pharmacol.
Ohta et al., 2003, Effects of dopamine agonists bromocriptine, pergolide, cabergoline, and SKF-38393 on GDNF, NGF, and BDNF synthesis in cultured mouse astrocytes., Life Sci.
Wynalda et al., 1997, Assessment of potential interactions between dopamine receptor agonists and various human cytochrome P450 enzymes using a simple in vitro inhibition screen., Drug Metab. Dispos.

BROMOCRIPTINE NPY

Interaction Score: 0.91

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1679226

Sources:
NCI
BROMOCRIPTINE SAG

Interaction Score: 0.91

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3494043

Sources:
NCI
BROMOCRIPTINE GDNF

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12770616

Sources:
NCI
BROMOCRIPTINE FOS

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11680511

Sources:
NCI
BROMOCRIPTINE LEP

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12088923

Sources:
NCI
BROMOCRIPTINE DRD2

Interaction Score: 0.15

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name bromocriptine mesylate,Cycloset, Ergoset

Novel drug target Established target

Specific Action of the Ligand Full agonist

PMIDs:
12010185 10626749 11752352 12753422 11444429 10721819 18691132 10641988

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD
BROMOCRIPTINE DRD5

Interaction Score: 0.14

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
18691132

Sources:
GuideToPharmacology
BROMOCRIPTINE IL2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8191163

Sources:
NCI
BROMOCRIPTINE HTR2B

Interaction Score: 0.13

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
18691132 10641988 18703043

Sources:
GuideToPharmacology
BROMOCRIPTINE ADRA2B

Interaction Score: 0.13

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
20138024 18691132 10641988

Sources:
GuideToPharmacology
BROMOCRIPTINE HTR1D

Interaction Score: 0.11

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
18691132 10641988

Sources:
GuideToPharmacology
BROMOCRIPTINE MYC

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11680511

Sources:
NCI
BROMOCRIPTINE ADRA2C

Interaction Score: 0.11

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
20138024 18691132 10641988

Sources:
GuideToPharmacology
BROMOCRIPTINE ADRA2A

Interaction Score: 0.11

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
20138024 18691132 10641988

Sources:
GuideToPharmacology
BROMOCRIPTINE HTR1B

Interaction Score: 0.11

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
18691132 10641988

Sources:
GuideToPharmacology
BROMOCRIPTINE DRD3

Interaction Score: 0.1

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

PMIDs:
18691132 10641988

Sources:
TdgClinicalTrial GuideToPharmacology
BROMOCRIPTINE HTR2C

Interaction Score: 0.09

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
18691132 10641988 18703043

Sources:
GuideToPharmacology
BROMOCRIPTINE DRD4

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
18691132

Sources:
GuideToPharmacology
BROMOCRIPTINE HTR1A

Interaction Score: 0.07

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
18691132 10641988

Sources:
GuideToPharmacology
BROMOCRIPTINE HTR2A

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
18691132 10641988 18703043

Sources:
GuideToPharmacology
BROMOCRIPTINE HTR6

Interaction Score: 0.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
BROMOCRIPTINE DRD1

Interaction Score: 0.04

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
18691132

Sources:
DTC GuideToPharmacology
BROMOCRIPTINE ABCB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9514944 11856485

Sources:
NCI
BROMOCRIPTINE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9321526

Sources:
NCI
BROMOCRIPTINE NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18455424

Sources:
NCI
BROMOCRIPTINE VDR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BROMOCRIPTINE AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BROMOCRIPTINE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: BROMOCRIPTINE
- Version: 01-August-2011
Alternate Names:

BROMOCRIPTINE Primary Drug Name

Drug Info:

Year of Approval 1978

Drug Class antiparkinson agents

Publications:
TdgClinicalTrial: BROMOCRIPTINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antidiabetic

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: BROMOCRIPTINE

Version: 14-September-2017

Alternate Names:

C317 NCI drug code

Drug Info:

Publications:

Ohta et al., 2003, Effects of dopamine agonists bromocriptine, pergolide, cabergoline, and SKF-38393 on GDNF, NGF, and BDNF synthesis in cultured mouse astrocytes., Life Sci.

Wynalda et al., 1997, Assessment of potential interactions between dopamine receptor agonists and various human cytochrome P450 enzymes using a simple in vitro inhibition screen., Drug Metab. Dispos.

Figueroa et al., 1993, [Pharmacological modification of prolactinemia. Effects on cellular immune function in normal subjects]., Rev Med Chil

DTC: BROMOCRIPTINE
- Version: 02-September-2020
Alternate Names:

CHEMBL493 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Bromocriptine
- Version: 2020.06.01
Alternate Names:

D06YFA TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135650026
- Version: 29-September-2020
Alternate Names:

BROMOCRIPTINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL493
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	bromocriptine mesylate,Cycloset, Ergoset
Novel drug target	Established target
Specific Action of the Ligand	Full agonist

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

Specific Action of the Ligand	Partial agonist
Endogenous Drug?	False

Direct Interaction?	True
Endogenous Drug?	False
Specific Action of the Ligand	Partial agonist

agonist (activating)
antagonist (inhibitory)

agonist (activating)
antagonist (inhibitory)

agonist (activating)
antagonist (inhibitory)

agonist (activating)
antagonist (inhibitory)

BROMOCRIPTINE Drug Record

BROMOCRIPTINE chembl:CHEMBL493 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1679226

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3494043

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12770616

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11680511

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12088923

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name bromocriptine mesylate,Cycloset, Ergoset Novel drug target Established target Specific Action of the Ligand Full agonist

PMIDs: 12010185 10626749 11752352 12753422 11444429 10721819 18691132 10641988

Sources: TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False

PMIDs: 18691132

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8191163

Sources: NCI

Interaction Types & Directionality: agonist (activating) antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 18691132 10641988 18703043

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating) antagonist (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Antagonist

PMIDs: 20138024 18691132 10641988

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Partial agonist Endogenous Drug? False

PMIDs: 18691132 10641988

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11680511

Sources: NCI

Interaction Types & Directionality: agonist (activating) antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 20138024 18691132 10641988

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating) antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 20138024 18691132 10641988

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Partial agonist Endogenous Drug? False

PMIDs: 18691132 10641988

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Partial agonist

PMIDs: 18691132 10641988

Sources: TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Partial agonist Endogenous Drug? False

PMIDs: 18691132 10641988 18703043

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? True

PMIDs: 18691132

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Partial agonist Endogenous Drug? False

PMIDs: 18691132 10641988

Interaction Types & Directionality:

n/a

PMIDs:
1679226

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3494043

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12770616

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11680511

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12088923

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name bromocriptine mesylate,Cycloset, Ergoset

Novel drug target Established target

Specific Action of the Ligand Full agonist

PMIDs:
12010185 10626749 11752352 12753422 11444429 10721819 18691132 10641988

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
18691132

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
8191163

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
18691132 10641988 18703043

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
20138024 18691132 10641988

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
18691132 10641988

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
11680511

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
20138024 18691132 10641988

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
20138024 18691132 10641988

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
18691132 10641988

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

PMIDs:
18691132 10641988

Sources:
TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
18691132 10641988 18703043

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
18691132

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
18691132 10641988

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
18691132 10641988 18703043

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
18691132