DGIdb - BUCINDOLOL Drug Record

BUCINDOLOL chembl:CHEMBL321582

Alternate Names:

BUCINDOLOL

Drug Info:

FDA Approval	not approved
Drug Class	Small molecule
Drug Indications	for treatment of heart failure

(0 More Sources)

Publications:

Rau T et al., 2012, Impact of the β1-adrenoceptor Arg389Gly polymorphism on heart-rate responses to bisoprolol and carvedilol in heart-failure patients., Clin Pharmacol Ther
Huntgeburth M et al., 2011, The Arg389Gly β1-adrenoceptor gene polymorphism influences the acute effects of β-adrenoceptor blockade on contractility in the human heart., Clin Res Cardiol
Baudhuin LM et al., 2010, Relation of ADRB1, CYP2D6, and UGT1A1 polymorphisms with dose of, and response to, carvedilol or metoprolol therapy in patients with chronic heart failure., Am J Cardiol
Metra M et al., 2010, Role of beta-adrenergic receptor gene polymorphisms in the long-term effects of beta-blockade with carvedilol in patients with chronic heart failure., Cardiovasc Drugs Ther
Filigheddu F et al., 2010, Haplotypes of the adrenergic system predict the blood pressure response to beta-blockers in women with essential hypertension., Pharmacogenomics
Chen L et al., 2007, Arg389Gly-beta1-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilol., Pharmacogenet Genomics
Lobmeyer MT et al., 2007, Synergistic polymorphisms of beta1 and alpha2C-adrenergic receptors and the influence on left ventricular ejection fraction response to beta-blocker therapy in heart failure., Pharmacogenet Genomics
Liu J et al., 2006, beta1-Adrenergic receptor polymorphisms influence the response to metoprolol monotherapy in patients with essential hypertension., Clin Pharmacol Ther
Terra SG et al., 2005, Beta1-adrenergic receptor polymorphisms and left ventricular remodeling changes in response to beta-blocker therapy., Pharmacogenet Genomics
de Groote P et al., 2005, Association between beta-1 and beta-2 adrenergic receptor gene polymorphisms and the response to beta-blockade in patients with stable congestive heart failure., Pharmacogenet Genomics
Terra SG et al., 2005, beta-Adrenergic receptor polymorphisms and responses during titration of metoprolol controlled release/extended release in heart failure., Clin Pharmacol Ther
Liu et al., 2003, Gly389Arg polymorphism of beta1-adrenergic receptor is associated with the cardiovascular response to metoprolol., Clin. Pharmacol. Ther.
Mialet Perez J et al., 2003, Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure., Nat Med
White HL et al., 2003, An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals with heart failure: a MERIT-HF sub-study., Eur J Heart Fail
Johnson et al., 2003, Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol., Clin. Pharmacol. Ther.
Sofowora GG et al., 2003, A common beta1-adrenergic receptor polymorphism (Arg389Gly) affects blood pressure response to beta-blockade., Clin Pharmacol Ther
O'Connor CM et al., 2012, Combinatorial pharmacogenetic interactions of bucindolol and β1, α2C adrenergic receptor polymorphisms., PLoS One

BUCINDOLOL ADRB1

Interaction Score: 4.72

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name bucindolol hydrochloride,Gencaro

Novel drug target Established target

PMIDs:
22617224 21311897 20643254 20352314 20235788 18075464 17496726 16815314 15864115 15861037 15735607 14534524 14502278 12921807 12844134 12709726

Sources:
TdgClinicalTrial PharmGKB TTD
BUCINDOLOL ADRA2C

Interaction Score: 0.66

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23071495

Sources:
PharmGKB
BUCINDOLOL ADRB2

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name bucindolol hydrochloride,Gencaro

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD

TdgClinicalTrial: BUCINDOLOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of heart failure

Drug Class Small molecule

FDA Approval not approved

Publications:

PharmGKB: bucindolol

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

O'Connor CM et al., 2012, Combinatorial pharmacogenetic interactions of bucindolol and β1, α2C adrenergic receptor polymorphisms., PLoS One

Terra SG et al., 2005, Beta1-adrenergic receptor polymorphisms and left ventricular remodeling changes in response to beta-blocker therapy., Pharmacogenet Genomics

Baudhuin LM et al., 2010, Relation of ADRB1, CYP2D6, and UGT1A1 polymorphisms with dose of, and response to, carvedilol or metoprolol therapy in patients with chronic heart failure., Am J Cardiol

TTD: BUCINDOLOL
- Version: 2020.06.01
Alternate Names:

D03MZJ TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL321582
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	bucindolol hydrochloride,Gencaro
Novel drug target	Established target

BUCINDOLOL Drug Record

BUCINDOLOL chembl:CHEMBL321582

Alternate Names:

Drug Info:

Publications:

BUCINDOLOL ADRB1

Interaction Types & Directionality: n/a

Interaction Info: Trial Name bucindolol hydrochloride,Gencaro Novel drug target Established target

PMIDs: 22617224 21311897 20643254 20352314 20235788 18075464 17496726 16815314 15864115 15861037 15735607 14534524 14502278 12921807 12844134 12709726

Sources: TdgClinicalTrial PharmGKB TTD

BUCINDOLOL ADRA2C

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23071495

Sources: PharmGKB

BUCINDOLOL ADRB2

Interaction Types & Directionality: n/a

Interaction Info: Trial Name bucindolol hydrochloride,Gencaro Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TTD

TdgClinicalTrial: BUCINDOLOL

Alternate Names:

Drug Info: Drug Indications for treatment of heart failure Drug Class Small molecule FDA Approval not approved

Publications:

PharmGKB: bucindolol

Alternate Names:

Drug Info:

TTD: BUCINDOLOL

Alternate Names: D03MZJ TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL321582

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name bucindolol hydrochloride,Gencaro

Novel drug target Established target

PMIDs:
22617224 21311897 20643254 20352314 20235788 18075464 17496726 16815314 15864115 15861037 15735607 14534524 14502278 12921807 12844134 12709726

Sources:
TdgClinicalTrial PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
23071495

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name bucindolol hydrochloride,Gencaro

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD

Drug Info:

Drug Indications for treatment of heart failure

Drug Class Small molecule

FDA Approval not approved

Alternate Names:

D03MZJ TTD Drug ID