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BUDESONIDE Drug Record

  • Summary
  • Interactions
  • Claims
  • BUDESONIDE chembl:CHEMBL1370 ApprovedImmunotherapy

    Alternate Names:

    CORTIMENT
    AIRCORT
    RHINOCORT
    PULMICORT
    ORTIKOS
    PULMAXAN
    MAP-0010
    UCERIS
    BUDESONIDE
    PULMICORT L.S.
    PULMICORT FLEXHALER
    S-1320
    BUDENOFALK
    PULMICORT RESPULES
    RHINOCORT ALLERGY
    MAP0010
    ENTOCORT CR
    RHINOCORT AQUA
    DUORESP SPIROMAX
    ENTOCORT EC
    R01AD05
    SYMBICORT
    ENTOCORT
    BUDELIN NOVOLIZER
    PREFERID
    RHINOCORT AQUA 64
    BUDEFLAM AQUANASE

    Drug Info:

    Drug Class anti-allergic agents
    Drug Class anti-asthmastic agents
    Year of Approval 1994
    Drug Class anti-inflammatory agents
    Drug Class glucocorticoids
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antiinflammatory agent,glucocorticoid
    (4 More Sources)

    Publications:

    Henriksson et al., Effects of topical budesonide treatment on glucocorticoid receptor mRNA down-regulation and cytokine patterns in nasal polyps., Am J Rhinol
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Kompella et al., 2003, Subconjunctival nano- and microparticles sustain retinal delivery of budesonide, a corticosteroid capable of inhibiting VEGF expression., Invest. Ophthalmol. Vis. Sci.
    Kunz et al., 2003, Identification of a novel glucocorticoid receptor mutation in budesonide-resistant human bronchial epithelial cells., Mol. Endocrinol.
    Zhang et al., 2000, Enhancement of human eosinophil apoptosis by fluticasone propionate, budesonide, and beclomethasone., Eur. J. Pharmacol.
    Zhang et al., 2001, Beclomethasone, budesonide and fluticasone propionate inhibit human neutrophil apoptosis., Eur. J. Pharmacol.
    Tantisira KG et al., 2011, Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma., N Engl J Med
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Tsartsali L et al., 2012, Association of hypothalamic-pituitary-adrenal axis-related polymorphisms with stress in asthmatic children on inhaled corticosteroids., Neuroimmunomodulation
    Kim WJ et al., 2009, Association between CRHR1 polymorphism and improved lung function in response to inhaled corticosteroid in patients with COPD., Respirology
    Dijkstra A et al., 2008, Pharmacogenomics and outcome of asthma: no clinical application for long-term steroid effects by CRHR1 polymorphisms., J Allergy Clin Immunol
    Tantisira KG et al., 2004, Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids., Hum Mol Genet
    Andersson et al., 1995, Regulatory effects of aerosolized budesonide and adrenalectomy on the lung content of endothelin-1 in the rat., Respiration
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
  • BUDESONIDE   CRHR1

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22248724 19210659 18539200 15128701


    Sources:
    PharmGKB

  • BUDESONIDE   GLCCI1

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21991891


    Sources:
    PharmGKB

  • BUDESONIDE   EDN1

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7716352


    Sources:
    NCI

  • BUDESONIDE   NR3C1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Trial Name budesonide + formoterol,Symbicort
    Novel drug target Established target
    Trial Name budesonide inhalation suspension,Pulmicort Respules

    PMIDs:
    11258648 11752352 12601049 12920235 11040338 11730731


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • BUDESONIDE   NR1I2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • BUDESONIDE   CYP2C9

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • BUDESONIDE   CYP3A4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9187528 22931300


    Sources:
    DTC PharmGKB

  • BUDESONIDE   CYP2C19

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • BUDESONIDE   CYP1A2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • BUDESONIDE   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TEND: BUDESONIDE

    • Version: 01-August-2011

    Alternate Names:
    BUDESONIDE Primary Drug Name

    Drug Info:
    Drug Class glucocorticoids
    Drug Class anti-inflammatory agents
    Year of Approval 1994

    Publications:

  • TdgClinicalTrial: BUDESONIDE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antiinflammatory agent,glucocorticoid
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: BUDESONIDE

    • Version: 14-September-2017

    Alternate Names:
    C1027 NCI drug code

    Drug Info:

    Publications:
    Andersson et al., 1995, Regulatory effects of aerosolized budesonide and adrenalectomy on the lung content of endothelin-1 in the rat., Respiration

  • DTC: BUDESONIDE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1370 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • PharmGKB: budesonide

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Tantisira KG et al., 2011, Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma., N Engl J Med
    Kim WJ et al., 2009, Association between CRHR1 polymorphism and improved lung function in response to inhaled corticosteroid in patients with COPD., Respirology
    Tantisira KG et al., 2004, Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids., Hum Mol Genet

  • TTD: Budesonide

    • Version: 2020.06.01

    Alternate Names:
    D0Y7IU TTD Drug ID

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1370

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1370

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21