DGIdb - BUDESONIDE Drug Record

BUDESONIDE chembl:CHEMBL1370 ApprovedImmunotherapy

Alternate Names:

CORTIMENT
AIRCORT
RHINOCORT
PULMICORT
ORTIKOS
PULMAXAN
MAP-0010
UCERIS
BUDESONIDE
PULMICORT L.S.
PULMICORT FLEXHALER
S-1320
BUDENOFALK
PULMICORT RESPULES
RHINOCORT ALLERGY
MAP0010
ENTOCORT CR
RHINOCORT AQUA
DUORESP SPIROMAX
ENTOCORT EC
R01AD05
SYMBICORT
ENTOCORT
BUDELIN NOVOLIZER
PREFERID
RHINOCORT AQUA 64
BUDEFLAM AQUANASE

Drug Info:

Drug Class	anti-allergic agents
Drug Class	anti-asthmastic agents
Year of Approval	1994
Drug Class	anti-inflammatory agents
Drug Class	glucocorticoids
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antiinflammatory agent,glucocorticoid

(4 More Sources)

Publications:

Henriksson et al., Effects of topical budesonide treatment on glucocorticoid receptor mRNA down-regulation and cytokine patterns in nasal polyps., Am J Rhinol
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Kompella et al., 2003, Subconjunctival nano- and microparticles sustain retinal delivery of budesonide, a corticosteroid capable of inhibiting VEGF expression., Invest. Ophthalmol. Vis. Sci.
Kunz et al., 2003, Identification of a novel glucocorticoid receptor mutation in budesonide-resistant human bronchial epithelial cells., Mol. Endocrinol.
Zhang et al., 2000, Enhancement of human eosinophil apoptosis by fluticasone propionate, budesonide, and beclomethasone., Eur. J. Pharmacol.
Zhang et al., 2001, Beclomethasone, budesonide and fluticasone propionate inhibit human neutrophil apoptosis., Eur. J. Pharmacol.
Tantisira KG et al., 2011, Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma., N Engl J Med
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Tsartsali L et al., 2012, Association of hypothalamic-pituitary-adrenal axis-related polymorphisms with stress in asthmatic children on inhaled corticosteroids., Neuroimmunomodulation
Kim WJ et al., 2009, Association between CRHR1 polymorphism and improved lung function in response to inhaled corticosteroid in patients with COPD., Respirology
Dijkstra A et al., 2008, Pharmacogenomics and outcome of asthma: no clinical application for long-term steroid effects by CRHR1 polymorphisms., J Allergy Clin Immunol
Tantisira KG et al., 2004, Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids., Hum Mol Genet
Andersson et al., 1995, Regulatory effects of aerosolized budesonide and adrenalectomy on the lung content of endothelin-1 in the rat., Respiration
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

BUDESONIDE CRHR1

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22248724 19210659 18539200 15128701

Sources:
PharmGKB
BUDESONIDE GLCCI1

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21991891

Sources:
PharmGKB
BUDESONIDE EDN1

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7716352

Sources:
NCI
BUDESONIDE NR3C1

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name budesonide + formoterol,Symbicort

Novel drug target Established target

Trial Name budesonide inhalation suspension,Pulmicort Respules

PMIDs:
11258648 11752352 12601049 12920235 11040338 11730731

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
BUDESONIDE NR1I2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
BUDESONIDE CYP2C9

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
BUDESONIDE CYP3A4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528 22931300

Sources:
DTC PharmGKB
BUDESONIDE CYP2C19

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
BUDESONIDE CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
BUDESONIDE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

TEND: BUDESONIDE
- Version: 01-August-2011
Alternate Names:

BUDESONIDE Primary Drug Name

Drug Info:

Drug Class glucocorticoids

Drug Class anti-inflammatory agents

Year of Approval 1994

Publications:
TdgClinicalTrial: BUDESONIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiinflammatory agent,glucocorticoid

Drug Class Small Molecule

FDA Approval approved

Publications:
NCI: BUDESONIDE
- Version: 14-September-2017
Alternate Names:

C1027 NCI drug code

Drug Info:

Publications:

Andersson et al., 1995, Regulatory effects of aerosolized budesonide and adrenalectomy on the lung content of endothelin-1 in the rat., Respiration
DTC: BUDESONIDE
- Version: 02-September-2020
Alternate Names:

CHEMBL1370 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

PharmGKB: budesonide

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Tantisira KG et al., 2011, Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma., N Engl J Med

Kim WJ et al., 2009, Association between CRHR1 polymorphism and improved lung function in response to inhaled corticosteroid in patients with COPD., Respirology

Tantisira KG et al., 2004, Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids., Hum Mol Genet

TTD: Budesonide
- Version: 2020.06.01
Alternate Names:

D0Y7IU TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL1370
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1370
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	budesonide + formoterol,Symbicort
Novel drug target	Established target
Trial Name	budesonide inhalation suspension,Pulmicort Respules

agonist (activating)
antagonist (inhibitory)

BUDESONIDE Drug Record

BUDESONIDE chembl:CHEMBL1370 ApprovedImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22248724 19210659 18539200 15128701

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21991891

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7716352

Sources: NCI

Interaction Types & Directionality: agonist (activating) antagonist (inhibitory)

Interaction Info: Trial Name budesonide + formoterol,Symbicort Novel drug target Established target Trial Name budesonide inhalation suspension,Pulmicort Respules

PMIDs: 11258648 11752352 12601049 12920235 11040338 11730731

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528 22931300

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

TEND: BUDESONIDE

Alternate Names: BUDESONIDE Primary Drug Name

Drug Info: Drug Class glucocorticoids Drug Class anti-inflammatory agents Year of Approval 1994

Publications:

TdgClinicalTrial: BUDESONIDE

Alternate Names:

Drug Info: Drug Indications antiinflammatory agent,glucocorticoid Drug Class Small Molecule FDA Approval approved

Publications:

NCI: BUDESONIDE

Alternate Names: C1027 NCI drug code

Drug Info:

Publications: Andersson et al., 1995, Regulatory effects of aerosolized budesonide and adrenalectomy on the lung content of endothelin-1 in the rat., Respiration

DTC: BUDESONIDE

Alternate Names: CHEMBL1370 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

PharmGKB: budesonide

Alternate Names:

Drug Info:

TTD: Budesonide

Alternate Names: D0Y7IU TTD Drug ID

Drug Info:

Publications:

ChemblInteractions: CHEMBL1370

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1370

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
22248724 19210659 18539200 15128701

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21991891

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
7716352

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name budesonide + formoterol,Symbicort

Novel drug target Established target

Trial Name budesonide inhalation suspension,Pulmicort Respules

PMIDs:
11258648 11752352 12601049 12920235 11040338 11730731

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9187528 22931300

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

BUDESONIDE Primary Drug Name

Drug Info:

Drug Class glucocorticoids

Drug Class anti-inflammatory agents

Year of Approval 1994

Drug Info:

Drug Indications antiinflammatory agent,glucocorticoid

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C1027 NCI drug code

Publications:

Andersson et al., 1995, Regulatory effects of aerosolized budesonide and adrenalectomy on the lung content of endothelin-1 in the rat., Respiration

Alternate Names:

CHEMBL1370 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

D0Y7IU TTD Drug ID