DGIdb - BUMETANIDE Drug Record

BUMETANIDE chembl:CHEMBL1072 Approved

Alternate Names:

RO-106338
BETINEX
LIXIL
BURINEX
RO-10-6338
BUMETANIDE
BUMEX
3-(AMINOSULFONYL)-5-(BUTYLAMINO)-4-PHENOXYBENZOIC ACID
RO 10-6338
BURINEX®
BUMEX®
PF 1593
3-BUTYLAMINO-4-(PHENOXY)-5-SULFAMOYLBENZOIC ACID
rxcui:1808
drugbank:00887
pubchem.compound:2471
chembl:CHEMBL1072
chemidplus:28395-03-1

Drug Info:

Drug Class	diuretics
Year of Approval	1983
Drug Class	antihypertensive agents
FDA Approval	1983
Drug Class	small molecule
Drug Indications	Diuretics
Drug Indications	Antihypertensive Agents

(4 More Sources)

Publications:

Károlyi et al., 1998, The molecular genetic approach to "Bartter's syndrome"., J. Mol. Med.
Long et al., 2009, Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release., J. Biol. Chem.
Thakker, 1998, The role of renal chloride channel mutations in kidney stone disease and nephrocalcinosis., Curr. Opin. Nephrol. Hypertens.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Thakker, 1999, Chloride channels in renal disease., Adv. Nephrol. Necker Hosp.
Wall et al., 2001, Contribution of the Na+-K+-2Cl- cotransporter NKCC1 to Cl- secretion in rat OMCD., Am. J. Physiol. Renal Physiol.
Jiang et al., 2001, Growth factors stimulate the Na-K-2Cl cotransporter NKCC1 through a novel Cl(-)-dependent mechanism., Am. J. Physiol., Cell Physiol.
Panet et al., 2000, Overexpression of the Na(+)/K(+)/Cl(-) cotransporter gene induces cell proliferation and phenotypic transformation in mouse fibroblasts., J. Cell. Physiol.
Evans et al., 2000, Severe impairment of salivation in Na+/K+/2Cl- cotransporter (NKCC1)-deficient mice., J. Biol. Chem.
Akar et al., 2001, Contractile regulation of the Na(+)-K(+)-2Cl(-) cotransporter in vascular smooth muscle., Am. J. Physiol., Cell Physiol.
Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J
Vormfelde et al., 2007, Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs., Clin. Pharmacol. Ther.
Reid et al., 2000, Agents which block potassium-chloride cotransport prevent sound-triggered seizures in post-ischemic audiogenic seizure-prone rats., Brain Res.
Panet et al., 2002, Na(+)/K(+)/Cl(-) cotransporter activates mitogen-activated protein kinase in fibroblasts and lymphocytes., J. Cell. Physiol.
Jean-Xavier et al., 2006, Inhibitory postsynaptic potentials in lumbar motoneurons remain depolarizing after neonatal spinal cord transection in the rat., J. Neurophysiol.

BUMETANIDE SLC12A2

Interaction Score: 33.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11292635 11698253 10567922 10831596 11443057

Sources:
TdgClinicalTrial TEND
BUMETANIDE SLC12A4

Interaction Score: 19.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16807348 10793196

Sources:
TdgClinicalTrial TEND
BUMETANIDE SLC12A5

Interaction Score: 14.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10793196

Sources:
TdgClinicalTrial TEND
BUMETANIDE SLC12A1

Interaction Score: 3.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
9587066 19141616 9690036 11752352 10561751

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
BUMETANIDE NPPA-AS1

Interaction Score: 3.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298

Sources:
PharmGKB
BUMETANIDE ADD1

Interaction Score: 1.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298

Sources:
PharmGKB
BUMETANIDE SLC12A3

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298 17460608

Sources:
PharmGKB
BUMETANIDE GNB3

Interaction Score: 0.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298

Sources:
PharmGKB
BUMETANIDE ACE

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298

Sources:
PharmGKB
BUMETANIDE MAPK1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11807827

Sources:
NCI
BUMETANIDE KDM4E

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BUMETANIDE HSD17B10

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BUMETANIDE NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: BUMETANIDE
- Version: 01-August-2011
Alternate Names:

BUMETANIDE Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1983

Drug Class diuretics

Publications:
TdgClinicalTrial: BUMETANIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Diuretics

Drug Class small molecule

Publications:
NCI: BUMETANIDE
- Version: 14-September-2017
Alternate Names:

C28875 NCI drug code

Drug Info:

Publications:

Panet et al., 2002, Na(+)/K(+)/Cl(-) cotransporter activates mitogen-activated protein kinase in fibroblasts and lymphocytes., J. Cell. Physiol.

PharmGKB: bumetanide

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J

Vormfelde et al., 2007, Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs., Clin. Pharmacol. Ther.

DTC: BUMETANIDE
- Version: 02-September-2020
Alternate Names:

CHEMBL1072 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Bumetanide
- Version: 2020.06.01
Alternate Names:

D0R7HO TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1072
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1072
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Sodium-(potassium)-chloride cotransporter 2 inhibitor
Direct Interaction	yes
Trial Name	-

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

BUMETANIDE Drug Record

BUMETANIDE chembl:CHEMBL1072 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11292635 11698253 10567922 10831596 11443057

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16807348 10793196

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10793196

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor Direct Interaction yes Trial Name -

PMIDs: 9587066 19141616 9690036 11752352 10561751

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20877298

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20877298

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20877298 17460608

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20877298

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20877298

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11807827

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: BUMETANIDE

Alternate Names: BUMETANIDE Primary Drug Name

Drug Info: Drug Class antihypertensive agents Year of Approval 1983 Drug Class diuretics

Publications:

TdgClinicalTrial: BUMETANIDE

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents Drug Indications Diuretics Drug Class small molecule

Publications:

NCI: BUMETANIDE

Alternate Names: C28875 NCI drug code

Drug Info:

Publications: Panet et al., 2002, Na(+)/K(+)/Cl(-) cotransporter activates mitogen-activated protein kinase in fibroblasts and lymphocytes., J. Cell. Physiol.

PharmGKB: bumetanide

Alternate Names:

Drug Info:

Publications: Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J Vormfelde et al., 2007, Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs., Clin. Pharmacol. Ther.

DTC: BUMETANIDE

Alternate Names: CHEMBL1072 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Bumetanide

Alternate Names: D0R7HO TTD Drug ID

Drug Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11292635 11698253 10567922 10831596 11443057

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16807348 10793196

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10793196

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
9587066 19141616 9690036 11752352 10561751

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
20877298

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20877298

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20877298 17460608

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20877298

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20877298

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11807827

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

BUMETANIDE Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1983

Drug Class diuretics

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Diuretics

Drug Class small molecule

Alternate Names:

C28875 NCI drug code

Publications:

Panet et al., 2002, Na(+)/K(+)/Cl(-) cotransporter activates mitogen-activated protein kinase in fibroblasts and lymphocytes., J. Cell. Physiol.

Publications:

Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J

Vormfelde et al., 2007, Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs., Clin. Pharmacol. Ther.

Alternate Names:

CHEMBL1072 ChEMBL Drug ID

Alternate Names:

D0R7HO TTD Drug ID