DGIdb - BUPIVACAINE Drug Record

BUPIVACAINE chembl:CHEMBL1098 Approved

Alternate Names:

SKY-0402
LIQ-865
SENSORCAINE
EXPAREL
LIQ865
ANEKAIN
MARCAINE
BUPIVACAINE

Drug Info:

Year of Approval	approved before 1982
Drug Class	anesthetics, local
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	local anestethic,analgesic,neuralgia

(2 More Sources)

Publications:

Nilsson et al., 2003, Local anesthetic block of Kv channels: role of the S6 helix and the S5-S6 linker for bupivacaine action., Mol. Pharmacol.
Sheets et al., 2010, Sodium channel molecular conformations and antiarrhythmic drug affinity., Trends Cardiovasc. Med.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Sakuma et al., 2000, Differential adaptation of growth and differentiation factor 8/myostatin, fibroblast growth factor 6 and leukemia inhibitory factor in overloaded, regenerating and denervated rat muscles., Biochim. Biophys. Acta
Beloeil et al., 2005, Bupivacaine's action on the carrageenan-induced inflammatory response in mice: cytokine production by leukocytes after ex-vivo stimulation., Anesth. Analg.
Hirata et al., 2007, Increased expression of neuregulin-1 in differentiating muscle satellite cells and in motoneurons during muscle regeneration., Acta Neuropathol.
Duguez et al., 2003, Myogenic and nonmyogenic cells differentially express proteinases, Hsc/Hsp70, and BAG-1 during skeletal muscle regeneration., Am. J. Physiol. Endocrinol. Metab.
Tanaka et al., 2008, Expression of mRNA for specific fibroblast growth factors associates with that of the myogenic markers MyoD and proliferating cell nuclear antigen in regenerating and overloaded rat plantaris muscle., Acta Physiol (Oxf)
Galenko-Yaroshevskii et al., 2003, Pharmacokinetics and pharmacodynamics of a new local anesthetic agent., Bull. Exp. Biol. Med.

BUPIVACAINE FGF6

Interaction Score: 12.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10838161

Sources:
NCI
BUPIVACAINE MYOD1

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18429950

Sources:
NCI
BUPIVACAINE LIF

Interaction Score: 1.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10838161

Sources:
NCI
BUPIVACAINE KCNA1

Interaction Score: 1.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12761353

Sources:
NCI
BUPIVACAINE HSPA8

Interaction Score: 0.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12791605

Sources:
NCI
BUPIVACAINE BCHE

Interaction Score: 0.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14631501

Sources:
NCI
BUPIVACAINE NRG1

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17294200

Sources:
NCI
BUPIVACAINE SCN10A

Interaction Score: 0.49

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Durect

Trial Name DUR-843,Eladur, Transdur-Bupivacaine

Trial Name DepoBupivacaine, bupivacaine,Exparel

PMIDs:
20685573 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD
BUPIVACAINE TNF

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15781526

Sources:
NCI
BUPIVACAINE SCN4A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel protein type IV alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

TEND: BUPIVACAINE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Drug Class anesthetics, local

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: BUPIVACAINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications local anestethic,analgesic,neuralgia

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: BUPIVACAINE

Version: 14-September-2017

Alternate Names:

C28876 NCI drug code

Drug Info:

Publications:

Nilsson et al., 2003, Local anesthetic block of Kv channels: role of the S6 helix and the S5-S6 linker for bupivacaine action., Mol. Pharmacol.

Duguez et al., 2003, Myogenic and nonmyogenic cells differentially express proteinases, Hsc/Hsp70, and BAG-1 during skeletal muscle regeneration., Am. J. Physiol. Endocrinol. Metab.

Galenko-Yaroshevskii et al., 2003, Pharmacokinetics and pharmacodynamics of a new local anesthetic agent., Bull. Exp. Biol. Med.

TTD: Bupivacaine
- Version: 2020.06.01
Alternate Names:

D0A0FL TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL1098
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1098
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	Durect
Trial Name	DUR-843,Eladur, Transdur-Bupivacaine
Trial Name	DepoBupivacaine, bupivacaine,Exparel

Mechanism of Interaction	Sodium channel protein type IV alpha subunit blocker
Direct Interaction	yes

BUPIVACAINE Drug Record

BUPIVACAINE chembl:CHEMBL1098 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10838161

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18429950

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10838161

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12761353

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12791605

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14631501

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17294200

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Durect Trial Name DUR-843,Eladur, Transdur-Bupivacaine Trial Name DepoBupivacaine, bupivacaine,Exparel

PMIDs: 20685573 17016423 17139284

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15781526

Sources: NCI

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel protein type IV alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

TEND: BUPIVACAINE

Alternate Names:

Drug Info: Drug Class anesthetics, local Year of Approval approved before 1982

Publications:

TdgClinicalTrial: BUPIVACAINE

Alternate Names:

Drug Info: Drug Indications local anestethic,analgesic,neuralgia Drug Class Small Molecule FDA Approval approved

Publications:

NCI: BUPIVACAINE

Alternate Names: C28876 NCI drug code

Drug Info:

TTD: Bupivacaine

Alternate Names: D0A0FL TTD Drug ID

Drug Info:

Publications:

ChemblInteractions: CHEMBL1098

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1098

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
10838161

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18429950

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10838161

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12761353

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12791605

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14631501

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17294200

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Durect

Trial Name DUR-843,Eladur, Transdur-Bupivacaine

Trial Name DepoBupivacaine, bupivacaine,Exparel

PMIDs:
20685573 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
15781526

Sources:
NCI

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel protein type IV alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Drug Info:

Drug Class anesthetics, local

Year of Approval approved before 1982

Drug Info:

Drug Indications local anestethic,analgesic,neuralgia

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C28876 NCI drug code

Alternate Names:

D0A0FL TTD Drug ID