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BUTABARBITAL Drug Record

  • Summary
  • Interactions
  • Claims
  • BUTABARBITAL chembl:CHEMBL449 Approved

    Alternate Names:

    SECBUTABARBITAL
    SECBUTOBARBITONE
    BUTABARBITAL
    5-SEC-BUTYL-5-ETHYLBARBITURIC ACID
    5-ETHYL-5-(1-METHYLPROPYL)BARBITURIC ACID
    BUTISOL
    5-SEC-BUTYL-5-ETHYL-2,4,6(1H,3H,5H)-PYRIMIDINETRIONE
    5-SEC-BUTYL-5-ETHYLPYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE
    5-ETHYL-5-(1-METHYLPROPYL)-2,4,6(1H,3H,5H)-PYRIMIDINETRIONE
    BUTISOL®
    chembl:CHEMBL449
    rxcui:477631
    pubchem.compound:2479
    chemidplus:125-40-6
    drugbank:00237

    Drug Info:

    Year of Approval approved before 1982
    Drug Class hypnotics and sedatives
    FDA Approval Approved before 1982
    Drug Class small molecule
    Drug Indications Hypnotics and Sedatives
    Drug Categories anticholinergic agents
    Drug Categories anticonvulsants
    Drug Categories barbiturates
    Drug Categories drugs that are mainly renally excreted
    Drug Categories nervous system
    Drug Categories nicotinic antagonists
    Drug Categories psycholeptics
    (1 More Sources)

    Publications:

    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.
    Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.
  • BUTABARBITAL   GRIK5

    Interaction Score: 2.37

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 10487207


    Sources:
    DrugBank

  • BUTABARBITAL   GRIK3

    Interaction Score: 1.58

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 10487207


    Sources:
    DrugBank

  • BUTABARBITAL   GRIK4

    Interaction Score: 1.35

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 10487207


    Sources:
    DrugBank

  • BUTABARBITAL   GRIK1

    Interaction Score: 1.35

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 10487207


    Sources:
    DrugBank

  • BUTABARBITAL   CHRNA10

    Interaction Score: 1.15

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 16248797 10487207


    Sources:
    DrugBank

  • BUTABARBITAL   GRIK2

    Interaction Score: 0.72

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • BUTABARBITAL   GRIA4

    Interaction Score: 0.43

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 10487207


    Sources:
    DrugBank

  • BUTABARBITAL   GRIA3

    Interaction Score: 0.34

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 10487207


    Sources:
    DrugBank

  • BUTABARBITAL   GRIA2

    Interaction Score: 0.32

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 10487207


    Sources:
    TEND TdgClinicalTrial DrugBank

  • BUTABARBITAL   GRIA1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    11264449 10487207


    Sources:
    DrugBank

  • BUTABARBITAL   CHRNA4

    Interaction Score: 0.28

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 16248797 10487207


    Sources:
    TEND TdgClinicalTrial

  • BUTABARBITAL   CHRNA7

    Interaction Score: 0.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11264449 16248797 10487207


    Sources:
    TEND TdgClinicalTrial

  • BUTABARBITAL   GABRA1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    11264449 10209232


    Sources:
    TEND TdgClinicalTrial TTD DrugBank

  • BUTABARBITAL   GABRA4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial

  • BUTABARBITAL   GABRA6

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial

  • BUTABARBITAL   GABRA5

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial

  • BUTABARBITAL   GABRA2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial

  • BUTABARBITAL   GABRA3

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial

  • DrugBank: DB00237

    • Version: 5.1.7

    Alternate Names:
    BUTABARBITAL DrugBank Drug Name
    125-40-6 CAS Number
    Butalan Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups illicit

    Publications:
    Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
    Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.
    Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.

  • TEND: BUTABARBITAL

    • Version: 01-August-2011

    Alternate Names:
    BUTABARBITAL Primary Drug Name

    Drug Info:
    Drug Class hypnotics and sedatives
    Year of Approval approved before 1982

    Publications:

  • TdgClinicalTrial: BUTABARBITAL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Hypnotics and Sedatives
    Drug Class small molecule
    FDA Approval Approved before 1982

    Publications:

  • TTD: Butabarbital

    • Version: 2020.06.01

    Alternate Names:
    D0A4JK TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL449

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21