DGIdb - BUTETHAL Drug Record

BUTETHAL chembl:CHEMBL404422 Approved

Alternate Names:

BUTOBARBITAL
BUTOBARBITONE
NEONAL
BUTETHAL
SONERYL
drugbank:01353
chembl:CHEMBL404422
chemidplus:77-28-1
rxcui:19874
pubchem.compound:6473

Drug Info:

Drug Class	hypnotics and sedatives
Year of Approval	not approved by the fda
FDA Approval	not approved by the FDA
Drug Class	small molecule
Drug Indications	Hypnotics and Sedatives

(0 More Sources)

Publications:

Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.
Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.
Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.
Whiting, 2003, The GABAA receptor gene family: new opportunities for drug development., Curr Opin Drug Discov Devel
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

BUTETHAL GRIK2

Interaction Score: 1.65

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
TdgClinicalTrial TEND
BUTETHAL GRIA2

Interaction Score: 0.88

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
TdgClinicalTrial TEND
BUTETHAL CHRNA7

Interaction Score: 0.84

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND
BUTETHAL CHRNA4

Interaction Score: 0.81

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND
BUTETHAL GABRA1

Interaction Score: 0.68

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 14579514 10209232 11752352 10487207 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD
BUTETHAL GABRA6

Interaction Score: 0.37

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND
BUTETHAL GABRA5

Interaction Score: 0.34

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND
BUTETHAL GABRA3

Interaction Score: 0.33

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND
BUTETHAL GABRA2

Interaction Score: 0.32

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND
BUTETHAL GABRA4

Interaction Score: 0.28

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232

Sources:
TdgClinicalTrial TEND

TEND: BUTETHAL
- Version: 01-August-2011
Alternate Names:

BUTETHAL Primary Drug Name

Drug Info:

Year of Approval not approved by the fda

Drug Class hypnotics and sedatives

Publications:
TdgClinicalTrial: BUTETHAL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Hypnotics and Sedatives

Drug Class small molecule

FDA Approval not approved by the FDA

Publications:
TTD: Butethal
- Version: 2020.06.01
Alternate Names:

D0O3AB TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL404422
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

BUTETHAL Drug Record

BUTETHAL chembl:CHEMBL404422 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11264449 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11264449 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16248797 11264449 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16248797 11264449 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11264449 14579514 10209232 11752352 10487207 17016423 17139284

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: potentiator

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 10209232 11264449

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10209232 11264449

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10209232 11264449

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10209232 11264449

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10209232

Sources: TdgClinicalTrial TEND

TEND: BUTETHAL

Alternate Names: BUTETHAL Primary Drug Name

Drug Info: Year of Approval not approved by the fda Drug Class hypnotics and sedatives

Publications:

TdgClinicalTrial: BUTETHAL

Alternate Names:

Drug Info: Drug Indications Hypnotics and Sedatives Drug Class small molecule FDA Approval not approved by the FDA

Publications:

TTD: Butethal

Alternate Names: D0O3AB TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL404422

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 14579514 10209232 11752352 10487207 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10209232

Sources:
TdgClinicalTrial TEND

Alternate Names:

BUTETHAL Primary Drug Name

Drug Info:

Year of Approval not approved by the fda

Drug Class hypnotics and sedatives

Drug Info:

Drug Indications Hypnotics and Sedatives

Drug Class small molecule

FDA Approval not approved by the FDA

Alternate Names:

D0O3AB TTD Drug ID