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BUTORPHANOL Drug Record

  • Summary
  • Interactions
  • Claims
  • BUTORPHANOL chembl:CHEMBL33986 Approved

    Alternate Names:

    BUTORPHANOL
    LEVO-BC-2627
    (-)-N-CYCLOBUTYLMETHYL-3,14-DIHYDROXYMORPHINAN
    BUTORFANOL
    (-)-BUTORPHANOL
    BUTORPHANOLUM
    (-)-17-(CYCLOBUTYLMETHYL)MORPHINAN-3,14-DIOL
    BUTORPHANOL TARTRATE
    rxcui:1841
    pubchem.compound:5361092
    chembl:CHEMBL33986
    drugbank:00611
    chemidplus:42408-82-2

    Drug Info:

    Drug Class analgesics, opioid
    Year of Approval 1978
    FDA Approval 1978
    Drug Class small molecule
    Drug Indications Analgesics, Opioid
    (1 More Sources)

    Publications:

    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Fan et al., 2002, Withdrawal from dependence upon butorphanol uniquely increases kappa(1)-opioid receptor binding in the rat brain., Brain Res. Bull.
    Picker, 1997, Discriminative stimulus effects of the mixed-opioid agonist/antagonist dezocine: cross-substitution by mu and delta opioid agonists., J. Pharmacol. Exp. Ther.
    Vivian et al., 1999, kappa-Opioid receptor effects of butorphanol in rhesus monkeys., J. Pharmacol. Exp. Ther.
    Fan et al., 2002, Butorphanol dependence and withdrawal decrease hippocampal kappa 2-opioid receptor binding., Brain Res.
    Picker et al., 1996, Discriminative stimulus effects of butorphanol: influence of training dose on the substitution patterns produced by Mu, Kappa and Delta opioid agonists., J. Pharmacol. Exp. Ther.
    Walsh et al., 2008, Evaluation of the mu and kappa opioid actions of butorphanol in humans through differential naltrexone blockade., Psychopharmacology (Berl.)
    Narita et al., 1994, Repeated administration of opioids alters characteristics of membrane-bound phorbol ester binding in rat brain., Eur. J. Pharmacol.
    Commiskey et al., 2005, Butorphanol: effects of a prototypical agonist-antagonist analgesic on kappa-opioid receptors., J. Pharmacol. Sci.
    Wakabayashi et al., 1995, Simultaneous measurement of biogenic amines and their metabolites in rat brain regions after acute administration of and abrupt withdrawal from butorphanol or morphine., Neurochem. Res.
    Ohta et al., 1989, [Kappa-type opioid receptor in human placental membrane]., Masui
    Park et al., 2000, kappa-opioid agonist stimulated regional distribution of [(35)S]GTPgammas binding in butorphanol continuously infused rat., Brain Res. Bull.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
  • BUTORPHANOL   OPRD1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    12127012 8968334 12470863 17909753 7705457 15942128 11752352 8746803


    Sources:
    TdgClinicalTrial TEND TTD

  • BUTORPHANOL   OPRK1

    Interaction Score: 1.56

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    12127012 10381785 12470863 8968334 17909753 2555580 7705457 15942128 8746803 10779697


    Sources:
    TdgClinicalTrial TEND

  • BUTORPHANOL   OPRM1

    Interaction Score: 0.93

    Interaction Types & Directionality:
    agonist (activating)
    partial antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    12127012 9399970 10381785 12470863 8968334 17909753 7705457 15942128 8746803


    Sources:
    TdgClinicalTrial TEND

  • BUTORPHANOL   CYP2C9

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • BUTORPHANOL   CYP2C19

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • BUTORPHANOL   CYP1A2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • BUTORPHANOL   CYP3A4

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TEND: BUTORPHANOL

    • Version: 01-August-2011

    Alternate Names:
    BUTORPHANOL Primary Drug Name

    Drug Info:
    Year of Approval 1978
    Drug Class analgesics, opioid

    Publications:

  • TdgClinicalTrial: BUTORPHANOL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Analgesics, Opioid
    Drug Class small molecule
    FDA Approval 1978

    Publications:

  • DTC: BUTORPHANOL

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL33986 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • TTD: Butorphanol

    • Version: 2020.06.01

    Alternate Names:
    D0X9RG TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL33986

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21