DGIdb - CANDESARTAN Drug Record

CANDESARTAN chembl:CHEMBL1016

Alternate Names:

CV-11974
CANDESARTAN CILEXETIL RELATED COMPOUND G
CANDESARTAN
2-ETHOXY-1-{[2'-(1H-TETRAZOL-5-YL)BIPHENYL-4ETHYL]}-1H-BENZIMIDAZOLE-7-CARBOXYLIC ACID
2-ETHOXY-1-{[2'-(1H-TETRAZOL-5-YL)BIPHENYL-4-YL]METHYL}-1H-BENZIMIDAZOLE-7-CARBOXYLIC ACID
TCV-116 (PRODRUG)
2-ETHOXY-1-(P-(O-1H-TETRAZOL-5-YLPHENYL)BENZYL)-7-BENZIMIDAZOLECARBOXYLIC ACID
pubchem.compound:2541
rxcui:214354
drugbank:00796
chemidplus:139481-59-7
chembl:CHEMBL1016

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antihypertensive agent
Year of Approval	1998
Drug Class	antihypertensive agents

(1 More Sources)

Publications:

Iniesta R et al., 2019, Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals., Hypertension
de Denus S et al., 2008, Effects of AGTR1 A1166C gene polymorphism in patients with heart failure treated with candesartan., Ann Pharmacother
McInnes et al., 2000, Comparison of the AT1-receptor blocker, candesartan cilexetil, and the ACE inhibitor, lisinopril, in fixed combination with low dose hydrochlorothiazide in hypertensive patients., J Hum Hypertens
Mendis et al., 2009, Candesartan: widening indications for this angiotensin II receptor blocker?, Expert Opin Pharmacother
Caballero-George et al., 2003, In vitro effect of sanguinarine alkaloid on binding of [3H]candesartan to the human angiotensin AT1 receptor., Eur. J. Pharmacol.
Baguet et al., 2009, Candesartan cilexetil in the treatment of chronic heart failure., Vasc Health Risk Manag
Wada et al., 1996, Comparison of the antihypertensive effects of the new angiotensin II (AT1) receptor antagonist candesartan cilexetil (TCV-116) and the angiotensin converting enzyme inhibitor enalapril in rats., Hypertens. Res.
Meredith, 2007, Candesartan cilexetil--a review of effects on cardiovascular complications in hypertension and chronic heart failure., Curr Med Res Opin
Engelhorn et al., 2006, Reduction of cerebral infarct size by the AT1-receptor blocker candesartan, the HMG-CoA reductase inhibitor rosuvastatin and their combination. An experimental study in rats., Neurosci. Lett.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Malmqvist et al., 2000, Angiotensin II type 1 (AT1) receptor blockade in hypertensive women: benefits of candesartan cilexetil versus enalapril or hydrochlorothiazide., Am. J. Hypertens.
Cervenka et al., 1999, Renal responses of the nonclipped kidney of two-kidney/one-clip Goldblatt hypertensive rats to type 1 angiotensin II receptor blockade with candesartan., J. Am. Soc. Nephrol.
Vauquelin et al., 2006, Long-lasting angiotensin type 1 receptor binding and protection by candesartan: comparison with other biphenyl-tetrazole sartans., J Hypertens Suppl
Kurland L et al., 2001, Angiotensin converting enzyme gene polymorphism predicts blood pressure response to angiotensin II receptor type 1 antagonist treatment in hypertensive patients., J Hypertens
Ortlepp JR et al., 2002, Variants of the CYP11B2 gene predict response to therapy with candesartan., Eur J Pharmacol

CANDESARTAN SULT1C3

Interaction Score: 13.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31327267

Sources:
PharmGKB
CANDESARTAN SH2B3

Interaction Score: 13.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31327267

Sources:
PharmGKB
CANDESARTAN PLEKHJ1

Interaction Score: 13.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31327267

Sources:
PharmGKB
CANDESARTAN DOT1L

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31327267

Sources:
PharmGKB
CANDESARTAN GPR83

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CANDESARTAN CYP11B2

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12065207

Sources:
PharmGKB
CANDESARTAN AGTR1

Interaction Score: 2.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name candesartan cilexetil,Atacand

Novel drug target Established target

PMIDs:
18594050 10805052 19563275 12504781 19436650 10968199 17588300 16901636 11752352 10826401 9892163 16601569

Sources:
TdgClinicalTrial TEND PharmGKB TTD
CANDESARTAN KCNK3

Interaction Score: 1.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31327267

Sources:
PharmGKB
CANDESARTAN ACE

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11593098 12065207

Sources:
PharmGKB

TEND: CANDESARTAN
- Version: 01-August-2011
Alternate Names:

CANDESARTAN Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1998

Publications:
TdgClinicalTrial: CANDESARTAN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Publications:

PharmGKB: candesartan

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

de Denus S et al., 2008, Effects of AGTR1 A1166C gene polymorphism in patients with heart failure treated with candesartan., Ann Pharmacother

Iniesta R et al., 2019, Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals., Hypertension

Ortlepp JR et al., 2002, Variants of the CYP11B2 gene predict response to therapy with candesartan., Eur J Pharmacol

TTD: Candesartan
- Version: 2020.06.01
Alternate Names:

D0D5SQ TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1016
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	candesartan cilexetil,Atacand
Novel drug target	Established target

CANDESARTAN Drug Record

CANDESARTAN chembl:CHEMBL1016

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31327267

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31327267

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31327267

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31327267

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12065207

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name candesartan cilexetil,Atacand Novel drug target Established target

PMIDs: 18594050 10805052 19563275 12504781 19436650 10968199 17588300 16901636 11752352 10826401 9892163 16601569

Sources: TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31327267

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11593098 12065207

Sources: PharmGKB

TEND: CANDESARTAN

Alternate Names: CANDESARTAN Primary Drug Name

Drug Info: Drug Class antihypertensive agents Year of Approval 1998

Publications:

TdgClinicalTrial: CANDESARTAN

Alternate Names:

Drug Info: Drug Indications antihypertensive agent Drug Class Small Molecule FDA Approval approved

Publications:

PharmGKB: candesartan

Alternate Names:

Drug Info:

TTD: Candesartan

Alternate Names: D0D5SQ TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1016

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
31327267

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
31327267

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
31327267

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
31327267

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12065207

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name candesartan cilexetil,Atacand

Novel drug target Established target

PMIDs:
18594050 10805052 19563275 12504781 19436650 10968199 17588300 16901636 11752352 10826401 9892163 16601569

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
31327267

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11593098 12065207

Sources:
PharmGKB

Alternate Names:

CANDESARTAN Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 1998

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

D0D5SQ TTD Drug ID