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CANNABIDIOL Drug Record

  • Summary
  • Interactions
  • Claims
  • CANNABIDIOL chembl:CHEMBL190461 Approved

    Alternate Names:

    CBD
    GWP42003
    GWP-42003-P
    GWP-42003
    CANNABIDIOL
    BTX-1503
    EPIDIOLEX
    GWP42003-P

    Drug Info:

    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational
    Drug Categories agents producing tachycardia
    Drug Categories agents that produce hypertension
    Drug Categories anticonvulsants
    Drug Categories antidepressive agents
    Drug Categories bcrp/abcg2 inhibitors
    Drug Categories cannabinoids and similars
    Drug Categories central nervous system depressants
    Drug Categories cytochrome p-450 cyp1a2 inhibitors
    Drug Categories cytochrome p-450 cyp1a2 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp2c19 substrates
    Drug Categories cytochrome p-450 cyp2c9 substrates
    Drug Categories cytochrome p-450 cyp2d6 inhibitors
    Drug Categories cytochrome p-450 cyp2d6 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp2d6 substrates
    Drug Categories cytochrome p-450 cyp3a inhibitors
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 cyp3a4 substrates
    Drug Categories cytochrome p-450 cyp3a5 inhibitors
    Drug Categories cytochrome p-450 cyp3a5 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp3a5 substrates
    Drug Categories cytochrome p-450 cyp3a7 inhibitors
    Drug Categories cytochrome p-450 cyp3a7 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 enzyme inhibitors
    Drug Categories cytochrome p-450 substrates
    Drug Categories nervous system
    Drug Categories serotonergic drugs shown to increase risk of serotonin syndrome
    Drug Categories serotonin 5-ht1 receptor agonists
    Drug Categories serotonin 5-ht2 receptor agonists
    Drug Categories serotonin agents
    Drug Categories serotonin receptor agonists
    Drug Categories terpenes
    (1 More Sources)

    Publications:

    Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics
    Laprairie RB et al., 2015, Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor., Br J Pharmacol
    Ryberg et al., 2007, The orphan receptor GPR55 is a novel cannabinoid receptor., Br. J. Pharmacol.
    De Petrocellis L et al., 2011, Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes., Br J Pharmacol
    Gonca E et al., 2015, The effect of cannabidiol on ischemia/reperfusion-induced ventricular arrhythmias: the role of adenosine A1 receptors., J Cardiovasc Pharmacol Ther
    Yang KH et al., 2010, The nonpsychoactive cannabinoid cannabidiol inhibits 5-hydroxytryptamine3A receptor-mediated currents in Xenopus laevis oocytes., J Pharmacol Exp Ther
    Brown KJ et al., 2017, Cannabidiol, a novel inverse agonist for GPR12., Biochem Biophys Res Commun
    De Petrocellis L et al., 2012, Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation., Acta Physiol (Oxf)
    Russo EB et al., 2005, Agonistic properties of cannabidiol at 5-HT1a receptors., Neurochem Res
    Stout SM et al., 2014, Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review., Drug Metab Rev
    Xiong W et al., 2012, Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors., J Exp Med
    Ahrens J et al., 2009, The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function., Pharmacology
    Watanabe K et al., 2005, Marijuana extracts possess the effects like the endocrine disrupting chemicals., Toxicology
    Bisogno T et al., 2001, Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide., Br J Pharmacol
    Iannotti FA et al., 2014, Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability., ACS Chem Neurosci
    Morales P et al., 2017, An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol., Front Pharmacol
    Scuderi C et al., 2014, Cannabidiol promotes amyloid precursor protein ubiquitination and reduction of beta amyloid expression in SHSY5YAPP+ cells through PPARγ involvement., Phytother Res
  • CANNABIDIOL   TRPV2

    Interaction Score: 1.06

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Specific Action of the Ligand Activation
    Endogenous Drug? False

    PMIDs:
    21175579 26264914


    Sources:
    DrugBank GuideToPharmacology

  • CANNABIDIOL   GPX1

    Interaction Score: 0.88

    Interaction Types & Directionality:
    stimulator (activating)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • CANNABIDIOL   ACAT1

    Interaction Score: 0.88

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • CANNABIDIOL   NAAA

    Interaction Score: 0.88

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • CANNABIDIOL   GPR18

    Interaction Score: 0.79

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    26264914


    Sources:
    DrugBank GuideToPharmacology

  • CANNABIDIOL   VDAC1

    Interaction Score: 0.66

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • CANNABIDIOL   CAT

    Interaction Score: 0.66

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • CANNABIDIOL   TRPV4

    Interaction Score: 0.53

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    21726418


    Sources:
    DrugBank

  • CANNABIDIOL   AANAT

    Interaction Score: 0.53

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • CANNABIDIOL   GPR12

    Interaction Score: 0.44

    Interaction Types & Directionality:
    inverse agonist (inhibitory)

    Interaction Info:

    PMIDs:
    28888984


    Sources:
    DrugBank

  • CANNABIDIOL   TRPV3

    Interaction Score: 0.4

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    21726418 26264914


    Sources:
    DrugBank

  • CANNABIDIOL   CYP3A7

    Interaction Score: 0.33

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    24160757 26264914


    Sources:
    DrugBank

  • CANNABIDIOL   GLRA3

    Interaction Score: 0.3

    Interaction Types & Directionality:
    potentiator

    Interaction Info:

    PMIDs:
    22585736 26264914


    Sources:
    DrugBank

  • CANNABIDIOL   TRPM8

    Interaction Score: 0.3

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand None

    PMIDs:
    26264914


    Sources:
    DrugBank GuideToPharmacology

  • CANNABIDIOL   CYP17A1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    15588936 26264914


    Sources:
    DrugBank

  • CANNABIDIOL   GPR55

    Interaction Score: 0.28

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    17876302 26264914


    Sources:
    DrugBank GuideToPharmacology

  • CANNABIDIOL   SOD1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • CANNABIDIOL   IDO1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • CANNABIDIOL   TRPV1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    21175579 11606325 25029033 26264914


    Sources:
    DrugBank

  • CANNABIDIOL   CNR1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    allosteric modulator
    antagonist (inhibitory)
    modulator

    Interaction Info:
    Specific Action of the Ligand Negative
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    26218440


    Sources:
    DrugBank GuideToPharmacology ChemblInteractions

  • CANNABIDIOL   GLRA1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:

    PMIDs:
    19204413 26264914


    Sources:
    DrugBank

  • CANNABIDIOL   TRPA1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    21175579 26264914


    Sources:
    DrugBank

  • CANNABIDIOL   CYP1B1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    24160757 26264914


    Sources:
    DrugBank

  • CANNABIDIOL   GSR

    Interaction Score: 0.11

    Interaction Types & Directionality:
    stimulator (activating)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • CANNABIDIOL   CACNA1I

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • CANNABIDIOL   NQO1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • CANNABIDIOL   CACNA1G

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • CANNABIDIOL   HMGCR

    Interaction Score: 0.09

    Interaction Types & Directionality:
    stimulator (activating)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • CANNABIDIOL   CACNA1H

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • CANNABIDIOL   ADORA1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    24853683


    Sources:
    DrugBank

  • CANNABIDIOL   HTR3A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    20160007


    Sources:
    DrugBank

  • CANNABIDIOL   CHRNA7

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • CANNABIDIOL   CNR2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • CANNABIDIOL   OPRD1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • CANNABIDIOL   HTR1A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    26264914 16258853


    Sources:
    DrugBank

  • CANNABIDIOL   CYP3A5

    Interaction Score: 0.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • CANNABIDIOL   PTGS1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • CANNABIDIOL   PPARG

    Interaction Score: 0.02

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    24288245 26264914


    Sources:
    DrugBank

  • CANNABIDIOL   PTGS2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • CANNABIDIOL   HTR2A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    28701957 26264914


    Sources:
    DrugBank

  • CANNABIDIOL   OPRM1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • CANNABIDIOL   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    24160757 26264914


    Sources:
    DrugBank

  • CANNABIDIOL   CYP2D6

    Interaction Score: 0.0

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • DrugBank: DB09061

    • Version: 5.1.7

    Alternate Names:
    CANNABIDIOL DrugBank Drug Name
    13956-29-1 CAS Number
    Cybid 10 Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational

    Publications:
    Brown KJ et al., 2017, Cannabidiol, a novel inverse agonist for GPR12., Biochem Biophys Res Commun
    Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics
    Russo EB et al., 2005, Agonistic properties of cannabidiol at 5-HT1a receptors., Neurochem Res

  • TTD: Cannabidiol

    • Version: 2020.06.01

    Alternate Names:
    D0O1UZ TTD Drug ID

    Drug Info:

    Publications:

  • GuideToPharmacology: 178100971

    • Version: 29-September-2020

    Alternate Names:
    CANNABIDIOL GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL190461

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL190461

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21