DGIdb - CARFILZOMIB Drug Record

CARFILZOMIB chembl:CHEMBL451887 ApprovedAntineoplasticImmunotherapy

Alternate Names:

CARFILZOMIB
PR-171
KYPROLIS
KYPROLIS®
drugbank:08889
rxcui:1302966
pubchem.compound:11556711
chemidplus:868540-17-4
chembl:CHEMBL451887

Drug Info:

FDA Approval	Multiple myeloma
Drug Class	Small molecule inhibitor
FDA Approval	not approved
Drug Class	Small molecule
Drug Indications	antineoplastic agent

(3 More Sources)

Publications:

Kuhn et al., 2007, Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma., Blood
Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem
Kortuem et al., 2013, Carfilzomib., Blood
Kawamura S et al., 2013, Potent proteasome inhibitors derived from the unnatural cis-cyclopropane isomer of Belactosin A: synthesis, biological activity, and mode of action., J Med Chem
Lin PL et al., 2016, Cytoplasmic localization of Nrf2 promotes colorectal cancer with more aggressive tumors via upregulation of PSMD4., Free Radic Biol Med

CARFILZOMIB PSMD4

Interaction Score: 1.3

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
24524217 27033953

Sources:
DTC MyCancerGenome ChemblInteractions CIViC
CARFILZOMIB PSMB1

Interaction Score: 1.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

Trial Name Carfilzomib

PMIDs:
24524217 17591945

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions
CARFILZOMIB PSMD1

Interaction Score: 1.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMD11

Interaction Score: 1.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMC2

Interaction Score: 1.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMD8

Interaction Score: 1.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMB10

Interaction Score: 1.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
17591945 24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMD12

Interaction Score: 1.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMC4

Interaction Score: 1.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMD7

Interaction Score: 1.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMD2

Interaction Score: 1.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMC3

Interaction Score: 1.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMD3

Interaction Score: 1.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMC1

Interaction Score: 1.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMD6

Interaction Score: 1.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMC6

Interaction Score: 1.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMD13

Interaction Score: 1.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMB9

Interaction Score: 1.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
24524217 17591945

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMB2

Interaction Score: 0.93

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

Novel drug target Established target

PMIDs:
17591945 24524217

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions
CARFILZOMIB PSMB3

Interaction Score: 0.87

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMA1

Interaction Score: 0.87

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMB6

Interaction Score: 0.87

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMA7

Interaction Score: 0.87

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMB7

Interaction Score: 0.87

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMA3

Interaction Score: 0.87

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMA2

Interaction Score: 0.87

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMA5

Interaction Score: 0.87

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMA6

Interaction Score: 0.87

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMC5

Interaction Score: 0.87

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMA8

Interaction Score: 0.87

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMB4

Interaction Score: 0.87

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMB5

Interaction Score: 0.84

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Carfilzomib

Novel drug target Established target

Direct Interaction yes

PMIDs:
23393020 23547757 24524217

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions
CARFILZOMIB ADRM1

Interaction Score: 0.81

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC ChemblInteractions
CARFILZOMIB SEM1

Interaction Score: 0.81

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC ChemblInteractions
CARFILZOMIB PSMB8

Interaction Score: 0.77

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
17591945 24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMA4

Interaction Score: 0.72

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PSMB11

Interaction Score: 0.65

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC ChemblInteractions
CARFILZOMIB PSMC3IP

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
CARFILZOMIB PSMD9

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
CARFILZOMIB PSMF1

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
CARFILZOMIB PSMD10P1

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
CARFILZOMIB PSMD10

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
CARFILZOMIB PSME3

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
CARFILZOMIB PSME4

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
CARFILZOMIB PSMC1P1

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
CARFILZOMIB PSMD4P1

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
CARFILZOMIB PSME2P2

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
CARFILZOMIB PSMD10P3

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
CARFILZOMIB PSME1

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
CARFILZOMIB PSMD5

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
CARFILZOMIB PIPSL

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
CARFILZOMIB PSMD10P2

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
CARFILZOMIB PSME2

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
CARFILZOMIB PSMD14

Interaction Score: 0.39

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
CARFILZOMIB PRB2

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CARFILZOMIB NFE2L2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CARFILZOMIB AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

MyCancerGenome: CARFILZOMIB
- Version: 20-Jun-2017
Alternate Names:

PR-171 Development Name

CARFILZOMIB Generic Name

KYPROLIS Trade Name

Drug Info:

Drug Class Small molecule inhibitor

FDA Approval Multiple myeloma

Publications:
TdgClinicalTrial: CARFILZOMIB
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antineoplastic agent

Drug Class Small molecule

FDA Approval not approved

Publications:

DTC: CARFILZOMIB

Version: 02-September-2020

Alternate Names:

CHEMBL451887 ChEMBL Drug ID

Drug Info:

Publications:

Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

Kawamura S et al., 2013, Potent proteasome inhibitors derived from the unnatural cis-cyclopropane isomer of Belactosin A: synthesis, biological activity, and mode of action., J Med Chem

CIViC: CARFILZOMIB
- Version: 14-September-2020
Alternate Names:

Drug Info:

Publications:

Lin PL et al., 2016, Cytoplasmic localization of Nrf2 promotes colorectal cancer with more aggressive tumors via upregulation of PSMD4., Free Radic Biol Med
TTD: Carfilzomib
- Version: 2020.06.01
Alternate Names:

D00UVA TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL451887
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL451887
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	26S proteosome inhibitor

Trial Name	Carfilzomib
Novel drug target	Established target
Direct Interaction	yes

PR-171	Development Name
CARFILZOMIB	Generic Name
KYPROLIS	Trade Name

CARFILZOMIB Drug Record

CARFILZOMIB chembl:CHEMBL451887 ApprovedAntineoplasticImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction 26S proteosome inhibitor

PMIDs: 24524217 27033953

Sources: DTC MyCancerGenome ChemblInteractions CIViC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes Trial Name Carfilzomib

PMIDs: 24524217 17591945

Sources: DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: 24524217

Sources: DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: 24524217

Sources: DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: 24524217

Sources: DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: 24524217

Sources: DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: 17591945 24524217

Sources: DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: 24524217

Sources: DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: 24524217

Sources: DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: 24524217

Sources: DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: 24524217

Sources: DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: 24524217

Sources: DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: 24524217

Sources: DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction 26S proteosome inhibitor

PMIDs: 24524217

Sources: DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction 26S proteosome inhibitor

PMIDs: 24524217

Sources: DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: 24524217

Sources: DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: 24524217

Sources: DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction 26S proteosome inhibitor

PMIDs: 24524217 17591945

Sources: DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes Novel drug target Established target

PMIDs: 17591945 24524217

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
24524217 27033953

Sources:
DTC MyCancerGenome ChemblInteractions CIViC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

Trial Name Carfilzomib

PMIDs:
24524217 17591945

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
17591945 24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
24524217 17591945

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

Novel drug target Established target

PMIDs:
17591945 24524217

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions