DGIdb - CARISOPRODOL Drug Record

CARISOPRODOL chembl:CHEMBL1233

Alternate Names:

CARISOPRODOL CIV
NSC-172124
SOMA
CARISOMA
RELA
CARISOPRODOL
CARISOPRODATE
ISOBAMATE
CARBAMIC ACID 2-ISOPROPYLCARBAMOYLOXYMETHYL-2-METHYL-PENTYL ESTER
SOMA®
2-METHYL-2-PROPYLTRIMETHYLENE CARBAMATE ISOPROPYLCARBAMATE
2-METHYL-2-PROPYL-1,3-PROPANEDIOL CARBAMATE ISOPROPYLCARBAMATE
ISOPROPYL MEPROBAMATE
(+-)-2-METHYL-2-PROPYL-1,3-PROPANEDIOL CARBAMATE ISOPROPYLCARBAMATE
(1-METHYLETHYL)CARBAMIC ACID 2-(((AMINOCARBONYL)OXY)METHYL)-2-METHYLPENTYL ESTER
N-ISOPROPY-2-METHYL-2-PROPYL-1,3-PROPANEDIOL DICARBAMATE
CARISOPRODOLUM
ISOPROPYLMEPROBAMATE
(RS)-2-{[(AMINOCARBONYL)OXY]METHYL}-2-METHYLPENTYL ISOPROPYLCARBAMATE
SOMEPROBAMATE
ISOMEPROBAMATE
chembl:CHEMBL1233
pubchem.compound:2576
chemidplus:78-44-4
drugbank:00395
rxcui:2101

Drug Info:

Drug Type	small molecule
Drug Groups	approved
Drug Categories	carbamates
Drug Categories	carbamic acid esters
Drug Categories	central nervous system agents
Drug Categories	central nervous system depressants
Drug Categories	centrally-mediated muscle relaxation
Drug Categories	cytochrome p-450 cyp2c19 substrates
Drug Categories	cytochrome p-450 substrates
Drug Categories	muscle relaxants
Drug Categories	muscle relaxants, centrally acting agents
Drug Categories	musculo-skeletal system

(0 More Sources)

Publications:

Kumar M et al., 2017, A Single Amino Acid Residue at Transmembrane Domain 4 of the <i>α</i> Subunit Influences Carisoprodol Direct Gating Efficacy at GABA<sub>A</sub> Receptors., J Pharmacol Exp Ther
Kumar M et al., 2016, Assessment of direct gating and allosteric modulatory effects of meprobamate in recombinant GABA(A) receptors., Eur J Pharmacol
Gonzalez LA et al., 2009, Abuse Potential of Soma: the GABA(A) Receptor as a Target., Mol Cell Pharmacol
Gonzalez et al., 2009, Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies., J. Pharmacol. Exp. Ther.

CARISOPRODOL GABRG2

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20419052 28642232 19244096

Sources:
DrugBank
CARISOPRODOL GABRB2

Interaction Score: 0.45

Interaction Types & Directionality:

modulator

Interaction Info:

PMIDs:
20419052 26872987 19244096

Sources:
DrugBank
CARISOPRODOL GABRA3

Interaction Score: 0.27

Interaction Types & Directionality:

modulator

Interaction Info:

PMIDs:
28642232 26872987

Sources:
DrugBank
CARISOPRODOL GABRA1

Interaction Score: 0.25

Interaction Types & Directionality:

activator (activating)

modulator

Interaction Info:

PMIDs:
20419052 26872987 19244096

Sources:
DrugBank
CARISOPRODOL GABRA5

Interaction Score: 0.19

Interaction Types & Directionality:

modulator

Interaction Info:

PMIDs:
26872987

Sources:
DrugBank
CARISOPRODOL CBX1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CARISOPRODOL CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA

DrugBank: DB00395

Version: 5.1.7

Alternate Names:

CARISOPRODOL DrugBank Drug Name

78-44-4 CAS Number

CARISOPRODOL Immediate release Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories carbamates

Publications:

Kumar M et al., 2017, A Single Amino Acid Residue at Transmembrane Domain 4 of the <i>α</i> Subunit Influences Carisoprodol Direct Gating Efficacy at GABA<sub>A</sub> Receptors., J Pharmacol Exp Ther

Kumar M et al., 2016, Assessment of direct gating and allosteric modulatory effects of meprobamate in recombinant GABA(A) receptors., Eur J Pharmacol

Gonzalez LA et al., 2009, Abuse Potential of Soma: the GABA(A) Receptor as a Target., Mol Cell Pharmacol

DTC: CARISOPRODOL
- Version: 02-September-2020
Alternate Names:

CHEMBL1233 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1233
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Carisoprodol
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

CARISOPRODOL	DrugBank Drug Name
78-44-4	CAS Number
CARISOPRODOL Immediate release	Drug Brand

activator (activating)
modulator

CARISOPRODOL Drug Record

CARISOPRODOL chembl:CHEMBL1233

Alternate Names:

Drug Info:

Publications:

CARISOPRODOL GABRG2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20419052 28642232 19244096

Sources: DrugBank

CARISOPRODOL GABRB2

Interaction Types & Directionality: modulator

Interaction Info:

PMIDs: 20419052 26872987 19244096

Sources: DrugBank

CARISOPRODOL GABRA3

Interaction Types & Directionality: modulator

Interaction Info:

PMIDs: 28642232 26872987

Sources: DrugBank

CARISOPRODOL GABRA1

Interaction Types & Directionality: activator (activating) modulator

Interaction Info:

PMIDs: 20419052 26872987 19244096

Sources: DrugBank

CARISOPRODOL GABRA5

Interaction Types & Directionality: modulator

Interaction Info:

PMIDs: 26872987

Sources: DrugBank

CARISOPRODOL CBX1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

CARISOPRODOL CYP2C19

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: FDA

DrugBank: DB00395

Alternate Names: CARISOPRODOL DrugBank Drug Name 78-44-4 CAS Number CARISOPRODOL Immediate release Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories carbamates

DTC: CARISOPRODOL

Alternate Names: CHEMBL1233 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1233

Alternate Names:

Drug Info:

Publications:

FDA: Carisoprodol

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
20419052 28642232 19244096

Sources:
DrugBank

Interaction Types & Directionality:

modulator

PMIDs:
20419052 26872987 19244096

Sources:
DrugBank

Interaction Types & Directionality:

modulator

PMIDs:
28642232 26872987

Sources:
DrugBank

Interaction Types & Directionality:

activator (activating)

modulator

PMIDs:
20419052 26872987 19244096

Sources:
DrugBank

Interaction Types & Directionality:

modulator

PMIDs:
26872987

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA

Alternate Names:

CARISOPRODOL DrugBank Drug Name

78-44-4 CAS Number

CARISOPRODOL Immediate release Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories carbamates

Alternate Names:

CHEMBL1233 ChEMBL Drug ID