• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

CEFOTAXIME Drug Record

  • Summary
  • Interactions
  • Claims
  • CEFOTAXIME chembl:CHEMBL1730 Approved

    Alternate Names:

    CEFOTAXIME
    CEFOTAXIMA
    CEFOTAXIM
    CEFOTAXIMUM
    (6R,7R)-3-(ACETOXYMETHYL)-7-{[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ACETYL]AMINO}-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID
    (6R,7R)-3-ACETOXYMETHYL-7-{2-(2-AMINO-THIAZOL-4-YL)-2-[(Z)-METHOXYIMINO]-ACETYLAMINO}-8-OXO-5-THIA-1-AZA-BICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID
    (6R,7R,Z)-3-(ACETOXYMETHYL)-7-(2-(2-AMINOTHIAZOL-4-YL)-2-(METHOXYIMINO)ACETAMIDO)-8-OXO-5-THIA-1-AZA-BICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID
    CEPHOTAXIME
    KEFOTEX
    CÉFOTAXIME
    CLAFORAN
    CEFOTAX
    rxcui:2186
    drugbank:00493
    chemidplus:63527-52-6
    chembl:CHEMBL1730
    pubchem.compound:5742673

    Drug Info:

    (1 More Sources)

    Publications:

    Friedland et al., 1993, Comparison of endotoxin release by different antimicrobial agents and the effect on inflammation in experimental Escherichia coli meningitis., J. Infect. Dis.
    Bessler et al., 2000, Effect of cefotaxime on cytokine production in newborns and adults in vitro., Biomed. Pharmacother.
    Yee SW et al., 2013, Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8)., J Pharm Sci
    Takeda et al., 2002, Interaction of human organic anion transporters with various cephalosporin antibiotics., Eur. J. Pharmacol.
    Erat et al., 2005, Effects of some antibiotics on glutathione reductase activities from human erythrocytes in vitro and from rat erythrocytes in vivo., J Enzyme Inhib Med Chem
  • CEFOTAXIME   SLC22A8

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23649425 11909604


    Sources:
    PharmGKB

  • CEFOTAXIME   GSR

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15895687


    Sources:
    NCI

  • CEFOTAXIME   TNF

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8354907 10989981


    Sources:
    NCI

  • CEFOTAXIME   CBX1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CEFOTAXIME   VDR

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CEFOTAXIME   EHMT2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NCI: CEFOTAXIME

    • Version: 14-September-2017

    Alternate Names:
    C354 NCI drug code

    Drug Info:

    Publications:
    Friedland et al., 1993, Comparison of endotoxin release by different antimicrobial agents and the effect on inflammation in experimental Escherichia coli meningitis., J. Infect. Dis.
    Bessler et al., 2000, Effect of cefotaxime on cytokine production in newborns and adults in vitro., Biomed. Pharmacother.
    Erat et al., 2005, Effects of some antibiotics on glutathione reductase activities from human erythrocytes in vitro and from rat erythrocytes in vivo., J Enzyme Inhib Med Chem

  • PharmGKB: cefotaxime

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Yee SW et al., 2013, Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8)., J Pharm Sci

  • TTD: Cefotaxime

    • Version: 2020.06.01

    Alternate Names:
    D0D1HA TTD Drug ID

    Drug Info:

    Publications:

  • DTC: CEFOTAXIME

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1730 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1730

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21