DGIdb - CEFTRIAXONE Drug Record

CEFTRIAXONE chembl:CHEMBL161 Approved

Alternate Names:

CEFTRIAXONE
ROCEPHIN
(6R,7R)-7-{[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ACETYL]AMINO}-3-{[(2-METHYL-5,6-DIOXO-1,2,5,6-TETRAHYDRO-1,2,4-TRIAZIN-3-YL)SULFANYL]METHYL}-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID
CEFTRIAXONA
ROCEPHIN®
FIDATO
CEFTRIAXONUM
CEFATRIAXONE
C18H18N8O7S3
CEFTRIAZONE
chembl:CHEMBL161
drugbank:01212
chemidplus:73384-59-5
rxcui:2193
pubchem.compound:5479530

Drug Info:

(2 More Sources)

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Allegra S et al., 2018, Effect of ABCC2 and ABCG2 Gene Polymorphisms and CSF-to-Serum Albumin Ratio on Ceftriaxone Plasma and Cerebrospinal Fluid Concentrations., J Clin Pharmacol
de Waart DR et al., 2012, Oral availability of cefadroxil depends on ABCC3 and ABCC4., Drug Metab Dispos
Pacheco et al., 1994, Antibiotics and production of granulocyte-macrophage colony-stimulating factor by human bronchial epithelial cells in vitro. A comparison of cefodizime and ceftriaxone., Arzneimittelforschung

CEFTRIAXONE CYB5R3

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CEFTRIAXONE ABCC3

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
CEFTRIAXONE ABCC2

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29873816 22166395

Sources:
DTC PharmGKB
CEFTRIAXONE ABCC4

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22166395

Sources:
DTC
CEFTRIAXONE CXCL8

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8011012

Sources:
NCI
CEFTRIAXONE ABCG2

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29873816

Sources:
PharmGKB
CEFTRIAXONE G6PD

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
CEFTRIAXONE CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CEFTRIAXONE CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CEFTRIAXONE CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CEFTRIAXONE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CEFTRIAXONE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

DTC: CEFTRIAXONE

Version: 02-September-2020

Alternate Names:

CHEMBL161 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

de Waart DR et al., 2012, Oral availability of cefadroxil depends on ABCC3 and ABCC4., Drug Metab Dispos

NCI: CEFTRIAXONE

Version: 14-September-2017

Alternate Names:

C817 NCI drug code

Drug Info:

Publications:

Pacheco et al., 1994, Antibiotics and production of granulocyte-macrophage colony-stimulating factor by human bronchial epithelial cells in vitro. A comparison of cefodizime and ceftriaxone., Arzneimittelforschung

PharmGKB: ceftriaxone
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Allegra S et al., 2018, Effect of ABCC2 and ABCG2 Gene Polymorphisms and CSF-to-Serum Albumin Ratio on Ceftriaxone Plasma and Cerebrospinal Fluid Concentrations., J Clin Pharmacol
TTD: Ceftriaxone
- Version: 2020.06.01
Alternate Names:

D07ACT TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL161
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Ceftriaxone
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

CEFTRIAXONE Drug Record

CEFTRIAXONE chembl:CHEMBL161 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29873816 22166395

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22166395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8011012

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29873816

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

DTC: CEFTRIAXONE

Alternate Names: CHEMBL161 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol de Waart DR et al., 2012, Oral availability of cefadroxil depends on ABCC3 and ABCC4., Drug Metab Dispos

NCI: CEFTRIAXONE

Alternate Names: C817 NCI drug code

Drug Info:

Publications: Pacheco et al., 1994, Antibiotics and production of granulocyte-macrophage colony-stimulating factor by human bronchial epithelial cells in vitro. A comparison of cefodizime and ceftriaxone., Arzneimittelforschung

PharmGKB: ceftriaxone

Alternate Names:

Drug Info:

Publications: Allegra S et al., 2018, Effect of ABCC2 and ABCG2 Gene Polymorphisms and CSF-to-Serum Albumin Ratio on Ceftriaxone Plasma and Cerebrospinal Fluid Concentrations., J Clin Pharmacol

TTD: Ceftriaxone

Alternate Names: D07ACT TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL161

Alternate Names:

Drug Info:

Publications:

FDA: Ceftriaxone

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
29873816 22166395

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22166395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
8011012

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
29873816

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

CHEMBL161 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

de Waart DR et al., 2012, Oral availability of cefadroxil depends on ABCC3 and ABCC4., Drug Metab Dispos

Alternate Names:

C817 NCI drug code

Publications:

Pacheco et al., 1994, Antibiotics and production of granulocyte-macrophage colony-stimulating factor by human bronchial epithelial cells in vitro. A comparison of cefodizime and ceftriaxone., Arzneimittelforschung

Publications:

Allegra S et al., 2018, Effect of ABCC2 and ABCG2 Gene Polymorphisms and CSF-to-Serum Albumin Ratio on Ceftriaxone Plasma and Cerebrospinal Fluid Concentrations., J Clin Pharmacol

Alternate Names:

D07ACT TTD Drug ID