DGIdb - CETIRIZINE Drug Record

CETIRIZINE chembl:CHEMBL1000 Approved

Alternate Names:

AC-170
CETIRIZINE
(2-{4-[(4-CHLOROPHENYL)(PHENYL)METHYL]PIPERAZIN-1-YL}ETHOXY)ACETIC ACID
chembl:CHEMBL1000
drugbank:00341
pubchem.compound:2678
chemidplus:83881-51-0
rxcui:20610

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antiallergy agent
Year of Approval	1995
Drug Class	anti-allergic agents

(4 More Sources)

Publications:

Christophe et al., 2003, Histamine H1 receptor antagonism by cetirizine in isolated guinea pig tissues: influence of receptor reserve and dissociation kinetics., Eur. J. Pharmacol.
Tamura et al., 2005, Effect of olopatadine and other histamine H1 receptor antagonists on the skin inflammation induced by repeated topical application of oxazolone in mice., Pharmacology
Tashiro et al., 2004, Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography., J Clin Pharmacol
Tillement et al., 2003, Compared pharmacological characteristics in humans of racemic cetirizine and levocetirizine, two histamine H1-receptor antagonists., Biochem. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Cavero et al., 1999, Preclinical in vitro cardiac electrophysiology: a method of predicting arrhythmogenic potential of antihistamines in humans?, Drug Saf
Zhang L et al., 2013, The clinical use of cetirizine in the treatment of allergic rhinitis., Pharmacology
Portnoy JM et al., 2004, Review of cetirizine hydrochloride for the treatment of allergic disorders., Expert Opin Pharmacother
Gong et al., 2012, Discovery of loperamide as an antagonist of angiopoietin1 and angiopoietin2 by virtual screening., Bioorg. Med. Chem. Lett.
Bruno et al., Serum tryptase in allergic rhinitis: effect of cetirizine and fluticasone propionate treatment., Clin Ter
Cheng et al., 2006, Influence of cetirizine and loratadine on granulocyte-macrophage colony-stimulating factor and interleukin-8 release in A549 human airway epithelial cells stimulated with interleukin-1beta., J Microbiol Immunol Infect
Caproni et al., 1995, Pharmacologic modulation by cetirizine of some adhesion molecules expression in psoriatic skin lesions., Int. J. Dermatol.

CETIRIZINE TPSD1

Interaction Score: 12.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11794849

Sources:
NCI
CETIRIZINE TEK

Interaction Score: 1.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22406116

Sources:
DTC
CETIRIZINE HRH1

Interaction Score: 0.98

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name cetirizine HCl,Zyrtec

Novel drug target Established target

Endogenous Drug? False

PMIDs:
12787835 15942272 15286093 14505791 11752352 10597865 23867423 14680442

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD
CETIRIZINE IL2RA

Interaction Score: 0.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7591422

Sources:
NCI
CETIRIZINE CSF2

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16783450

Sources:
NCI

TEND: CETIRIZINE
- Version: 01-August-2011
Alternate Names:

CETIRIZINE Primary Drug Name

Drug Info:

Drug Class anti-allergic agents

Year of Approval 1995

Publications:
TdgClinicalTrial: CETIRIZINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiallergy agent

Drug Class Small Molecule

FDA Approval approved

Publications:
DTC: CETIRIZINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1000 ChEMBL Drug ID

Drug Info:

Publications:

Gong et al., 2012, Discovery of loperamide as an antagonist of angiopoietin1 and angiopoietin2 by virtual screening., Bioorg. Med. Chem. Lett.

NCI: CETIRIZINE

Version: 14-September-2017

Alternate Names:

C1042 NCI drug code

Drug Info:

Publications:

Bruno et al., Serum tryptase in allergic rhinitis: effect of cetirizine and fluticasone propionate treatment., Clin Ter

Cheng et al., 2006, Influence of cetirizine and loratadine on granulocyte-macrophage colony-stimulating factor and interleukin-8 release in A549 human airway epithelial cells stimulated with interleukin-1beta., J Microbiol Immunol Infect

Caproni et al., 1995, Pharmacologic modulation by cetirizine of some adhesion molecules expression in psoriatic skin lesions., Int. J. Dermatol.

GuideToPharmacology: 135650064
- Version: 29-September-2020
Alternate Names:

CETIRIZINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Cetirizine
- Version: 2020.06.01
Alternate Names:

D0DK8V TTD Drug ID

Drug Info:

Publications:
TTD: AC-170
- Version: 2020.06.01
Alternate Names:

D01JFM TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1000
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	cetirizine HCl,Zyrtec
Novel drug target	Established target
Endogenous Drug?	False

CETIRIZINE Drug Record

CETIRIZINE chembl:CHEMBL1000 Approved

Alternate Names:

Drug Info:

Publications:

CETIRIZINE TPSD1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11794849

Sources: NCI

CETIRIZINE TEK

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22406116

Sources: DTC

CETIRIZINE HRH1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name cetirizine HCl,Zyrtec Novel drug target Established target Endogenous Drug? False

PMIDs: 12787835 15942272 15286093 14505791 11752352 10597865 23867423 14680442

Sources: TdgClinicalTrial TEND GuideToPharmacology TTD

CETIRIZINE IL2RA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7591422

Sources: NCI

CETIRIZINE CSF2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16783450

Sources: NCI

TEND: CETIRIZINE

Alternate Names: CETIRIZINE Primary Drug Name

Drug Info: Drug Class anti-allergic agents Year of Approval 1995

Publications:

TdgClinicalTrial: CETIRIZINE

Alternate Names:

Drug Info: Drug Indications antiallergy agent Drug Class Small Molecule FDA Approval approved

Publications:

DTC: CETIRIZINE

Alternate Names: CHEMBL1000 ChEMBL Drug ID

Drug Info:

Publications: Gong et al., 2012, Discovery of loperamide as an antagonist of angiopoietin1 and angiopoietin2 by virtual screening., Bioorg. Med. Chem. Lett.

NCI: CETIRIZINE

Alternate Names: C1042 NCI drug code

Drug Info:

GuideToPharmacology: 135650064

Alternate Names: CETIRIZINE GuideToPharmacology Ligand Name

Drug Info:

Publications:

TTD: Cetirizine

Alternate Names: D0DK8V TTD Drug ID

Drug Info:

Publications:

TTD: AC-170

Alternate Names: D01JFM TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1000

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
11794849

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22406116

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name cetirizine HCl,Zyrtec

Novel drug target Established target

Endogenous Drug? False

PMIDs:
12787835 15942272 15286093 14505791 11752352 10597865 23867423 14680442

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
7591422

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16783450

Sources:
NCI

Alternate Names:

CETIRIZINE Primary Drug Name

Drug Info:

Drug Class anti-allergic agents

Year of Approval 1995

Drug Info:

Drug Indications antiallergy agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

CHEMBL1000 ChEMBL Drug ID

Publications:

Gong et al., 2012, Discovery of loperamide as an antagonist of angiopoietin1 and angiopoietin2 by virtual screening., Bioorg. Med. Chem. Lett.

Alternate Names:

C1042 NCI drug code

Alternate Names:

CETIRIZINE GuideToPharmacology Ligand Name

Alternate Names:

D0DK8V TTD Drug ID

Alternate Names:

D01JFM TTD Drug ID