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CETIRIZINE Drug Record

  • Summary
  • Interactions
  • Claims
  • CETIRIZINE chembl:CHEMBL1000 Approved

    Alternate Names:

    AC-170
    CETIRIZINE
    (2-{4-[(4-CHLOROPHENYL)(PHENYL)METHYL]PIPERAZIN-1-YL}ETHOXY)ACETIC ACID
    chembl:CHEMBL1000
    drugbank:00341
    pubchem.compound:2678
    chemidplus:83881-51-0
    rxcui:20610

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antiallergy agent
    Year of Approval 1995
    Drug Class anti-allergic agents
    (3 More Sources)

    Publications:

    Christophe et al., 2003, Histamine H1 receptor antagonism by cetirizine in isolated guinea pig tissues: influence of receptor reserve and dissociation kinetics., Eur. J. Pharmacol.
    Tamura et al., 2005, Effect of olopatadine and other histamine H1 receptor antagonists on the skin inflammation induced by repeated topical application of oxazolone in mice., Pharmacology
    Tashiro et al., 2004, Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography., J Clin Pharmacol
    Tillement et al., 2003, Compared pharmacological characteristics in humans of racemic cetirizine and levocetirizine, two histamine H1-receptor antagonists., Biochem. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Cavero et al., 1999, Preclinical in vitro cardiac electrophysiology: a method of predicting arrhythmogenic potential of antihistamines in humans?, Drug Saf
    Zhang L et al., 2013, The clinical use of cetirizine in the treatment of allergic rhinitis., Pharmacology
    Portnoy JM et al., 2004, Review of cetirizine hydrochloride for the treatment of allergic disorders., Expert Opin Pharmacother
    Gong et al., 2012, Discovery of loperamide as an antagonist of angiopoietin1 and angiopoietin2 by virtual screening., Bioorg. Med. Chem. Lett.
    Bruno et al., Serum tryptase in allergic rhinitis: effect of cetirizine and fluticasone propionate treatment., Clin Ter
    Cheng et al., 2006, Influence of cetirizine and loratadine on granulocyte-macrophage colony-stimulating factor and interleukin-8 release in A549 human airway epithelial cells stimulated with interleukin-1beta., J Microbiol Immunol Infect
    Caproni et al., 1995, Pharmacologic modulation by cetirizine of some adhesion molecules expression in psoriatic skin lesions., Int. J. Dermatol.
  • CETIRIZINE   TPSD1

    Interaction Score: 12.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11794849


    Sources:
    NCI

  • CETIRIZINE   TEK

    Interaction Score: 1.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22406116


    Sources:
    DTC

  • CETIRIZINE   HRH1

    Interaction Score: 1.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name cetirizine HCl,Zyrtec
    Novel drug target Established target

    PMIDs:
    12787835 15942272 15286093 14505791 11752352 10597865 23867423 14680442


    Sources:
    TdgClinicalTrial TEND TTD

  • CETIRIZINE   IL2RA

    Interaction Score: 0.85

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7591422


    Sources:
    NCI

  • CETIRIZINE   CSF2

    Interaction Score: 0.6

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16783450


    Sources:
    NCI

  • TEND: CETIRIZINE

    • Version: 01-August-2011

    Alternate Names:
    CETIRIZINE Primary Drug Name

    Drug Info:
    Drug Class anti-allergic agents
    Year of Approval 1995

    Publications:

  • TdgClinicalTrial: CETIRIZINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antiallergy agent
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • DTC: CETIRIZINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1000 ChEMBL Drug ID

    Drug Info:

    Publications:
    Gong et al., 2012, Discovery of loperamide as an antagonist of angiopoietin1 and angiopoietin2 by virtual screening., Bioorg. Med. Chem. Lett.

  • NCI: CETIRIZINE

    • Version: 14-September-2017

    Alternate Names:
    C1042 NCI drug code

    Drug Info:

    Publications:
    Bruno et al., Serum tryptase in allergic rhinitis: effect of cetirizine and fluticasone propionate treatment., Clin Ter
    Cheng et al., 2006, Influence of cetirizine and loratadine on granulocyte-macrophage colony-stimulating factor and interleukin-8 release in A549 human airway epithelial cells stimulated with interleukin-1beta., J Microbiol Immunol Infect
    Caproni et al., 1995, Pharmacologic modulation by cetirizine of some adhesion molecules expression in psoriatic skin lesions., Int. J. Dermatol.

  • TTD: Cetirizine

    • Version: 2020.06.01

    Alternate Names:
    D0DK8V TTD Drug ID

    Drug Info:

    Publications:

  • TTD: AC-170

    • Version: 2020.06.01

    Alternate Names:
    D01JFM TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1000

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21