CETUXIMAB Drug Record
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CETUXIMAB chembl:CHEMBL1201577 ApprovedAntineoplastic
Alternate Names:
CETUXIMAB CMAB009 MOAB C225 CETUXIMAB (GENETICAL RECOMBINATION) ABP-494 IMC-225 C225 ERBITUX CMAB-009 C-225 IMC-C225 ANTI EGFR rxcui:318341 chemidplus:205923-56-4 chembl:CHEMBL1201577 drugbank:00002 Drug Info:
FDA Approval Colorectal cancer (KRAS wild type), Squamous cell carcinoma of the head and neck Drug Class Therapeutic Antibodies Year of Approval 2004 Drug Class antineoplastic agents Pharmaceutical Developer Bristol-Myers Squibb Source Reported Drug Name(s) Cetuximab Drug Class Monoclonal Antibody FDA Approval approved Drug Indications antineoplastic agent Publications:
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Interaction Types & Directionality:
n/a Interaction Info:
combination therapy Cetuximab + PLX4720 combination therapy Vemurafenib + Cetuximab combination therapy Cetuximab + Dabrafenib + SCH772984 PMIDs:
26287849 28363909 28783719 22270724 22281684 24523613 26208524 26916115 27312529 25838391 27002107 25714871 23325582 21163703 20619739 22038996 19773371 23845441 14679157 22180495 21156289 21663470 22356324 12460918 18541894 23406027 21129611 22536370 23470635 23251002 24594804 19018267 22586120 24388723 19010912 24508103 20857202 19537845 21975775 26678033 22448344 25024077 20350999 24163374 19561230 19255327 23031422 22351686 22048237 23833300 24576830 22389471 23020132 22997239 19238210 23524406 22735384 19404918 25370471 24570209 23612012 20630094 23489023 21426297 21639808 20413299 23812671 23614898 22649091 22972589 24396464 24583796 20368568 19001320 24107445 22241789 26619011 24586605 23918947 24354346 21594703 15035987 22663011 23549875 21683865 22805292 23934108 25157968 25989278 20818844 22773810 22608338 21483012 12460919 22743296 12068308 26989027 19603024 27729313 19603018 31566309 19571295 31515458 28972961
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Interaction Types & Directionality:
antibody (inhibitory) antagonist (inhibitory) inhibitor (inhibitory) Interaction Info:
Notes Mechanism of Interaction Epidermal growth factor receptor erbB1 inhibitor Direct Interaction yes PMIDs:
24934779 22270724 26888827 18003960 18794099 24653627 24894453 25623215 26059438 10480573 11408594 10628369 11431346 11752352 10601294 19455431 23948351 20022809 22285168 19692680 23816960 21670455 19096302 18303429 22452895 19692684 20573926 21783417 22452896 17332364 24065731 16258541 15737014 20033049 25923549 26515464 24623981 18227510 16912157 15728811 21531810 24658966 22215752 23816963 20068085 24893891 21430269 22588155 26720284 24729716 25668228 25923550 21194487 24636847 21233402 17653080 19147750 16707764 18089823 16043828 18458038 23242437 2302402 23945392 16204070 16187797 18199554 25157968 22753918 20479403 15118125 15329413 23102728 19922469 15118073 19671738 16115929 15710947 26619011 16011858 23578570 27102076 24063894 24813888 26341921 27149458 25948633 27251290 27207775 24141978 27312529 27216155 26843189 28287083 22152101 29196463
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Interaction Types & Directionality:
n/a Interaction Info:
Clinical Status late trials Pathway activation Variant Effect gain-of-function PMIDs:
20978259 3122217 21398618 19679400 18316791 19075190 23182985 21975775 26812186 19018267 23406027 22734028 19114683 16618717 25157968 21228335 17384584 19255327 26371285 20921462 18794081 16434492 19773371 22392911 16361624 26623049 22407852 24558511 20921465 12460918 2278970 20570890 28179366 28280091 27458141 28632865 19064407 25714871 27002107 24304820 25605843 26715098 25838391 18202412 26341921 27312529 26666244 27897268 26438111 26162609 25210463 25183481 24727325 23324806 23090619 23071293 22537608 25666295 19603018 22722830 28275037 22586653 20956938 19223544 19603024 20619739 18946061 22246397 23404247 25673644 21575616
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Interaction Types & Directionality:
n/a Interaction Info:
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- Version: 20-Jun-2017
Alternate Names:
IMC-C225 Development Name CETUXIMAB Generic Name ERBITUX Trade Name Drug Info:
Drug Class Therapeutic Antibodies FDA Approval Colorectal cancer (KRAS wild type), Squamous cell carcinoma of the head and neck Publications:
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Alternate Names:
CETUXIMAB Primary Drug Name Drug Info:
Drug Class antineoplastic agents Year of Approval 2004 Publications:
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- Version: 25-July-2013
Alternate Names:
IFL Protocol PubChem Drug Name 56842117 PubChem Drug ID Erbitux Drug Trade Name Drug Info:
Drug Class Monoclonal Antibody Source Reported Drug Name(s) Cetuximab Pharmaceutical Developer Bristol-Myers Squibb Publications:
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- Version: January-2014
Alternate Names:
Drug Info:
Drug Indications antineoplastic agent Drug Class monoclonal antibody FDA Approval approved Publications:
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Alternate Names:
C1723 NCI drug code Drug Info:
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- Version: 14-September-2017
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C225 NCI drug code Drug Info:
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C1723 NCI drug code Drug Info:
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- Version: 14-September-2017
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C225 NCI drug code Drug Info:
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CETUXIMAB Primary Drug Name CETUXIMAB Drug Generic Name ERBITUX Drug Trade Name Drug Info:
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D0N5OV TTD Drug ID Drug Info:
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- Version: ChEMBL_27
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- Version: 26-July-2013
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- Version: chembl_23
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